Papers - Kasahara, Tadashi

Temporal expression and mitochondrial localization of a Foxp2 isoform lacking the forkhead domain in developing Purkinje cells.

KASAHARA Tadashi

J Neurochem. 0 ( 0 ) 0 2011.11

Research paper (scientific journal), Single Work

Anti-inflammatory activity of structurally related flavonoids, Apigenin, Luteolin and Fisetin.

KASAHARA Tadashi

Int Immunopharmacol 11 ( 9 ) 1150-1159 2011.09

Research paper (scientific journal), Single Work

Aurora kinase A critically contributes to the resistance to anti-cancer drug cisplatin in JAK2 V617F mutant-induced transformed cells.

KASAHARA Tadashi

FEBS letters 585 ( 12 ) 1884-1890 2011.06

Research paper (scientific journal), Single Work, Accepted

Akt activation through the phosphorylation of erythropoietin receptor at tyrosine 479 is required for myeloproliferative disorder-associated JAK2 V617F mutant-induced cellular transformation.

Kamishimoto J, Tago K, Kasahara T, Funakoshi-Tago M.

Cell Signaling 23 ( 5 ) 849-856 2011.05

Research paper (scientific journal), Single Work, Accepted

JAK2 is an important signal transducer in IL-33-induced NF-κB activation.

Funakoshi-Tago M, Tago K, Sato Y, Tominaga S, Kasahara T.

Cell Signaling 23 ( 2 ) 363-370 2011.02

Research paper (scientific journal), Single Work, Accepted

Role of Bone Marrow-Derived Monocytes/Macrophages in the Repair of Mucosal Damage Caused by Irradiation and/or Anticancer Drugs in Colitis Model.

Takaba J, Mishima Y, Hatake K, Kasahara T.

Mediators Inflamm 2010 ( 0 ) 634145 2011.01

Research paper (scientific journal), Single Work, Accepted

Licochalcones suppress degranulation by decreasing the intracellular Ca2+ level and tyrosine phosphorylation of ERK in RBL-2H3 cells.

Tanifuji S, Aizu-Yokota E, Funakoshi-Tago M, Sonoda Y, Inoue H, Kasahara T.

Int Immunopharmacol 10 ( 7 ) 769-776 2010.07

Research paper (scientific journal), Single Work

The fixed structure of Licochalcone A by alpha, beta-unsaturated ketone is necessary for anti-inflammatory activity through the inhibition of NF-kappaB activation.

Funakoshi-Tago M, Nakamura K, Tsuruya R, Hatanaka M, Mashino T, Sonoda Y, Kasahara T.

Int Immunopharmacol 10 ( 5 ) 562-571 2010.05

Research paper (scientific journal), Single Work, Accepted

STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutant.

Funakoshi-Tago M, Tago K, Abe M, Sonoda Y, Kasahara T.

J Biol Chem 285 ( 8 ) 5296-5307 2010.02

Research paper (scientific journal), Single Work, Accepted

Proteolipid protein 2 is associated with melanoma metastasis.

Sonoda Y, Warita M, Suzuki T, Ozawa H, Fukuda Y, Funakoshi-Tago M, Kasahara T.

Oncol Report 23 ( 2 ) 371-376 2010.02

Research paper (scientific journal), Single Work, Accepted

Pyrrolidinium-type fullerene derivative-induced apoptosis by the generation of reactive oxygen species in HL-60 cells.

Nishizawa C, Hashimoto N, Yokoo S, Funakoshi-Tago M, Kasahara T, Takahashi K, Nakamura S, Mashino T.

Free Radic Res 43 ( 12 ) 1240-1247 2009.12

Research paper (scientific journal), Single Work, Accepted

Licochalcone A potently inhibits tumor necrosis factor alpha-induced nuclear factor-kappaB activation through the direct inhibition of IkappaB kinase complex activation.

Funakoshi-Tago M, Tanabe S, Tago K, Itoh H, Mashino T, Sonoda Y, Kasahara T.

Mol Pharmacol 76 ( 4 ) 745-753 2009.10

Research paper (scientific journal), Single Work, Accepted

The polycythemia vera-associated Jak2 V617F mutant induces tumorigenesis in nude mice.

Abe M, Funakoshi-Tago M, Tago K, Kamishimoto J, Aizu-Yokota E, Sonoda Y, Kasahara T.

