Arai, Yasumichi



Faculty of Nursing and Medical Care Center for Supercentenarian Medical Research (Shonan Fujisawa)



Related Websites

External Links

Academic Background 【 Display / hide

  • 1985.04

    Keio University, Medical School

    University, Graduated


Papers 【 Display / hide

  • Cardiovascular health and cognitive functioning among centenarians: A comparison between the Tokyo and Georgia centenarian studies

    Martin P., Gondo Y., Arai Y., Ishioka Y., Johnson M., Miller L., Woodard J., Poon L., Hirose N.

    International Psychogeriatrics (International Psychogeriatrics)  31 ( 4 ) 455 - 465 2019.04

    ISSN  10416102

     View Summary

    © International Psychogeriatric Association 2019. Objectives: Centenarians have survived into very late life, but whether they reach very old age in good health remains unclear. The purpose of this study was to compare the cardiovascular health status and cognitive functioning of centenarians in the United States with centenarians in Japan.Design, Setting, and Participants: This cross-national design compared centenarians from the United States and Japan. The sample of U.S. centenarians was recruited from the Georgia Centenarian Study and included 287 centenarians. The sample of Japanese centenarians was recruited from the Tokyo Centenarian Study and included 304 centenarians.Measurements: Cognitive functioning was assessed with a mental status questionnaire, and cardiovascular disease by a health history assessment, blood pressure, and selected blood parameters.Results: The results suggest that Tokyo centenarians had lower disease experiences and BMI values, when compared to Georgia centenarians, but blood pressure was higher among Japanese centenarians. Lower levels of hemoglobin in Japanese centenarians and higher levels of C-reactive protein in Georgia were also found. The positive association of hypertension and albumin levels with cognitive functioning and the negative association of stroke occurrence with cognitive functioning were replicated in both countries. Differential effects were obtained for heart problems, BMI, and C-reactive protein (with positive effects for Tokyo centenarians, except for C-reactive protein).Conclusion: For extremely old individuals, some markers of cardiovascular disease are replicable across countries, whereas differential effects for cardiovascular health also need to be considered in cardiovascular health.

  • Subiculum volumes associated with memory function in the oldest-old individuals aged 95 years and older

    Eguchi Y., Noda Y., Nakajima S., Tsugawa S., Kida H., Plitman E., Graff-Guerrero A., Chakravarty M., Takayama M., Arai Y., Matsuda H., Mimura M., Niimura H.

    Geriatrics and Gerontology International (Geriatrics and Gerontology International)  19 ( 4 ) 347 - 351 2019.04

    ISSN  14441586

     View Summary

    © 2019 Japan Geriatrics Society Aim: Few cohort studies targeting the oldest-old individuals have been carried out. The subiculum in the hippocampus is thought to be related to memory function, and atrophy of this structure might result in the conversion from amnestic mild cognitive impairment to Alzheimer's disease. Thus, we sought to examine the relationship between subiculum volumes and memory function in individuals aged ≥95 years, using a novel cognitive examination called the Addenbrooke's Cognitive Examination III (ACE-III) and an advanced magnetic resonance imaging analytical method, Multiple Automatically Generated Templates Brain Segmentation Algorithm (MAGeTbrain), to measure hippocampal subfield volumes. Methods: A part of the cohort data of the Arakawa 95+ study for the oldest-old aged ≥95 years was used. A total of 10 individuals completed all of the examinations. The MAGeT brain was applied to estimate the subfield volumes of the hippocampus. Correlation analyses and multiple regression analyses were carried out to examine a relationship among ACE-III memory scores and the subfield volumes in the hippocampus, including the subiculum. Results: There was a significant relationship between ACE-III memory scores and subdivision volumes. Regression analyses showed that subiculum volumes were associated with ACE-III memory scores in the oldest-old individuals (β = 0.721, P = 0.019; F 1, 8 = 8.67, adjusted R 2 = 0.46). Conclusions: The subiculum might play a pivotal role in memory function in the oldest-old individuals aged ≥95 years. The present finding warrants further research including larger sample sizes. Geriatr Gerontol Int 2019; 19: 347–351.

