KEIO RESEARCHERS INFORMATION SYSTEM

Other Affiliation 【 Display / hide 】

Other Affiliation 【 Display / hide 】

• School of Medicine, Vice Dean

• Keio Information Technology Center, Deputy Director

• 教学マネジメント推進センター, Deputy Director

Career 【 Display / hide 】

Career 【 Display / hide 】

• 1991.04

  -

  1992.03

  慶應義塾大学病院内科研修医

• 1996.01

  -

  1998.12

  学術振興会特別研究員(PD)

• 1999.01

  -

  1999.06

  慶應義塾大学医学部助手（医学部）

• 1999.07

  -

  2002.03

  Division of Nephrology, University of Washington Research Fellow

• 2002.04

  -

  2007.03

  慶應義塾大学医学部腎臓内分泌代謝内科助手

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Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 1991

  Keio University, School of Medicine

  University, Graduated

• 1996.03

  Keio University, Graduate School, Division of Medicine, 内科学

  Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• 博士（医学）, Keio University, Coursework, 1996.03

Licenses and Qualifications 【 Display / hide 】

Licenses and Qualifications 【 Display / hide 】

• 医師免許, 1991.05

• 日本内科学会認定内科医, 1996.09

• 労働衛生コンサルタント（保健衛生）, 1998.06

• 日本腎臓学会腎臓専門医, 2003.04

• 日本透析医学会専門医, 2005.04

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Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Life Science / Nephrology (Nephrology)

• 医学教育学

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• 医学教育学

• electrolyte, acid-base disorder

Research Themes 【 Display / hide 】

Research Themes 【 Display / hide 】

• Interprofessional education, 

  2011.04

  -

  Present

• 医学教育学, 

  2011.04

  -

  Present

• electrolyte, acid-base disorder, 

  2002.04

  -

  Present

• development and induction of renal tubular cells, 

  2002.04

  -

  Present

Books 【 Display / hide 】

Books 【 Display / hide 】

• ハルペリン 病態から考える電解質異常

  Kamel S. Kamel、Mitchell L. Halperin著、門川俊明 翻訳, メディカルサイエンスインターナショナル, 2018.06

• なぜパターン認識だけで腎病理は読めないのか?

  MONKAWA TOSHIAKI, 医学書院, 2017.05

• 電解質輸液塾

  MONKAWA TOSHIAKI, 中外医学社, 2013.04

• レジデントのための血液透析患者マネジメント

  MONKAWA TOSHIAKI, 医学書院, 2011.06

• 研究留学術

  MONKAWA TOSHIAKI, 医歯薬出版, 2002.07

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Taurine supplementation improves physical activity level in a hemodialysis patient with mitochondrial disease: a case report

  Yoshida R., Mitsuno R., Nakayama T., Azegami T., Hashiguchi A., Torimitsu T., Yoshimoto N., Hisikawa A., Hagiwara A., Nakamura T., Meguro S., Katsumata M., Endo J., Matsunaga T., Yoshino J., Kanda T., Morimoto K., Monkawa T., Yoshida T., Nakahara J., Yamaguchi S., Hayashi K.

  Cen Case Reports 14 ( 3 ) 366 - 373 2025.06

  　View Summary

  Mitochondrial diseases (MDs) are inherited metabolic disorders that affect multiple organ systems, including the kidneys. Variability in disease onset and phenotypic expression, combined with the absence of specific kidney pathological findings, pose significant challenges in diagnosing MD. Consequently, many undiagnosed cases of MD may exist among patients undergoing dialysis. No effective treatment for mitochondrial nephropathy has been established. We report the case of a 27-year-old female patient who presented with leg edema, nephrotic range proteinuria attributed to focal segmental glomerulosclerosis, and bilateral sensorineural hearing loss. Immunosuppressive therapy failed to achieve remission, resulting in progressive kidney function decline and eventual end-stage kidney disease. At hemodialysis initiation, worsening atypical cardiac function and hypertrophy prompted genetic testing, which identified an MT-TL1 m.3243 A > G mutation and confirmed the diagnosis of MD. After hemodialysis initiation, the patient experienced persistent fatigue and decreased physical activity levels despite dry weight management. Suspected stroke-like symptoms prompted the initiation of taurine supplementation, which significantly improved headache severity, cardiac function, and physical activity levels. This case highlights the therapeutic potential of taurine supplementation in patients with MD undergoing dialysis and the importance of maintaining clinical vigilance for MD across all stages of chronic kidney disease, even without characteristic renal pathological findings of mitochondrial nephropathy.