Int Immunopharmacol 9 ( 7-8 ) 870-877 2009.07

Research paper (scientific journal), Single Work, Accepted

The acute lymphoblastic leukemia-associated Jak2 L611S mutant induces tumorigenesis in nude mice.

Funakoshi-Tago M, Tago K, Sumi K, Abe M, Aizu-Yokota E, Oshio T, Sonoda Y, Kasahara T.

J Biol Chem 284 ( 19 ) 12680-12690 2009.05

Research paper (scientific journal), Single Work, Accepted

Licochalcone A significantly suppresses LPS signaling pathway through the inhibition of NF-kappaB p65 phosphorylation at serine 276.

Furusawa JI,Funakoshi-Tago M, Tago K, Mashino T,Inoue H, Sonoda Y, Kasahara T

Cell Signaling 21 ( 5 ) 778-785 2009.05

Research paper (scientific journal), Single Work, Accepted

Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway.

Furusawa J, Funakoshi-Tago M, Mashino T, Tago K, Inoue H, Sonoda Y, Kasahara T.

Int Immunopharmacol 9 ( 4 ) 499-507 2009.04

Research paper (scientific journal), Single Work, Accepted

Dermatophagoides farinaeextract induces severe atopic dermatitis in NC/Nga mice, which is effectively suppressed by the administration of tacrolimus ointment.

Oshio T, Sasaki Y, Funakoshi-Tago M, Aizu-Yokota E, Sonoda Y, Matsuoka H, Kasahara T.

Int Immunopharmacol 9 ( 4 ) 403-411 2009.04

Research paper (scientific journal), Single Work, Accepted

Cytoprotective role of mitochondrial amyloid beta peptide-binding alcohol dehydrogenase against a cytotoxic aldehyde.

Murakami Y, Ohsawa I, Kasahara T, Ohta S

Neurobiol Aging 30 ( 2 ) 325-329 2009.02

Research paper (scientific journal), Single Work, Accepted

TRAF6 negatively regulates TNFalpha-induced NF-kappaB activation.

Funakoshi-Tago M, Kamada N, Shimizu T, Hashiguchi Y, Tago K, Sonoda Y, Kasahara T

Cytokine 45 ( 2 ) 72-79 2009.02

Research paper (scientific journal), Single Work, Accepted

Licochalcone A is a potent inhibitor of TEL-Jak2-mediated transformation through the specific inhibition of Stat3 activation.

Funakoshi-Tago M, Tago K, Nishizawa C, Takahashi K, Mashino T, Iwata S, Inoue H, Sonoda Y, Kasahara T.

Biochem Pharmacol 76 ( 12 ) 1681-1693 2008.12

Research paper (scientific journal), Single Work, Accepted

Mutation of Y925F in focal adhesion kinase (FAK) suppresses melanoma cell proliferation and metastasis.

Kaneda T, Sonoda Y, Ando K, Suzuki T, Sasaki Y, Oshio T, tago M, Kasahara T.

Cancer Letter 270 ( 2 ) 354-361 2008.11

Research paper (scientific journal), Joint Work, Accepted

Negative regulation of Jak2 by its auto-phosphorylation at tyrosine 913 via the Epo signaling pathway.

Funakoshi-Tago M,Tago K, Kasahara T, Parganas E, Ihle JN

Cell Signaling 20 ( 11 ) 1995-2001 2008.11

Research paper (scientific journal), Single Work, Accepted

Synthetic studies on glycosphingolipids from Protostomia phyla: syntheses and biological activities of amphoteric glycolipids containing a phosphocholine residue from the earthworm Pheretima hilgendorfi.

Hada N, Shida Y, Shimamura H, Sonoda Y, Kasahara T, Sugita M, Takeda T

Carbohydr Res 343 ( 13 ) 2221-2228 2008.09

Research paper (scientific journal), Single Work, Accepted

Neuronal RA175/SynCAM1 isoforms are processed by tumor necrosis factor-alpha-converting enzyme(TACE)/ADAM17-like proteases.

Tanabe Y, Kasahara T, Momoi T, Fujita E.

Neurosci Letter 444 ( 1 ) 16-21 2008.08

Research paper (scientific journal), Joint Work, Accepted

TRAF6 is a critical signal transducer in IL-33 signaling pathway.

