Fujimoto, Keiji

写真a

Affiliation

Faculty of Science and Technology, Department of Applied Chemistry ( Yagami )

Position

Professor

Related Websites

External Links
Scopus Paper Info  
Paper Count: 120 Citation Count: 3184 h-index: 30

Click to view the Scopus page. The data was downloaded from Scopus API in September 06, 2026, via http://api.elsevier.com and http://www.scopus.com .

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Career 【 Display / hide 】

  • 1990.04
    -
    1996.03

    慶應義塾大学（理工学部） ,助手

  • 1994.09
    -
    1995.08

    米国マサチューセッツ州立大学訪問研究員

  • 1996.04
    -
    1999.03

    慶應義塾大学（理工学部） ,専任講師

  • 1999.04
    -
    2008.03

    慶應義塾大学（理工学部） ,助教授

  • 2000.04
    -
    2002.03

    大学院学習指導副主任（物質科学専攻）

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Academic Background 【 Display / hide 】

  • 1985.03

    Kyoto University, Faculty of Engineering, 高分子化学科

    University, Graduated

  • 1987.03

    Kyoto University, 工学部工学研究科, 高分子化学専攻

    Graduate School, Completed, Master's course

  • 1990.03

    Kyoto University, 工学部工学研究科, 高分子化学専攻

    Graduate School, Withdrawal after completion of doctoral course requirements, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 京都大学博士（工学）, Kyoto University, Coursework, 1993.03

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Licenses and Qualifications 【 Display / hide 】

  • 昭和６２年国家公務員採用１種, 1987

  • 昭和６３年国家公務員採用１種, 1988

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Research Areas 【 Display / hide 】

  • Nanotechnology/Materials / Composite materials and interfaces

  • Nanotechnology/Materials / Nanobioscience (Nano Materials/Nano Bioscience)

  • Nanotechnology/Materials / Polymer chemistry (Polymer Science and Engineering)

  • Nanotechnology/Materials / Polymer materials (Polymer/Textile Materials)

  • Nanotechnology/Materials / Organic functional materials

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Research Keywords 【 Display / hide 】

  • Green particle

  • エコマテリアル

  • ソフトマテリアル

  • ドラッグデリバリーシステム

  • ナノコーティング

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Proposed Theme of Joint Research 【 Display / hide 】

  • リポナノカプセル

    Interested in joint research with industry (including private organizations, etc.),  Desired form： Technical Consultation, Funded Research

  • cosmetics

    Interested in joint research with industry (including private organizations, etc.),  Desired form： Technical Consultation, Funded Research

  • 微粒子組織体

  • 細胞表層改質

  • 組織マテリアル工学

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Books 【 Display / hide 】

  • 高分子微粒子の最新技術動向　高分子微粒子の構造・配列・付着・埋没・ナノインプリントを利用した表面改質

    藤本啓二、福井有香, シー・エム・シー, 2022.07

    Contact page： 11-19

  • 高分子基礎ガイド

    藤本啓二、川口正剛、小泉智、福井有香、箕田雅彦、本柳仁, 朝倉書店, 2022.02

  • ドラッグデリバリーシステム　リポソームの表面改質によるナノカプセルの作製と機能化

    福井有香、藤本啓二, シーエムシー出版, 2018.06

    Contact page： 195-206

  • 高分子微粒子ハンドブック　高分子微粒子とは

    藤本 啓二, シーエムシー出版, 2017.07

    Scope: 高分子微粒子とは,  Contact page： 1-14

  • 高分子微粒子ハンドブック　コアシェル微粒子の作製と機能化

    藤本 啓二, シーエムシー出版, 2017.07

    Contact page： 167-175

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Papers 【 Display / hide 】

  • Suspension of liposome-based nanocapsules in organic solvents via surface acetylation of chitosan-deposited liposomes.

