Onoe, Hiroaki



Faculty of Science and Technology, Department of Mechanical Engineering (Yagami)



E-mail Address

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Related Websites

Career 【 Display / hide

  • 2005.04

    The University of Tokyo, Graduate School of Information Science and Technology, JSPS Research Fellowship for Young Scientists (DC2-PD)

  • 2007.04

    The University of Tokyo, Institute of Industrial Science, JSPS Research Fellowship for Young Scientists (PD)

  • 2007.08

    University of California Berkeley, Department of Chemistry, Visiting Scholar

  • 2009.04

    The University of Tokyo, Institute of Industrial Science, Assistant Professor

  • 2010.10

    Japan Science and Technology Agency, ERATO assistant research director

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Academic Background 【 Display / hide

  • 1997.04

    The University of Tokyo, School of Engineering, Department of Mechano-Informatics

    Japan, University, Graduated

  • 2001.04

    The University of Tokyo, Graduate School of Information Science and Technology, Department of Mechano-Informatics

    Japan, Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide

  • 博士(情報理工学), The University of Tokyo, Coursework, 2006.03



Research Areas 【 Display / hide

  • Nano/Microsystems

  • Intelligent mechanics/Mechanical systems

  • Biomedical engineering/Biomaterial science and engineering

Research Keywords 【 Display / hide

  • Micro-Nano system

  • Microfluidics

  • Self-assembly

  • Soft material

  • Tissue engineering


Books 【 Display / hide

  • マイクロ・ナノ熱工学の進展

    吉田光輝, 尾上弘晃, NTS, 2021.05

    Scope: 熱駆動マイクロゲルデバイス,  Contact page: 505-513

  • Integrated microsystems for bridging multiscale elements

    Yoshida K., Onoe H., Advances in Chemical Engineering, 2021.01

     View Summary

    Hydrogels are emerging as enabling materials for a wide range of new applications for soft robots because of their flexibility. Some of the polymer chains that make up the hydrogel have a nano-scale function of swelling and contracting in response to external stimuli. In addition, because the network of polymer chains is on the nanometer order, it is possible to encapsulate various functional materials. Therefore, stimulus-responsive hydrogels and functional materials encapsulating hydrogels are also being actively studied for use as soft robot components. From a fundamentals point of view, the nano-scale functions of hydrogels, fabrication method, and integration with functional materials must be considered for each specific application. This section provides a basic understanding of hydrogels and the recent development of novel fabrication and integration of hydrogel with functional materials such as magnetic nanoparticles, Pt catalyst, graphene, photonic colloidal crystal, and living cells.

  • Microspring Fabrication by Anisotropic Gelation (Micro and Nano Fabrication Technology)

    Hiroaki Onoe, Koki Yoshida, Springer Nature Singapore, 2018.04

    Scope: pp. 1-20

  • ハイドロゲルをマイクロスケールで精密加工するには?(ゲル化・増粘剤の使い方,選び方 事例集)

    中島駿介,尾上 弘晃, 技術情報協会, 2018.02

    Scope: pp. 374-382

  • Fabrication of 3D cellular tissue utilizing MEMS technologies (Hyper Bio Assembler for 3D Cellular Systems)

    Shotaro Yoshida, Daniela Serien, Fumiaki Tomoike, Hiroaki Onoe, Shoji Takeuchi, Springer, 2015.07

    Scope: pp. 177-202

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Papers 【 Display / hide

  • Microfabrication of cellulose nanofiber-reinforced hydrogel by multiphoton polymerization

    Sugiyama H., Tsunemitsu K., Onoe H., Obata K., Sugioka K., Terakawa M.

    Scientific Reports (Scientific Reports)  11 ( 1 )  2021.12

     View Summary

    The mechanical strength of hydrogel microstructures is crucial for obtaining the desired flexibility, robustness, and biocompatibility for various applications such as cell scaffolds and soft microrobots. In this study, we demonstrate the fabrication of microstructures composed of cellulose nanofibers (CNFs) and poly(ethylene glycol) diacrylate (PEGDA) hydrogels by multiphoton polymerization. The stress of the fabricated microstructure during tensile testing increased with an increase in the CNF concentration, indicating that the mechanical strength of the microstructure was enhanced by using CNFs as fillers. Moreover, the swelling ratio of the microstructure increased with increasing CNF concentration in the PEGDA hydrogel. Our results show the potential of the technique for the microfabrication of advanced cell scaffolds and soft microrobots with the desired mechanical strength.

