Details of a Researcher

Ihara, Naho

写真a

Affiliation: School of Medicine, Department of Anesthesiology ( Shinanomachi )

Position: Senior Assistant Professor (Non-tenured)/Assistant Professor (Non-tenured)

External Links

https://orcid.org/0000-0001-7914-2199

Scopus Paper Info

Paper Count: 9 Citation Count: 163 h-index: 5

Click to view the Scopus page. The data was downloaded from Scopus API in September 06, 2026, via http://api.elsevier.com and http://www.scopus.com .

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Career 【 Display / hide 】

2013.04

-

Present

慶應義塾大学医学部　, 麻酔学教室, 助教

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Academic Background 【 Display / hide 】

2001.04

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2007.03

慶應義塾大学, 医学部, 医学科

University, Graduated

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Books 【 Display / hide 】

『麻酔科トラブルシューティングAtoZ』

伊原奈帆、橋口さおり, 2022

Scope: 術後に痛みのない管理を希望している．, Contact page： 324-325
『がん性疼痛: 薬の使い方』

伊原奈帆, 2022

Scope: アセトアミノフェン．, Contact page： 19-24
複合性局所疼痛症候群(CRPS)をもっと知ろう－病態・診断・治療から後遺障害診断まで－

Ihara Naho,Tsuzaki Koichi, 全日本病院出版会, 2015.10

Scope: CRPSのペインクリニックにおける治療－早期治療と慢性疼痛対策

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Papers 【 Display / hide 】

人工呼吸管理下にあるCOVID-19肺炎の呼吸困難に高用量静注フェンタニルから低用量静注モルヒネ投与へのスイッチングが有効であった1症例．

1. 伊原奈帆、瀧野陽子、大岸美和子、竹内麻理、阿部晃子、金子健、櫻井洋臣、藤田幸子、長田大雅、橋口さおり、森﨑浩

Palliat Care Res 16 301 - 306 2021

Lead author
Altered functional connectivity associated with time discounting in chronic pain

Wakaizumi K., Jabakhanji R., Ihara N., Kosugi S., Terasawa Y., Morisaki H., Ogaki M., Baliki M.N.

Scientific Reports (Scientific Reports) 9 ( 1 ) 2019.12

　View Summary

Chronic pain (CP) is a global problem extensively associated with an unhealthy lifestyle. Time discounting (TD), a tendency to assign less value to future gains than to present gains, is an indicator of the unhealthy behaviors. While, recent neuroimaging studies implied overlapping neuro mechanisms underlying CP and TD, little is known about the specific relationship between CP and TD in behavior or neuroscience. As such, we investigated the association of TD with behavioral measures in CP and resting-state brain functional network in both CP patients and healthy subjects. Behaviorally, TD showed a significant correlation with meaningfulness in healthy subjects, whereas TD in patients only correlated with pain intensity. We identified a specific network including medial and dorsolateral prefrontal cortex (PFC) in default mode network (DMN) associated with TD in healthy subjects that showed significant indirect mediation effect of meaningfulness on TD. In contrast, TD in patients was correlated with functional connectivity between dorsolateral PFC (DLPFC) and temporal lobe that mediated the effect of pain intensity on TD in patients. These results imply that TD is modulated by pain intensity in CP patients, and the brain function associated to TD is shifted from a medial to lateral representation within the frontal regions.
- Access to Document (DOI)
Effects of prophylactic dexamethasone on postoperative nausea and vomiting in scoliosis correction surgery: a double-blind, randomized, placebo-controlled clinical trial

Wakamiya R., Seki H., Ideno S., Ihara N., Minoshima R., Watanabe K., Sato Y., Morisaki H.

Scientific Reports (Scientific Reports) 9 ( 1 ) 2019.12

　View Summary

Dexamethasone is widely used for postoperative nausea and vomiting (PONV) prophylaxis, but its effect on PONV prevention in paediatric patients is validated only in short minor surgical procedures. In this study, we aimed to determine whether a single dose of dexamethasone reduces PONV in highly invasive surgeries that require opioid-based postoperative analgesia. One hundred adolescents undergoing scoliosis correction surgery were randomized to receive intravenous dexamethasone 0.15 mg/kg (dexamethasone group) or saline (control group) at induction of anaesthesia. The primary outcome was the incidence of PONV in the 72 h postoperatively. Data for 98 patients were available for analysis. The 72-h incidence of PONV was significantly lower in the dexamethasone group than in the control group (62.5% vs 84.0%; RR 0.74, 95% CI 0.58–0.96, P = 0.02). During the first and second 24-h postoperative intervals, fewer patients in the dexamethasone group received rescue antiemetics. Visual analogue scale scores for nausea and pain were lower in the dexamethasone group than in the control group during the first 24 h postoperatively. Dexamethasone did not increase the number of adverse events. The results of this study showed that a single dose of dexamethasone was effective for reducing PONV after paediatric scoliosis correction surgery.
- Access to Document (DOI)
Aberrant resting-state functional connectivity of the dorsolateral prefrontal cortex to the anterior insula and its association with fear avoidance belief in chronic neck pain patients

Ihara N., Wakaizumi K., Nishimura D., Kato J., Yamada T., Suzuki T., Hashiguchi S., Terasawa Y., Kosugi S., Morisaki H.

