Hashiguchi, Akinori

写真a

Affiliation

School of Medicine, Department of Pathology (Shinanomachi)

Position

Assistant Professor/Senior Assistant Professor

External Links
Page Top ▲

Career 【 Display / hide 】

  • 1995.04
    -
    1997.03

    慶應義塾大学医学部, 病理学教室, 慶應義塾大学医学部助手（病理学）

  • 1997.04
    -
    2007.03

    慶應義塾大学医学部, 病理学教室, 慶應義塾大学助手（医学部病理学）

  • 2007.04
    -
    2013.11

    慶應義塾大学医学部, 病理学教室, 慶應義塾大学助教（医学部病理学）

  • 2013.12
    -
    Present

    慶應義塾大学医学部, 病理学教室, 慶應義塾大学専任講師（医学部病理学）

Page Top ▲

Academic Background 【 Display / hide 】

  • 1989.04
    -
    1995.03

    Keio University, School of Meicine

    University, Graduated

Page Top ▲

Academic Degrees 【 Display / hide 】

  • 博士（医学）, Keio University, Dissertation, 2010.11

    Using immunofluorescent digital slide technology to quantify protein expression in archival paraffin-embedded tissue sections

Page Top ▲
 

Research Areas 【 Display / hide 】

  • Life Science / Human pathology

Page Top ▲

Research Keywords 【 Display / hide 】

  • Digital Pathology

  • Renal Pathology

Page Top ▲
 

Papers 【 Display / hide 】

  • DNA damage in proximal tubules triggers systemic metabolic dysfunction through epigenetically altered macrophages

    Nishimura E.S., Hishikawa A., Nakamichi R., Akashio R., Chikuma S., Hashiguchi A., Yoshimoto N., Hama E.Y., Maruki T., Itoh W., Yamaguchi S., Yoshino J., Itoh H., Hayashi K.

    Nature Communications 16 ( 1 ) 3958 2025.12

    Joint Work

    　View Summary

    DNA damage repair is a critical physiological process closely linked to aging. The accumulation of DNA damage in renal proximal tubular epithelial cells (PTEC) is related to a decline in kidney function. Here, we report that DNA double-strand breaks in PTECs lead to systemic metabolic dysfunction, including weight loss, reduced fat mass, impaired glucose tolerance with mitochondrial dysfunction, and increased inflammation in adipose tissues and the liver. Single-cell RNA sequencing analysis reveals expansion of CD11c+ Ccr2+ macrophages in the kidney cortex, liver, and adipose tissues and Ly6C<sup>hi</sup> monocytes in peripheral blood. DNA damage in PTECs is associated with hypomethylation of macrophage activation genes, including Gasdermin D, in peripheral blood cells, which is linked to reduced DNA methylation at KLF9-binding motifs. Macrophage depletion ameliorates metabolic abnormalities. These findings highlight the impact of kidney DNA damage on systemic metabolic homeostasis, revealing a kidney-blood-metabolism axis mediated by epigenetic changes in macrophages.

  • Polyclonal immunoglobulin G deposits with distinctive appearance in the tubular basement membrane: a report of two cases

    Sakamaki Y., Hashiguchi A., Konishi K., Araki T., Tokuyama H.

    BMC Nephrology 26 ( 1 ) 591 2025.12

    Joint Work

    　View Summary

    Background: Tubulointerstitial diseases arise from various etiologies, including infections, medications, autoimmune conditions, and systemic disorders. The histological presentation of the tubulointerstitium in renal biopsies can vary considerably. When tubulointerstitial alterations are identified through light microscopy, additional evaluation with immunofluorescence and electron microscopy may assist in diagnosis. This report describes two slowly progressive atypical cases of tubulointerstitial disease. Renal biopsy in both cases revealed tubular atrophy and interstitial fibrosis with limited inflammatory cell infiltration, along with polyclonal linear immunoglobulin G (IgG) staining pattern along the thickened tubular basement membrane (TBM) and distinctive electron-dense deposits. Case 1: Case presentation: A 65-year-old Japanese man with a history of chronic obstructive pulmonary disease, benign prostatic hyperplasia, and hypertension presented with anorexia and malaise 1 week prior to admission. Blood tests demonstrated marked renal impairment. Renal biopsy findings included relatively preserved glomeruli, widespread tubular atrophy, and significant interstitial fibrosis. Immunofluorescence showed linear deposition of IgG as well as kappa and lambda light chains along the TBM. Complement components C3 was also positive, and C1q were weakly positive. IgG subclass staining revealed positivity for IgG1, IgG2, and IgG4. Electron microscopy revealed electron-dense deposits within the TBM and on the epithelial side of the TBM, exhibiting a mottled and speckled appearance. Case 2: A 52-year-old Japanese man who had undergone allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia developed mild proteinuria and renal dysfunction 7 years after transplant. Renal biopsy indicated thrombotic microangiopathy, with glomeruli showing diffuse mesangial expansion and focal mesangiolysis. There was also diffuse TBM thickening and interstitial fibrosis with scattered cellular infiltration. Immunofluorescence demonstrated linear staining of polyclonal IgG and both light chains along the TBM. C3 was also positive while C1q was negative. IgG subclass staining revealed positivity for IgG1 and IgG4. Electron microscopy again identified electron-dense deposits within the reticulated TBM. Conclusions: These two cases demonstrated linear IgG immunofluorescence and distinctive electron-dense deposits in the TBM characterized by a mottled and speckled pattern. Although the underlying pathophysiological mechanisms remain unclear, further research is necessary to elucidate the nature of this form of tubulointerstitial disease.