    Mihara T, Fukui Y, Fujimoto K

    Colloids and surfaces. B, Biointerfaces (Elsevier)  259   115346 2026.03

    Research paper (scientific journal), Joint Work, Last author, Accepted,  ISSN  0927-7765

    　View Summary

    Liposomes are valuable drug and cosmetic carriers but face limitations in stability and active loading from external phases. Polymer-coated liposomes (liponanocapsules) have improved robustness, and this study advances the approach by acetylating chitosan-coated liposomes to form chitin-deposited capsules, leveraging chitin's biocompatibility and insolubility to enhance the structural and colloidal stability in organic solvents and oils. This represents the first report of suspensions of liposome-based capsules in such media. Anionic liposomes prepared from dilauroyl phosphatidyl acid acquire a hydrodynamic diameter increase from 100 to 190 nm and shift in ζ-potential from negative to positive upon chitosan deposition. Surface acetylation of the deposited chitosan with sodium acetate and a condensing agent yields chitin-deposited liposomes (Lipo[-]-chitin), with the degree of acetylation (DA) controlled by changing the reagent concentration. Lipo[-]-chitin shows a shift in the phase transition of the lipid membrane to a higher temperature owing to the suppression of lipid fluidity, suggesting that the capsules become rigid and robust. The hydrodynamic diameter of Lipo[-]-chitin in water increases with the DA because of capsule aggregation. By contrast, Lipo[-]-chitin becomes smaller in mixtures of water and water-miscible organic solvents, such as dimethyl sulfoxide (DMSO), ethanol, and acetone, indicating a positive impact of acetylation on the colloidal stability. In mixtures of water with DMSO or ethanol, a higher DA reduces the colloidal stability, whereas the opposite trend is observed in acetone. These results indicate that the colloidal stability of the acetylated capsules is strongly governed by the DA. Notably, Lipo[-]-chitin with a higher DA can be suspended in 100 % ethanol without aggregation or rupture. The solvent can then be replaced with poorly water-soluble organic solvents, such as isododecane. This enabled active loading of α-tocopherol as a lipophilic cargo into the capsule. Overall, surface acetylation of chitosan-coated liposomes produces chitin-deposited nanocapsules with enhanced solvent resistance, offering a promising platform for pharmaceutical, cosmetic, and nanocomposite applications.

  • Preparation of hydrogel and xerogel nanoparticles composed of methylcellulose: possible use in drug delivery and polymer composites

    Fukui Y., Wada K., Fujimoto K.

    Polymer Journal (Springer Nature )  58   287 - 299 2025.12

    Research paper (scientific journal), Joint Work, Last author, Accepted,  ISSN  00323896

    　View Summary

    To improve the water resistance of products prepared from water-soluble cellulose derivatives, we prepared cellulose-based nanoparticles without chemical modifications such as crosslinking. We employed a W/O (water-in-oil) miniemulsion as a nanoreactor to prepare cellulose-based particles. Methylcellulose (MC) was selected as the cellulose-derived biomass polymer. Aqueous nanodroplets, including MC, were suspended in corn oil by homogenization and ultrasonication. MC hydrogel nanoparticles (MC-H) were subsequently obtained via the gelation of MC within the nanodroplets with increasing temperature. Next, to obtain MC xerogel nanoparticles (MC-X), we carried out water evaporation from MC-H. Furthermore, MC-X with different inner structures could be obtained by tuning the temperature and pressure of the evaporation conditions. MC-H and MC-X showed high water resistance because of the strong association of MC chains, which was promoted in confined vessels such as nanodroplets and nanoparticles. In addition, the release of water-soluble substances from MC-H was promoted at 4 °C below the dissolution temperature of MC, whereas MC-X exhibited suppressed release because of the strong association of MC chains. To explore the utility of MC-X as a biomass-derived filler, it was embedded in the polymer film. MC-X was slightly aggregated but evenly distributed within the film without compromising its transparency.

