Hosoe, Naoki

写真a

Affiliation

School of Medicine, Center for Preventive Medicine ( Shinanomachi )

Position

Professor

Related Websites
Scopus Paper Info  
Paper Count: 137 Citation Count: 2874 h-index: 30

Click to view the Scopus page. The data was downloaded from Scopus API in April 05, 2026, via http://api.elsevier.com and http://www.scopus.com .

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Academic Degrees 【 Display / hide 】

  • 医学博士, Keio University

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Research Areas 【 Display / hide 】

  • Life Science / Gastroenterology

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Research Keywords 【 Display / hide 】

  • endoscopy

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Books 【 Display / hide 】

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Papers 【 Display / hide 】

  • Underestimation of the horizontal extent of ulcerative colitis-associated neoplasia may lead to incomplete endoscopic resection and subsequent recurrence

    Murakami S., Sugimoto S., Iwao Y., Takabayashi K., Kiyohara H., Yoshimatsu Y., Sakakibara R., Kaieda Y., Shigehara A., Hosoe N., Kato M., Mikami Y., Kanai T.

    Therapeutic Advances in Gastroenterology 19 2026.01

    ISSN  1756283X

    　View Summary

    Background: Endoscopic resection (ER) is increasingly utilized for ulcerative colitis-associated neoplasias (UCANs); however, these lesions demonstrate higher rates of local residuals and recurrences compared with sporadic neoplasias. This may be partly explained by challenges in accurately delineating lesion borders preoperatively, though their clinicopathologic features remain incompletely understood. Objectives: This study aimed to characterize the endoscopic and histologic features associated with local residuals and recurrences following ER for UCAN. Design: A retrospective observational study. Methods: Patients diagnosed with UCAN exhibiting a p53 mutation pattern between 2005 and 2024 and suspected of having local residual or recurrent lesions after ER were included. Endoscopic and histologic features were evaluated. Results: Of 122 UCAN patients, 13 (6 underwent initial ER at our institution before 2018, and 7 underwent initial ER elsewhere) were identified with suspected local residuals or recurrences. Prior to initial ER, p53 immunostaining was not performed in eight cases (five without biopsy and three with biopsy specimens not stained), and only two patients underwent biopsy of the surrounding tissue. Ten tumors had positive or potentially positive horizontal margins (HMs) that were not identified endoscopically at the time of ER. All local recurrences were associated with suspected positive HMs, with a median time to recurrence of 16.5 (8.5–23.8) months. At recurrence, 50% of the lesions appeared flat, while the remaining 50% were superficial elevated lesions with adjacent flat dysplasia. Conclusion: Inadequate preoperative assessment of the horizontal extent of UCANs may contribute to residual or recurrent disease after ER. Comprehensive evaluation—including p53 immunostaining and careful inspection for surrounding flat dysplasia—may improve curative outcomes in UCAN management.

  • Adjustment of Surveillance Intervals for Ulcerative Colitis-Associated Neoplasia Based on Disease Duration

    Sakakibara R., Sugimoto S., Kaieda Y., Kiyohara H., Yoshimatsu Y., Takabayashi K., Murakami S., Kawaida M., Sujino T., Hosoe N., Kato M., Iwao Y., Mikami Y., Kanai T.

    Digestive Endoscopy 37 ( 10 ) 1068 - 1077 2025.10

    ISSN  09155635

    　View Summary

    Objectives: The risk of colitis-associated cancer increases with disease duration in ulcerative colitis (UC), yet surveillance colonoscopy protocols generally stratify risk uniformly for patients with disease lasting over 8 years. This study evaluated whether shorter surveillance intervals might enhance lesion detection rates in patients with extended disease duration. Methods: This retrospective observational study analyzed patients diagnosed with UC-associated neoplasms between 2010 and 2023. Colonoscopies before lesion detection were retrospectively reviewed, and risk stratification was applied according to four established guidelines. The recommended surveillance intervals were recalculated based on the stratified risk, and lesion detection rates were compared across increasing risk categories for specific disease duration. Results: A total of 39 patients were included, with a median disease duration of 21 years (14–27), and a median colonoscopy interval of 1.3 years (1.1–2.2). Lesion detection rates were 72%, 59%, 44%, and 56% for American Society for Gastrointestinal Endoscopy (ASGE), American Gastroenterological Association (AGA), European Crohn's and Colitis Organisation (ECCO), and British Society of Gastroenterology (BSG) guidelines, respectively. Adjusting risk stratification upward by one rank for disease durations of ≥ 15, ≥ 20, ≥ 25, and ≥ 30 years resulted in increased detection rates: 90%, 87%, 82%, and 72% for ASGE; 85%, 82%, 74%, and 64% for AGA; 82%, 74%, 62%, and 49% for ECCO; and 82%, 79%, 72%, and 62% for BSG, respectively. The longest period with a significant difference in detection rates was observed in patients with disease durations of 20–25 years. Conclusions: For patients with long-standing UC, reducing surveillance intervals may improve the detection of colitis-associated neoplasia, with a practical focus on those with 20–25 years of disease duration.