  • Janus hydrogel microbeads for glucose sensing with ph calibration

    Ando M., Tsuchiya M., Itai S., Murayama T., Kurashina Y., Heo Y.J., Onoe H.

    Sensors (Sensors)  21 ( 14 )  2021.07

    ISSN  14248220

     View Summary

    We present fluorescent Janus hydrogel microbeads for continuous glucose sensing with pH calibration. The Janus hydrogel microbeads, that consist of fluorescent glucose and pH sensors, were fabricated with a UV-assisted centrifugal microfluidic device. The microbead can calibrate the pH values of its surroundings and enables accurate measurements of glucose within various pH condi-tions. As a proof of concept, we succeeded in obtaining the accurate value of glucose concentration in a body-fluid-like sample solution. We believe that our fluorescent microbeads, with pH calibration capability, could be applied to fully implantable sensors for continuous glucose monitoring.

  • Ultrasound-triggered on-demand drug delivery using hydrogel microbeads with release enhancer

    Kubota T., Kurashina Y., Zhao J.Y., Ando K., Onoe H.

    Materials and Design (Materials and Design)  203 2021.05

    ISSN  02641275

     View Summary

    Ultrasound-triggered drug delivery has been widely researched for its potential to improve the therapeutic efficacy of drugs. This paper presents drug release using hydrogel microbeads with release enhancer for efficient ultrasound-triggered drug delivery. By using a centrifuge-based microfluidic device, drug-model-encapsulating calcium alginate hydrogel microbeads containing tungsten particles with high acoustic impedance were fabricated. Because the tungsten particles work as release enhancer, the hydrogel microbeads become to have high sensitivity to ultrasound with localized variation in acoustic impedance so that the release rate of drug models improves. By applying ultrasound at 20 kHz to the hydrogel microbeads, the release of fluorescent silica nanoparticles that are a drug model for virus vectors, micelles, and proteins was tested. Importantly, the proposed hydrogel microbeads released the drug model even under a cavitation-suppressed environment. Furthermore, the additional coating on the hydrogel microbeads with poly-L-lysine enabled us to adjust the release rate of the drug model. The proposed ultrasound-triggered drug release system using release enhancer is expected to be an effective approach for expanding the varieties of applicable treatments using on-demand drug delivery systems.

  • Shape-recognizable origami sheet device with single walled carbon nanotube strain sensor

    Mori T., Onoe H.

    Journal of Microelectromechanical Systems (Journal of Microelectromechanical Systems)  30 ( 2 ) 234 - 242 2021.04

    ISSN  10577157

     View Summary

    This article describes a shape-recognizable sheet device using origami structures with single-walled carbon nanotubes (SWCNTs) strain sensors. Recently, a sheet-like measurement system that is directly attached to an object has been attracting attention for obtaining the shape, motion, and deformation of the object as alternative systems with external cameras. However, previous sheet-like measurement systems are difficult to distinguish between the stretch and the bend of the object appropriately. Here we propose a sheet-like measurement system that can distinguish the stretch and the bend individually by using origami structures. We formed a strain sensor using SWCNTs that was deposited on a substrate to form a 5-7 nm thin film. By patterning the SWCNTs strain sensors, origami-based sheet devices were fabricated. We confirmed that our origami sheet device obtained the bending and stretching information separately by attaching the device to cylinders. We believe that the origami system could contribute to the observation of complex deformations such as artificial skin, human interface, and biomedical applications. [2020-0324]

  • Simultaneous crosslinking induces macroscopically phase-separated microgel from a homogeneous mixture of multiple polymers

    Kurashina Y., Tsuchiya M., Sakai A., Maeda T., Heo Y.J., Rossi F., Choi N., Yanagisawa M., Onoe H.

