論文 - 渡邉　航太

Response to Lefebvre et al

Takeda K, Kou I, Kawakami N, Yasuhiko Y, Ogura Y, Imagawa E, Miyake N, Matsumoto N, Sudo H, Kotani T, Japan Early Onset Scoliosis Research Group, Nakamura M, Matsumoto M, Watanabe K, Ikegawa S

Clinical genetics 92 （ 5 ） 563 - 564 2017年

研究論文（学術雑誌）

A functional variant in MIR4300HG, the host gene of microRNA MIR4300 is associated with progression of adolescent idiopathic scoliosis

Ogura Y, Kou I, Takahashi Y, Takeda K, Minami S, Kawakami N, Uno K, Ito M, Yonezawa I, Kaito T, Yanagida H, Watanabe K, Taneichi H, Harimaya K, Taniguchi Y, Kotani T, Tsuji T, Suzuki T, Sudo H, Fujita N, Yagi M, Chiba K, Kubo M, Kamatani Y, Nakamura M, Matsumoto M, Japan Scoliosis Clinical Research Group, Watanabe K, Ikegawa S, Japan Scoliosis Clinical Research Group

Human molecular genetics 26 （ 20 ） 4086 - 4092 2017年

研究論文（学術雑誌）

Exploration for reliable radiographic assessment method for hinge-like hypermobility at atlanto-occipital joint

Kaneko S., Ishii K., Watanabe K., Tsuji T., Nakamura M., Matsumoto M., Yato Y., Asazuma T.

European Spine Journal （European Spine Journal）  27 （ 6 ） 1303 - 1308 2017年

研究論文（学術雑誌）,  ISSN  09406719

　概要を見る

© 2017, The Author(s). Purpose: Hinge-like hyper-mobility is occasionally observed at the atlanto-occipital (O-C1) joint. However, it has not been clear if this kind of hinge-like hyper-mobility at the O-C1 joint should be regarded as “pathologic”, or referred to as “instability”. To solve this issue, we aimed to establish a reliable radiographic assessment method for this specific type of O-C1 instability and figure out the “standard value” for the range of motion (ROM) of the O-C1 joint. Methods: To figure out the standard range of the O-C1 angle, we acquired magnetic resonance imaging (MRI) sagittal views of the cervical spine for 157 healthy volunteers [average: 37.4 year-old (yo)] without spine diseases, at neutral, maximum flexion and maximum extension positions. Results: The average value (AVE) for ROM of O-C1 angle was 9.91°. The standard value for ROM of O-C1 angle was calculated as 0°–21°. There was no statistically significant gender difference. We also found that the older population (≧ 40 yo) significantly had a larger ROM of O-C1 angle (AVE: 11.72°) compared to the younger population (< 40 yo) (AVE: 8.99°). Conclusions: We consider that hinge-like instability at O-C1 joint, which cannot be assessed by measuring Powers ratio, can be assessed by measuring the range of O-C1 angles using dynamic-MRI. Evaluation of O-C1 instability is important especially when we perform surgical treatment for diseases with upper cervical instability (such as retro-odontoid pseudotumor). We consider that the current study provides important information in such a case.

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The unfolded protein response mediated by PERK is casually related to the pathogenesis of intervertebral disc degeneration

Fujii T., Fujita N., Suzuki S., Tsuji T., Takaki T., Umezawa K., Watanabe K., Miyamoto T., Horiuchi K., Matsumoto M., Nakamura M.

