KEIO RESEARCHERS INFORMATION SYSTEM

Profile 【 Display / hide 】

Profile 【 Display / hide 】

• 2003 - Today Professor, School of Medicine, Keio University 2002 - 2003 Associate Professor, St. Jude Children's Research Hospital 1995 - 2002 Assistant Professor, St. Jude Children's Research Hospital 1993 - 1995 HFSP long-term fellow, Roche Institute for Molecular Biology 1989 - 1993 JSPS fellow, Jichi Medical School

Career 【 Display / hide 】

Career 【 Display / hide 】

• 2003.04

  -

  Present

  Keio University, School of Medicine, Dept Physiology, Professor

Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 1985.03

  Jichi Medical University, Faculty of Medicine, 医学科

  University, Graduated

• 1993.03

  Jichi Medical University, Graduate School, Division of Medicine, Neuroscience

  Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• 医学博士, Jichi Medical University, Coursework, 1993.03

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Life Science / Neuroscience-general (General Neuroscience)

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• glutamate receptor

• synaptic plasticity

• synapse formation

• cerebellum

Research Themes 【 Display / hide 】

Research Themes 【 Display / hide 】

• Functional and morphological synaptic plasticity underlying learning and memory, 

  2003.04

  -

  Present

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• The C-terminal juxtamembrane region of the δ2 glutamate receptors controls its export from the endoplasmic reticulum

  'MATSUDA SHINJI, HANNEN ROSALIND, MATSUDA KEIKO, YAMADA NOBUAKI, TUBBS THOMAS, YUZAKI MICHISUKE'

  European Journal of Neuroscience 19   1683-1690 2004.02

  Research paper (scientific journal), Joint Work, Accepted

• Specific assembly with NR3B subunit controls surface expression and calcium permeability of NMDA receptors.

  'MATSUDA KEIKO, FLETCHER MATT, KAMIYA YOSHINORI, YUZAKI MICHISUKE'

  Journal of Neuroscience  （ 23 ） 10064-10073 2003

  Research paper (scientific journal), Joint Work

• Novel role of δ2-glutamate receptors in AMPA receptor trafficking and cerebellar learning

  'HIRAI HIROKAZU, LAUNEY, THOMAS, MIKAWA SUMIKO, TORASHIMA TAKASHI, YANAGIHARA DAY, KASAURA TSUYOSHI, MIYAMOTO AKIHIRO, YUZAKI MICHISUKE'

  Nature Neuroscience  （ 6 ） 869-876 2003

  Research paper (scientific journal), Joint Work

• A hot spot for hotfoot mutations in the gene encoding δ2 glutamate receptor.

  'WANG YING, MATSUDA SHINJI, DREWS VALERIE, TORASHIMA TAKASHI, MEISLER MIRIAM H., YUZAKI MICHISUKE'

  European Journal of Neuroscience  （ 17 ） 1581-1590 2003

  Research paper (scientific journal), Joint Work

• New insights into the structure and function of glutamate receptors - The orphan receptor δ2 reveals its family’s secrets.

  YUZAKI MICHISUKE

  The Keio Journal of Medicine  （ 52 ） 92-99 2003

  Research paper (scientific journal), Single Work

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• Analysis of novel synapse organizers which underlie cerebellar synapse circuits and motor memory

  Yuzaki, Michisuke

  科学研究費補助金研究成果報告書 2019

• Regulation of synapse formation, maintenance, elimination and plasticity by C1q family proteins

  Yuzaki, Michisuke

  科学研究費補助金研究成果報告書 2019

• A novel role of adhesion-GPCR in synaptic functions and motor learning.

  Yuzaki, Michisuke

  科学研究費補助金研究成果報告書 2017

• Application of epitope-tag insertion for the analysis of synaptic molecules splicing isoform expressions in the brain

  Yuzaki, Michisuke

  科学研究費補助金研究成果報告書 2017

• Analysis of novel C1q-family proteins that regulate functional synaptic circuits and memory.

  Yuzaki, Michisuke

  科学研究費補助金研究成果報告書 2016

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Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• La Dolce Vita of Neurexin: Synaptic Partnerships through Glycosaminoglycans

  Suzuki K., Yuzaki M.

