KEIO RESEARCHERS INFORMATION SYSTEM

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Effects of N-glycosylation on the transport kinetics of organic anion transporting polypeptide (OATP) 1B1.

  Tanino M, Tsujii K, Kataoka H, Takahashi R, Imaoka A, Akiyoshi T, Ohtani H.

  Biochimica et Biophysica Acta (BBA) - Biomembranes 1868 ( 2 ) 184509 2026

  Research paper (scientific journal), Joint Work, Accepted

• Genetic polymorphisms of OATP1B1 influence the inhibitory potency of inhibitors and their pre-incubation effect.

  Tsujii K, Hirano T, Tanino M, Imaoka A, Akiyoshi T, Ohtani H.

  Scientific Reports  2026

  Research paper (scientific journal), Joint Work, Accepted

• Stoichiometric transport of estrone 3-sulfate among genetic variants of OATP1A2 and OATP2B1 and structural analysis by molecular dynamics simulation: Impairment of gating mechanism in the unstable inward-open conformation of OATP2B1 (Asp215Val) significantly suppress the transport activity.

  Takeshi Akiyoshi, Arun Kumar Tonduru, Hiroki Kataoka, Tokio Morita, Kodai Yajima, Ayuko Imaoka, Kazuhiro Katayama, Prasanthi Medarametla, Yasuo Uchida, Antti Poso, Hisakazu Ohtani, Tetsuya Terasaki

  Drug Metab Dispos. 53 ( 12 ) 100198 2025.12

  Joint Work, Accepted

• Inhibition kinetics of citrus jabara juice and its components on CYP2C9 activity.

  Koinuma K, Morita T, Uekusa Y, Kikuchi H, Imaoka A, Akiyoshi T, Ohtani H.

  J Pharm Sci. 114 ( 11 ) 103983 2025.09

  Research paper (scientific journal), Joint Work, Accepted

• Comparative analysis of the single-molecule transport kinetics of OATP1B1 genetic variants.

  Tsujii K, Yajima K, Akiyoshi T, Sakamoto K, Suzuki Y, Oka T, Imaoka A, Yamamura H, Kurokawa J, Ohtani H.

  J Pharmacol Sci. 158 ( 3 ) 166 - 171 2025.07

  Research paper (scientific journal), Joint Work, Accepted

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• The effects of food type on the extent of drug-food interactions.

  Imaoka, Ayuko

  福澤諭吉記念慶應義塾学事振興基金事業報告集 (福澤基金運営委員会)  2023

• Evaluation of aluminium absorption under the co-administration of antibiotics.

  Imaoka, Ayuko

  科学研究費補助金研究成果報告書 2022

• Evaluation of magnesium oxide and antimicrobial agents during the administration of anticancer drugs.

  Imaoka, Ayuko

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2022

• The effect of milk and milk-derived components on phenobarbital absorption.

  Imaoka, Ayuko

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2021

• Analysis of the inter-individual variations of food-drug interactions via CYP2Cs and OATPs

  Imaoka, Ayuko

  科学研究費補助金研究成果報告書 2020

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Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• Hyper-Glycosylation of Intestinal P-glycoprotein Associated with Increased Expression and Reduced Intrinsic Activity in Irinotecan-Induced Gastrointestinal Damage

  [Domestic presentation]  日本薬物動態学会第41回年会, 

  2026.11

  , 

  Oral presentation (general)

• OATP1A2 輸送活性および基質特異性に対する遺伝的変異の影響 ―単分子輸送特性の比較—

  [Domestic presentation]  第20回次世代を担う若手のための医療薬科学シンポジウム, 

  2026.10

  , 

  Oral presentation (general)

• アジア産果実による小腸OATP2B1阻害を介したin vitro飲食物相互作用評価

  [Domestic presentation]  第70回日本薬学会関東支部大会, 

  2026.09

  , 

  Poster presentation

• テイコプラニン過剰曝露の1例：早期再投与における残存濃度の影響

  [Domestic presentation]  第70回日本薬学会関東支部大会, 

  2026.09

  , 

  Oral presentation (general)

• Development and validation of an LC-MS/MS method for the determination of psilocin, the active metabolite of psilocybin from Psilocybe mushrooms, in human plasma.

  [International presentation]  The 5th International Conference on Herbal and Traditional Medicine, 

  2026.04

  , 

  Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• 抗菌薬併用によるアルミニウム吸収亢進の全身曝露評価およびメカニズムの解明

  2020.04

  -

  2023.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists , Principal investigator

• キレート形成による薬物相互作用に関する新規機序の解明と金属吸収亢進のリスクの検討

  2018.04

  -

  2020.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists , Principal investigator

Awards 【 Display / hide 】

Awards 【 Display / hide 】

• Excellent Award.

  2026.04, Food-Drug Interactions via Intestinal OATPs Inhibition by Thai Fruits: -International Collaboration Study-.

  Type of Award： Award from international society, conference, symposium, etc.

• 優秀発表賞

  2026.03, 組換え CYP2C19 変異型酵素に対する 6’, 7’-dihydroxybergamottin の MBI キネティクスとその基質依存性

  Type of Award： Award from Japanese society, conference, symposium, etc.

• 優秀発表賞

  2026.03, 柑橘マーマレードによる消化管 CYPs および OATPs の阻害を介した相互作用リスク評価

  Type of Award： Award from Japanese society, conference, symposium, etc.

• 優秀発表賞

  2024.03, OATP1B1各種遺伝的変異型の単分子輸送特性の比較

  Type of Award： Award from Japanese society, conference, symposium, etc.

• 優秀発表賞

  2023.06, 柑橘系果物に含有される CYPs 阻害成分の含量とその果実間差の網羅的解析

  Type of Award： Award from Japanese society, conference, symposium, etc.

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Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• BACHELOR'S THESIS

  2026

• PRIOR LEARNING FOR CLINICAL PRACTICE 2

  2026

• RESEARCH FOR BACHELOR'S THESIS 1

  2026

• PRE-CLINICAL TRAINING IN PRESCRIPTION PROCESSING FOR HOSPITAL & COMMUNITY PHARMACY

  2026

• PRE-CLINICAL TRAINING FOR HOSPITAL & COMMUNITY PHARMACY

  2026

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