Journal of Orthopaedic Research （Journal of Orthopaedic Research）  36 （ 5 ） 1334 - 1345 2017年

研究論文（学術雑誌）,  ISSN  07360266

　概要を見る

© 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. Although the number of patients with intervertebral disc (IVD) degeneration is increasing in aging societies, its etiology and pathogenesis remain elusive and there is currently no effective treatment to prevent this undesirable condition. The unfolded protein response (UPR) is a cellular machinery that plays critical roles in handling endoplasmic reticulum (ER) stress, a condition caused by the accumulation of unfolded proteins in the ER lumen. This study aimed to elucidate the potential role of the UPR mediated by pancreatic endoplasmic reticulum kinase (PERK), one of the major ER stress sensors in mammalian cells, in the development of IVD degeneration. IVD degeneration was artificially induced in Wister rats by percutaneously puncturing the coccyx IVDs and human IVDs were collected from patients who underwent spinal surgery. Expression of the UPR target genes was elevated in degenerative IVDs in both humans and rats. The induction of ER stress in annulus fibrosus cells significantly increased the transcripts for tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) in a nuclear factor (NF)-κB pathway-dependent manner. The expression of TNF-α and IL-6 was significantly reduced by treatment with a selective PERK inhibitor, GSK2606414, and by gene silencing against PERK and activating transcription factor 4 (ATF4) transcripts. Our findings indicate that the UPR mediated by the PERK pathway is causally related to the development of IVD degeneration, suggesting that PERK may be a potential molecular target for suppressing the degenerative changes in IVDs. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1334–1345, 2018.

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Epithelioid Hemangioma of the Thoracic Spine: A Case Report and Review of the Literature

Okada E., Matsumoto M., Nishida M., Iga T., Morishita M., Tezuka M., Mukai K., Kobayashi E., Watanabe K.

Journal of Spinal Cord Medicine （Journal of Spinal Cord Medicine）  42 （ 6 ） 1 - 6 2017年

研究論文（学術雑誌）,  ISSN  10790268

　概要を見る

Context: Osseous epithelioid hemangioma is uncommon, and reports of epithelioid hemangiomas of the spine are especially rare. Study Design: Case report. Findings: A 43-year-old male was referred to our department with progressive gait disturbance. CT scans showed a lucent mass in the vertebral body at the T3 level. MRI of the thoracic spine showed a strongly enhanced mass compressing the spinal cord. The patient underwent laminectomy from T2 to T4, debulking of the tumor, and posterior fusion from T1 to T5. After the operation, the patient's neurological status improved significantly, and he was able walk without assistance. Histological examination determined that the tumor was an epithelioid hemangioma. The patient was treated with 40 Gy radiation for local control of the tumor. The patient could walk without difficulty 12 months after the surgery. Conclusion: This is a rare example of an epithelioid hemangioma that developed in the thoracic spine and compressed the spinal cord, and was treated successfully.

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Surgical Correction of Severe Kyphoscoliosis Associated with Crouzon Syndrome with Serious Postoperative Respiratory Problems

Umezu T, Fujita N, Yagi M, Tsuji O, Nagoshi N, Ishii K, Nakamura M, Matsumoto M, Watanabe K

JBJS case connector 7 （ 4 ） e98 2017年

研究論文（学術雑誌）

Response to Lefebvre et al

Takeda K, Kou I, kawakami N, Yasuhiko Y, Ogura Y, Imagawa E, Miyake N, Matsumoto N, Sudo H, Kotani T, Japan Early Onset Scoliosis Research Group, Nakamura M, Matsumoto M, Watanabe K, Ikegawa S

Clinical Genetics 2017年

研究論文（学術雑誌）

Physical Activities and Lifestyle Factors Related to Adolescent Idiopathic Scoliosis.

Watanabe K, Michikawa T, Yonezawa I, Takaso M, Minami S, Soshi S, Tsuji T, Okada E, Abe K, Takahashi M, Asakura K, Nishiwaki Y, Matsumoto M

The Journal of bone and joint surgery 99 （ 4 ） 284 - 294 2017年

研究論文（学術雑誌）

Increased sorbitol levels in the hypertrophic ligamentumflavum of diabetic patients with lumbar spinal canal stenosis

Luo J, Huang L, Chen Z, Zeng Z, Miyamoto T, Wu H, Zhang Z, Pan Z, Fujita N, Hikata T, Iwanami A, Tsuji T, Ishii K, Nakamura M, Matsumoto M, Watanabe K, Cao K

