TERASAWA Yuri

写真a

Affiliation

Faculty of Letters （Hiyoshi）

Position

Associate Professor

External Links
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Career 【 Display / hide 】

  • 2011.04
    -
    2014.03

    National Center of Neurology and Psychiatry, Department of Psychophysiology, 研究員

  • 2014.04
    -
    2019.03

    Keio University, Department of Psychology, Faculty of Literature, Assistant Professore

  • 2019.04
    -
    Present

    Keio University, Department of Psychology, Associate Professor

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Academic Background 【 Display / hide 】

  • 2001.04
    -
    2005.03

    Keio University, Faculty of Literature, Department of Psychology

    University, Graduated

  • 2005.04
    -
    2007.03

    Keio University, Graduate School of Human Relations, Department of Psychology

    Graduate School, Completed, Master's course

  • 2007.04
    -
    2010.03

    Keio University, Graduate School of Human Relations, Department of Psychology

    Graduate School, Withdrawal after completion of doctoral course requirements, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 博士(心理学), 慶應義塾大学, Coursework, 2013.02

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Research Areas 【 Display / hide 】

  • Humanities & Social Sciences / Experimental psychology

  • Life Science / Basic brain sciences

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Research Keywords 【 Display / hide 】

  • Interoception

  • Affective neuroscience

  • emotion

  • Neuropsychology

  • Cognitive neuroscience

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Books 【 Display / hide 】

  • Neurocognitive mechanisms of social anxiety and interoception

    Terasawa Y., Umeda S., Island of Reil (Insula) in the Human Brain: Anatomical, Functional, Clinical and Surgical Aspects, 2018.07

  • Island of Reil (Insula) in the Human Brain

    TERASAWA Yuri, UMEDA Satoshi, Springer, 2018.01

    Scope: Neurocognitive Mechanisms of Social Anxiety and Interoception

  • Memory in a Social Context

    Terasawa Yuri, Umeda Satoshi, Springer, 2017.12

    Scope: The impact of interoception on memory

    　View Summary

    <p>Using interoception as a keyword, this chapter has summarized how changes in the internal physical state are encoded and how the processing of interoceptive information affects the memory of episodes and events. Interoceptive information processing is discussed frequently in the context of emotion in psychology. On the other hand, research studies and literature that have examined its relation to episodic memory are rare. However, changes in the internal physical state exist at the foundation of various concepts that have examined its relationship with memory. To understand the relationship more precisely, we focused on the following issues in this chapter: emotional arousal and bodily responses; effects of bodily responses on memory encoding; judgment related to memories and bodily response; and insular cortex and memory consolidation. Throughout the chapter, we presented the possibility that change in the physical state itself plays a role in latently supporting the encoding and recollection process.</p>

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Papers 【 Display / hide 】

  • Paradoxical somatic information processing for interoception and anxiety in alexithymia

    Yuri Terasawa, Kentaro Oba, Yuki Motomura, Ruri Katsunuma, Hiroki Murakami, Yoshiya Moriguchi

    European Journal of Neuroscience （Wiley)  54 （ 11 ） 8052 - 8068 2021.11

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  0953816X

    　View Summary

    The concept of alexithymia has garnered much attention in an attempt to understand the psychological mechanisms underlying the experience of feeling an emotion. In this study, we aimed to understand how the interoceptive processing in an emotional context relates to problems of alexithymia in recognizing self-emotions. Therefore, we prepared experimental conditions to induce emotional awareness based on interoceptive information. As such, we asked participants to be aware of interoception under an anxiety-generating situation anticipating pain, having them evaluate their subjective anxiety levels in this context. High alexithymia participants showed attenuated functional connectivity within their ‘interoception network’, particularly between the insula and the somatosensory areas when they focused on interoception. In contrast, they had enhanced functional connectivity between these regions when they focused on their anxiety about pain. Although access to somatic information is supposed to be more strongly activated while attending to interoception in the context of primary sensory processing, high alexithymia individuals were biased as this process was activated when they felt emotions, suggesting they recognize primitive and unprocessed bodily sensations as emotions. The paradoxical somatic information processing may reflect their brain function pathology for feeling emotions and their difficulty with context-dependent emotional control.

  • Effects of insular resection on interactions between cardiac interoception and emotion recognition

    Terasawa Y., Motomura K., Natsume A., Iijima K., Chalise L., Sugiura J., Yamamoto H., Koyama K., Wakabayashi T., Umeda S.