  • Access to Document (DOI)

• Water and electrolyte abnormalities in novel pharmacological agents for kidney disease and cancer

  Terashita M., Yazawa M., Murakami N., Nishiyama A., Tominaga N., Electrolyte Winter Seminar Collaborative Group , Sumi H., Shimizu H., Shibagaki Y., Ryuge A., Ogata M., Nagahama M., Monkawa T., Kawada K., Hirose K., Fujita Y., Fujimaru T.

  Clinical and Experimental Nephrology 29 ( 5 ) 521 - 533 2025.05

  ISSN  13421751

  　View Summary

  This review article series on water and electrolyte disorders is based on the ‘Electrolyte Winter Seminar’ held annually for young nephrologists in Japan. This is the third article in this series that focuses on water and electrolyte disturbances caused by novel pharmacological agents for kidney disease and cancer. The advent of novel pharmacological agents in cardiorenal medicine and oncology has introduced both therapeutic benefits and challenges in managing medication-induced water and electrolyte disturbances. These medications, including sodium–glucose cotransporter-2 (SGLT2) inhibitors, non-steroidal mineralocorticoid receptor antagonists (ns-MRAs), and immune checkpoint inhibitors (ICIs), significantly impact water and electrolyte homeostasis. SGLT2 inhibitors used widely in diabetes mellitus, heart failure, and chronic kidney disease mitigate hyperkalemia and hypomagnesemia but increase the risk of hypernatremia in patients on fluid restriction. Conversely, they are beneficial for managing hyponatremia in the syndrome of inappropriate antidiuresis (SIAD). ns-MRAs, prescribed for diabetic kidney disease, exhibit a high risk of hyperkalemia, particularly when combined with renin–angiotensin system inhibitors. ICIs, a breakthrough in oncology, frequently induce hyponatremia through immune-related adverse events, such as hypophysitis and non-immune-related adverse events like SIAD. Understanding the pathophysiology of these disturbances and implementing timely interventions, including hormone replacement and water and electrolyte management, is critical for optimizing treatment outcomes.

  • Access to Document (DOI)

• Early Initiation of Icodextrin Reduces Peritoneal Dialysis-Associated Peritonitis Risk: A Retrospective Cohort Study

  Mitsuno R., Nakayama T., Morimoto K., Uchiyama K., Washida N., Kusahana E., Hama E.Y., Tonomura S., Yoshimoto N., Hishikawa A., Hagiwara A., Azegami T., Yoshino J., Monkawa T., Yoshida T., Yamaguchi S., Hayashi K.

  Blood Purification 54 ( 3 ) 174 - 183 2025.04

  ISSN  02535068

  　View Summary

  Introduction: Peritonitis is a common and serious complication of peritoneal dialysis (PD) that leads to its discontinuation and death. Icodextrin (ICO) improves peritoneal ultrafiltration and its early use reduces mortality. However, its effectiveness in reducing PD-associated infections remains to be elucidated. Methods: This retrospective observational study enrolled patients who underwent PD between September 2011 and March 2020. The patients were classified into two groups: those who received ICO at the initiation of PD therapy (early ICO) and those who received ICO later or not at all (late/no ICO) and were followed up from PD induction until PD cessation, death, or 3 years had passed. Results: Of the 82 patients (age, 61 [53–72] years), 21 received early ICO. During follow-up (36 [14–36] months), the incidence of PD-associated peritonitis was 0.17 episodes per patient-year. Log-rank tests indicated that PD-associated peritonitis and tunnel infection (TI)-free survival rates were significantly better with the early use of ICO than with late/no ICO (p = 0.02 and p = 0.01, respectively). The early use of ICO remained significantly associated with decreased incidence of both peritonitis and TI (hazard ratio [HR], 0.19; 95% confidence interval [CI], 0.06–0.69 and HR, 0.10; 95% CI, 0.01–0.78, respectively) using Cox regression analysis adjusted for potential confounders. Conclusion: Beginning ICO administration at the initiation of PD shows promise for mitigating the risks of PD-associated peritonitis and TI.

