Takebayashi, Toru

写真a

Affiliation

School of Medicine, Department of Preventive Medicine and Public Health （Shinanomachi）

Position

Professor

Related Websites

External Links
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Academic Background 【 Display / hide 】

  • 1983.04
    -
    1989.03

    Keio University, 医学部

    University, Graduated

  • 1989.04
    -
    1993.03

    Keio University, 医学研究科

    Graduate School, Completed, Doctoral course

  • 1993.09
    -
    1994.06

    Harvard Uuniversity, School of Public Health, Master of Public Health

    United States, Graduate School, Completed, Master's course

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Academic Degrees 【 Display / hide 】

  • Master of Public Health, Harvard University, Coursework

  • Master of Public Health, Harvard University, Coursework, 1994.06

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Licenses and Qualifications 【 Display / hide 】

  • 医師免許, 1989

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Research Areas 【 Display / hide 】

  • Life Science / Medical management and medical sociology

  • Life Science / Hygiene and public health (laboratory)

  • Life Science / Hygiene and public health (non-laboratory)

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Research Keywords 【 Display / hide 】

  • 予防医学

  • 環境と健康

  • 疫学

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Books 【 Display / hide 】

  • からだの科学増刊 これからの保健師

    榎悦子，武林亨, 東京：日本評論社, 2006.09

    Scope: 90-94

  • 職業・環境がんの疫学：低レベル曝露でのリスク評価

    山口直人，　武林亨，　菊池有利子，　秋葉澄伯, 東京：篠原出版新社, 2004.02

    Scope: 59-70

  • 管理栄養士講座　公衆衛生学

    武林亨, 東京：建帛社, 2003.05

    Scope: 203-207

  • 管理栄養士講座　公衆衛生学

    武林亨, 東京：建帛社, 2003.05

    Scope: 191-192

  • 管理栄養士講座　公衆衛生学

    武林亨, 東京：建帛社, 2003.05

    Scope: 216-217

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Papers 【 Display / hide 】

  • Association between visual classification of kyphosis and future ADL decline in community-dwelling elderly people: the Kurabuchi study

    Sugai K., Michikawa T., Takebayashi T., Matsumoto M., Nakamura M., Nishiwaki Y.

    Archives of Osteoporosis （Archives of Osteoporosis)  14 （ 1 ）  2019.12

    ISSN  18623522

    　View Summary

    © 2018, The Author(s). Summary: This cohort study conducted in Japan showed that severe age-related kyphosis was visually detected. The visual assessment of kyphosis was associated with declines in ADL, suggesting that we can easily identify people at high risk to develop future ADL reduction in the community setting. Purpose: Age-related kyphosis is related with declines in activities of daily living (ADL). Its conventional diagnosis has been made by orthopedic surgeons and trained examiners using specialized equipment such as X-rays. We investigated whether visual classification of kyphosis by laypersons accurately predicted future ADL decline. Methods: This study was part of the Kurabuchi Study, a cohort study of community-dwelling elderly Japanese. Between 2009 and 2010, three layperson raters used reference illustrations to classify 532 participants without ADL decline at study baseline into four categories. Other examiners used conventional methods to assess kyphosis in the same participants: curve ruler, Spinal Mouse, and the block method. ADL decline was defined as the development of dependence according to the Katz Index, admission to a nursing home, or certification of long-term care need. Results: Thirty-five of the participants (6.6%) were classified with the most severe degree of kyphosis at baseline by visual assessment. Interrater agreement was high (Kappa = 0.73) for the most severe group. During 4.5 years of follow-up, 106 participants (19.9%) showed ADL decline. On the basis of visual assessment, the adjusted risk ratio for ADL decline among the participants with the most severe kyphosis was 2.6 (95% CI: 1.4–4.6). Assessments of kyphosis made with the Spinal Mouse also accurately predicted ADL decline. Conclusions: Visual assessment of kyphosis predicted future declines in ADL in this study. Since our method requires no special tools or training, it may be useful for identifying those at high risk of ADL decline.

  • Association of blood pressure with estimates of 24-h urinary sodium and potassium excretion from repeated single-spot urine samples

    Thi Minh Nguyen T., Miura K., Tanaka-Mizuno S., Tanaka T., Nakamura Y., Fujiyoshi A., Kadota A., Tamaki J., Takebayashi T., Okamura T., Ueshima H.