    Cortex （Cortex)  137   271 - 281 2021.04

    Accepted,  ISSN  00109452

    　View Summary

    The insular cortex is considered an important region for feeling emotions through interoception. Most studies that report the role of the insula in integrating interoception and emotion have used neuroimaging techniques such as functional magnetic resonance imaging (fMRI); however, there are limited neuropsychological studies. The effects of insular lesions on emotion and interoception have not been suitably investigated. In this study, we examined the role of the insular cortex in cardiac interoception and recognizing emotions from facial expressions by comparing them pre- and post-operatively in patients with glial tumors or brain metastases associated with the insular lobe. Although no significant difference in interoceptive accuracy was observed between the two phases, there were significant associations between the changes in interoceptive accuracy and sensitivity to expressions of anger and happiness. An increased error rate in the heartbeat counting task in the post-operation phase was associated with a decreased accuracy in recognizing anger and happiness. Since most patients had left insula lesions, generalizability of the findings to patients with right lesions is a future subject. To the best of our knowledge, this is the first study to examine the change in interoception and emotion after insular resection in humans. The study results indicate that removal of the insula affects the recognition of emotions such as anger and happiness through interoceptive processing.

  • Effect of subconscious changes in bodily response on thought shifting in people with accurate interoception

    Sakuragi M., Shinagawa K., Terasawa Y., Umeda S.

    Scientific Reports （Scientific Reports)  13 （ 1 ）  2023.12

    　View Summary

    Our thought states shift from one state to another from moment to moment. The relationship between the thought shifting and bodily responses is yet to be directly examined. This exploratory study examined the influence of cardiovascular reactivity and interoception—sensing an internal bodily state—on the shifting of thought states. Participants (N = 100, 70 women) completed two tasks: the heartbeat counting task (HCT) and the vigilance task (VT). We assessed their interoceptive accuracy through their performance on the HCT. The VT was a simple sustained attention task in which participants pressed a key when the target stimulus appeared and were asked to report their thoughts. We presented subliminal vibration stimuli to induce alterations in heart rate (i.e., vibration block). Results showed that participants with higher interoceptive accuracy reported more continuation of self-referential thought (about past episodes and future plans regarding themselves) during the vibration block than did those with lower interoceptive accuracy. These results suggest that individuals with higher interoceptive accuracy are more likely to be influenced by their subliminal bodily response, resulting in divergent attention from the task and intermittent self-referential thought.

  • Modulation of heartbeat-evoked potential and cardiac cycle effect by auditory stimuli

    Tanaka Y., Ito Y., Terasawa Y., Umeda S.

    Biological Psychology （Biological Psychology)  182 2023.09

    ISSN  03010511

    　View Summary

    Interoception has been proposed as a factor that influences various psychological processes (Khalsa et al., 2018). Afferent signals from the cardiovascular system vary across cardiac cycle phases. Heartbeat-evoked potentials (HEP) and event-related potentials (ERP) were measured to examine whether interoceptive signals differed between cardiac cycle phases. Simultaneously, participants performed an auditory oddball task in which the timing of the presenting stimulus was synchronized with the heartbeat. Pure tones were presented at 10 ms (late diastole condition), 200 ms (systole condition), or 500 ms after the R wave (diastole condition). Greater HEP amplitudes were observed when the tone was presented during diastole than during systole or late diastole. ERP showed the same tendency: a greater amplitude was observed during diastole than systole or late diastole. These results suggest that the processing of interoception reflected by HEP and exteroception reflected by ERP share attentional resources when both stimuli coincide. When the tone was presented during systole, attention to the internal state decreased compared with when the tone was presented during diastole, and attention was distributed to both exteroception and interoception. Our study suggests that HEP may be considered an indication of a relative amount of resources to process the interoception.

  • Functional connectivity changes between frontopolar cortex and nucleus accumbens following cognitive behavioral therapy in major depression: A randomized clinical trial

    Katayama N., Nakagawa A., Umeda S., Terasawa Y., Shinagawa K., Kikuchi T., Tabuchi H., Abe T., Mimura M.

    Psychiatry Research - Neuroimaging （Psychiatry Research - Neuroimaging)  332 2023.07

    ISSN  09254927

    　View Summary

    Cognitive behavioral therapy (CBT) is a psychotherapy that challenges distorted cognitions; however, the neural mechanisms that underpin CBT remain unclear. Hence, we aimed to assess the treatment-related resting-state functional connectivity (rsFC) changes in the brain regions associated with future thinking and the associations between rsFC changes and clinical improvements. Thirty-eight adult patients with MDD were randomly assigned with equal likelihood to receive 16-week individual CBT or talking control with a 12-month follow-up period. We evaluated the rsFC changes in the frontal regions, nucleus accumbens, amygdala, and limbic structures key to the depression pathophysiology and future thinking with 2 × 2 mixed ANOVA interaction analysis. Pearson's correlation analysis with Bonferroni's correction was also performed to examine the associations with clinical symptoms, such as depression severity and automatic thoughts in follow-up evaluations. Treatment-specific changes include enhancement in frontopolar connectivity with the nucleus accumbens. An increased rsFC was associated with lower negative automatic thoughts postoperatively, together with lower depressive symptoms and higher positive automatic thoughts at follow-up. Conclusively, rsFC changes in the fronto-limbic neural control circuit after CBT, particularly between the frontal pole and nucleus accumbens, may be clinically meaningful functional changes related to the depression recovery process.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • 内受容感覚を媒介とするアロスタシスと感情