  • Access to Document (DOI)

• Treatment of hyponatremia: comprehension and best clinical practice

  Sumi H., Tominaga N., Fujita Y., Verbalis J.G., Yazawa M., Terashita M., Shimizu H., Shibagaki Y., Ryuge A., Ogata M., Nagahama M., Monkawa T., Kawada K., Hirose K., Fujimaru T.

  Clinical and Experimental Nephrology 29 ( 3 ) 249 - 258 2025.03

  ISSN  13421751

  　View Summary

  This review article series on water and electrolyte disorders is based on the ‘Electrolyte Winter Seminar’ held annually for young nephrologists in Japan. The seminar features dynamic case-based discussions, some of which are included as self-assessment questions in this series. The second article in this series focuses on treatment of hyponatremia, a common water and electrolyte disorder frequently encountered in clinical practice. Hyponatremia presents diagnostic challenges due to its various etiologies and the presence of co-morbidities that affect water and electrolyte homeostasis. Furthermore, limited evidence, including a lack of robust randomized controlled trials, complicates treatment decisions and increases the risk of poor outcomes from inappropriate management of both acute and chronic hyponatremia. This review provides a comprehensive overview of treatment of hyponatremia for better comprehension and improved clinical practice.

  • Access to Document (DOI)

• Pathophysiology, symptoms, outcomes, and evaluation of hyponatremia: comprehension and best clinical practice

  Sumi H., Tominaga N., Fujita Y., Verbalis J.G., Yazawa M., Terashita M., Shimizu H., Shibagaki Y., Ryuge A., Ogata M., Nagahama M., Monkawa T., Kawada K., Hirose K., Fujimaru T.

  Clinical and Experimental Nephrology 29 ( 2 ) 134 - 148 2025.02

  ISSN  13421751

  　View Summary

  This review article series on water and electrolyte disorders is based on the 'Electrolyte Winter Seminar' held annually for young nephrologists in Japan. The seminar includes lively discussions based on cases, which are also partly included in this series as self-assessment questions. The first article in this series focuses on pathophysiology, symptoms, outcomes, and evaluation of hyponatremia, a common water and electrolyte disorder in clinical practice. Diagnosing the root cause(s) of hyponatremia can be challenging due to various etiologies and co-morbidities that affect water and electrolyte homeostasis, which can result in inappropriate management and worse outcomes in acute and chronic hyponatremia. This review provides an overview of pathophysiology, symptoms, outcomes, and evaluation of hyponatremia for better comprehension and improved clinical practice.

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• Master regulatory factors for regeneration and EMT of kidney tubular cells

  Monkawa, Toshiaki

  科学研究費補助金研究成果報告書 2017

• The direct differentiation method of renal tubular cells by master transcription factors identified from TF-inducible human ES bank

  Monkawa, Toshiaki

  科学研究費補助金研究成果報告書 2015

• An investigation of mechanism of progression of kidney disease using renal tubular cells differentiated from ES/iPS cells

  Monkawa, Toshiaki

  科学研究費補助金研究成果報告書 2014

• Mechanism of regeneration of renal tubular cells and differentiation from ES and iPS cells to renal tubular cells

  Monkawa, Toshiaki

  科学研究費補助金研究成果報告書 2011

Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• 慶應義塾大学における海外施設での臨床実習プログラム

  MONKAWA TOSHIAKI

  第49回日本教育学会大会, 

  2017.08

  , 

  Oral presentation (general)

