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Affiliation
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Faculty of Science and Technology, Department of Applied Chemistry Yagami Campus 23-603 (Yagami)
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Position
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Associate Professor
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Related Websites
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Contact Address
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3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa
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External Links
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Takahashi, Daisuke
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Career 【 Display / hide 】
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2005.04-2006.03
Japan Society for the Promotion of Science (JSPS) Research Fellow (DC2)
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2006.04-2007.03
Japan Society for the Promotion of Science (JSPS) Research Fellow (PD)
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2007.04-2008.03
Carlsberg Laboratory, Postdoctoral Fellow
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2008.04-2011.03
Keio University, Department of Applied Chemistry, Faculty of Science and Technology, Research Associate (Non-tenured)
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2011.04-2012.03
Keio University, Department of Applied Chemistry, Faculty of Science and Technology, Research Associate
Academic Background 【 Display / hide 】
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1997.04-2001.03
Tokyo Institute of Technology, Faculty of Engineering, Applied chemistry
University, Graduated
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2001.04-2006.03
Tokyo Institute of Technology, Graduate School of Science and Technology, Department of Applied Chemistry
Graduate School, Completed, Doctoral course
Academic Degrees 【 Display / hide 】
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Ph.D., Tokyo Institute of Technology, Coursework, 2006.03
Research Areas 【 Display / hide 】
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Nanotechnology/Materials / Structural organic chemistry and physical organic chemistry (Carbohydrate Chemistry)
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Life Science / Bioorganic chemistry (Carbohydrate Chemistry)
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Nanotechnology/Materials / Structural organic chemistry and physical organic chemistry (Synthetic Organic Chemistry)
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Life Science / Bioorganic chemistry (Synthetic Organic Chemistry)
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Nanotechnology/Materials / Chemical biology
Research Keywords 【 Display / hide 】
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Carbohydrate Chemistry
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Synthetic Organic Chemistry
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Glycosylation Reaction
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Chemical Biology
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Glycosylated Natural Products
Books 【 Display / hide 】
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Modern Natural Product Synthesis -Overcoming Difficulties
*DAISUKE TAKAHASHI, *Kazunobu Toshima, Springer Nature, 2024.05, Page： 20
Scope: Complex Oligosaccharides Synthesis—Challenges and Tactics, Contact page： 299-318 , Accepted
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Comprehensive Glycoscience: Second Edition
*DAISUKE TAKAHASHI, *Kazunobu Toshima, Elsevier, 2021.06, Page： 48
Scope: 1,2-cis O-Glycosylation Methods, Contact page： 365-412 , Accepted
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糖鎖の新機能開発・応用ハンドブック
高橋大介、戸嶋一敦, エヌ・ティー・エス, 2015.08
Scope: 標的糖鎖光分解用生体機能分子, pp. 377-379.
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糖鎖の新機能開発・応用ハンドブック
佐々木要、高橋大介、戸嶋一敦, エヌ・ティー・エス, 2015.08
Scope: 環境調和型グリコシル化反応, pp. 339-342.
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機能性配糖体の合成と応用－糖転移酵素を中心に－
関根麻衣子、高橋大介、戸嶋一敦, シーエムシー出版, 2013
Scope: イオン液体を用いたバイオマス糖質からの配糖体合成, 第12章, pp. 115-123.
