Suenaga, Kiyotake

写真a

Affiliation

Faculty of Science and Technology, Department of Chemistry (Yagami)

Position

Professor

E-mail Address

E-mail address

Related Websites

External Links

Career 【 Display / hide

  • 1995.03
    -
    1996.03

    名古屋大学理学部助手

  • 1996.04
    -
    2001.03

    名古屋大学大学院理学研究科助手

  • 2001.04
    -
    2003.03

    静岡県立大学薬学部助手

  • 2003.04
    -
    2004.03

    筑波大学化学系講師

  • 2004.04
    -
    2006.03

    筑波大学大学院数理物質科学研究科講師

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Academic Background 【 Display / hide

  • 1992.03

    Nagoya University, Faculty of Science, Department of Chemistry

    University, Graduated

  • 1995.02

    Nagoya University, 理学研究科, 化学専攻

    Graduate School, Withdrawal before completion, Doctoral course

Academic Degrees 【 Display / hide

  • 博士(理学), 名古屋大学, Dissertation, 1997.03

 

Research Areas 【 Display / hide

  • Biomolecular chemistry (Natural Products Chemistry)

Research Keywords 【 Display / hide

  • Total Synthesis

  • Isolation and Structure Determination

  • Mode of Action

  • Marine Cyanobacteria

  • Bioactive Substances

 

Books 【 Display / hide

  • 天然物化学II—自然からの贈り物—、科学のとびら64

    末永 聖武, 東京化学同人, 2018

    Scope: ビセリングビアサイドの化学

  • 天然物化学—魅力と展望— 科学のとびら60

    末永 聖武, 東京化学同人, 2016

    Scope: ラン藻類の化学

  • Marine Pharmacognosy: Trends and Applications

    Toshiaki Teruya, Osamu Ohno, Kiyotake Suenaga, CRC Press, 2012.12

    Scope: Bioactive Compounds from Okinawan Marine Cyanobacteria.

  • ソレル 有機化学

    SUENAGA Kiyotake, 東京化学同人, 2009.12

    Scope: 551-610

  • 天然物化学—海洋生物編

    末永聖武、照屋俊明, アイピーシー, 2008

    Scope: サンゴの生態化学

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Papers 【 Display / hide

  • First Total Synthesis and Structure-Activity Relationship of Iheyamide A, an Antitrypanosomal Linear Peptide Isolated from a Dapissp. Marine Cyanobacterium

    Iwasaki A., Teranuma K., Kurisawa N., Rahmawati Y., Jeelani G., Nozaki T., Gerwick W.H., Suenaga K.

    Journal of Natural Products (Journal of Natural Products)  84 ( 9 ) 2587 - 2593 2021.09

    ISSN  01633864

     View Summary

    Iheyamide A ( 1 ) is an antitrypanosomal linear peptide isolated from aDapissp. marine cyanobacterium by our group in 2020, and based on structure-activity relationships of its natural analogues, the C-terminal pyrrolinone moiety has been identified as the phamacophore for its antiparasitic activity. Further, we isolated this pyrrolinone moiety by itself as a new natural product from the marine cyanobacterium and named it iheyanone ( 2 ). As expected, iheyanone ( 2 ) showed antitrypanosomal activity, but its potency was weaker than iheyamide A ( 1 ). To clarify more detailed structure-activity relationships, we completed a total synthesis of iheyamide A ( 1 ) along with iheyanone ( 2 ) and evaluated the antitrypanosomal activities of several synthetic intermediates. As a result, we found that the longer the peptide chain, the stronger the antitrypanosomal activity. As iheyamide A ( 1 ) showed selective toxicity againstTrypanosoma brucei rhodesiense, these findings can provide design guidelines for antitrypanosomal drugs.

  • Isolation and Total Synthesis of Kinenzoline, an Antitrypanosomal Linear Depsipeptide Isolated from a Marine Salileptolyngbya sp. Cyanobacterium

    Kurisawa N., Otomo K., Iwasaki A., Jeelani G., Nozaki T., Suenaga K.

    Journal of Organic Chemistry (Journal of Organic Chemistry)  86 ( 18 ) 12528 - 12536 2021.09

    ISSN  00223263

     View Summary

    Kinenzoline (1), a new linear depsipeptide, was isolated from a marine Salileptolyngbya sp. cyanobacterium. Its structure was elucidated by spectroscopic analyses and degradation reactions. In addition, we achieved a total synthesis of 1 and confirmed its structure. Kinenzoline (1) showed highly selective antiproliferative activity against the causative organism of sleeping sickness, Trypanosoma brucei rhodesiense (IC50 4.5 μM), compared to normal human cells (WI-38, IC50 > 100 μM). Kinenzoline (1) is a promising lead compound for the development of new antitrypanosomal drugs.

