Hotta, Atsushi

写真a

Affiliation

Faculty of Science and Technology, Department of Mechanical Engineering ( Yagami )

Position

Professor

Related Websites

External Links
Scopus Paper Info  
Paper Count: 153 Citation Count: 3775 h-index: 36

Click to view the Scopus page. The data was downloaded from Scopus API in April 05, 2026, via http://api.elsevier.com and http://www.scopus.com .

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Profile 【 Display / hide 】

  • Our group will adopt both experimental and theoretical approaches to connect the physical properties of novel soft materials (or soft matter) with their underlying chemical structures (ranging from atomic-, through nano-, to micron-scales) as well as their industrial applications (e.g. nanomaterials, biomaterials, eco-friendly materials). Our primary research targets are polymers, and the key concepts of our research projects include "multi-scale structures", "self-assembly", "functionalization", "gels", and "composites".

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Career 【 Display / hide 】

  • 1994.04
    -
    2004.12

    Bridgestone Corporation

  • 2002.09
    -
    2002.12

    Research and Postdoctoral Fellow (Univ of Cambridge, Cavendish Laboratory)

  • 2003.01
    -
    2005.03

    Postdoctoral Fellow (Univ of California, Santa Barbara)

  • 2005.04
    -
    2008.03

    Assistant Professor, Keio University

  • 2007.04
    -
    2009.03

    機械工学科2年生クラス担任

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Academic Background 【 Display / hide 】

  • 1990.04
    -
    1994.03

    The University of Tokyo, Faculty of Engineering, Department of Applied Physics

    University, Graduated

  • 1999.10
    -
    2002.09

    University of Cambridge, Graduate School, Department of Physics (Cavendish Laboratory)

    United Kingdom, Graduate School, Graduated, Doctoral course

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Academic Degrees 【 Display / hide 】

  • PhD, University of Cambridge, Coursework, 2002.09

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Research Areas 【 Display / hide 】

  • Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Mechanics of materials and materials (Machine Material/Material Mechanics)

  • Nanotechnology/Materials / Polymer materials (Polymer/Textile Materials)

  • Nanotechnology/Materials / Composite materials and interfaces

  • Natural Science / Biophysics, chemical physics and soft matter physics

  • Life Science / Biomedical engineering

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Research Keywords 【 Display / hide 】

  • Eco-materials

  • Gels

  • Composites

  • Soft materials

  • ナノ構造

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Research Themes 【 Display / hide 】

  • ソフトマテリアル・バイオマテリアル・エコマテリアル・ナノマテリアルの微細構造、表面、物性、力学物性、粘弾性、複合化、高機能化とその実用化検討, 

    2005.04
    -
    Present

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Books 【 Display / hide 】

  • シンジオタクチックポリプロピレン(sPP)多孔質材料の力学物性（次世代ポリオレフィン総合研究会, Vol.15）

    前田知貴，堀田篤, 三恵社, 2022.12

  • シンジオタクチックポリプロピレン（sPP）乾燥ゲルの構造と吸油性（次世代ポリオレフィン総合研究，Vol.14）

    前田知貴，堀田篤, 三恵社, 2021.12,  Page： pp.29-33

  • Polymer nanofabrication and plasma processing

    Maeda T., Endo F., Tsuji K., Hotta A., Handbook of Modern Coating Technologies: Fabrication Methods and Functional Properties, 2021.01

    　View Summary

    Nanofabricated polymers are extremely useful due to their high functionalities caused by the inherent multiscale structures of the nanostructured polymers. Nanostructured polymers for biocoatings can be classified into zero-dimensional (0D) polymeric nanoparticles, 1D polymeric nanofibers, and 2D polymeric nanosheets. The nanostructured polymers with such different dimensions were most often fabricated by emulsion polymerization, electrospinning, and spin coating. To add a desirable and advanced functionality to the targeted nanostructured polymers, surface modifications of the polymers can be highly advantageous. The surface modifications such as plasma etching, plasma-induced cross-linking, plasma polymerization, and chemical vapor deposition can effectively modify the surface characteristics of the nanofabricated polymers, leading to the enhancement of the bulk physical properties of the polymers. In this chapter, the fabrication methods of such nanostructured polymers are reviewed. In addition, several successful cases of well-controlled surface conditions of polymers by plasma processing are introduced.