  • Core-shell Particle Embedding into Human Hair: A Novel Approach for Surface Modification and Long-Lasting Hair Coloration

    Fujimoto K., Nishimura M., Fukui Y.

    ACS Omega (ACS)  10 ( 20 ) 20585 - 20592 2025.05

    Research paper (scientific journal), Joint Work, Lead author, Corresponding author, Accepted,  ISSN  2470-1343

    　View Summary

    To embed particles into human hair, core-shell (CS) particles were prepared by seeded emulsion polymerization and were arrayed to the surface of natural hair via dip coating. The particle-coated natural hair was treated at various temperatures in a controlled environment with a relative humidity of 5% (5% RH). No particle embedding was observed at 25 °C. However, the degree of particle embedding (DE) slightly increased at 50 °C and substantially at 150 °C. At 100% RH, embedding was effectively achieved at 50 °C, probably because the adsorbed water acted as a plasticizer, softening the hair. Bleached hair exhibited a significant reduction in surface wettability, whereas the DE of CS particles remained comparable to that of natural hair, indicating that surface wettability does not affect the particle embedding process. On the other hand, hair treated with a reducing agent displayed a notable increase in the DE, reaching approximately 20% even at 25 °C and increasing to 35% at 150 °C. At 100% RH, DE values dramatically increased to approximately 35%, even at 25 °C. Sudan Black B was incorporated into the CS particles to produce stained particles (CS(B) particles). This staining process enabled the coloration of bleached hair by arranging and embedding CS(B) particles. Visual observation confirmed uniform coloration of the hair samples. The color difference (ΔE*) results strongly indicated that bleached hair could be effectively dyed with CS(B) particles. Additionally, the color of CS(B) particle-embedded hair remained stable after ultrasonication, demonstrating that particle embedding ensures long-lasting hair coloration by securely embedding the stained particles within the hair samples.

  • Preparation of a CNF porous membrane and in situ synthesis of silver nanoparticles (AgNPs)

    Fukui Y., Baba E., Fujimoto K.

    RSC Advances (RSC)  15 ( 2 ) 1115 - 1124 2025.01

    Research paper (scientific journal), Joint Work, Last author, Accepted

    　View Summary

    We prepared a cellulose nanofiber (CNF)-based porous membrane with three dimensional cellular structures. CNF was concentrated via a surfactant-induced assembly by mixing CNF with a cationic surfactant, domiphen bromide (DB). Furthermore, they were accumulated by centrifugation to obtain a CNF-DB sol. Next, when the CNF-DB sol was naturally dried, a membrane composed of densely packed CNF was obtained. On the other hand, when the CNF-DB sol was freeze-dried, a porous membrane with the anisotropic cellular structure could be obtained. The interspace between layered CNF sheets was tunable by the DB concentration in the assembly process and the centrifugal force in the accumulation process. FT-IR analysis of the porous membrane showed the formation of hydrogen bonds between the CNF, resulting in facilitation of crosslinking of the CNF and formation of the cellular structures. The obtained CNF-DB membrane exhibited high water resistance. They showed a high ability to absorb hydrophobic dyes such as Nile red and rhodamine B (RhB) due to the presence of the hydrophobic core of DB micelles. Then, the release of RhB could be controlled by the ionic strength in the medium. In addition, they possessed a high ability to adsorb cationic metals such as Ag ions due to the presence of carboxyl moieties of CNF. Next, in situ synthesis of silver nanoparticles (AgNPs) was carried out by employing the CNF-DB membrane as a template for Ag ion adsorption and reduction. Deposition of AgNPs could be observed on the CNF-DB membrane, which suppressed aggregation of AgNPs. Almost all AgNPs were arrayed apart from each other to generate the hotspots, which could enhance surface-enhanced Raman scattering (SERS) of AgNPs. Such an AgNPs-CNF composite membrane could be applied for a label-free analysis of adsorbed RhB.