    Hypertension Research （Hypertension Research)  42 （ 3 ） 411 - 418 2019.03

    ISSN  09169636

    　View Summary

    © 2018, The Japanese Society of Hypertension. While the association between 24-h urinary sodium and potassium excretion with blood pressure is well established, the relationships of these ions to spot urine measurements are unclear. Our purpose is to assess the association between blood pressure and the estimated 24-h sodium and potassium excretion from repeated single-spot urine samples. Spot urine and blood pressure were collected annually during a 5-year period from 4360 Japanese workers with ages ranging from 19 to 55 years. Estimates of 24-h sodium and potassium excretion were based on Tanaka’s formula. Overall, a single standard deviation increase in the estimated sodium excretion (36.5 mmol/day) was associated with a 1.3 mmHg higher systolic blood pressure and a 0.8 mmHg higher diastolic blood pressure (P < 0.001). A single standard deviation increase in estimated potassium excretion (8.9 mmol/day) was associated with a 1.1 mmHg lower systolic blood pressure and a 0.7 mmHg lower diastolic blood pressure (P < 0.001). As a combined measure of the excretion of both electrolytes, the estimated 24-h sodium-to-potassium ratio was positively associated with both blood pressures (P < 0.001). Associations of blood pressure with sodium and the sodium-to-potassium ratio increased with age and were stronger in men compared to women. Associations with potassium and the sodium-to-potassium ratio were stronger in individuals who were overweight. The findings provide evidence for an association between blood pressure and the estimated 24-h sodium and potassium excretion from repeated single-spot urine samples. As convenient measures of dietary intake for each electrolyte, repeated spot urine samples may be useful for assessing hypertension risk, especially in men, older individuals, and overweight individuals.

  • Does social interaction influence the effect of cognitive intervention program? A randomized controlled trial using Go game

    Iizuka A., Suzuki H., Ogawa S., Kobayashi-Cuya K., Kobayashi M., Inagaki H., Sugiyama M., Awata S., Takebayashi T., Fujiwara Y.

    International Journal of Geriatric Psychiatry （International Journal of Geriatric Psychiatry)  34 （ 2 ） 324 - 332 2019.02

    ISSN  08856230

    　View Summary

    © 2018 The Authors. International Journal of Geriatric Psychiatry Published by John Wiley & Sons Ltd. Objectives: The purpose of this study is to clarify the influence of social interaction on the effect of a cognitive intervention program using Go. Methods: A single-blind, randomized controlled trial using a classical board game “Go” was conducted. A total of 72 community-dwelling older adults, without previous experience playing Go, were randomly assigned to three groups: (1) a face-to-face group (FG) in which members attended 12 Go group lessons held once a week; (2) a non-face-to-face group (NFG) in which members individually underwent the same Go lessons as the FG using a tablet computer; or (3) a health education control group (CG). The main outcome variable, working memory, was assessed before and after the interventions using the Visual Memory Span Test (VMST) and the Visual Memory Span Backward (VMSB) task. Go performance and additional cognitive domains were also examined. Results: Analysis of covariance revealed that VMST scores significantly improved after the intervention in both the FG and NFG (both P <.05). Compared with the CG, the effect size of the FG (Cohen's d = 0.89) was greater than that of the NFG (Cohen's d = 0.67). Although VMSB scores significantly improved after the intervention in the FG (P <.05), no significant changes were observed in other groups. Conclusions: This study showed that Go game could improve visual working memory regardless of social interaction. Furthermore, findings suggested that playing board games face-to-face with others is more effective for cognitive function than playing alone.

  • Biological monitoring of o-toluidine in urine pretreated by an enzymatic deconjugation method

    Eitaki Y., Nakano M., Kawai T., Omae K., Takebayashi T.