  • Isolation and Total Synthesis of Bromoiesol sulfates, Antitrypanosomal arylethers from a Salileptolyngbya sp. Marine Cyanobacterium

    Ebihara A., Iwasaki A., Miura Y., Jeelani G., Nozaki T., Suenaga K.

    Journal of Organic Chemistry (Journal of Organic Chemistry)  86 ( 17 ) 11763 - 11770 2021.09

    ISSN  00223263

     View Summary

    Bromoiesol sulfates A (1) and B (2), new polyhalogenated aryl sulfates, were isolated from a Salileptolyngbya sp. marine cyanobacterium along with their hydrolyzed compounds, bromoiesols A (3) and B (4). To pick up the candidates of their structures, we used Small Molecule Accurate Recognition Technology (SMART), an artificial intelligence-based structure-prediction tool, and their structures were elucidated on the basis of single-crystal X-ray diffraction analysis of bromoiesols (3 and 4). In addition, to verify the structures, the total synthesis of bromoiesol A sulfate (1) and bromoiesol A (3) was achieved. The bromoiesol family, especially bromoiesols (3 and 4), selectively inhibited the growth of the bloodstream form of Trypanosoma brucei rhodesiense, the causative agent of human African sleeping sickness.

  • Phytotoxicity of the novel compound 3-hydroxy-4-oxo-β-dehydroionol and compound 3-oxo-α-ionone from Albizia richardiana (Voigt.) King & Prain

    Hossen K., Iwasaki A., Suenaga K., Kato-Noguchi H.

    Environmental Technology and Innovation (Environmental Technology and Innovation)  23 2021.08

     View Summary

    To protect our environment from the toxic effect of herbicides, it is necessary to reduce the application of synthetic herbicides for controlling weeds in crop fields as well as to increase the use of natural herbicides produced from plant sources. Phytotoxic compounds obtained from plant species have gained attention as an alternate biological method for managing weeds. Albizia richardiana was previously reported to contain a number of phytotoxic substances. Therefore, we carried out this study to investigate more allelopathic substances in Albizia richardiana leaves. Aqueous methanol extracts of Albizia richardiana leaves were significantly inhabited the seedling growth of the two test species (alfalfa and timothy) in a concentration-dependent manner. The two most active substances were separated through different chromatographic steps and characterized as a novel compound 3-hydroxy-4-oxo-β-dehydroionol [(E)-6-hydroxy-3-(3-hydroxybut-1-en-1-yl)-2,4,4-trimethylcyclohexa-2,5-dien-1-one], and compound 3-oxo-α-ionone [3,5,5-trimethyl-4-(3-oxo-1-butenyl)-2-cyclohexen-1-one]. The novel compound 3-hydroxy-4-oxo-β-dehydroionol showed relatively stronger growth inhibitory potential compare to the compound 3-oxo-α-ionone and significantly restricted the seedling growth of crees and timothy. The required concentration for 50% reduction in the growth (I50 values) of the cress and timothy seedlings varied from 63.78 to 141.61 μM for 3-hydroxy-4-oxo-β-dehydroionol and 1059.60 to 1616.10 μM for 3-oxo-α-ionone. The results indicate that these two allelopathic compounds may be responsible for the phytotoxicity of Albizia richardiana leaves.

  • Lingaoamide, a cyclic heptapeptide from a Chinese freshwater cyanobacterium Oscillatoria sp.

    Iwasaki A., Kurisawa N., Wang T., Li X., Luo H., Zhu C., Patial G., Yan X., He S., Luzzatto-Knaan T., Tian F., Naman C.B., Suenaga K.

    Tetrahedron Letters (Tetrahedron Letters)  75 2021.07

    ISSN  00404039

     View Summary

    Lingaoamide (1), a new cyclic heptapeptide natural product, was isolated from a freshwater Oscillatoria cyanobacterium. The producing organism was collected in Chinese water spinach paddy farm fields in Lingao County, Hainan, China. The structure of 1 was determined by conventional mass spectrometry, NMR spectroscopy, and chemical degradation studies. Lingaoamide concentration-dependently up-regulates the biogenesis of pro-pathogenic melanin pigments (melanogenesis) in the rice blast fungus, Magnaporthe grisea, when tested in vitro. This molecule also exhibits weak in vitro inhibition (MIC 32 μg/mL) of Gram-negative Pseudomonas aeruginosa and Gram-positive Bacillus pumilus, and does not appear to impact plant growth or immune response in vivo using the model organism, Arabidopsis thaliana.