  • Preparation of a robust and degradable nanocapsule by polymer deposition over the liposome for loading and release of cargos

    Fukui Y., Ito J., Takeiri M., Fujimoto K.

    Colloids and Surfaces A: Physicochemical and Engineering Aspects (Elsevier)  676   132160 2023.11

    Research paper (scientific journal), Joint Work, Last author, Accepted,  ISSN  09277757

    　View Summary

    We prepared biobased nanocapsules by the polymer deposition over the ceramide-containing liposomes to render abilities to load versatile substances and to release them in response to enzymatic degradation of the capsule wall. First, we carried out phosphorylation of chitosan (CHI) to make it amphoteric. Then, we prepared a liposome containing glucosylceramide (GlcCer) and carried out deposition of phosphorylated chitosan (PCHI). The obtained capsule showed high structural stability against solubilization by surfactants and organic solvents, where it maintained its size even in 90 vol% DMSO. Next, we attempted to load various substances into the capsule. A lipophilic Nile red dissolved in 50 vol% DMSO could be loaded into the capsule without rupturing. The loading capacity of PCHI-deposited liposomes was almost three times higher than that of bare liposomes. Its release was suppressed to less than 10 % in an aqueous solution, whereas it could be released to more than 40 % when a small amount of surfactant was added to mimic a lipophilic environment. Also, an amphoteric nature of the capsule derived from PCHI allowed for loading of both cationic and anionic substances. Furthermore, lysozyme (Lyso) was deposited onto the capsule to provide the capsule wall with the enzymatic degradability. Although the release of substances from the capsule was suppressed to less than 10 % without Lyso, it was increased to approximately 50 % by enzymatic degradation of the PCHI layer.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • Development of Multi-Functional Nanocapsules by Surface and Inner Modifications of Liposomes with Polymers

    藤本啓二、福井有香

    月刊ファインケミカル ((株)シーエムシー出版)  54 ( 2 ) 5 - 11 2025.05

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Corresponding author

  • Fabrication of Polymer Particle Adhesives for Multi-material Joining

    FUJIMOTO Keiji

    Hosokawa Powder Technology Foundation ANNUAL REPORT (Hosokawa Powder Technology Foundation)  28   82 - 87 2021.05

    Internal/External technical report, pre-print, etc., Single Work

    　View Summary

    <p>There are plenty of adhesive supra-structures in nature. For instance, geckos have a number of submicron-sized fibers on their feet, which allow it to stick and adhere strongly along the contour of the surface. This structure makes it possible for geckos to show strong adhesiveness to various surfaces. Inspired by such adhesion mechanism derived from micro- and nano-structures, I aimed to create a multi-layered gel membrane possessing surface adhesiveness and followability. The layer-by-layer deposition of gel particles via a polymer complex was carried out onto the gel base to create 3D gel structures. By tuning the type and the number of the layer-by-layer deposition, I could modulate elasticity and surface followability of the gel membrane to improve its adhesiveness.</p>

  • 高分子微粒子の作り方と活かし方

    藤本啓二, 福井有香

    粉体技術 13   27 - 34 2021

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Lead author

  • 高分子微粒子のつくり方と活かし方

    藤本啓二、福井有香

    塗装工学 54   394 - 403 2019

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Lead author

  • 高分子微粒子の創りかたと医用高分子への活かしかた

    藤本啓二, 福井有香

    工業材料 65   36 - 42 2017

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Lead author

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Presentations 【 Display / hide 】