Journal of orthopaedic research 35 （ 5 ） 1058 - 1066 2017年

研究論文（学術雑誌）

Compound Heterozygosity for Null Mutations and a Common Hypomorphic Risk Haplotype in TBX6 Causes Congenital Scoliosis

Takeda K, Kou I, Kawakami N, Iida A, Nakajima M, Ogura Y, Imagawa E, Miyake N, Matsumoto N, Yasuhiko Y, Sudo H, Kotani T, Japan Early Onset Scoliosis Research Group, Nakamura M, Matsumoto M, Watanabe K, Ikegawa S

Human mutation 38 （ 3 ） 317 - 323 2017年

研究論文（学術雑誌）

Scoliosis is a Risk Factor for Gastroesophageal Reflux Disease in Adult Spinal Deformity

Hosogane N, Watanabe K, Yagi M, Kaneko S, Toyama Y, Matsumoto M

Clinical spine surgery 30 （ 4 ） E480 - E484 2017年

研究論文（学術雑誌）

Onset and remodeling of coronal imbalance after selective posterior thoracic fusion for Lenke 1C and 2C adolescent idiopathic scoliosis (a pilot study)

Ishikawa M, Cao K, Pang L, Fujita N, Yagi M, Hosogane N, Tsuji T, Machida M, Ishihara S, Nishiyama M, Fukui Y, Nakamura M, Matsumoto M, Watanabe K

Scoliosis and Spinal Disorders 12   16 2017年

研究論文（学術雑誌）

Histomorphometric analysis of minimodeling in the vertebrae in postmenopausal patients treated with anti-osteoporotic agents

Hikata T, Hasegawa T, Horiuchi K, Fujita N, Iwanami A, Watanabe K, Ishii K, Nakamura M, Amizuka N, Matsumoto M

Bone reports 5   286 - 291 2017年

研究論文（学術雑誌）

Effect of the upper instrumented vertebral level (upper vs. lower thoracic spine) on gait ability after corrective surgery for adult spinal deformity

Yagi M., Fujita N., Tsuji O., Nagoshi N., Yato Y., Asazuma T., Ishii K., Nakamura M., Matsumoto M., Watanabe K.