  • 樹脂/繊維複合材料の界面制御、成形加工と評価

    犬飼駿也，黒川成貴，堀田篤, 技術情報協会, 2018.01

    Scope: 416-423 長繊維セルロースナノファイバーを複合したPVAの力学物性

  • 生体吸収性材料の開発と安全性評価

    北川みどり，谷本啓示，前田知貴，堀田篤, 技術情報協会, 2017.12

    Scope: 45-52 ポリエチレングリコールをベースとしたナノコンポジットハイドロゲルの温度応答性と分解挙動

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Papers 【 Display / hide 】

  • Development of a Water-Soluble Filter for Potential Use in the Toxicity Evaluation of Ambient Particulate Matter

    Yang L., Nishita-Hara C., Shiraishi M., Tsubakida K., Shibata Y., Jing W., Li D., Yoshimura K., Kurokawa N., Hotta A., Okuda T.

    Aerosol and Air Quality Research 26 ( 1 )  2026.01

    ISSN  16808584

    　View Summary

    Assessment of the toxicity of insoluble particulate matter (PM) in the atmosphere is crucially important. However, because of challenges associated with extracting insoluble PM from filters, the toxicity of insoluble PM remains largely uncharacterized. For this study, the water-soluble filter made of poly (vinyl alcohol) (PVA) was developed with high particle collection efficiency, durability, and weather resistance, which are necessary for ambient PM sampling. The PVA filter is water-soluble under certain conditions, allowing for the recovery of insoluble PM, which can be exposed directly to cells or animals for toxicological studies. The PVA filter was made from PVA nanofibers using the electrospinning (ES) method. Its durability and weather resistance were comparable to those of polytetrafluoroethylene (PTFE) and quartz fiber (QF) filters, and were superior to those of commercially available gelatin filters. The PVA filter particle collection efficiency was evaluated by comparing concentrations of inorganic elements (Mg, Al, Si, P, S, Cl, K, Ca, Ti, V, Cr, Mn, Fe, Ni, Cu and Zn) and water-soluble ionic components (Na<sup>+</sup>, NH<inf>4</inf><sup>+</sup>, K<sup>+</sup>, Mg<sup>2+</sup>, Ca<sup>2+</sup>, Cl<sup>−</sup>, NO<inf>3</inf><sup>−</sup>, and SO<inf>4</inf><sup>2−</sup>) in the PVA filter-collected ambient PM with those in the PTFE filter-collected PM. The concentrations of almost all measured components in the PVA filter-collected PM were comparable to those in the PTFE filter-collected PM. When the PVA filter dissolved in cell culture medium was exposed to cells, no significant difference was found in cell viability compared to a blank solution containing only culture medium, suggesting that the PVA filter has potential use for cell exposure experiments.

  • Endothelial cell adhesion and proliferation on wrinkled diamond-like carbon films on grooved PDMS substrates

    Nagashima S., Hasebe T., Hotta A., Suzuki T.

    Rsc Applied Interfaces  2026

    　View Summary

    Controlling the adhesion and proliferation of endothelial cells is essential for the development of functional vascular materials. In this study, we show that wrinkled diamond-like carbon (DLC) films formed on grooved PDMS substrates regulate endothelial cell alignment and proliferation through combined micro- and nanoscale topographical cues. Human umbilical vein endothelial cells cultured on these hierarchical patterns exhibited directional elongation along the grooves, while their lamellipodia and filopodia preferentially adhered to the wrinkle crests. Enzymatic assays confirmed sustained viability and proliferation across different wrinkle dimensions. These results demonstrate that hierarchical micro-/nanoscale topographies on DLC-coated PDMS substrates can effectively modulate endothelial cell behavior, offering promise for vascular tissue engineering.