  • S/O/Wエマルションによる油滴への鉄イオンの封入と細胞死誘導に向けた放出制御

    福井 有香、白木 麻衣、藤本 啓二

    [Domestic presentation]  第75回高分子討論会 (東京理科大学葛飾キャンパス) , 

    2026.09
    , 

    Oral presentation (general), 高分子学会

  • リポソーム表面へのポリマー層の構築による油中分散型ナノカプセルの作製と難水溶性物質の封入

    三原友美、福井有香、藤本啓二

    [Domestic presentation]  第55回医用高分子シンポジウム (産総研、お台場) , 

    2026.07
    , 

    Poster presentation, 高分子学会

  • ミニエマルションを用いたキトサングリーン微粒子の作製と抗酸化剤の保持・放出

    福井有香、澤田さくら、藤本啓二、茂垣里奈、五十島健史

    [Domestic presentation]  (産総研、お台場) , 

    2026.07
    , 

    Oral presentation (general), 高分子学会

  • アルギン酸とアガロースのゲル化を用いたリポナノカプセル含有ゲルの作製

    廣田彩、福井有香、藤本啓二

    [Domestic presentation]  第55回医用高分子シンポジウム (産総研、お台場) , 

    2026.07
    , 

    Poster presentation, 高分子学会

  • 可能性志向研究による微粒子材料の創製と機能化

    藤本啓二

    第158回学術大会, 

    2026.05
    , 

    Oral presentation (invited, special), 毛髪科学技術者協会

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Therapeutic biofilmによる歯周病・根面う蝕治療アプローチの転換

    2019.04
    -
    2021.03

    日本学術振興会, 科学研究費助成事業, Research grant, Coinvestigator(s)

  • フレイルとAMRの課題に対応する食品由来機能ペプチドを素材とした歯周病医薬開発

    2019.04
    -
    2021.03

    日本学術振興会, 科学研究費助成事業, Research grant, Coinvestigator(s)

  • マルチマテリアル接合を目指した微粒子構造体の創製

    2018.04
    -
    2019.03

    ホソカワ粉体工学振興財団, 研究助成, Research grant, Principal investigator

  • 細胞表層工学による次世代ナノバイオマテリアルの創製

    2008.04
    -
    2011.03

    日本学術振興会, 科学研究費助成事業, 基盤研究B, Research grant, Principal investigator

  • ミルクタンパク質からなる無機有機ハイブリッドナノスフェアの創製

    2007.04
    -
    2008.03

    コスメトロジー研究振興財団, 研究助成, Research grant, Principal investigator

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Works 【 Display / hide 】

  • ナノバイオマテリアル設計特論

    FUJIMOTO KEIJI

    2005.04
    -
    Present
    , 

    Other, Single

  • 現代化学概論

    FUJIMOTO KEIJI

    　
    , 

    Other, Joint

  • 現代生物学概論

    FUJIMOTO KEIJI

    　
    , 

    Other, Joint

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Intellectual Property Rights, etc. 【 Display / hide 】

  • 天然高分子の複合粒子３

    Date applied： 特願2024-196136  2024 

    Patent, Joint

  • 天然高分子の複合粒子１

    Date applied： 特願2024-114767  2024 

    Date issued： 特願2024-114767 

    Patent, Joint

  • 天然高分子の複合粒子２

    Date applied： 特願2024-196135  2024 

    Patent, Joint

  • リポソームを鋳型とする中空ナノ粒子の作製方法

    Date applied： 2006-512275  2005.02 

    Date announced： WO2005/099889   

    Patent, Joint

  • 光学結晶微粒子を用いた蛍光標識化合物およびそれを用いた生体高分子検出方法

    Date applied： 特願2004-350107  2004.12 

    Patent, Joint

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Awards 【 Display / hide 】

  • BEST POSTER PRIZE in 2010 MRS Fall Meeting

    FUJIMOTO KEIJI, 2010.12, MRS, Development of a particle nano-imprinting technique by core-shell particles

    Type of Award： International academic award (Japan or overseas)

  • スマートポリマー国際シンポジウム・ベストポスター賞

    藤本 啓二, 1998.06, スマートポリマー国際シンポジウム

  • 高分子学会研究奨励賞

    藤本 啓二, 1997.05, 高分子学会

  • 日本MRS学会研究奨励賞

    藤本 啓二, 1993.12, 日本MRS学会

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Courses Taught 【 Display / hide 】