    寺澤 悠理, 是木 明宏

    BRAIN and NERVE (医学書院)  75 ( 11 ) 1251 - 1257 2023.11

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Lead author

  • 内受容感覚とアロスタシスからみた精神疾患

    是木 明宏, 寺澤 悠理

    BRAIN and NERVE (医学書院)  75 ( 11 ) 1245 - 1250 2023.11

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work

  • Effects of insular resection on interactions between cardiac interoception and emotion recognition

    Yuri Terasawa and Kazuya Motomura and Atsushi Natsume and Kentaro Iijima and Lushun Chalise and Junko Sugiura and Hiroyasu Yamamoto and Kyohei Koyama and Toshihiko Wakabayashi and Satoshi Umeda

    Cortex (Elsevier {BV})  137   271 - 281 2021.02

    Article, review, commentary, editorial, etc. (scientific journal)

  • Interoception and Mental Health: A Roadmap

    Khalsa, S.S. and Adolphs, R. and Cameron, O.G. and Critchley, H.D. and Davenport, P.W. and Feinstein, J.S. and Feusner, J.D. and Garfinkel, S.N. and Lane, R.D. and Mehling, W.E. and Meuret, A.E. and Nemeroff, C.B. and Oppenheimer, S. and Petzschner, F.H. and Pollatos, O. and Rhudy, J.L. and Schramm, L.P. and Simmons, W.K. and Stein, M.B. and Stephan, K.E. and Van den Bergh, O. and Van Diest, I. and von Leupoldt, A. and Paulus, M.P. and Ainley, V. and Al Zoubi, O. and Aupperle, R. and Avery, J. and Baxter, L. and Benke, C. and Berner, L. and Bodurka, J. and Breese, E. and Brown, T. and Burrows, K. and Cha, Y.-H. and Clausen, A. and Cosgrove, K. and Deville, D. and Duncan, L. and Duquette, P. and Ekhtiari, H. and Fine, T. and Ford, B. and Garcia Cordero, I. and Gleghorn, D. and Guereca, Y. and Harrison, N.A. and Hassanpour, M. and Hechler, T. and Heller, A. and Hellman, N. and Herbert, B. and Jarrahi, B. and Kerr, K. and Kirlic, N. and Klabunde, M. and Kraynak, T. and Kriegsman, M. and Kroll, J. and Kuplicki, R. and Lapidus, R. and Le, T. and Hagen, K.L. and Mayeli, A. and Morris, A. and Naqvi, N. and Oldroyd, K. and Pan{\'e}-Farr{\'e}, C. and Phillips, R. and Poppa, T. and Potter, W. and Puhl, M. and Safron, A. and Sala, M. and Savitz, J. and Saxon, H. and Schoenhals, W. and Stanwell-Smith, C. and Teed, A. and Terasawa, Y. and Thompson, K. and Toups, M. and Umeda, S. and Upshaw, V. and Victor, T. and Wierenga, C. and Wohlrab, C. and Yeh, H.-W. and Yoris, A. and Zeidan, F. and Zotev, V. and Zucker, N.

    Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 3 ( 6 ) 501 - 513 2018

    ISSN  24519030 24519022

  • 感情認識における島皮質の機能

    TERASAWA Yuri

    神経心理学 30 ( 1 ) 61 - 68 2014.03

    Article, review, commentary, editorial, etc. (scientific journal)

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Presentations 【 Display / hide 】

  • TEMPORAL AND AFFECTIVE ORIENTATION OF THOUGHT IN DEPRESSION AND ANXIETY: AN ERP AND HEP STUDY

    Ito, Yuichi, Shibata, Midori, Tanaka, Yuto, Terasawa, Yuri, Umeda, Satoshi

    PSYCHOPHYSIOLOGY, 

    2017.12
    , 

    Poster presentation

  • FEELING CHANGES OF INTERNAL BODILY STATE DURING EMOTIONAL RECOGNITION: AN ERP AND HEP STUDY

    Tanaka, Yuto, Ito, Yuichi, Shibata, Midori, Terasawa, Yuri, Umeda, Satoshi

    PSYCHOPHYSIOLOGY, 

    2017.12
    , 

    Poster presentation

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Investigating the autonomic nervous system function associated with the insular cortex using awake brain mapping