    Applied Materials Today (Applied Materials Today)  22 2021.03

     View Summary

    This paper reports a unique phase separation behavior, a simultaneous-crosslinking-driven phase separation in co-gelation (SPSiC) core–shell microgel that spontaneously forms from a homogeneous pre-gel solution of multiple polymers. The SPSiC microgel, composed of an alginate shell and an N-isopropylacrylamide (NIPAM) core, were synthesized by a single fabrication step wherein a mixed pre-gel solution of sodium alginate and NIPAM monomer was ejected by centrifugation with photo-polymerization and ion crosslinking instantaneously. Phase separation was modeled by varying the degree of polymerization and the size of the polymer chain. Moreover, an implantable, multi-functional drug delivery system combined with a transdermal glucose sensor was demonstrated with core–shell Janus SPSiC microgels. This work shows a macroscopic phase separation behavior, which occurs during the gelation process, and also provides a simple and unique methodology to create multifunctional bio-microprobes.

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Reviews, Commentaries, etc. 【 Display / hide

  • 3次元灌流共培養のためのマイクロゲルチューブデバイス


    ケミカルエンジニヤリング 63 ( 11 ) 52 - 57 2018.11

    Introduction and explanation (commerce magazine), Joint Work

  • 細胞ファイバの形成技術と再生組織移植への応用

    尾上弘晃, 興津輝

    実験医学 33 ( 8 ) 1235 - 1241 2015

    Introduction and explanation (commerce magazine), Joint Work

  • 生体組織構築のための細胞ファイバ技術

    尾上弘晃, 竹内昌治

    生物物理 55 ( 4 ) 206 - 207 2015

    Introduction and explanation (commerce magazine), Joint Work

  • 曲面や粗面をつかむロボットハンドの実現に求められる樹脂吸盤 –そのニーズと開発事例-

    西田知司, 尾上弘晃

    MATERIAL STAGE 15 ( 3 ) 63 - 67 2015

    Introduction and explanation (commerce magazine), Joint Work

  • 人工的に構築したヒモ状細胞組織

    平山佳代子, 尾上弘晃, 竹内昌治

    整形・災害外科 57 ( 5 ) 563 - 570 2014

    Introduction and explanation (scientific journal), Joint Work

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Presentations 【 Display / hide

  • Microfluidic reflective display with primary color sub-pixels

    Junpei Muramatsu, Hiroaki Onoe

    The 33rd International Conference on Micro Electro Mechanical Systems (MEMS 2020), 2020.01, Poster (general)

  • Locally bendable stimuli-responsive hydrogel actuator with axially patterned functional materials

    Nobuki Takeuchi, Shunsuke Nakajima, Yutaka Hori, Ryuji Kawano, Hiroaki Onoe

    The 33rd International Conference on Micro Electro Mechanical Systems (MEMS 2020), 2020.01, Oral Presentation(general)

  • pNIPAM/SWCNT-based hydrogel micro-gripper driven by infrared light for intravascular surgery

    Takaya Kuroda, Hiroaki Onoe

    The 33rd International Conference on Micro Electro Mechanical Systems (MEMS 2020), 2020.01, Poster (general)

  • Self-folding acute-angel origami driven by surface bending force

    Takuya Uchida, Hiroki Yasuga, Tomohiro Tachi, Eiji Iwase, Hiroaki Onoe

    The 33rd International Conference on Micro Electro Mechanical Systems (MEMS 2020), 2020.01, Poster (general)

  • ECM-based gradient generator for tunable surface environment by interstitial flow

    Azusa Shimizu, Wei H. Goh, Rahul Karyappa, Michinao Hashimoto, Hiroaki Onoe

    The 33rd International Conference on Micro Electro Mechanical Systems (MEMS 2020), 2020.01, Oral Presentation(general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 機械的メタマテリアルとDNAゲルの融合による生化学構造色センサの高感度化


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 尾上 弘晃, Grant-in-Aid for Challenging Research (Pioneering), Principal Investigator

  • 力学刺激の知能化によるin vitro3次元組織の超効率的成熟化


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 尾上 弘晃, Grant-in-Aid for Scientific Research (A) , Principal Investigator

  • ナノグルコースセンサが取り込まれた人工組織の開発


    日本学術振興会, Grant-in-Aid for Scientific Research, Research grant, Principal Investigator

  • 炎症が惹起する神経変性機構解明のためのヒト血液脳関門の構築


    日本学術振興会, Grant-in-Aid for Scientific Research, 根岸みどり, Research grant, Co-investigator