• もう一度やり直す腎生理

  MONKAWA TOSHIAKI

  第46回日本腎臓学会東部学術大会, 

  2016.10

  , 

  Symposium, workshop panel (public)

• タブレット端末iPad配付と教学システムのデジタル化

  MONKAWA TOSHIAKI

  第48回日本教育学会大会, 

  2016.07

  , 

  Oral presentation (general)

• 腎臓専門医制度 腎臓専門医(内科)のカリキュラム

  MONKAWA TOSHIAKI

  第59回日本腎臓学会学術大会, 

  2016.06

  , 

  Symposium, workshop panel (public)

• K代謝異常

  MONKAWA TOSHIAKI

  第25回臨床内分泌代謝アップデート, 

  2015.11

  , 

  Symposium, workshop panel (nominated)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• Master regulatory factors for regeneration and EMT of kidney tubular cells

  2015.04

  -

  2018.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

Awards 【 Display / hide 】

Awards 【 Display / hide 】

• Best Teacher

  2015.03, Keio University School of Medicine

• 日本内科学会奨励賞

  MONKAWA TOSHIAKI, 2004.04, 日本内科学会

  Type of Award： Award from Japanese society, conference, symposium, etc.

Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• SYMPTOMATOLOGY

  2025

• PATHOPHYSIOLOGICAL ISSUES IN CHRONIC CARE

  2025

• MEDICAL PROFESSIONALISM 4

  2025

• MEDICAL PEDAGOGY: SEMINAR

  2025

• MEDICAL PEDAGOGY: PRACTICE

  2025

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Courses Previously Taught 【 Display / hide 】

Courses Previously Taught 【 Display / hide 】

• 選択臨床実習

  Keio University

  2017.04

  -

  2018.03

  , 

  Full academic year, Laboratory work/practical work/exercise

• 診断学実習

  Keio University

  2017.04

  -

  2018.03

  , 

  Full academic year, Laboratory work/practical work/exercise, Within own ｆaculty

• 地域基盤型臨床実習

  Keio University

  2017.04

  -

  2018.03

  , 

  Full academic year, Laboratory work/practical work/exercise, Within own ｆaculty, 110people

• CLINICAL REASONING

  Keio University

  2015.04

  -

  2016.03

  , 

  Full academic year, Laboratory work/practical work/exercise, Within own ｆaculty, 118people

• CLINICAL TRAINING IN DIAGNOSIS

  Keio University

  2015.04

  -

  2016.03

  , 

  Full academic year, Laboratory work/practical work/exercise, Within own ｆaculty, 118people

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Educational Activities and Special Notes 【 Display / hide 】

Educational Activities and Special Notes 【 Display / hide 】

• なぜパターン認識だけで腎病理は読めないのか?

  2017.05

  , Development of Textbook and Teaching Material

• Denkaishitsu-Yueki-Juku

  2013.04

  , Development of Textbook and Teaching Material

• Management of hemodialysis patient for residents

  2011.06

  , Development of Textbook and Teaching Material

• Interprofessional education at Keio University

  2011.04

  -

  Present

  , Special Affairs

Social Activities 【 Display / hide 】

Social Activities 【 Display / hide 】

• 医学中央雑誌

  2010

  -

  Present

• 医学のあゆみ

  2007

  -

  Present

Memberships in Academic Societies 【 Display / hide 】

Memberships in Academic Societies 【 Display / hide 】

• 日本腎臓学会, 

  1995.11

  -

  Present

• 日本透析医学会

  　

• 日本内科学会

  　

• 日本医学教育学会, 

  2008

  -

  Present

Committee Experiences 【 Display / hide 】

Committee Experiences 【 Display / hide 】

• 2024.07

  -

  Present

  理事, 日本医学教育学会

• 2020.06

  -

  Present

  理事, 日本腎臓学会

• 1995.11

  -

  Present

  評議員, 日本腎臓学会

• 2008

  -

  Present

  representative, 日本医学教育学会

• 2010

  -

  Present

  Editor, 医学中央雑誌

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