  • Prevalence and predictability of the Chicago Classification of Pouchitis in ulcerative colitis: a multicenter study in Japan

    Akiyama S., Hayashi R., Takasago T., Kusunoki K., Ikeuchi H., Takenaka K., Watanabe K., Koganei K., Ueno N., Fujiya M., Hosoe N., Koyama F., Sakata Y., Esaki M., Takeuchi K., Naganuma M., Tsuchiya K.

    Journal of Gastroenterology 60 ( 6 ) 715 - 726 2025.06

    ISSN  09441174

    　View Summary

    Background: Endoscopic phenotypes of pouchitis according to the Chicago Classification have been reported to be associated with poor pouch outcomes in ulcerative colitis (UC). Here, we aimed to assess the prevalence of endoscopic phenotypes and their predictability for pouch outcomes. Methods: This retrospective multicenter study included UC patients aged 18 years or older who underwent total colectomy between January 2000 and March 2020. The primary endpoints were frequencies of endoscopic phenotypes of the Chicago Classification and their predictability for chronic pouchitis and pouch failure. Endoscopic findings were evaluated at the initial pouchoscopy and at 3 and 10 years after ileostomy takedown. Results: A total of 392 eligible patients were identified. The frequencies of chronic pouchitis and pouch failure were 32% and 4.9%, respectively. Focal inflammation and inlet involvement at the initial postoperative pouchoscopy were significantly associated with subsequent risk of chronic pouchitis and pouch failure, respectively. Thirty percent of the patients with focal inflammation progressed to diffuse inflammation when chronic pouchitis developed. Multivariate analysis showed chronic pouchitis was significantly associated with diffuse inflammation and cuffitis observed throughout the clinical course. The proportion of pouch-related fistula was significantly lower in our cohort than in the US cohort (4.8% vs 19%, P < 0.001), and pouch-related fistula was an independent risk factor for pouch failure. Conclusions: We demonstrated the predictability of the Chicago Classification for pouch outcomes, and a lower prevalence of pouch-related fistula, resulting in a lower pouch failure risk in our multicenter cohort.

  • CHARACTERISTICS OF FLAT-TYPE ULCERATIVE COLITIS-ASSOCIATED NEOPLASIA ON CHROMOENDOSCOPIC IMAGING WITH INDIGO CARMINE DYE SPRAYING

    Takabayashi K., Sugimoto S., Nanki K., Yoshimatsu Y., Kiyohara H., Mikami Y., Sujino T., Kato M., Hosoe N., Shimoda M., Yahagi N., Ogata H., Iwao Y., Kanai T.

    Gastroenterological Endoscopy 67 ( 5 ) 1109 - 1118 2025.05

    ISSN  03871207

    　View Summary

    Objectives: Despite recent advances in endoscopic equipment and diagnostic techniques, early detection of ulcerative colitis-associated neoplasia (UCAN) remains difficult because of the complex background of the inflamed mucosa of ulcerative colitis and the morphologic diversity of the lesions. We aimed to describe the main diagnostic patterns for UCAN in our cohort, including lateral extension surrounding flat lesions. Methods: Sixty-three lesions in 61 patients with flat-type dysplasia that were imaged with dye chromoendoscopy (DCE) were included in this analysis. These DCE images were analyzed to clarify the dye-chromoendoscopic imaging characteristics of flat dysplasia, and the lesions were broadly classified into dysplastic and nondysplastic mucosal patterns. Results: Dysplastic mucosal patterns were classified into two types: small round patterns with round to roundish structures, and mesh patterns with intricate mesh-like structures. Lesions with a nondysplastic mucosal pattern were divided into two major types: a ripple-like type and a gyrus-like type. Of note, 35 lesions (55.6%) had a small round pattern, and 51 lesions (80.9%) had some type of mesh pattern. About 70% of lesions with small round patterns and 49% of lesions with mesh patterns were diagnosed as high-grade dysplasia or carcinoma, while about 30% of lesions with small round patterns and 51% of lesions with mesh patterns were diagnosed as low-grade dysplasia. Conclusion: When a characteristic mucosal pattern, such as a small round or mesh pattern, is found by DCE, the possibility of UCAN should be considered.