    Journal of Occupational Health （Journal of Occupational Health)   2019

    ISSN  13419145

    　View Summary

    © 2019 The Authors. Journal of Occupational Health published by John Wiley & Sons Australia, Ltd on behalf of The Japan Society for Occupational Health Objectives: To establish an enzymatic deconjugation method to separately quantify urinary o-toluidine (OT), its six metabolites, another six chemicals present in an OT-processing plant, and one metabolite of p-toluidine, and to propose optimal urinary biological monitoring items of OT exposure. Methods: Thirty-six urine samples of an OT-processing plant's workers were obtained and pretreated by an enzymatic deconjugation method employing β-glucuronidase/arylsulfatase for 3 hours at 37°C and measured by liquid chromatograph-mass spectrometry (LC-MS). An alkaline hydrolytic pretreatment and 1-chlorobutane extraction procedure was also examined as a widely used urinary OT measurement method. Results: The 14 chemicals were separated by LC-MS condition set by us and 13 chemicals other than 2-chloroaniline showed satisfiable linearity and limits of determination. Standard substances of six OT metabolites decomposed after the alkaline heating. In the 36 urine samples, OT, N-(4-hydroxy-2-methylphenyl) acetamide (NHM), and 4-amino-m-cresol (ACR) accounted for approx. 90% of the total OT and OT metabolites, but inter-individual variation of the three substance excretion seemed to be wide. Time course of urinary excretion revealed that concentration of the three substances was higher 24 hours after the work shift's end rather than just after the work shift. Conclusions: OT and its six metabolites can each be determined with LC-MS. The alkaline method is not so optimal for exact biological monitoring. Rather, the sum of urinary OT, NHM, and ACR measured by the enzymatic method is a better index, and "end of the workweek" is a good urine-sampling time for the biological monitoring of OT exposure.

  • Clinical differences between elderly-onset ulcerative colitis and non-elderly-onset ulcerative colitis: A nationwide survey data in Japan

    Komoto S., Higashiyama M., Watanabe C., Suzuki Y., Watanabe M., Hibi T., Takebayashi T., Asakura K., Nishiwaki Y., Miura S., Hokari R.

    Journal of Gastroenterology and Hepatology (Australia) （Journal of Gastroenterology and Hepatology (Australia))  33 （ 11 ） 1839 - 1843 2018.11

    ISSN  08159319

    　View Summary

    © 2018 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd Background and Aim: Studies on the characteristics of elderly-onset ulcerative colitis (EOUC) and non-elderly-onset ulcerative colitis (NEOUC) have reported conflicting findings. The aim of this study was to compare disease characteristics of EOUC and NEOUC by analyzing the database of the Japanese nationwide inflammatory bowel disease (IBD) registry. Methods: We analyzed the age of disease onset, sex, disease severity, and disease extent in patients with ulcerative colitis that were newly diagnosed and registered within 1 year between 2004 and 2009 (n = 28 179). We also analyzed the medical treatment, rate of IBD-related surgery, and postoperative complications. We compared them between younger than 65 years old (NEOUC group) and 65 years old or older (EOUC group) patients. Results: A total of 25 401 (90.1%) and 2778 (9.9%) patients were included in the NEOUC and EOUC groups, respectively. In the EOUC group, disease activity was significantly higher, and extent of pathological changes in the colon more extended significantly. Laboratory findings showed that inflammatory markers were elevated significantly in the EOUC group. The proportion of those with IBD-related hospitalization was significantly higher in the EOUC group (54.2% vs 35.7%, P < 0.001). The proportion of patients who were treated with corticosteroids was significantly higher in the EOUC group (36.7% vs 30.8%, P < 0.001). Significantly more number of patients underwent IBD-related surgery in the EOUC group (0.68% vs 0.27%, P < 0.001). Conclusion: Elderly patients show higher disease activity, with a higher proportion requiring IBD-related hospitalization and IBD-related surgery, according to the nationwide registry in Japan.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

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Presentations 【 Display / hide 】

  • 加齢性難聴に対する聴覚教育・補聴器プログラムの効果に関する地域介入研究　―高齢者の聴力障害の実態について―

    齊藤秀行，水足邦雄，西脇祐司，道川武紘，榎本千江子，武林亨，小川郁

    第53回日本聴覚医学会総会・学術講演会 (東京) , 

    2008.10
    , 

    Oral presentation (general)

  • 加齢性難聴に対する聴覚教育・補聴器プログラムの効果に関する地域介入研究　―高齢者の聴力障害の実態について―

    齊藤秀行，水足邦雄，西脇祐司，道川武紘，榎本千江子，武林亨，小川郁

    第53回日本聴覚医学会総会・学術講演会 (東京) , 

    2008.10
    , 

    Oral presentation (general)