PLoS ONE (PLoS ONE) 14 ( 8 ) 2019.08

　View Summary

Chronic neck pain (CNP), a global health problem, involves a large amount of psychological and socioeconomic burdens. Not only physical causes but also behavioral disorders such as a fear-avoidance belief (FAB) can associate with the chronicity of neck pain. However, functional brain mechanisms underlying CNP and its related behavioral disorders remain unknown. The aim of the current resting-state functional magnetic resonance imaging (fMRI) study was to explore how the functional brain networks differed between CNP patients and age- and sex-matched healthy, pain-free controls (HCs). We also investigated whether these possible brain network changes in CNP patients were associated with fear avoidance belief (FAB) and the intensity of pain. We analyzed the resting-state fMRI data of 20 CNP patients and 20 HCs. FAB and the intensity of pain were assessed by Tampa Scale for Kinesiophobia (TSK) and Visual Analog Scale (VAS) of pain. The whole brain analysis showed that CNP patients had significant different functional connectivity (FC) compared with HCs, and the right dorsolateral prefrontal cortex (DLPFC) was a core hub of these altered functional networks. Furthermore, general linear model analyses showed that, in CNP patients, the increased FC between the right DLPFC and the right anterior insular cortex (aIC) significantly associated with increased TSK (p = 0.01, statistical significance after Bonferroni correction: p<0.025), and the FC between the right DLPFC and dorsal posterior cingulate cortex had a trend of inverse association with VAS (p = 0.04). Our findings suggest that aberrant FCs between the right DLPFC and aIC associated with CNP and its related FAB.
- Access to Document (DOI)
Prediction of postoperative pain and opioid requirement in patients chronically using opioids.

2. Ihara N, Kosugi S, Wakaizumi K, Nishimura D, Fukuda Y, Nagata H, Yamada T, Hashiguchi S, Morisaki H

J Clin Anesth 19 ( 60 ) 14 - 15 2019

Lead author, Accepted

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Papers, etc., Registered in KOARA 【 Display / hide 】

慢性頸肩腕痛患者における、背外側前頭前野と前部島皮質との安静状態機能的結合性の異常と恐怖回避思考との関連

Ihara, Naho

(慶應義塾大学大学院医学研究科) 2019
慢性頸肩腕痛患者における、背外側前頭前野と前部島皮質との安静状態機能的結合性の異常と恐怖回避思考との関連

Ihara, Naho

(慶應義塾大学大学院医学研究科) 2019
慢性頸肩腕痛患者における、背外側前頭前野と前部島皮質との安静状態機能的結合性の異常と恐怖回避思考との関連

Ihara, Naho

(慶應義塾大学大学院医学研究科) 2019
Inhibition of prolyl hydroxylase improves myocardial dysfunction following endotoxin shock via activation of kynurenic acid production

Ihara, Naho

科学研究費補助金研究成果報告書 2018

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Presentations 【 Display / hide 】

「麻酔科医が伝えたいこと　～知っておいてほしい周術期のオピオイド管理と神経ブロック～」文献から紐解く周術期のオピオイド管理．

伊原奈帆

第31回日本緩和医療学会学術大会,

2026.06
,
Symposium, workshop panel (nominated)
経皮的僧帽弁接合不全修復術（MitraClip®）術後の急性心不全に対し、インペラ補助循環用ポンプカテーテルImpellaを使用し術前体重管理を行い、外科的僧帽弁置換術に至った1症例

9. 伊原奈帆、長田大雅、岡本泰治、生駒祐介、鈴木悠太、壽原朋宏、山田高成

[Domestic presentation] 日本集中治療医学会第8回関東甲信越支部学術集会,

2024.08
,
Oral presentation (general)
がん疼痛治療の成功率を高めるためのひと工夫～患者の痛みは本当に取れているのか～

伊原奈帆

[Domestic presentation] 第26回緩和医療学会学術大会,

2021.06
,
Symposium, workshop panel (nominated)
オンコロジーエマージェンシーの麻酔管理

伊原奈帆

[Domestic presentation] 日本麻酔科学会第66回学術集会,

2019.05
,
Other
慢性頸肩腕痛患者における恐怖回避思考が安静時脳機能的結合に及ぼす影響についての検討―患者対照比較試験

Ihara Naho

[Domestic presentation] 第65回日本麻酔科学会学術集会,

2018.05
,
Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

低酸素応答の活性化を介した新たな敗血症性心筋症治療戦略の検討

2016.04

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2019.03

MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Principal investigator

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