Funakoshi-Tago M, Tago K, Hayakawa M, Tominaga S-I, Ohshio T, Sonoda Y, Kasahara T

Cell Signaling 20 ( 9 ) 1679-1686 2008.07

Research paper (scientific journal), Joint Work, Accepted

Celecoxib potently inhibits TNFalpha-induced nuclear translocation and activation of NF-kappaB.

Funakoshi-Tago M,Shimizu T,Tago K,Nakamura M,Itoh H,Sonoda Y,kasahara T.

Biochem Pharmacol 76(5)   p662-71 2008.07

Research paper (conference, symposium, etc.), Joint Work, Accepted

A synthetic glycosphingolipid-induced antiproliferative effect in melanoma cells is associated with suppression of FAK, Akt, and Erk activation.

Sonoda Y*, Hada N, Kaneda T, Suzuki T, Ohshio T, Takeda T, Kasahara T.

Biol Pharm Bull 31 ( 6 ) 1279-1283 2008.06

Research paper (scientific journal), Joint Work, Accepted

Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice.

Fujita E, Tanabe Y, Hirose T, Aurrand-Lions M, Kasahara T, Imhof BA, Ohno S, Momoi T.

Amer J Pathology 171 ( 6 ) 1800-1810 2007.12

Research paper (conference, symposium, etc.), Joint Work, Accepted

Production and regulation of eotaxin-2/CCL24 in a differentiated human leukemic cell line, HT93.

Yoshida N, Aizu-Yokota E, Sonoda Y, Moriwaki Y, Kishi K, Kasahara T*.

Biol Pharm Bull 30(10)   1826-1832 2007.10

Research paper (conference, symposium, etc.), Joint Work, Accepted

Enhanced serum antigen-specific IgG(1) and proinflammatory cytokine production in nicotinic acetylcholine receptor a7 subunit gene knockout mice.

Fujii YX, Fujigaya H, Moriwaki Y, Misawa H, Kasahara T, Grando SA, Kawashima K*.

J Neuroimmunol 189(1-2)   69-74 2007.09

Research paper (conference, symposium, etc.), Joint Work, Accepted

Cytoprotective role of mitochondrial amyloid beta peptide-binding alcohol dehydrogenase against a cytotoxic aldehyde.

Murakami Y, Ohsawa I, Kasahara T, Ohta S.

Neurobiol Aging 0   0-0 2007.08

Research paper (conference, symposium, etc.), Joint Work, Accepted

MEK-ERK is involved in SUMO-1 foci formation on apoptosis.

Utsubo-Kuniyoshi, Terui R, Mishima Y, Rokudai A, Sugimura N, Kojima K, Sonoda Y, Kasahara T, Hatake K.

Cancer Sci 98(4)   569-576 2007.04

Research paper (conference, symposium, etc.), Joint Work, Accepted

Focal adhesion kinase determines the fate of death or survival of cells in response to TNFa in the presence of actinomycin D.

Takahashi R, Sonoda Y*, Ichikawa D, Yoshida N, Aizu-Yokota E, Kasahara T.

Biochim Biophys Acta 1770   518-526 2007.04

Research paper (conference, symposium, etc.), Joint Work, Accepted

Suppression of Endoplasmic Reticulum Stress-induced Caspase Activation and Cell Death by the Overexpression of Bcl-xL or Bcl-2.

Murakami Y, Aizu-Yokota E, Sonoda Y, Ohta S, Kasahara T.

J Biochem (Tokyo) 141(3)   401-410 2007.03

Research paper (conference, symposium, etc.), Joint Work, Accepted

Cofilin plays a critical role in IL-8-dependent chemotaxis of neutrophilic HL-60 cells through changes in phosphorylation.

Hirayama A, Adachi R, Otani S, Kasahara T, Suzuki K.

J Leukoc Biol 81(3)   720-728 2007.03

Research paper (conference, symposium, etc.), Joint Work, Accepted

TGN1412事件と今後の課題.

山崎恒義、笠原 忠.

臨床評価 (/臨床評価刊行会)  34   49-70 2006.11

Research paper (scientific journal), Joint Work, Accepted

TNF-receptor associated factor 6-deficient fibroblast is sensitive to the TNF-α-induced cell death:Involvement of reactive oxygen species.

Ichikawa D,Funakoshi-Tago M,Aizu-Yokota E,Sonoda Y,Inoue J-I,Kasahara T.

Biochem Biophys Res Commun 351   93-98 2006.10

Research paper (conference, symposium, etc.), Joint Work, Accepted

c/EBPalpha inactivation in FAK-overexpressed HL-60 cells impairs cell differentiation.