  • FUNDAMENTAL POLYMER CHEMISTRY

    2026

  • GRADUATE RESEARCH ON FUNDAMENTAL SCIENCE AND TECHNOLOGY 1

    2026

  • DESIGN AND SYNTHESIS OF POLYMERIC BIOMATERIALS

    2026

  • DOCTORAL RESEARCH ON CHEMISTRY, LIFE SCIENCE, AND INFORMATICS

    2026

  • GRADUATE RESEARCH ON CHEMISTRY, LIFE SCIENCE, AND INFORMATICS 1

    2026

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Courses Previously Taught 【 Display / hide 】

  • 高分子化学基礎

    Keio University

    2018.04
    -
    2019.03
    , 

    Autumn Semester, Lecture, Within own ｆaculty, 200people

  • バイオマテリアル特論

    Keio University

    2018.04
    -
    2019.03
    , 

    Spring Semester, Lecture, Within own ｆaculty, 40people

  • 高分子化学

    Keio University

    2018.04
    -
    2019.03
    , 

    Spring Semester, Lecture, Within own ｆaculty, 135people

  • 応用高分子化学

    慶應義塾大学

    2017.04
    -
    2018.03

  • 天然高分子

    Keio Univiersity

    1999.04
    -
    2000.03
    , 

    Spring Semester, Lecture, Within own ｆaculty

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Social Activities 【 Display / hide 】

  • 可能性志向研究による微粒子材料の創製と機能化

    毛髪科学技術者協会, 第158回学術大会 (ハイアットリージェンシー東京)

    , 
    2026.05

  • バイオナノ粒子からミニエマルションを用いたグリーン微粒子と多孔質体の作製へ

    近畿化学協会重合工学部会, 近畿化学協会重合工学部会 令和 5 年度 重合工学レクチャーシリーズ No.10 (大阪科学技術センター)

    , 
    2024.01

  • 先端応用化学特別講義Ⅲ

    東京農工大

    2023.11

  • 微粒子材料とバイオ・化粧品素材との接点

    日本接着学会, 微粒子設計セミナー (東京)

    , 
    2014.02

  • 生体類似のナノスケール反応場におけるものづくり

    大阪商工会議所, 次世代医療システム産業化フォーラム, 

    , 
    2007.08

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Media Coverage 【 Display / hide 】

  • 慶大　表面が硬い層のナノ粒子開発　歯・骨の欠損治療に応用へ

    日経産業新聞, 2018.01

  • 培養細胞シート　傷つけずに簡単はく離　表面微粒子化の基材開発

    日刊工業新聞, 2007.05

  • マイクロアクチュエーター試作　線虫状に多様な動き　ゲル粒子をpHで膨潤・収縮

    日刊工業新聞, 2005.07

  • 薬物送達システム向け　ナノカプセル３種開発　還元剤や温度、pHに応答リポソームの補強も

    日刊工業新聞, 2005.05

  • 蛍光体ナノ粒子作成　リポソーム上に均一分散　バイオチップなどに応用も

    化学工業日報, 2004.03

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Memberships in Academic Societies 【 Display / hide 】

  • 高分子学会, 

    2011.04
    -
    Present

  • 日本バイオマテリアル学会, 

    2002
    -
    Present

  • American Chemcal Society, 

    1998.04
    -
    Present

  • 繊維学会, 

    1991
    -
    Present

  • 日本DDS学会

    　
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Committee Experiences 【 Display / hide 】

  • 2023.04
    -
    Present

    医用高分子研究会アドバイザー, 高分子学会

  • 2012.04
    -
    2014.03

    高分子学会　医用高分子研究会　委員長, 高分子学会

  • 2011.04
    -
    2017.03

    代表会員, 高分子学会

  • 2006.06
    -
    2008.05

    代議員, 高分子学会

  • 2004.06
    -
    2008.05

    高分子学会湘北懇話会世話人, 高分子学会

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