Shimazaki, Takuya



School of Medicine, Department of Physiology (Shinanomachi)


Associate Professor

E-mail Address

E-mail address

External Links

Academic Degrees 【 Display / hide

  • 博士(医学), 東京大学大学院医学系研究科, Coursework, 1995.03


Research Areas 【 Display / hide

  • Neurophysiology / General neuroscience

  • Developmental biology

Research Keywords 【 Display / hide

  • Neural Development

  • Neural Stem Cell

  • Central Nervous System Regeneration


Papers 【 Display / hide

  • Current understanding of adult neurogenesis in the mammalian brain: How does adult neurogenesis decrease with age?

    Kase Y., Kase Y., Shimazaki T., Okano H.

    Inflammation and Regeneration (Inflammation and Regeneration)  40 ( 1 )  2020.06

     View Summary

    © 2020 The Author(s). Adult neurogenesis occurs throughout life in restricted brain regions in mammals. However, the number of neural stem cells (NSCs) that generate new neurons steadily decreases with age, resulting in a decrease in neurogenesis. Transplantation of mesenchymal cells or cultured NSCs has been studied as a promising treatment in models of several brain injuries including cerebral infarction and cerebral contusion. Considering the problems of host-versus-graft reactions and the tumorigenicity of transplanted cells, the mobilization of endogenous adult NSCs should be more feasible for the treatment of these brain injuries. However, the number of adult NSCs in the adult brain is limited, and their mitotic potential is low. Here, we outline what we know to date about why the number of NSCs and adult neurogenesis decrease with age. We also discuss issues applicable to regenerative medicine.

  • Involvement of p38 in Age-Related Decline in Adult Neurogenesis via Modulation of Wnt Signaling

    Kase Y., Otsu K., Shimazaki T., Okano H.

    Stem Cell Reports (Stem Cell Reports)  12 ( 6 ) 1313 - 1328 2019.06

    ISSN  22136711

     View Summary

    © 2019 The Author(s) Neurogenesis in specific brain regions in adult mammals decreases with age. Progressive reduction in the proliferation of neural stem and progenitor cells (NS/PCs) is a primary cause of this age-associated decline. However, the mechanism responsible for this reduction is poorly understood. We identify p38 MAPK as a key factor in the proliferation of neural progenitor cells (NPCs) in adult neurogenic niches. p38 expression in adult NS/PCs is downregulated during aging. Deletion of p38α in NS/PCs specifically reduces the proliferation of NPCs but not stem cells. Conversely, forced expression of p38α in NS/PCs in the aged mouse subventricular zone (SVZ) restores NPC proliferation and neurogenesis, and prevents age-dependent SVZ atrophy. We also found that p38 is necessary for suppressing the expression of Wnt antagonists DKK1 and SFRP3, which inhibit the proliferation of NPCs. Age-related reduction in p38 thus leads to decreased adult neurogenesis via downregulation of Wnt signaling. Kase et al. show that p38 expression in neural stem and progenitor cells (NS/PCs) in the adult brain decreases with aging. This reduction specifically causes proliferation defect in neural progenitor cells (NPCs), leading to the age-dependent decline of adult neurogenesis. Conversely, overexpression of p38α in NS/PCs in the aged brain restores NPC proliferation without exhaustion of neural stem cells.

  • Vertebrate Neural Stem cells: Development, Plasticity and Regeneration.


    The Keio Journal of Medicine 65 ( 1 ) 1 - 15 2016.02

    Research paper (scientific journal), Single Work, Accepted

  • Heterochronic microRNAs in temporal specification of neural stem cells: application toward rejuvenation.


    NPJ Aging and Mechanisms of Diseases 2   15014 2016.01

    Research paper (scientific journal), Joint Work, Accepted

  • MicroRNA-153 Regulates the Acquisition of Gliogenic Competence by Neural Stem Cells

    Tsuyama, Jun,Bunt, Jens, Richards, Linda J, Iwanari, Hiroko, Mochizuki, Yasuhiro, Hamakubo, Takao, Shimazaki, Takuya, Okano, Hideyuki

    Stem Cell Reports 5 ( 3 ) 365 - 377 2015.09

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  2213-6711

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • Biology and clinical application of neural stem cells

    Shimazaki, T

    HORMONE RESEARCH 60   1 - 9 2003

    Introduction and explanation (international conference proceedings), Single Work,  ISSN  0301-0163

  • Isolation and transplantation of dopaminergic neurons and neural stem cells

    Okano, H, Yoshizaki, T, Shimazaki, T, Sawamoto, K

    PARKINSONISM & RELATED DISORDERS 9 ( 1 ) 23 - 28 2002.10

    Introduction and explanation (scientific journal), Joint Work,  ISSN  1353-8020

Presentations 【 Display / hide

  • 神経幹細胞の分化に及ぼす外傷性脳損傷後の炎症性サイトカインの影響

    '並木淳, 島崎琢也, 鈴木さゆり, 岡野栄之'

    第27回日本神経外傷学会 (東京) , 2004.03, Oral Presentation(general)

  • ES細胞を利用した神経再生の可能性

    '島崎琢也, 岡野栄之'

    第3回日本再生医療学会総会・シンポジウム (千葉) , 2004.03, Oral Presentation(guest/special)

  • 骨髄由来の神経幹細胞選択的nestin遺伝子発現細胞

    '並木淳, 島崎琢也, 松崎有未, 鈴木さゆり, 岡野栄之'

    第3回日本再生医療学会総会 (千葉) , 2004.03, Poster (general)

  • 比較ゲノム情報学を用いたIslet-1遺伝子の神経細胞サブタイプ特異的発現機構の解明

    '植村修, 岡田洋平, 安藤秀樹, Guedj Mikael, 東島眞一, 島崎琢也, 千野直一, 岡野栄之, 岡本仁'

    第26回日本分子生物学会年会 ('Kobe, Japan') , 2003.12, Oral Presentation(general)

  • O3K-8 Galectin-1is a key regulator of Neural Stem Cell proliferation

    'Sakaguchi Masanori, Ishibashi Satoru, Kuroiwa Toshihiko, Mieko Shiwa, Wakatabe Rumi, Fukase Yu, Kadoya Toshihiko, Osawa Mitsujiro, Kaneko Shin, Shimazaki Takuya, Sawamoto Kazunobu, Okano James Hirotaka, Kitamura Toshio, Horie Hidenori, Mizusawa Hidehiro, Nakauchi Hiromitsu, Okano Hideyuki'

    第26回日本分子生物学会年会 ('Kobe, Japan') , 2003.12, Poster (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • Transcription factors regulating temporal specification of neuronal subtypes.


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 島崎 琢也, Grant-in-Aid for Scientific Research on Innovative Areas, Principal Investigator

  • Regulatory mechanisms of aging of adult neural stem/progenitor cells via p38 MAPK


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 島崎 琢也, Grant-in-Aid for Scientific Research (C), Principal Investigator

  • Mechanisms of glial development


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 島崎 琢也, Grant-in-Aid for Scientific Research (C), Principal Investigator


Courses Taught 【 Display / hide











Courses Previously Taught 【 Display / hide

  • 再生・遺伝子の科学

    Keio University, 2015, Autumn Semester

  • 生理学II

    Keio University, 2015, Autumn Semester, Major subject, Laboratory work/practical work/exercise

  • 生理学II

    Keio University, 2015, Spring Semester, Major subject, Lecture

  • 生理学II

    Keio University, 2014, Spring Semester, Major subject, Lecture

  • 生理学II

    Keio University, 2013, Spring Semester, Major subject, Lecture

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