  • Association between long-term care and chronic and lifestyle-related disease modified by social profiles in community-dwelling people aged 80 and 90; SONIC study

    Kiyoshige E., Kabayama M., Gondo Y., Masui Y., Ryuno H., Sawayama Y., Inoue T., Akagi Y., Sekiguchi T., Tanaka K., Nakagawa T., Yasumoto S., Ogawa M., Inagaki H., Oguro R., Sugimoto K., Akasaka H., Yamamoto K., Takeya Y., Takami Y., Itoh N., Takeda M., Nagasawa M., Yokoyama S., Maeda S., Ikebe K., Arai Y., Ishizaki T., Rakugi H., Kamide K.

    Archives of Gerontology and Geriatrics (Archives of Gerontology and Geriatrics)  81   176 - 181 2019.03

    ISSN  01674943

     View Summary

    © 2018 Elsevier B.V. Background: Chronic and lifestyle-related diseases and social status were reported to be associated with long-term care (LTC). The social factors should be treated as social sub-groups of which characteristics show social profiles. However, few previous studies considered that. The present study aimed to investigate the associations between LTC and chronic and lifestyle-related diseases, and whether the associations were modified by the social sub-groups in the community-dwelling elderly. Method: A cross-sectional study was conducted among 1004 community-dwelling participants aged 80 and 90. LTC was used as the outcome. Chronic and lifestyle-related diseases (i.e., stroke, heart disease, joint pain, osteoporosis, lung disease, cancer, hypertension, dyslipidemia, and diabetes) were used as the predictors. Education, household income, residential area, and support environment were analyzed by latent class analysis (LCA) to derive social profiles. We obtained odds ratios (ORs) of LTC from those diseases and tested interactions between those diseases and the social profiles by logistic regression analyses. Result: The participants were categorized into two sub-groups of social factors (n = 675 and 329) by LCA. Logistic regression analyses showed ORs (95% CI) of LTC were 4.69 (2.49, 8.71) from stroke, 2.22 (1.46, 3.38) from joint pain, 1.99 (1.22, 3.25) from osteoporosis, and 2.05 (1.22, 3.40) from cancer adjusting for the social sub-groups. There were no significant interactions between the social subgroups and those diseases in relation to LTC except for osteoporosis. Conclusion: The associations between LTC and chronic and lifestyle-related diseases were significant with adjusting for the social sub-groups, and not modified by that except osteoporosis.

  • Relative validity of brief-type self-administered diet history questionnaire among very old Japanese aged 80 years or older

    Kobayashi S., Yuan X., Sasaki S., Osawa Y., Hirata T., Abe Y., Takayama M., Arai Y., Masui Y., Ishizaki T.

    Public Health Nutrition (Public Health Nutrition)  22 ( 2 ) 212 - 222 2019.02

    ISSN  13689800

     View Summary

    © The Authors 2018. Objective Dietary questionnaires for assessing dietary intakes among populations of individuals aged 80 years or older (the very old) are very limited. We examined the relative validity of forty-three nutrients and twenty-seven food groups estimated by a brief-type self-administered diet history questionnaire (BDHQ) targeting very old Japanese, using semi-weighed dietary records (DR) as a reference.Design Between June and August 2012 and between June 2015 and February 2016, a three-day non-consecutive DR (at two-week intervals) and a BDHQ were completed.Setting Tokyo, the capital prefecture of Japan.Subjects Eighty very old Japanese (thirty-six men and forty-four women) aged 82-94 years.Results The median intakes of 40-70 % of the crude and energy-adjusted nutrients estimated by the BDHQ were significantly different from those estimated by the DR. The median Spearman's correlation coefficient of nutrient intakes between the BDHQ and the DR was 0·39-0·46. About half (48-56 %) of the food groups were significantly different in terms of the median intakes estimated by the BDHQ and the DR in crude and energy-adjusted values. The median Spearman's correlation coefficient between the BDHQ and the DR was 0·45-0·48.Conclusions Acceptable Spearman's correlations (≥0·3) were obtained for many dietary intakes among the very old Japanese population. The BDHQ is a good candidate for epidemiological studies among very old Japanese, although, for some nutrients and food groups, the difficulty of estimating accurate median intakes is one of the limitations for the tool. Further efforts to enhance the validity of the BDHQ for very old populations are needed.

  • Hardness of the habitual diet and its relationship with cognitive function among 70-year-old Japanese elderly: Findings from the SONIC Study

    Okubo H., Murakami K., Inagaki H., Gondo Y., Ikebe K., Kamide K., Masui Y., Arai Y., Ishizaki T., Sasaki S., Nakagawa T., Kabayama M., Sugimoto K., Rakugi H., Maeda Y., Ogawa M., Ishioka Y., Inomatae C., Ogawa T., Matsuda K., Ryuno H., Oguro R., Yamamoto K., Takeya Y., Takami Y., Ito N.

