KEIO RESEARCHERS INFORMATION SYSTEM

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• 免疫関連有害事象(irAE)に対するステロイド中止により筋炎の再燃を繰り返した1例

  大山 宗徳, 関 守信, 松原 四郎, 宮本 和人, 中原 仁, 鈴木 重明

  神経治療学 ((一社)日本神経治療学会)  36 ( 6 ) S277 - S277 2019.10

  ISSN  0916-8443

• Tertiary lymphoid organs in the inflammatory myopathy associated with PD-1 inhibitors

  Matsubara S., Seki M., Suzuki S., Komori T., Takamori M.

  Journal for ImmunoTherapy of Cancer (Journal for ImmunoTherapy of Cancer)  7 ( 1 ) 256 2019.09

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  © 2019 The Author(s). Background: Programmed cell death 1 inhibitors have revolutionized therapy for cancer by their outstanding effectiveness. However, they may cause adverse effects, among which inflammatory myopathy is one of the most disabling. To elucidate its mechanism, we analysed muscle biopsies and compared them with other inflammatory myopathies. Methods: Muscle biopsies from three patients with inflammatory myopathy after treatment with PD-1 inhibitors for cancer were subjected to immunohistochemical and ultrastructural analyses to localize CD8+ cytotoxic cells and markers of lymphoid follicles. For comparison, two cases of polymyositis and one of juvenile dermatomyositis were examined. Results: Nearly identical pathological features were observed in the three cases. In the island-like foci of inflammation, muscle fibers were undergoing degeneration. CD8+ cytotoxic T cells, macrophages, CD4+ cells, and B cells were observed in the foci. CD8+ cells were seen outside and inside the basal lamina of non-necrotic muscle fibers. Lymphoid follicle-like structures with CD21+ follicular dendritic cells were present. The blood vessels in the foci showed features consistent with the high endothelial venules, on which their markers, PNAd and CCL21, were expressed. In polymyositis, blood vessels stained only faintly for PNAd and CCL21, while in juvenile dermatomyositis, in which tertiary lymphoid follicle-like structure was reported in the past, they stained positively. Conclusions: In inflammatory myopathy associated with PD-1 inhibitors, CD8+ cells appear to predominantly destruct muscle fibers. The presence of lymphoid follicle-like structures and expression of PNAd and CCL21 on the endothelial cells suggest the tertiary lymphoid organs are formed, and involved in the leakage of lymphocytes. Thus, in the three cases examined, formation of the tertiary lymphoid organs is likely to play an important role in genesis of the PD-1 myopathy.

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• ニボルマブ投与中に発症した免疫介在性ニューロパチーの3例の臨床像

  岡田 健佑, 山田 哲, 作田 健一, 関 守信, 大木 宏一, 谷口 洋, 中原 仁, 鈴木 重明

  神経免疫学 ((一社)日本神経免疫学会)  24 ( 1 ) 165 - 165 2019.09

  ISSN  0918-936X

• Diagnostic Potential of Multimodal MRI Markers in Atypical Parkinsonian Disorders.

  Seki M, Seppi K, Mueller C, Potrusil T, Goebel G, Reiter E, Nocker M, Kremser C, Wildauer M, Schocke M, Gizewski ER, Wenning GK, Poewe W, Scherfler C

  Journal of Parkinson's disease (Journal of Parkinson's disease)  9 ( 4 ) 681 - 691 2019.08