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

Presentations 【 Display / hide

  • 特異な化学構造をもつ海洋産リポペプチドの生合成機構解明に基づく人工誘導体生産

    末永聖武

    新学術領域研究「生合成リデザイン」第9回公開シンポジウム (オンライン開催) , 2020.11, Oral Presentation(general)

  • 海洋シアノバクテリア由来の新規鎖状ペプチドiheyamide類の構造と生物活性

    栗澤尚瑛、岩﨑有紘、Ghulam Jeelani、野崎智義、末永聖武

    第62回天然有機化合物討論会 (オンライン開催) , 2020.09, Poster (general)

  • 海洋シアノバクテリア由来の生物活性物質

    末永聖武、岩﨑有紘、森田真布、佐藤英祐、照屋俊明、大野修

    農芸化学会2020年度大会、シンポジウム「シアノバクテリアと未来を描く」 (誌上開催) , 2020.03, Oral Presentation(guest/special)

  • 細胞老化に関わるLncRNA(LINC00942)の発現を制御する成分の探索

    礒田隆宏、岩﨑有紘、岡部伊織、宍戸まゆみ、斉藤優子、末永聖武、楊 一幸

    日本薬学会第140年会 (誌上開催) , 2020.03

  • Synthetic Studies on Ikoamide

    末永聖武、駱永翰、岩﨑有紘

    日本化学会第100春季年会 (誌上開催) , 2020.03, Oral Presentation(general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 海洋シアノバクテリア由来の熱帯病治療薬リード化合物の創製

    2020.04
    -
    2024.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 末永 聖武, Grant-in-Aid for Scientific Research (B), Principal Investigator

  • 特異な化学構造をもつ海洋産リポペプチドの生合成機構解明に基づく人工誘導体生産

    2019.06
    -
    2021.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 末永 聖武, Grant-in-Aid for Scientific Research on Innovative Areas, Principal Investigator

  • 特異な化学構造をもつ海洋産リポペプチドの生合成機構解明に基づく人工誘導体生産

    2017.04
    -
    2019.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 末永 聖武, Grant-in-Aid for Scientific Research on Innovative Areas, Principal Investigator

  • カルシウムポンプに作用する海洋天然物を基盤とした破骨細胞分化抑制剤の創製

    2016.04
    -
    2020.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 末永 聖武, Grant-in-Aid for Scientific Research (B), Principal Investigator

  • Cultivation of Useful Marine Cyanobacteria and Analysis of Biosynthetic genes

    2016.04
    -
    2018.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 末永 聖武, Grant-in-Aid for Challenging Exploratory Research, Principal Investigator

Awards 【 Display / hide

  • The CSJ Award for Young Chemists

    SUENAGA Kiyotake, 2003.03, 日本化学会, Bioorganic Studies on Marine Natural Products with Bioactivities Such As Antitumor Activity and Feeding Attractance

    Type of Award: Awards of National Conference, Council and Symposium

  • 井上研究奨励賞

    SUENAGA Kiyotake, 1998.02, 井上科学振興財団

    Type of Award: Awards of Publisher, Newspaper Company and Foundation

 

Courses Taught 【 Display / hide

  • TOPICS IN BIOORGANIC CHEMISTRY

    2021

  • SEMINAR IN CHEMISTRY

    2021

  • ORGANIC STRUCTURAL DETERMINATION

    2021

  • MICROBIOLOGY

    2021

  • LABORATORY IN SCIENCE

    2021

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Memberships in Academic Societies 【 Display / hide

  • 日本薬学会, 

    2001.04
    -
    Present
  • 有機合成化学協会, 

    1995.04
    -
    Present
  • 日本化学会, 

    1992.04
    -
    Present

Committee Experiences 【 Display / hide

  • 2015.04
    -
    Present

    理事, 私立大学環境保全協議会

  • 2014.04
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    Present

    企画委員, 私立大学環境保全協議会

  • 2013.01
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    2013.03

    審査員, 関東地区化学クラブ発表会

  • 2011.11
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    2016.03

    審査員, 文部科学省 サイエンスインカレ

  • 2011.04
    -
    Present

    代表正会員, 日本化学会関東支部

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