  • Nationwide multicenter prospective study on the usefulness, safety, and acceptability of colon capsule endoscopy in Japan

    Hotta N., Ohmiya N., Hiraga H., Nakaji K., Osawa S., Omori T., Mitsufuji S., Hosoe N., Nouda S., Kobayashi T., Nakamura M., Oka S., Nonogaki K., Baba Y., Mukai R., Matsumoto H., Ikebuchi Y., Shimada M., Togashi K., Katsuki S., Sasaki Y., Sawada R., Kawano S., Furuta T., Tajiri H., Tanaka S.

    Gastrointestinal Endoscopy 101 ( 5 ) 1051 - 1063.e7 2025.05

    ISSN  00165107

    　View Summary

    Background and Aims: We determined the factors influencing total capsule colonoscopy, adequate cleansing, and detectability of second-generation colon capsule endoscopy (CCE) for colorectal polyps or tumors (CRTs), adverse events, and acceptability. Methods: Among 44 Japanese hospitals, 1006 patients with suspected or documented colorectal diseases who underwent CCE were enrolled prospectively. Results: The total capsule colonoscopy rate was 86.1%. Age younger than 63 years (adjusted odds ratio [aOR], 1.525), male sex (aOR, 1.496), inflammatory bowel disease (aOR, 1.889), lavage intake on day –1 (aOR, 1.625), ≥1800-mL lavage intake on day 0 (aOR, .595), prokinetics on day 0 (aOR, .608), and ≥30-mL castor oil booster on day 0 (aOR, 1.734) were significant independent predictors. The overall adequate cleansing rate was 65.5%. Constipation (aOR, .527), lavage intake on day –1 (aOR, 1.822), laxative intake on day –1 (aOR, 2.616), and ≥1900-mL lavage intake on day 0 (aOR, 1.449) were significant independent predictors. The detection rates for patients with CRTs ≥6 mm and ≥10 mm were 92% (95% confidence interval, 84-97) and 89% (95% confidence interval, 78-96), respectively. Inadequate cleansing in the ascending colon (aOR, .184), ≥6-mm CRT in the transverse colon (aOR, 4.703), and ≥6-mm CRT in the left-sided colon (aOR, 32.013) were significant independent predictors. CCE retention occurred in 2 patients (.20%) requiring endoscopic and surgical interventions. In total, 63% of patients desired CCE for their next colonoscopy. Conclusions: CCE was relatively safe, well tolerated, and useful for detecting colorectal lesions when adequate bowel preparation was made. (Clinical trial registration number: UMIN000021936.)

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

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Presentations 【 Display / hide 】

  • Developing a Colon Capsule Endoscopy Score to Assess the Severity of Ulcerative Colitis: the Capsule Scoring of Ulcerative Colitis (CSUC)

    Hosoe N, Takabayashi K, Ishikawa K, Horie T, Miyanaga R, Fukuhara S, Kimura K, Mizuno S, Naganuma M, Ogata H, Kanai T

    [International presentation]  DDW 2018, 

    2018.06
    , 

    Poster presentation

  • 潰瘍性大腸炎患者に対する大腸カプセル内視鏡検査　前処置、運用法を含めて

    Hosoe Naoki

    [Domestic presentation]  第95回日本消化器内視鏡学会総会, 

    2018.05
    , 

    Symposium, workshop panel (public)

  • 透析患者の全消化管をカプセル内視鏡でスクリーニングできるか?

    Hosoe Naoki

    [Domestic presentation]  第62回日本透析医学会学術集会・総会, 

    2017.06
    , 

    Symposium, workshop panel (public)

  • 拡大シングルバルーン小腸内視鏡、プローブ型共焦点レーザー内視鏡を使用した小腸病変の観察

    Hosoe Naoki

    第93回日本消化器内視鏡学会総会, 

    2017.05
    , 

    Symposium, workshop panel (public)

  • 拡大シングルバルーン小腸内視鏡、プローブ型共焦点レーザー内視鏡を使用した小腸観察

    Hosoe Naoki

    [Domestic presentation]  第103回日本消化器病学会総会, 

    2017.04
    , 

    Symposium, workshop panel (public)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Understanding endoscopic morphology during immune reconstitution using single cell analysis of small intestinal disease

    2022.04
    -
    2025.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 基盤研究(C), Principal investigator

  • 超拡大内視鏡観察、走査電顕によるナノレベル観察を用いたヒト腸管上皮機能解明

    2019.04
    -
    2022.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

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Courses Taught 【 Display / hide 】

  • LECTURE SERIES, INTERNAL MEDICINE (GASTROENTEROLOGY)

    2024

  • LECTURE SERIES, INTERNAL MEDICINE (GASTROENTEROLOGY)

    2023

  • LECTURE SERIES, INTERNAL MEDICINE (GASTROENTEROLOGY)

    2022

  • LECTURE SERIES, INTERNAL MEDICINE (GASTROENTEROLOGY)

    2021

  • LECTURE SERIES, INTERNAL MEDICINE (GASTROENTEROLOGY)

    2020

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