    Journal of Oral Rehabilitation (Journal of Oral Rehabilitation)  46 ( 2 ) 151 - 160 2019.02

    ISSN  0305182X

     View Summary

    © 2018 John Wiley & Sons Ltd Background: There is increasing evidence of causal links between poor mastication and cognitive impairment, but possible effects of dietary hardness, which clearly affects mastication, on cognitive function are unknown. Objective: We investigated the hypothesis that hardness of the habitual diet would be associated with cognitive function among older Japanese adults. Methods: The subjects of this cross-sectional study were 635 Japanese community-dwelling people aged 69-71 years. The masticatory muscle activity required for the habitual diet was used to determine dietary hardness. Consumption of 38 foods was assessed by a validated, brief-type, self-administered diet history questionnaire. A published database was then used to estimate the masticatory muscle activity involved in the ingestion of these foods. The Japanese version of the Montreal Cognitive Assessment (MoCA-J) was used for the measurement of cognitive function. Results: The principal contributors to dietary hardness were cooked rice (28.0%), green leafy vegetables (5.1%), dried fish (4.9%), and pork and beef (4.6%). There was a positive association between dietary hardness and MoCA-J score that was robust to adjustment for potential confounders (MoCA-J score per 100-unit increase in dietary hardness: β = 0.83 [95% CI: 0.08, 1.59], P = 0.03). These results did not change materially even after exclusion of subjects who reported substantial changes in their diet for any reason (β = 0.94 [95% CI: 0.02, 1.86], P = 0.04). Conclusion: This preliminary cross-sectional study suggests that dietary hardness might have a beneficial effect on cognitive function in older Japanese people. Further prospective studies with more accurate measurements are needed to confirm this finding.

display all >>

Papers, etc., Registered in KOARA 【 Display / hide

display all >>

Presentations 【 Display / hide

  • The association of dopamine receptor 4 and serotonin transporter gene polymorphism with longevity

    Gondoh Y, Hirose N, Arai Y, Masui Y, Ohno Y, Inagaki H et al

    Gerontological society of America Annual scientific meeting, 


    Poster presentation

  • The medical records of Japanese centenarians and its effects on their autonomy

    Takayama Michiyo, Masui Yukie, Nakazawa Susumu, Yamamura Ken, Arai Yasumichi, Shimizu Kenichiro, Ebihara Yoshinori, Abe Yukiko, Inagaki Hiroki, Gondo Yasuyuki, Konishi Kanoko, Kanno Yoshiko, Fujimori Junko, Kitagawa Koji, Hirose Nobuyoshi

    Gerontological Society of America. Annual scientific Meeting, 


    Poster presentation

  • 百寿者の認知機能と内皮障害マーカーおよびACE遺伝子多型の関連について

    Arai Yasumichi, Hirose Nobuyoshi



    Oral presentation (general)

  • Endothelial nitric oxide synthethase 遺伝子多型と長寿の関連について

    Nakazawa Susumu, Hirose Nobuyoshi, Arai Yasumichi, Yamamura Ken, Abe Yukiko



    Poster presentation

  • コレステロール逆転送系関連遺伝子の多型と長寿の関連について

    Arai Yasumichi, Hirose Nobuyoshi, Yamamura Ken, Nakazawa Susumu, Abe Yukiko



    Oral presentation (general)

display all >>

Research Projects of Competitive Funds, etc. 【 Display / hide

  • 統合栄養学とニュートリジェネティックスによる老化遅延介入の開発に向けた基盤研究


    基盤研究(B), Principal investigator

  • 医療・介護保険情報と融合した地域高齢者コホート研究による要介護プロセスの解明


    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

  • Exceptional longevity and stress resistance: an integrated research between iPS cell biology and epidemiology


    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

  • 超高齢期における慢性腎臓病のバイオメーカーと臨床的意義の検討


    Grant-in-Aid for Scientific Research, Research grant, No Setting

  • 超高齢社会におけるSuccessful Agingに関する学際的ジェロントロジー研究


    Keio University Special Grant-in-Aid for Innovative Collaborative Research Projects, Research grant, No Setting

Works 【 Display / hide

  • EEP小委員会委員




Courses Taught 【 Display / hide











display all >>