Spine Journal （Spine Journal）  18 （ 1 ） 130 - 138 2017年

研究論文（学術雑誌）,  ISSN  15299430

　概要を見る

© 2017 Elsevier Inc. Background Context The relationship between gait pattern and the level of upper instrumented vertebra (UIV) in surgically treated patients with adult spinal deformity (ASD) has not been fully documented. Purpose This study aimed to assess the effect of UIV level for the gait pattern in ASD. Study Design/Setting A prospective case series was carried out. Patient Sample Thirty surgically treated consecutive female ASD with lumbosacral fusion (age 67.0±8.4 years; body mass index 22.7±2.4 kg/m 2 ; Cobb angle 49.9°±21.3°; coronal vertical axis 1.5±3.6 cm; C7 sagittal vertical axis [C7SVA] 9.3±5.3 cm; pelvic incidence-lumbar lordosis 35.4°±25.8°; and lean volume of the lower leg 5.5±0.9 kg) were categorized into upper thoracic [UT] group or lower thoracic [LT] group based on the level of UIV (UT; UIV T2–T5, LT; UIV T9–T11), and the gait pattern were compared before and after corrective spine surgery. Outcome Measures Scoliosis Research Society Patient Questionnaire, Oswestry Disability Index, and force plate analysis were the outcome measures. Methods All subjects underwent gait analysis on a custom-built force plate. Dual-energy X-ray absorptiometry. Subjects were followed-up for at least 2 years postoperation. Results The UT group had larger baseline Cobb angle, whereas the LT group had larger C7SVA (UT vs. LT; Cobb angle: 59.2±22.9 vs. 44.6±17.4° p=.03, C7SVA: 10.9±8.7 vs. 12.0±7.1 cm, p=.03). Preoperatively, no difference was found in gait velocity and stride between UT and LT group, whereas the right and left difference of step length was significantly large in UT group (velocity: 55.0±12.5 vs. 53.6±9.0 m/min, stride: 99.7±13.0 vs. 97.8±13.6 cm, step length; 10.4±4.9 vs. 5.6%±3.3%). Coronal and sagittal alignments were significantly improved in both groups (total; Cobb angle: 19.4°±10.6° C7SVA: 5.3±2.9 cm, PI–LL: 12.1°±5.1°). Gait pattern, stride, and velocity all improved significantly after surgery (total; velocity: 62.3±8.9m/min, stride: 106.8±12.3 cm, p=.01). The knee angle at the heel contact phase and hip range of motion (ROM) were also significantly improved at postoperation (total; hip ROM: preoperation: 29.2°±9.1° postoperation: 36.2°±4.8° knee angle; preoperation: 10.6°±6.6° postoperation: 4.4°±2.8°). No difference was observed for the pelvis and shoulder rotation on the horizontal plane at postoperation in both groups (total; pelvis rotation; preoperation: 7.4°±3.4° postoperation: 7.9°±2.4° shoulder rotation; preoperation: 7.4°±2.9° postoperation: 8.7°±3.6°). The head vertical deviation was also not changed postoperatively in both groups (preoperation: 3.1±0.9 cm, postoperation: 3.1±0.8 cm). Conclusions Both UT and LT groups achieved similar improvement of gait ability and pattern after surgery. Additional studies will be needed to further define the effect of UIV for the activity of daily living such as fast walking, stepping the stairs, or standing from the chair in ASDs.

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脊髄離断術後に脊髄摘出を２回施行した胸髄発生Glioblastomaの1例．

櫻井孝紀, 岩波明生, 藤田順之, 日方智宏, 渡辺航太, 石井　賢, 松本守雄, 中村雅也

日本脊髄障害医学会雑誌　 29 （ 1 ） 132-134 2016年05月

研究論文（学術雑誌）

Genome-wide association study for adolescent idiopathic scoliosis.

Ogura Y, Kou I, Scoliosis J, Matsumoto M, Watanabe K, Ikegawa S

Clincal Calcium 26 （ 4 ） 553-00 2016年04月

研究論文（学術雑誌）

A chordoma-derived cell line U-CH1-N recapitulates the biological of notochordal nucleus pulposus cells

Fujita N, Suzuki S, Watanabe K, Ishii K, Watanabe R, Shimoda M, Takubo K, Tsuji T, Toyama Y, Miyamoto T, Horiuchi K, Nakamura M, Matsumoto M

Journal of Orthopaedic Research 34 （ 8 ） 1341-50 2016年

研究論文（学術雑誌）

Risk Factors of radiological adjacent disc degeneration with lumbar interbody fusion for degenerative spondylolisthesis.

Tsuji T, Watanabe K, Hosogane N, Fujita N, Ishi K, Chiba K, Toyama Y, Nakamura M, Matsumoto M

Journal of Orthopaedic Science 21 （ 2 ） 133 - 137 2016年

研究論文（学術雑誌）

Automatic Screening System for Scoliosis Utilizing Moire Pattern.

Choi R, Watanabe K, Nakamura M, Matsumoto M, Fujita N, Ogura Y, Tuji T, Wata K, Kotani T, Miyazaki M, Shigematsu H, Demura S, Takahashi M, Abe K, Yoshimtsu A.

FCV2016, Gifu 2016年

研究論文（学術雑誌）

Epidemiological survey of ossification of the posterior longitudinal ligament by using clinical investigation registration forms .

Tuji T, Chiba K, Hosogane N, Fujita N, Hikata T, Iwanami A, Watanabe K, Ishii K, Toyama Y, Nakamura M, Matsumoto M.

Journal of Orthopaedic Science 21   291-4 2016年

研究論文（学術雑誌）