Papers 【 Display / hide 】
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Photo-induced glycosylation using edible polyphenol ellagic acid
Hidenari Shigeta, Satomi Goi, DAISUKE TAKAHASHI, *Kazunobu Toshima
Carbohydrate Research (Elsevier) 552 109461 2025.03
Research paper (scientific journal), Joint Work, Accepted
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Creation of a New Macrolide Antibiotic against Non-tuberculous Mycobacterium Using Late-stage Boron-mediated Aglycon Delivery
Yuka Isozaki, Takumi Makikawa, Kosuke Kimura, Daiki Nishihara, Fujino, Yoshikazu Tanaka, Chigusa Hayashi, Yoshimasa Ishizaki, *Masayuki Igarashi, *Takeshi Yokoyama, *Kazunobu Toshima, *DAISUKE TAKAHASHI
Science Advances (American Association for the Advancement of Science) 11 ( 10 ) eadt2352 2025.03
Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted
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A novel porphyrin-based theranostic agent activated by cysteine over-expressed in cancer cells shows promise for tumour-targeted monitoring and phototherapy
Fumihisa Ishida, Satoe Moriya, DAISUKE TAKAHASHI, *Kazunobu Toshima
Bioorganic & Medicinal Chemistry (Elsevier) 121 118131 2025.02
Research paper (scientific journal), Joint Work, Accepted
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Synthesis of Low-Molecular-Weight Fucoidan Analogue and Its Inhibitory Activities against Heparanase and SARS-CoV-2 Infection
Aoi Sugimoto, Tatsuki Koike, Yuya Kuboki, Sumika Komaba, Shuhei Kosono, Maniyamma Aswathy, Itsuki Anzai, Tokiko Watanabe, *Kazunobu Toshima, *DAISUKE TAKAHASHI
Angewandte Chemie International Edition (Wiley-VCH) 64 ( 6 ) e202411760 2024.10
Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted
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A novel photosensitizer based on hypocrellin B activated by cysteine over-expressed in cancer cells
Fumihisa Ishida, Rikuto Onishi, DAISUKE TAKAHASHI, *Kazunobu Toshima
Organic & Biomolecular Chemistry (Royal Society of Chemistry) 22 7187 - 7193 2024.08
Research paper (scientific journal), Joint Work, Accepted
Papers, etc., Registered in KOARA 【 Display / hide 】
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Takahashi, Daisuke
科学研究費補助金研究成果報告書 2022
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Challenges in the development of glycoconjugate vaccines against zoonosis based on organic chemistry
Takahashi, Daisuke
科学研究費補助金研究成果報告書 2021
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Takahashi, Daisuke
学事振興資金研究成果実績報告書 (慶應義塾大学) 2020
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Takahashi, Daisuke
学事振興資金研究成果実績報告書 (慶應義塾大学) 2019
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Synthetic and structure-activity relationship studies on a natural glycolipid, terpioside B
Takahashi, Daisuke
学事振興資金研究成果実績報告書 (慶應義塾大学) 2018
Reviews, Commentaries, etc. 【 Display / hide 】
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高機能性化粧品素材の創製を指向したマンノシルエリスリトールリピッド（MEL）類縁体の合成と構造活性相関研究
孟継坤, *戸嶋一敦, *高橋大介
オレオサイエンス 24 ( 11 ) 475 - 481 2024.11
Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Last author, Corresponding author
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ホウ素媒介アグリコン転移反応の新展開:反応開発,有用糖質合成,およびケミカルバイオロジーへの応用
*高橋大介, *戸嶋一敦
有機合成化学協会誌 82 ( 9 ) 856 - 866 2024.09
Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Lead author, Corresponding author
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Total Synthesis of Mannosylerythritol Lipids and Structure-Function Relationship Studies
*DAISUKE TAKAHASHI, Kazunobu Toshima
Journal of Oleo Science 73 ( 4 ) 539 - 546 2024.04
Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Lead author, Corresponding author
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Photo-Induced Glycosylations Using Organophotoacids: A New Environmentally Benign Carbohydrate Synthesis
*Kazunobu Toshima, DAISUKE TAKAHASHI, Yuka Isozaki
Synlett 35 777 - 788 2023.07
Article, review, commentary, editorial, etc. (scientific journal), Joint Work
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有機化学を基盤とした鳥類病原性大腸菌に対する複合糖質ワクチン開発への挑戦
<u>高橋大介</u>