  • 単独ないし複合感覚器障害が高齢者のwell-beingに与える影響

    道川武紘，西脇祐司，菊池有利子，朝倉敬子，石上愛，岩澤聡子，中野真規子，武林亨

    第18回日本疫学会学術総会 (東京) , 

    2008.01
    , 

    Oral presentation (general)

  • 日本人高齢者の皮膚エイジング指標の定量評価と関連するライフスタイル・環境要因の検討

    朝倉敬子，西脇祐司，石上愛，道川武紘，菊池有利子，中野真規子，岩澤聡子，Greg Hillebrand，宮本久喜三，小野雅司，金城芳秀，秋葉澄伯，武林亨

    第18回日本疫学会学術総会 (東京) , 

    2008.01
    , 

    Oral presentation (general)

  • エイジングにおけるDHEA-Sの役割：地域在住高齢者コホート研究より

    西脇祐司，道川武紘，菊池有利子，朝倉敬子，石上愛，岩澤聡子，中野真規子，武林亨

    第18回日本疫学会学術総会 (東京) , 

    2008.01
    , 

    Poster presentation

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Usefulness of metabolite biomarker as a common pathway for the prevention of non-communicable diseases and frailty

    2023.04
    -
    2028.03

    基盤研究(A), Principal investigator

  • Development of risk prediction models for mild cognitive decline and frailty using metabolomics in a population-based cohort

    2018.04
    -
    2023.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A) , Principal investigator

  • 慢性腎臓病の個別化予防実現へ向けたゲノム・メタボローム疫学研究

    2017.06
    -
    2019.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory) , Principal investigator

  • メタボロームワイドな代謝プロファイリングに基づく生活習慣病予防の地域コホート研究

    2015.04
    -
    2019.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

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Works 【 Display / hide 】

  • 入学試験検討委員会委員

    2003.10
    -
    2005.09
    , 

    Other

  • カリキュラム委員会委員

    2003.10
    -
    2005.09
    , 

    Other

  • 入試検討委員会委員

    2001.10
    -
    2003.09
    , 

    Other

  • カリキュラム委員会委員

    2001.10
    -
    2003.09
    , 

    Other

  • カリキュラム委員会委員

    1999.10
    -
    2001.09
    , 

    Other

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Awards 【 Display / hide 】

  • 日本衛生学会奨励賞

    武林亨, 2005.03, 日本衛生学会, 二硫化炭素曝露作業者の健康影響に関するコホート研究

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 日本衛生学会奨励賞

    2005, 二硫化炭素曝露作業者の健康影響に関するコホート研究

  • 日本産業衛生学会奨励賞

    武林亨, 2003.04, 日本産業衛生学会, 疫学手法を用いた2,2-Dichloro-1,1,1-trifluoroethane(HCFC-123)の肝毒性の確立

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 日本産業衛生学会奨励賞

    2003.04, 日本産業衛生学会, 疫学手法を用いた2,2-Dichloro-1,1,1-trifluoroethane (HCFC-123)の肝毒性の確立

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Courses Taught 【 Display / hide 】

  • RESEARCH FRONTIERS IN BIOMEDICAL SCIENCE

    2024

  • PUBLIC HEALTH 2 (ADVANCED)

    2024

  • PUBLIC HEALTH 1 (BASIC)

    2024

  • PROJECT FOR MULTIDISCIPLINARY AND INTERDISCIPLINARY KNOWLEDGE (SUSTAINABLE ENVIRONMENT)

    2024

  • PREVENTIVE MEDICINE AND PUBLIC HEALTH: SEMINAR

    2024

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Courses Previously Taught 【 Display / hide 】

  • Epidemiology and Environmental Health

    Keio University

    2015.04
    -
    2016.03
    , 

    Autumn Semester, Seminar, Within own ｆaculty, 110people

  • Public Health

    Keio University

    2015.04
    -
    2016.03
    , 

    Autumn Semester, Lecture, Within own ｆaculty, 110people

  • public Health Pratice and Management

    Keio University

    2015.04
    -
    2016.03
    , 

    Spring Semester, Lecture

  • Basic Epidemiology

    Keio University

    2015.04
    -
    2016.03
    , 

    Spring Semester, Lecture, Within own ｆaculty

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