  • Human chorionic gonadotropin-positive cystic duct carcinoma with trophoblastic differentiation that exhibited an aggressive clinical course.

    Takemura Y, Matsuda K, Abe Y, Hashiguchi A, Kitago M, Nakano Y, Sonoda K, Kitagawa Y

    BMJ case reports 18 ( 11 )  2025.11

    Joint Work

  • Quantification-based explainable artificial intelligence for deep learning decisions: clustering and visualization of quantitative morphometric features in hepatocellular carcinoma discrimination.

    Takagi G, Takeyama S, Abe T, Hashiguchi A, Sakamoto M, Suzuki K, Yamaguchi M

    Journal of medical imaging (Bellingham, Wash.) 12 ( 6 ) 061407 2025.11

    Joint Work,  ISSN  2329-4302

  • Association Between Urinary Fractional Excretion of Potassium and Proteinuria Remission in Adult Nephrotic Syndrome.

    Yoshida R, Nakayama T, Mitsuno R, Komatsu M, Oshima Y, Iwabuchi S, Itoh T, Matsumoto D, Kusahana E, Hoshi K, Nakamura K, Fujii K, Hara Y, Kawaguchi T, Futatsugi K, Yamaji Y, Tokuyama H, Murakami M, Takimoto C, Matsuda H, Ando T, Hashiguchi A, Kaneko Y, Azegami T, Hayashi K

    Kidney360  2025.10

    Joint Work

display all >>

Page Top ▲

Papers, etc., Registered in KOARA 【 Display / hide 】

Page Top ▲

Reviews, Commentaries, etc. 【 Display / hide 】

  • Erratum: DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation (Cell Reports (2023) 42(4), (S2211124723003133), (10.1016/j.celrep.2023.112302))

    Nakamichi R., Hishikawa A., Chikuma S., Yoshimura A., Sasaki T., Hashiguchi A., Abe T., Tokuhara T., Yoshimoto N., Nishimura E.S., Hama E.Y., Azegami T., Nakayama T., Hayashi K., Itoh H.

    Cell Reports (Cell Reports)  42 ( 5 )  2023.05

    Joint Work

    　View Summary

    (Cell Reports 42, 112302; April 25, 2023) In the originally published version of this article, Figure 4 was accidentally constructed with a duplicate of panel (D) in place of the intended panel (E). The figure has been corrected online. The authors regret this error. [Formula presented] [Formula presented]

  • Minimal Change Disease Associated With Durvalumab

    Toda M.G., Fujii K., Kato A., Yoshifuji A., Komatsu M., Amino Y., Kitazono S., Hashiguchi A., Ryuzaki M.

    Kidney International Reports (Kidney International Reports)  6 ( 10 ) 2733 - 2734 2021.10

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work,  ISSN  24680249

  • IgA腎症のOxford分類と日本分類(組織学的重症度分類)の腎機能予後予測に関する比較

    城 謙輔, 中里 毅, 橋口 明典, 清水 章, 久野 敏, 片渕 律子, 川村 哲也

    日本腎臓学会誌 ((一社)日本腎臓学会)  61 ( 3 ) 394 - 394 2019.05

    Other, Joint Work,  ISSN  0385-2385

  • IgA腎症の生検時の臨床データと病理所見の関連性

    鎌野 千佐子, 清水 章, 城 謙輔, 橋口 明典, 久野 敏, 片渕 律子, 川村 哲也

    日本腎臓学会誌 ((一社)日本腎臓学会)  61 ( 3 ) 395 - 395 2019.05

    Other, Joint Work,  ISSN  0385-2385

  • 前立腺癌の腫瘍局在が診断・治療・予後に及ぼす影響

    松本 一宏, 高松 公晴, 武田 利和, 小坂 威雄, 田中 伸之, 森田 伸也, 水野 隆一, 篠島 利明, 菊地 栄次, 浅沼 宏, 橋口 明典, 陣崎 雅弘, 大家 基嗣