  • Self-foleded complex 3D structures with microfibers


    Grant-in-Aid for Scientific Research, Hiroaki Onoe, Research grant, Principal Investigator

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Works 【 Display / hide

  • Biohybird Art

    Biohybrid Art Lab with Fu Tsurumaki

    Spiral Independent Creator’s Festival, 2011, 


    Other, Joint

Intellectual Property Rights, etc. 【 Display / hide

  • 給電型遠心駆動微小液滴生成装置およびその生成物

    Application No.: 特願2018-76379  2018.05 

    Patent, Joint, National application

  • 多層構造体とその製造方法及び利用方法

    Application No.: 特願2017-92602  2017.05 

    Patent, Joint, National application

  • 刺激応答性ファイバ,刺激応答性ファイバの製造方法,及び刺激応答性ファイバの製造装置

    Application No.: 特願2016-199517  2016.10 

    Patent, Single, National application

  • カラーフィルタ、これを用いた表示装置、及びカラーフィルタの作製方法

    Application No.: 特願2016-10932  2016.01 

    Patent, Joint, National application

  • マイクロビーズ及びその製造方法

    Application No.: 特願2015-210971  2015.10 

    Patent, Joint, National application

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Awards 【 Display / hide

  • The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology

    2017.04, Minister of Education, Culture, Sports, Science and Technology, マイクロ加工技術を利用した人工生体組織構築の研究

  • 第4回新化学技術研究奨励賞

    尾上弘晃, 2014.05, 公益財団法人 新化学技術推進協会, マイクロゲルファイバのself-foldingによる複合3次元機能材料構築法の創生

  • Outstanding paper award

    1. Yuya Morimoto, Hiroaki Onoe, Shoji Takeuchi, 2013, Twenty Sixth International Conference on Micro Electro Mechanical Systems, Muscle Based Bioactuator Driven in Air

    Type of Award: International Academic Awards

  • Igarashi Prize (Best presentation award)

    2011.09, IEEJ sensors and micromachines, Construction of centimeter-scale three-dimensional tissue with cell fibers

  • JIEP best paper award

    3. Tetsuo Kan, Yusuke Takei, Hiroaki Onoe, Eiji Iwase, Tetsuji Dohi, Kiyoshi Matsumoto, Isao Shimoyama, 2009, The International Conference on Electronics Packaging, Nano-Mechanical Structure Fabrication Technology for Highly Integrated, Complex MEMS

    Type of Award: International Academic Awards

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Courses Taught 【 Display / hide











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Courses Previously Taught 【 Display / hide

  • 機械工学実験

    Keio University, 2015, Spring Semester, Major subject, Laboratory work/practical work/exercise, Outside own faculty (within Keio), 3h, 140people

  • 機械工学創造演習

    Keio University, 2015, Autumn Semester, Seminar, Outside own faculty (within Keio), 2h, 140people

  • 理工学基礎実験

    Keio University, 2015, Spring Semester, General education subject, Laboratory work/practical work/exercise, Outside own faculty (within Keio), 2h

  • プロダクションエンジニアリング

    Keio University, 2015, Spring Semester, Major subject, Seminar, Outside own faculty (within Keio), 2h, 140people

  • 機械工学創造演習

    Keio University, 2014, Autumn Semester, Seminar

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Memberships in Academic Societies 【 Display / hide

  • IEEE, 

  • 電気学会, 

  • Japanese Society of Mechanical Engineering, 

  • Society for Chemistry and Micro-Nano Systems, 

  • The Biophysical Society of Japan, 


Committee Experiences 【 Display / hide

  • 2017.04

    広報担当・幹事, 日本機械学会マイクロ・ナノ工学部門 総務委員会

  • 2017.02

    主査, 電気学会 第34回センサ・マイクロマシンと応用システムシンポジウム論文委員会

  • 2017.02

    広報委員, 日本機械学会 第8回マイクロ・ナノ工学 実行委員会

  • 2017.01

    委員, 電気学会 立体構造や柔軟材料への微細加工、実装技術に関する若手研究者を中心とした調査専門委員会

  • 2016.02

    副主査, 電気学会 第33回センサ・マイクロマシンと応用システムシンポジウム論文委員会

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