Hashimoto K, Sonoda Y*, Yamakado M, Funakoshi-Tago M, Yoshida N, Rokudai A, Aizu-Yokota E, Kasahara T.

Cell Signaling 18   955-963 2006.07

Research paper (conference, symposium, etc.), Joint Work, Accepted

Differential Regulation of Eotaxin-1/CCL11 and Eotaxin-3/CCL26 Production by the TNF-α and IL-4 stimulated Human Lung Fibroblast.

Rokudai A,Terui Y,Kuniyoshi R,Mishima Y,Mishima Y,Mishima Y,Aizu-Yokota E,Snoda Y,Kasahara T,Hatake K.

Biol Pharm Bull 29(6)   1102-1109 2006.06

Research paper (conference, symposium, etc.), Joint Work, Accepted

Glycyrrhizin derivative inhibits eotaxin 1 production via STAT6 in human lung fibroblasts.

Matsui S, Sonoda Y, Sekiya T, Aizu-Yokota E, Kasahara T*.

Int Immunopharmacol. 6   369-75 2006.03

Research paper (conference, symposium, etc.), Joint Work, Accepted

Functional role of c-Src in IL-1-induced NF-kB activation: c-Src is one of the components of IKK complex.

Funakoshi-Tago M, Tago K, Andoh K, Sonoda Y, Tominaga S-I, Kasahara T*.

J Biochemistry 137   189-197 2005.10

Research paper (conference, symposium, etc.), Single Work, Accepted

Improved gene expression in resting macrophage using an oligopeptide derived from Vpr of human immunodeficienty virus type-1.

Mizoguchi I, Ooe Y, Hoshino S, Shimura M, Kasahara T, Kano S, Ohta T, Takaku F, Nakayama Y, Ishizaka Y*.

Biochem Biophys Res Commun 338   1499-1506 2005.10

Research paper (conference, symposium, etc.), Joint Work, Accepted

これから私立大学院「医療系における大学院のこれから」.

笠原 忠.

大学時報 (/日本私立大学連盟)  304   48-53 2005.09

Research paper (scientific journal), Single Work

Indirubin, a Chinese anti-leukaemia drug,promotes neutrophilic differentiation of human myelocytic HL-60 cells.

Suzuki K, Adachi R, Hirayama, Watanabe H, Otani S, Watanabe Y, Kasahara T*.

British J Haematol 130   681-690 2005.09

Research paper (conference, symposium, etc.), Joint Work, Accepted

Functional Role of c-Src in IL-1-Induced NF-{kappa}B Activation: c-Src Is a Component of the IKK Complex.

Funakoshi-Tago M, Tago K, Andoh K, Sonoda Y, Tominaga S, Kasahara T*.

J Biochem 137(2)   189-197 2005.02

Research paper (conference, symposium, etc.), Joint Work, Accepted

Glycyrrhizin and related compounds downregulate production of inflammatory chemokines IL-8 and eotaxin 1 in a human lung fibroblast cell line.

Matsui S, Matsumoto H, Sonoda Y, Aizu-Yokota E, Sato T, Kasahara T*.

International Immunopharmacol 4   1633-1644 2004.10

Research paper (conference, symposium, etc.), Joint Work, Accepted

Down-regulation of procaspase-8 expression by focal adhesion kinase protects HL-60 cells from TRAIL-induced apoptosis.

Tamagiku Y, Sonoda Y*, Kunisawa M, Ichikawa D, Murakami Y, Aizu-Yokota E, Kasahara T.

Biochem Biophys Res Commun 323   445-452 2004.10

Research paper (conference, symposium, etc.), Joint Work, Accepted

Proteome analysis of focal adhesion kinase (FAK)-overexpressing cells overexpressing cells.

Utsubo R, Sonoda Y, Takahashi R, Iijima S, Yokota-Aizu E, Kasahara T*.

Biol Pharm Bull 27   1735-41 2004.10

Research paper (conference, symposium, etc.), Joint Work, Accepted

Effect of various catechins on the IL-12p40 production by murine peritoneal macrophages and a macrophage cell line, J774.1.

Ichikawa D, Matsui A, Imai M, Sonoda Y, Kasahara T*.