  • Fabrication and structural analyses of electrospun syndiotactic propylene-ethylene copolymer nanofibers

    Endo F., Di Girolamo R., Talarico G., Scoti M., Kurokawa N., Hotta A.

    Polymer 337 2025.10

    ISSN  00323861

    　View Summary

    Fabrication and structural characterization of syndiotactic propylene-ethylene (sPPEt) copolymer nanofibers were conducted. When using a mixture of methylcyclohexane/DMF/acetone (8:1:1 (wt/wt)) as a solvent, semi-crystalline sPPEt copolymers with ethylene compositions ranging from 1.9 to 11.8 mol% were successfully fabricated into nanofibers via electrospinning. Copolymerization of sPP with ethylene significantly promoted the formation of thinner and smoother nanofibers by suppressing gelation of the spinning solution, thereby enhancing the electrospinnability of the sPP-based copolymer. FTIR and X-ray structural analyses on sPPEt nanofiber membranes revealed that the electrostatic stretching force during the electrospinning process led to a larger proportion of syndiotactic propylene units in the trans-planar conformation and the resulting formation of mesomorphic form crystals, similar to what has been observed during mechanical stretching and subsequent relaxation.

  • Tunable wrinkles in diamond-like carbon films on PDMS substrates

    Nagashima S., Hasebe T., Hotta A., Suzuki T.

    Diamond and Related Materials 151 2025.01

    ISSN  09259635

    　View Summary

    Diamond-like carbon (DLC) films are widely used in engineering applications owing to their excellent mechanical, optical, and biological properties. However, the simple deposition of a DLC film on a soft polymer, including poly(dimethylsiloxane) (PDMS), results in a coarsened surface composed of instability-induced hierarchical wrinkles with limited ability to adjust the dimensions. Overcoming this issue would help create fabrication opportunities for functional surfaces. Here, we demonstrate the controlled formation of wrinkles with tunable wavelengths and amplitudes on the surface of DLC-coated PDMS substrates. Pre-treatment of the substrates with Ar plasma prior to film deposition allows for the formation of wrinkles without structural hierarchy. The wavelength and amplitude can be controlled by adjusting the duration of the plasma treatment while maintaining the film thickness constant. The static contact angles of water droplets on the wrinkled surfaces remain nearly constant regardless of the wavelength of the wrinkles. These tunable wrinkles in DLC films on PDMS substrates have potential engineering applications, including cell scaffolds.

  • Application of low-birefringence polystyrene in high-resolution imaging-lens systems

    Tamura M., Kurokawa N., Hotta A.

    Optical Review 31 ( 4 ) 430 - 439 2024.08

    ISSN  13406000

    　View Summary

    Polystyrene (PS) has not been much used as an optical material due to the considerably high birefringence of PS. For the extensive use of PS in the imaging-lens systems, lower birefringence should be attained for the enhancement of the resolution. Previously, we have developed PS with extremely low birefringence (LB-PS) even when the molecular chain orientation of PS occurred. It indicates that PS may now become an effective material with excellent properties for optical lenses. In this paper, we compared the birefringence of our developed LB-PS with ones of commercial optical polymers that are most commonly utilized in imaging-lens systems. It was confirmed that the birefringence of LB-PS was comparable or even better than that of the commercial ones with high resolution. By designing an imaging-lens system, it was also confirmed that employing PS with the Abbe number of 31.5 could be highly effective in compensating for chromatic aberration as well as obtaining high optical resolution. Moreover, the resolution performance of several lens systems was calculated, analyzed, and compared by considering the birefringence of cyclo-olefin polymer (COP), normal PS, and LB-PS. It was found that LB-PS could maintain high resolution, while normal PS with high birefringence exhibited significant decrease in resolution. It was also found that LB-PS generated higher resolution than COP. All these results revealed that LB-PS could be an excellent optical material to compensate for the chromatic aberration of lens systems, leading to the enhancement of the actual resolution performance. It was, therefore, expected that LB-PS could contribute to improving the resolution performance of smartphone cameras and security cameras.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • 炭素材料が開く新世代医療機器の開発