    日本泌尿器科学会総会 ((一社)日本泌尿器科学会総会事務局)  107回   PP1 - 075 2019.04

    Other, Joint Work

display all >>

Page Top ▲

Presentations 【 Display / hide 】

  • Focal global glomerulosclerosis経過中にネフローゼ症候群を発症したMinimal change diseaseの1例

    吉見 公志, 大島 洋一, 圓谷 泰章, 加藤 亜唯, 橋口 明典, 小松 素明

    日本内科学会関東地方会, 

    2025.07
    , 

    日本内科学会-関東地方会

  • 【ヘマトネフロロジー】各疾患と腎障害の相互の病態関連と腎障害に対する治療　原発性マクログロブリン血症の病理と鑑別疾患

    橋口 明典

    腎と透析, 

    2025.07
    , 

    (株)東京医学社

    　View Summary

    ＜文献概要＞はじめに　原発性マクログロブリン血症(Waldenstroemマクログロブリン血症:WM)は,1944年,Jan Goesta Waldenstroemによって,口・鼻腔出血,リンパ節腫大,貧血,血小板減少,赤沈更新,高血漿粘度,骨放射線画像正常,リンパ球優位の骨髄を有した2名の患者について記述されたのが,最初の報告である。現在では,リンパ形質細胞性リンパ腫のサブセットとして,骨髄のリンパ形質細胞性リンパ腫(lymphoplasmacytic lymphoma:LPL)と血中単クローン性免疫グロブリンM(IgM)によって定義される。本稿では,WM血液腫瘍としての鑑別診断と,本疾患によって起こる腎疾患の形態分類について概説したい。

  • DAB染色標本画像の色補正手法による色再現性向上の評価

    阿部 時也, 眞杉 洋平, 橋口 明典, 小笠原 直子, 五十嵐 比菜, 前田 晃宏, 荻野 芳彦, 梶村 陽一, 坂元 亨宇

    日本病理学会会誌, 

    2025.03
    , 

    (一社)日本病理学会

  • 病理診断画像表示用ディスプレイ性能評価への核抽出モデルの適用

    阿部 時也, 眞杉 洋平, 上野 彰久, 河村 大生, 黒川 愛里, 大喜多 肇, 橋口 明典

    日本病理学会会誌, 

    2025.03
    , 

    (一社)日本病理学会

  • 異なるスキャナーで撮影した病理画像に対する核抽出モデルの精度検証

    阿部 時也, 眞杉 洋平, 江本 桂, 橋口 明典, 小笠原 直子, 五十嵐 比菜, 前田 晃宏, 荻野 芳彦, 梶村 陽一, 坂元 亨宇

    日本病理学会会誌, 

    2025.03
    , 

    (一社)日本病理学会

display all >>

Page Top ▲
 

Courses Taught 【 Display / hide 】

  • GENERAL PATHOLOGY

    2025

  • DISEASES OF ORGAN SYSTEMS

    2025

  • GENERAL PATHOLOGY

    2024

  • DISEASES OF ORGAN SYSTEMS

    2024

  • GENERAL PATHOLOGY

    2023

display all >>

Page Top ▲

Courses Previously Taught 【 Display / hide 】

  • 臨床実習（病理診断部）

    Keio University

    2017.04
    -
    2018.03
    , 

    Laboratory work/practical work/exercise

  • 病理学各論（実習）

    Keio University

    2017.04
    -
    2018.03
    , 

    Laboratory work/practical work/exercise

  • 病理学総論（実習）

    Keio University

    2017.04
    -
    2018.03
    , 

    Laboratory work/practical work/exercise

  • 病理学各論（講義）

    Keio University

    2017.04
    -
    2018.03
    , 

    Lecture

  • 病理学各論（講義）

    Keio University

    2016.04
    -
    2017.03
    , 

    Lecture

display all >>

Page Top ▲
 

Memberships in Academic Societies 【 Display / hide 】

  • The Japanese Society of Pathology

    　

  • Japanese Society of Nephrology

    　

  • The Japanese Society of Digital Pathology

    　
Page Top ▲