Biol Pharm Bull 27   1353-1358 2004.09

Research paper (conference, symposium, etc.), Joint Work, Accepted

Induction of antioxidant enzymes by FAK in a human leukemic cell line, HL-60.

Sonoda Y*, Aiba N, Utsubo R, Koguchi E, Hasegawa M, Kasahara T.

Biochim Biophys Acta 1683   22-32 2004.07

Research paper (conference, symposium, etc.), Joint Work, Accepted

Elevated interleukin-8 in cervical mucus as an indicator for treatment to prevent premature birth and preterm, pre-labor rupture of membranes: a prospective study.

Sakai M, Sasaki Y, Yoneda S, Kasahara T, Arai T, Okada M, Hosokawa H, Kato K, Soeda Y, Saito S.

Am J Reprod Immunol 51(3)   220-225 2004.05

Research paper (conference, symposium, etc.), Joint Work, Accepted

薬学における免疫学の研究と教育.

笠原 忠.

学術月報 (日本学術振興会)  57（３）   257-260 2004.03

Research paper (scientific journal), Single Work, Accepted

TNFαの多彩な生理作用（２）.

笠原 忠.

REMEDY (/田辺製薬)  2   9-11 2004.02

Research paper (scientific journal), Single Work

Bisphenol A significantly enhances the neutrophilic differentiation of promyelocytic HL-60 cells.

Watanabe H, Adachi R, Kusui K, Hirayama A, Kasahara T, Suzuki K.

Int Immunopharmacol 3(12)   1601-1608 2003.11

Research paper (conference, symposium, etc.), Joint Work, Accepted

IL-10-induced CCR5 expression in macrophage-like HL-60 cells: Involvement of Erk1/2 and STAT3.

Makuta Y, Sonoda Y, Yamamoto D, Funakoshi-Tago M, Aizu-Yokota E, Takebe Y, Kasahara T*.

Biol Pharm Bull 26 (8)   1076-1081 2003.09

Research paper (conference, symposium, etc.), Single Work, Accepted

TNF-αの多彩な生理活性（１）.

笠原 忠.

REMEDY (/田辺製薬)  1   10-12 2003.08

Research paper (scientific journal), Single Work

IL-10-induced CCR5 expression in macrophage-like HL-60 cells: Involvement of Erk1/2 and STAT3.

Makuta Y,Sonoda Y, Yamamoto D, Funakoshi-Tago F, Aizu-Yokota E, Takebe Y, Kasahara T*.

Biol Pharm Bull 26(8)   1076-1081 2003.08

Research paper (conference, symposium, etc.), Joint Work, Accepted

TNFa-Induced NF-kB Activation is Impaired in the Focal Adhesion Kinase (FAK)-deficient Fibroblasts: Essential Role of FAK in TNFa-induced NF-kB Activation.

Funakoshi-Tago M, Sonoda Y, Tanaka S, Hashimoto K, Tago K, Tominaga SI, Kasahara T*.

J Biol Chem 278 (31)   29359-29365 2003.08

Research paper (conference, symposium, etc.), Joint Work, Accepted

FAK overexpression upregulates cyclin D3 and enhances cell proliferation via the PKC and PI3-kinase-Akt pathways.

Yamamoto D, Sonoda Y, Hasegawa M, Funakoshi-Tago F, Aizu-Yokota E, Kasahara T.

Cell Signalling 15(6)   575-83 2003.08

Research paper (conference, symposium, etc.), Single Work, Accepted

TNF-Induced NF-B Activation is Impaired in the Focal Adhesion Kinase (FAK)-deficient Fibroblasts: Essential Role of FAK in TNF-induced NF-B Activation.

Funakoshi-Tago M, Sonoda Y, Tanaka S, Hashimoto K, Tago K, Tominaga SI, Kasahara T*.

J Biol Chem 278(31)   29359-29365 2003.06

Research paper (conference, symposium, etc.), Single Work, Accepted

FAK overexpression upregulates cyclin D3 and enhances cell proliferation via the PKC and PI3-kinase-Akt pathways.

Yamamoto D, Sonoda Y, Hasegawa M, Funakoshi-Tago F, Aizu-Yokota E, Kasahara T*.

Cell Signal 15(6)   575-583 2003.06

Research paper (conference, symposium, etc.), Joint Work, Accepted

Triphenyltin enhances the neutrophilic differentiation of promyelocytic HL-60 cells.

Watanabe H, Adachi R, Hirayama A, Kasahara T, Suzuki K*.