日生研たより 69 ( 2 ) 3 - 11 2023.04
Article, review, commentary, editorial, etc. (scientific journal), Single Work, Lead author, Last author, Corresponding author
Presentations 【 Display / hide 】
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Synthesis of Useful Carbohydrates and Structure-Activity Relationship Studies Toward the Creation of Carbohydrate-Based Drugs
〇高橋 大介
日本化学会 第105春季年会 (関西大学 千里山キャンパス) ,
2025.03,Oral presentation (invited, special)
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Creation of a New Macrolide Antibiotic against Non-tuberculous Mycobacterium by Late-stage Boron-mediated Aglycon Delivery
〇Yuka Isozaki, Takumi Makikawa, Kosuke Kimura, Daiki Nishihara, Maho Fujino, Yoshikazu Tanaka, Chigusa Hayashi, Yoshimasa Ishizaki, Masayuki Igarashi, Takeshi Yokoyama, Kazunobu Toshima, Daisuke Takahashi
日本化学会 第105春季年会 (関西大学 千里山キャンパス) ,
2025.03,Oral presentation (general)
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Development of Microwave-Controlled Boron-Mediated Aglycon Delivery and Total Synthesis of Plant Hormone CLE2
〇Kazuki Senoo, Kazuki Inaba, Ayato Takayanagi, Yuji Wada, Makoto Yasuda, Kazunobu Toshima, Daisuke Takahashi
日本化学会 第105春季年会 (関西大学 千里山キャンパス) ,
2025.03,Oral presentation (general)
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Synthesis of Mannosylerythritol Lipid-Containing LNPs and Their Nucleotide Delivery Activities
〇Misuzu Iha, Itsuki Anzai, Tokiko Watanabe, Kotomi Aso, Yuuya Kasahara, Kazunobu Toshima, Daisuke Takahashi
日本化学会 第105春季年会 (関西大学 千里山キャンパス) ,
2025.03,Oral presentation (general)
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Precise Synthesis of Glycosides and Structure-Activity Relationship Studies Aimed at Creation of Lead Compounds for Drug Development
〇Daisuke Takahashi
12th SINGAPORE INTERNATIONAL CHEMISTRY CONFERENCE (SICC-12) (Max Atria @ Singapore Expo) ,
2024.12,Oral presentation (invited, special)
Research Projects of Competitive Funds, etc. 【 Display / hide 】
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精密糖鎖合成を基盤とした次世代創薬モダリティーの創出
2025.04-PresentMEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Transformative Research Areas (A), Principal investigator
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⾰新的配糖化技術を基盤とした肺⾮結核性抗酸菌（NTM）症に対する新規 抗菌物質の創製
2024.01-2025.12公益財団法人シオノギ感染症研究振興財団, 創薬研究助成金, Principal investigator
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ホウ素媒介アグリコン転移を用いた1,2-cis フラノシドの精密化学合成と応用
2023.04-PresentMEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator
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糖脂質型バイオサーファクタントの精密化学合成と構造機能相関による新規高機能性化粧品素材の創製
2022.12-2025.03公益財団法人コーセーコスメトロジー研究財団, Principal investigator
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広域スペクトルを有する抗ウイルス薬開発を目指した創薬標的探索と次世代創薬モダリティの基盤構築
2022.10-PresentAMED, AMED-CREST, Coinvestigator(s)
Intellectual Property Rights, etc. 【 Display / hide 】
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新規な抗生物質及びその製造方法
Date applied： 特願2023- 90620 2023.06
Patent, Joint
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抗腫瘍剤
Date applied： 特願2014-140761 2014.07
Date announced： 特開2015-38061 2015.02
Date issued： 特許6403317 2018.10
Date registered： 2018.09
Patent, Single
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ノイラミニダーゼに対する酵素阻害剤
Date applied： 特願2010-022168 2010.02
Date announced： 特開2011-157325 2011.08
Patent, Joint
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糖鎖アレイ及びその製造方法
Date applied： 特願2004-264922 2004.09
Date announced： 特開2006-78418 2006.03
Patent
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Ｎ-グリコシルアミドの製造方法
Date applied： 特願2003-436790 2003.12
Date announced： 特開2005-187441 2005.07
Patent, Single
Awards 【 Display / hide 】
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2023 Asian Core Program Lectureship Award
DAISUKE TAKAHASHI, 2023.12, The Organizing Committee of the 16th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-16), Efficient Synthesis of Biologically Active Glycosides by Boron-Mediated Aglycon Delivery and Their Applications in Chemical Biology
Type of Award： Award from international society, conference, symposium, etc.