    2021.04
    -
    2024.03

    Nagoya University, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), No Setting

    　View Summary

    本研究では、倫理委員会の承認を得て、島回摘出により自律神経機能がどのように変化するかを解析する。さらに、覚醒下手術中に島皮質を直接刺激し、心電図、心拍数、血圧変化の測定、さらに心拍検出課題を行うことで、島皮質における自律神経機能活動の神経基盤を解明し、自律神経機能の同定と機能温存、経時的な機能回復を目的とした次世代型覚醒下手術法の確立を目標とする。
    島皮質が自律神経と密接に関わることをヒトで検討できる脳神経外科学と、ヒトの感情や自律神経機能を多角的に捉えることができる認知神経科学が、分野融合型の共同研究を行うことは大変意義深いと考える。

  • Somatic symptoms and distortions of emotion and thought: Cognitive neuroscientific approach

    2020.04
    -
    2023.03

    Keio University, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), No Setting

    　View Summary

    我が国における不安神経症の患者数は300万人を超えるとも推定されており，これらの背後にあるメカニズムの解明が，喫緊の社会問題であるといえる．なかでも，身体に病気の症状がないにもかかわらず，病気であるという過度な不安を訴える身体症状症(身体表現性障害)は，実際には相当数の症例が存在するが，その発生メカニズムは十分に理解されていない．その主な原因は，これまでの身体症状症の研究において，「心ー脳ー身体」の三方向から統合的に理解しようとする試みが不十分であった点にある．本研究では，身体レベルの自律神経予測処理機能，内受容感覚の正確さ，思考の歪みに着目し，各要素について詳しく調べる課題を用いて検討する．

  • Exploratory study of the relationship between predictive processing of the autonomic nervous system and symptoms of psychiatric disorders

    2019.06
    -
    2022.03

    Keio University, Grants-in-Aid for Scientific Research, Umeda Satoshi, Grant-in-Aid for Challenging Research (Exploratory), No Setting

    　View Summary

    Interoception, the sense of the internal state of the body, plays an important role in anxiety disorders and other psychiatric disorders, as well as in neurological disorders that cause pain. This effect is likely to occur in situations where anticipatory processing is possible. However, the mechanisms behind these phenomena remain unresolved. We first conducted a study to develop an accurate autonomic index and showed that facial skin blood flow could be an appropriate marker to reflect the fine state of mind. The results of this study may be applied to the treatment of blushing disorder or other anxiety-related disorders. The results of other experiment for the patients with chronic cephalalgia showed that the interoceptive accuracy tended to be lower in the patients, suggesting that it relates to the intensity of pain felt, not the frequency of pain.

  • The effects of menstrual cycle and interoception on emotion recognition and regulation

    2019.04
    -
    2022.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Terasawa Yuri, Grant-in-Aid for Scientific Research (C), Principal investigator

    　View Summary

    Emotions arise from an integrated understanding of interoception and environmental information. However, this process in the brain has not been fully elucidated. In this study, we focused on fluctuations in autonomic nervous system activity during the female menstrual cycle as an example of how changes in internal body states affect emotions in daily life. One participant was asked to participate in the experiment during the follicular and luteal phases, and data were collected for 34 participants. In each experiment, we assessed interoception, autonomic responses, and emotion recognition tendencies. In addition, fMRI imaging was performed at rest and during task performance. Participants who understood the connection between the body and emotions were shown to be potentially more sensitive to changes in their physical physiological state due to fluctuations in their menstrual cycle.

  • Anterior insular cortex stimulation and its effects on emotion recognition

    2018.04
    -
    2022.03

    Nagoya University, Grants-in-Aid for Scientific Research, Wakabayashi Toshihiko, Grant-in-Aid for Scientific Research (B), No Setting

    　View Summary

    ○We assessed emotion processing in a series of patients who had undergone brain tumor resection in the insular lobe. We found that direct electrical stimulation over the anterior insular cortex during awake brain mapping enhanced anger recognition in these patients.
    ○The sensitivity of anger recognition significantly deteriorated, while that of sadness improved, when emotional sensitivity was compared before and after surgery.
    ○We showed that anger recognition is mainly associated with the left insula in a lesion symptom mapping study.

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Courses Taught 【 Display / hide 】

  • PSYCHOLOGY 2

    2024

  • PSYCHOLOGY 1

    2024

  • INTENSIVE SEMINAR: PSYCHOLOGY 4

    2024

  • INTENSIVE SEMINAR: PSYCHOLOGY 3

    2024

  • INTENSIVE SEMINAR: PSYCHOLOGY 2

    2024

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