Biochem Biophys Res Commun 306(1)   26-31 2003.06

Research paper (conference, symposium, etc.), Joint Work, Accepted

TRAF6 and C-SRC induce synergistic AP-1 activation via PI3-kinase-AKT-JNK pathway.

Funakoshi-Tago M, Tago K, Sonoda Y, Tominaga S, Kasahara T*.

Eur J Biochem 270(6)   1257-1268 2003.05

Research paper (conference, symposium, etc.), Joint Work, Accepted

TRAF6 and C-SRC induce synergistic AP-1 activation via PI3-kinase-AKT-JNK pathway.

Funakoshi-Tago M, Tago K, Sonoda Y, Tominaga S, Kasahara T*.

Eur J Biochem 270(6)   1257-1268 2003.03

Research paper (conference, symposium, etc.), Joint Work, Accepted

Inhibition by (+/-)-indenestrol A of interferon ganna-stimulated nitric oxide formation in murine macrophage RAW 264.7 cells.

Oda T*, So Y, Sato Y, Shimizu N, Handa H, Yasukochi Y, Kasahara T.

Mutat Res 534   187-195 2003.01

Research paper (conference, symposium, etc.), Joint Work, Accepted

TNFαの多様な生理活性.

笠原 忠,園田よし子.

治療学 (/ライフサイエンス出版)  36(2)   1231-1234 2002.12

Research paper (scientific journal), Joint Work, Accepted

Growth inhibition of plasmodium falciparum and IL-8 production by peripheral mononuclear and polymorphonuclear cells in vitro.

Ohya J-Y, Matsuoka H, Mukaida N, Kasahara T, Ishii A.

JPN J Trop Hyg 30(4)   351-355 2002.12

Research paper (conference, symposium, etc.), Single Work, Accepted

Gene expression profile analysis of the mouse liver during bacteria-induced fulminant hepatitis by a cDNA microarray system.

Dong H, Toyoda N, Yoneyama H, Kurachi M, Kasahara T, Kobayashi Y, Inadera H, Hashimoto S, Matsushima-K*.

Biochem Biophys Res Commun 298 (5)   675-686 2002.11

Research paper (conference, symposium, etc.), Joint Work, Accepted

Suppression monocyte chemoatractant protein 1, but not IL-8, by alprazolam:effect of alprazolam on c-Rel/p65 and c-Rel/p50 binding to the monocyte chemoattractant protein 1 promoter region.

Oda T*, Ueda A, Shimizu N, Handa H, Kasahara T.

J Immunol 169   3329-3335 2002.09

Research paper (conference, symposium, etc.), Joint Work, Accepted

Antiapoptotic action of focal adhesion kinase (FAK) against ionizing radiation.

Kasahara T*, Koguchi E, Funakoshi M, Yokota E, Sonoda Y.

Antioxidants Redox Signaling 4(3)   491-499 2002.06

Research paper (conference, symposium, etc.), Joint Work, Accepted

接着斑キナーゼ(FAK)の役割,とくに抗アポトーシス機能について.

笠原 忠,園田よし子.

炎症と免疫 (/先端医学社)  10(3)   309-314 2002.05

Research paper (scientific journal), Joint Work, Accepted

Antiapoptotic action of focal adhesion kinase (FAK) against ionizing radiation.

Kasahara T, Koguchi E, Funakoshi M, Yokota E, Sonoda Y*.

Antioxidants & Redox Signaling 4(3)   491-499 2002.05

Research paper (conference, symposium, etc.), Single Work, Accepted

Mutated focal adhesion kinase induces apoptosis in a human glioma cell, T98G.

Sakurai S, Sonoda Y, Koguchi, E, Shinoura N, Hamada H, Kasahara T*.

Biochem Biophys Res Commun 293 (1)   174-181 2002.04

Research paper (conference, symposium, etc.), Joint Work, Accepted

LIM kinase 1 modulates opsonized zymosan-triggered activation of macrophage-like U937 cells. Possible involvement of phosphorylation of cofilin and reorganization of actin cytoskeleton.

Matsui S, Matsumoto S, Adachi R, Kusui K, Hirayama A, Watanabe H, Ohashi K, Mizuno K, Yamaguchi T, Kasahara T, Suzuki K.

J Biol Chem 277(1)   544-549 2002.01

Research paper (conference, symposium, etc.), Joint Work, Accepted

Presence of a genistein-responsive inhibitory mechanism on interleukin-1alpha-induced NF-kappaB activation.