    長谷部光泉，松本知博，堀田篤，鈴木哲也

    New Diamond (ニューダイヤモンドフォーラム)  31 ( 117 ) 5 - 10 2015.04

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work

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Presentations 【 Display / hide 】

  • バイオマテリアルに向けた高密度ハロゲン結合を有する多機能性エラストマーの合成

    大山裕也，黒川成貴，堀田篤

    [Domestic presentation]  第72回高分子学会年次大会 (Ｇメッセ群馬) , 

    2023.05
    , 

    Poster presentation, 高分子学会

  • ハロゲン結合により自己修復性を有する生分解性・X線視認性エラストマーの合成

    大山裕也，黒川成貴，堀田篤

    [Domestic presentation]  第72回高分子学会年次大会 (Ｇメッセ群馬) , 

    2023.05
    , 

    Oral presentation (general), 高分子学会

  • 高弾性な人工水晶体に向けたポリジメチルシロキサン（PDMS）ボトルブラシポリマの開発

    浅野世夏，堀田篤

    [Domestic presentation]  日本機械学会第62回学生員卒業研究発表講演会 (web開催) , 

    2023.03
    , 

    Oral presentation (general), 日本機械学会

  • 腸リンパ管造影に向けたヨード化ケシ油脂肪酸エチルエステル胆汁酸ミセルの作製

    半谷隆弥，堀田篤

    [Domestic presentation]  日本機械学会第62回学生員卒業研究発表講演会 (web開催) , 

    2023.03
    , 

    Oral presentation (general), 日本機械学会

  • シクロオレフィンコポリマにセルロースナノファイバを複合した高強度透明耐熱材料の作製

    武内裕太郎，堀田篤

    [Domestic presentation]  日本機械学会第62回学生員卒業研究発表講演会 (web開催) , 

    2023.03
    , 

    Oral presentation (general), 日本機械学会

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Development of High-Performance Sustainable Polymers with Reversible Crosslinking via Diverse Intermolecular Interactions

    2025.06
    -
    2031.03

    挑戦的研究（開拓）, Principal investigator

  • 熱可逆性を有する含水率99%以上の高強度ダブルネットワークハイドロゲルの創製

    2019.06
    -
    2022.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory) , Principal investigator

  • 高耐熱・高強度スーパーエンプラナノファイバーを作る

    2019.04
    -
    2024.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A) , Principal investigator

  • ポリマーゲルを用いた人工血栓作製および血管内皮細胞を用いた血管内損傷試験モデル構築

    2018.04
    -
    Present

    Joint research, Principal investigator

  • ポリマーの熱可塑性・形状記憶性・自己修復性の基礎研究

    2018.04
    -
    2019.03

    Commissioned ｒesearch, No Setting

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Works 【 Display / hide 】

  • 血管再狭窄 長期防止に道 薬剤溶出ステント 被覆技術開発 血液付着せず内皮化増進

    長谷部光泉、鈴木哲也、堀田篤

    日刊工業新聞 朝刊21面, 

    2016.12
    -
    Present
    , 

    Other

    　View Details

    東海大学医学部の長谷部光泉教授と慶応義塾先端科学技術研究センターの鈴木哲也所長、慶応義塾大学理工学部の堀田篤教授らは、内皮細胞の増殖を促す薬剤溶出ステント用のコーティング技術を開発した。ステントへの血液成分の付着しにくさと、内皮細胞への覆われやすさを両立させた。患者の血管の再狭窄（きょうさく）を長期的に防げる可能性がある。新技術では、まずリン脂質ポリマー（ＭＰＣ）で表面を覆い、その上にダイヤモンド・ライク・カーボン（ＤＬＣ）を成膜する。

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Intellectual Property Rights, etc. 【 Display / hide 】