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Oleomaterial award
Daisuke Takahashi, 2022, Japan Oil Chemists' Society Oleomaterial Division, Efficient Total Synthesis of Mannosylerythritol Lipids and Their Structure-Function Studies
Type of Award： Award from Japanese society, conference, symposium, etc.
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The Carbohydrate Research Award for Creativity in Carbohydrate Chemistry
2021, The Editorial Board and Publisher of Carbohydrate Research
Type of Award： Award from publisher, newspaper, foundation, etc.
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Incentive Award in Synthetic Organic Chemistry, Japan (2016)
2017.02, The Society of Synthetic Organic Chemistry, Japan, Precise Synthesis and Chemical Biological Studies of Certain Carbohydrates, and Creation of Artificial Bio-functional Molecules
Type of Award： Award from Japanese society, conference, symposium, etc.
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2016 Incentive Award in the Japanese Society of Carbohydrate Research
2016.09, The Japanese Society of Carbohydrate Research, Target-Selective Synthesis and Photodegradation of Oligosaccharides Utilizing Chemical Properties of Organoboronic Acids
Type of Award： Award from Japanese society, conference, symposium, etc.
Courses Taught 【 Display / hide 】
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SEMINAR IN APPLIED CHEMISTRY
2025
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MOLECULAR LIFE CHEMISTRY 2
2025
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LABORATORY IN SCIENCE
2025
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LABORATORIES IN APPLIED CHEMISTRY D
2025
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INDEPENDENT STUDY ON FUNDAMENTAL SCIENCE AND TECHNOLOGY
2025
Courses Previously Taught 【 Display / hide 】
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Molecular Life Chemistry 1
Keio University
2018.04-2019.03,Autumn Semester, Lecture, Within own ｆaculty, 1h
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Molecular Life Chemistry 2
Keio University
2018.04-2019.03,Autumn Semester, Lecture, Within own ｆaculty, 1h
糖鎖、化学合成、生合成、酵素合成、糖鎖生物学、癌、インフルエンザ
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生体物質化学基礎
Keio University
2018.04-2019.03,Autumn Semester, Lecture, Within own ｆaculty, 1h, 161people
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LABORATORIES IN APPLIED CHEMISTRY D
Keio University
2018.04-2019.03,Autumn Semester, Laboratory work/practical work/exercise, Within own ｆaculty
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SEMINAR IN APPLIED CHEMISTRY
Keio University
2018.04-2019.03,Full academic year
Memberships in Academic Societies 【 Display / hide 】
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日本応用糖質科学会、会員,
2023.11-Present -
Japan Oil Chemists' Society, member,
2018.06-Present -
American Chemical Society, member,
2017.11-Present -
FCCA (Forum: Carbohydrates Coming of Age), member,
2012.09-Present -
日本ケミカルバイオロジー学会、会員,
2008-Present
Committee Experiences 【 Display / hide 】
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2023.07-2024.06
日本学術振興会特別研究員等審査会専門委員, 独立行政法人 日本学術振興会
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2023.03-Present
日本化学会 代表正会員, 日本化学会
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2023.01-Present
Associate Editor, Trends in Glycoscience and Glycotechnology
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2023.01-Present
TIGGトピック担当幹事, FCCA (Forum: Carbohydrates Coming of Age)
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2023.01-Present
幹事会員, FCCA (Forum: Carbohydrates Coming of Age)