  Cell (Cell)  174 ( 6 ) 1337 - 1338 2018.09

  ISSN  00928674

  　View Summary

  © 2018 Elsevier Inc. Various neurexin transcripts are thought to serve as presynaptic “hub” molecules by binding to their specific synaptic partners. In this issue, Zhang et al. demonstrate that neurexins are heparan sulfate (HS) proteoglycans and that the HS modification is important for synaptic function in vitro and in vivo. These findings open up the possibility of many more binding partners for the neurexins. Various neurexin transcripts are thought to serve as presynaptic “hub” molecules by binding to their specific synaptic partners. In this issue, Zhang et al. demonstrate that neurexins are heparan sulfate (HS) proteoglycans and that the HS modification is important for synaptic function in vitro and in vivo. These findings open up the possibility of many more binding partners for the neurexins.

  • Access to Document (DOI)

Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• Molecules controlling synapse structure and plasticity: Casting new light on two old molecules GluRδ2 and cerebellin

  YUZAKI MICHISUKE

  Neurobiology Seminar Program at UAB ('Birmingham, AL, USA') , 

  2003.03

  , 

  Oral presentation (invited, special)

• The δ2 glutamate receptor and the Lurcher mutant: what happens when a good receptor goes bad?

  YUZAKI MICHISUKE

  Spring Brain Conference 2004 ('Senoda, AZ, USA') , 

  2003.03

  , 

  Oral presentation (invited, special)

Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• 細胞外足場タンパク質によるシナプス・非シナプス機能制御機構の解明

  2020.07

  -

  2025.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Specially Promoted Research, Principal investigator

• Regulation of synaptic and non-synaptic functions by extracellular scaffolding proteins

  2020.04

  -

  2025.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A) , Principal investigator

• Dynamic regulation of cerebellar neural circuits by "scrap and build" mechanisms

  2016.06

  -

  2021.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas, Principal investigator

• 補体ファミリー分子によるシナプス形成・維持・除去と可塑性制御機構の解明

  2016.04

  -

  2021.03

  Grant-in-Aid for Scientific Research, Principal investigator

• Bridge over troubled synapses: synthetic extracellular protein scaffolds for neuronal connectivity

  2014.06

  -

  2017.12

  Human Frontier Science Program, Research grant, Principal investigator

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Works 【 Display / hide 】

Works 【 Display / hide 】

• 学務委員会委員

  2003.10

  -

  2005.09

  , 

  Other

Awards 【 Display / hide 】

Awards 【 Display / hide 】

• Science and Technology Award

  2012

  Type of Award： Other

• Tokizane Memorial Prize

  2012

  Type of Award： Award from publisher, newspaper, foundation, etc.

• 三四会北里賞

  YUZAKI MICHISUKE, 2005

  Type of Award： Keio commendation etc.

Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• PHYSIOLOGY: SEMINAR

  2024

• PHYSIOLOGY: PRACTICE

  2024

• PHYSIOLOGY 1

  2024

• PHYSIOLOGY

  2024

• HUMAN ANATOMY AND PHYSIOLOGY

  2024

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Social Activities 【 Display / hide 】

Social Activities 【 Display / hide 】

• Cerebellum誌

  2006

  -

  Present

• Frontiers in Molecular Neuroscience誌

  2008

  -

  Present

• European Journal of Neuroscience誌

  2008

  -

  Present

• Journal of Physiology

  2015

  -

  Present

• Neuroscience Research

  2009

  -

  Present

Memberships in Academic Societies 【 Display / hide 】

Memberships in Academic Societies 【 Display / hide 】

• 日本生理学会, 

  2008

  -

  Present

• 日本生理学会, 

  2008

  -

  Present

• 日本神経科学学会, 

  2008

  -

  Present

• 日本神経科学学会, 

  2006

  -

  Present

• 日本生理学会, 

  2007

  -

  2008

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Committee Experiences 【 Display / hide 】

Committee Experiences 【 Display / hide 】

• 2008

  -

  Present

  常任幹事, 日本生理学会

• 2008

  -

  Present

  生理学用語委員, 日本生理学会

• 2008

  -

  Present

  理事, 日本神経科学学会

• 2008

  -

  Present

  Director, 日本神経科学学会

• 2006

  -

  Present

  ホームページ編集小委員会委員長, 日本神経科学学会

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