  • 塞栓材及びその製造方法

    Date applied： 特願 2021-032665  2021.03 

    Patent, Joint

  • 塞栓材およびその製造方法

    Date applied： 特願 2021-008824  2021.01 

    Patent, Joint

  • 抗微生物性樹脂および塗材

    Date applied： 特願 2019-017544, 国際公開番号 WO 2019/208674 A1  2019.10 

    Patent, Joint

  • 化学修飾ナノダイヤモンド粒子，その製造方法，及びそれを用いたＭＲＩ造影剤

    Date applied： 特願2019-41536  2019.09 

    Patent, Joint

  • 固体（ポリ（2-メトキシエチルアクリレート）

    Date applied： 特願2018-35438  2018.02 

    Patent, Single

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Awards 【 Display / hide 】

  • Best Presentation Award

    内田陸登，堀田篤, 2023.03, The Japan Society of Mechanical Engineers, 分子末端にカチオン基を有する透明ポリマ樹脂の作製とその抗菌性

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • Best Presentation Award

    篠田祐樹，堀田篤, 2023.03, The Japan Society of Mechanical Engineers, ポリマ側鎖に官能基を有する生分解性ポリマの有機触媒合成

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • Best Presentation Award

    石塚駿介，堀田篤, 2022.03, The Japan Society of Mechanical Engineers, カチオン基の末端を有する分子量を制御したポリスチレンの抗菌性

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • Best Presentation Award

    高村修平，堀田篤, 2022.03, The Japan Society of Mechanical Engineers, 自然由来のポリメチルカプロラクトンを用いた自己修復性エラストマの作製

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 第54回リバネス研究費　東洋紡　高分子科学賞

    大山裕也, 2022.02, リバネス, 医療応用に向けた，使用用途に応じて機能性を付与できる生分解性ポリマーの合成とその高強度化

    Type of Award： Honored in official journal of a scientific society, scientific journal

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Courses Taught 【 Display / hide 】

  • PHYSICS A

    2025

  • MATERIAL DESIGN

    2025

  • LABORATORIES IN SCIENCE AND TECHNOLOGY

    2025

  • INTRODUCTION TO MATERIALS SCIENCE

    2025

  • INDEPENDENT STUDY ON SCIENCE FOR OPEN AND ENVIRONMENTAL SYSTEMS

    2025

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Courses Previously Taught 【 Display / hide 】

  • 物理学Ａ

    Keio University

    2018.04
    -
    2019.03
    , 

    Spring Semester, Lecture, Within own ｆaculty, 200people

  • 開放環境科学特別研究第2

    Keio University

    2018.04
    -
    2019.03
    , 

    Full academic year, Within own ｆaculty

  • 開放環境科学特別研究第１

    Keio University

    2018.04
    -
    2019.03
    , 

    Full academic year, Within own ｆaculty

  • 開放環境科学課題研究

    Keio University

    2018.04
    -
    2019.03
    , 

    Full academic year, Within own ｆaculty

  • 卒業研究

    Keio University

    2018.04
    -
    2019.03
    , 

    Full academic year, Within own ｆaculty

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Memberships in Academic Societies 【 Display / hide 】

  • 日本ポリオレフィン総合研究会, 

    2013.04
    -
    Present

  • Society of Polyolefin Science & Industry, Japan, 

    2009.04
    -
    Present

  • American Chemical Society, 

    2005.09
    -
    Present

  • Biophysical Society, 

    2005.09
    -
    Present

  • 日本機械学会, 

    2005.04
    -
    Present

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Committee Experiences 【 Display / hide 】

  • 2016.04
    -
    2017.03

    科学研究費補助金・第2段審査・審査第一部会工学小委員会・委員, 日本学術振興会

  • 2014.04
    -
    Present

    日本機械学会広報・情報部会委員, 日本機械学会

  • 2013
    -
    2015

    科学研究費補助金　第1段審査（書面審査）委員, 日本学術振興会

  • 2012.04
    -
    Present

    日本機械学会校閲委員, 日本機械学会

  • 2011.09
    -
    Present

    Editorial Advisory Board, Journal of Applied Polymer Science

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