  ISSN  1877-7171

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  BACKGROUND: The diagnostic potential of multimodal MRI approaches to discriminate among progressive supranuclear palsy (PSP), Parkinson variant of multiple system atrophy (MSA-P) and Parkinson's disease (PD) has not been well investigated. OBJECTIVE: To identify disease-specific neurodegenerative patterns and evaluate the diagnostic accuracy of dedicated MRI, iron concentration (R2*), microstructural integrity (mean diffusivity; MD and fractional anisotropy; FA) as well as volumes were analyzed in patients with PSP, MSA-P and PD. METHODS: 3T MRI of 18 PSP and 16 MSA-P patients were compared with 16 PD patients matched for age and disease duration as well as 21 healthy controls. Statistical parametric mapping (SPM) was applied to objectively identify focal MRI changes throughout the whole-brain. Following dimensionality reduction of significant and multiple comparison-corrected SPM clusters through principal component analysis (PCA), stepwise receiver-operating characteristic curve analysis (ROC) was applied to determine the diagnostic potential of multimodal MRI parameters. RESULTS: PCA revealed two components involving multiple regions identified from SPM analysis. The first component was primarily composed of the mean MD value of the thalamus and the mean MD and FA values of the dentatorubrothalamic tract and the corpus callosum. The second component mainly consisted of mean MD and FA values of the middle cerebellar peduncle. ROC analysis showed 92% of PSP patients were differentiated correctly from MSA-P and PD and 80% of MSA-P patients could be distinguished from PD. CONCLUSION: Multimodal MRI improved the detection of disease-specific neurodegenerative patterns in PSP and MSA-P and highlights its potential to improve the diagnostic accuracy of atypical parkinsonian disorders.

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• 繰り返す重症筋無力症クリーゼに対してエクリズマブが有効であった20代女性例

  岡田 健佑, 関 守信, 鈴木 重明, 中原 仁

  臨床神経学 ((一社)日本神経学会)  59 ( 7 ) 472 - 472 2019.07

  ISSN  0009-918X

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Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• Novel tau tracer, PI 2620, for Alzheimer's disease(AD) and non-AD tauopathies(和訳中)

  手塚 俊樹, 高畑 圭輔, 関 守信, 田渕 肇, 上田 亮, 馬島 恭子, 大山 宗徳, 岡田 健祐, 船木 桂, 山縣 文, 吉崎 崇仁, 中原 理紀, 百田 友紀, 白岩 美花, 柴田 護, 三浦 瑛祐, 陣崎 雅弘, 中原 仁, 三村 將, 伊東 大介

  Dementia Japan ((一社)日本認知症学会)  33 ( 4 ) 513 - 513 2019.10

  ISSN  1342-646X

• 磁化率強調画像におけるswallow tail signのパーキンソン病及び関連疾患診断における有用性

  関 守信, 上田 亮, 手塚 俊樹, 岡田 健佑, 馬島 恭子, 吉崎 崇仁, 中原 仁

  神経治療学 ((一社)日本神経治療学会)  36 ( 6 ) S262 - S262 2019.10

  ISSN  0916-8443

• 抗programmed cell death-1(PD-1)抗体による炎症性ミオパチーの治療と予後

  関 守信, 中原 仁, 鈴木 重明

  神経治療学 ((一社)日本神経治療学会)  36 ( 6 ) S263 - S263 2019.10

  ISSN  0916-8443

• 免疫関連有害事象(irAE)に対するステロイド中止により筋炎の再燃を繰り返した1例

  大山 宗徳, 関 守信, 松原 四郎, 宮本 和人, 中原 仁, 鈴木 重明

  神経治療学 ((一社)日本神経治療学会)  36 ( 6 ) S277 - S277 2019.10

  ISSN  0916-8443

• パーキンソン病ナース　その役割と海外の現状

  関 守信

  神経治療学 ((一社)日本神経治療学会)  36 ( 6 ) S206 - S206 2019.10

  ISSN  0916-8443

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• Functional assessment of the glymphatic system in alpha-synucleinopathy using MRI

  2025.04

  -

  2028.03

  基盤研究(C), Principal investigator

• Evaluation of the glymphatic system in synucleinopathy using MRI

  2022.04

  -

  2025.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, 基盤研究(C), Principal investigator

Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• NEUROANATOMY

  2026

• LECTURE SERIES, INTERNAL MEDICINE (NEUROLOGY)

  2026

• ANATOMY 2 AND EMBRYOLOGY

  2026

• ANATOMY AND EMBRYOLOGY 2

  2026

• ANATOMY

  2026

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