Tago K, Funakoshi M, Mano H, Yanagisawa K, Hayakawa M, Kuroiwa K, Iwahana H, Kasahara T, Tominaga S*.

Eur J Biochem 268(24)   6526-6633 2001.12

Research paper (conference, symposium, etc.), Joint Work, Accepted

Macrophage signaling, apoptosis, lectins and leukocyte trafficking.

Kasahara T*, Matsushima K.

Trends Immunol 22(11)   593-4 2001.11

Research paper (conference, symposium, etc.), Joint Work, Accepted

Presence of an inhibitory mechanism on interleukin1a-induced NF-kB activation.

Tago K, Funakoshi M, Mano H, Yanagisawa K, Hayakawa M, Kuroiwa K, Iwahana H, Kasahara T, and Tominaga S-I*,.

Eur J Biochem 268(24)   6526-6633 2001.10

Research paper (conference, symposium, etc.), Single Work, Accepted

酸化ストレスによるアポトーシス誘導と抗アポトーシス機序の解析.

笠原 忠, 園田よし子.

共立薬科大学ハイテクリサーチシンポジウム    講演要旨集-p274 2001.09

Research paper (conference, symposium, etc.), Joint Work

A MEK inhibitor, PD98059 enhances IL-1-induced NF-kB activation by the enhanced and sustained degradation of IkB.

Funakoshi M, Tago K, Sonoda Y,Tominaga S-I, and Kasahara T*.

Biochem Biophys Res Commun 283 (1)   248-253 2001.06

Research paper (conference, symposium, etc.), Single Work, Accepted

FTY720, a novel immunosuppressive agent, induce apoptosis in human glioma cells.

Sonoda Y, Yamamoto D, Sakurai S, Hasegawa M, Aizu-Yokota E, Momoi T, Kasahara T*.

Biochem Biophys Res Commun 281 (2)   282-288 2001.06

Research paper (conference, symposium, etc.), Joint Work, Accepted

Antitumor effect of beta2-microglobulin in leukemic cell-bearing mice via apoptosis-inducing activity: activation of caspase-3 and nuclear factor-kappaB.

Mori M, Terui Y, Tanaka M, Tomizuka H, Mishima Y, Ikeda M, Kasahara T, Uwai M, Ueda M, Inoue R, Itoh T, Yamada M, Hayasawa H, Furukawa Y, Ishizaka Y, Ozawa K, Hatake K.

Cancer Res 61(11)   4414-4417 2001.06

Research paper (conference, symposium, etc.), Joint Work, Accepted

Differential involvement of p38 mitogen-activated protein kinase and phosphatidyl inositol 3-kinase in the IL-1-mediated NF-kB and AP-1 activation.

Funakoshi M, Sonoda Y, Tago K, Tominaga S-I, and Kasahara T*.

International Immunopharmcol. 1(3)   595-604 2001.06

Research paper (conference, symposium, etc.), Single Work, Accepted

A MEK inhibitor, PD98059 enhances IL-1-induced NF-kappaB activation by the enhanced and sustained degradation of IkappaBalpha.

Funakoshi M, Tago K, Sonoda Y, Tominaga S, Kasahara T*.

Biochem Biophys Res Commun 283(1)   248-254 2001.04

Research paper (conference, symposium, etc.), Joint Work, Accepted

Differential involvement of p38 mitogen-activated protein kinase and phosphatidyl inositol 3-kinase in the IL-1-mediated NF-kB and AP-1 activation.

Funakoshi M, Sonoda Y, Tago K, Tominaga S-I, Kasahara T.

International Immunopharmacology 1(3)   595-604 2001.03

Research paper (conference, symposium, etc.), Joint Work, Accepted

U73122 inhibits the dephosphorylation and translocation of cofilin in activated macrophage-like U937 cells.

Matui S, Adachi R, Kusui K, Yamaguchi T, Kasahara T, Hayakawa T, Suzuki K.

Cellular Signalling 13 ( 1 ) 17-22 2001.01

Research paper (conference, symposium, etc.), Joint Work, Accepted

サイトカインと病態,炎症とサイトカインー炎症性腸疾患を中心にー.

笠原 忠,桜井伸也.

G.I.Research (/先端医学社)  8(6)   467-473 2000.12

Research paper (scientific journal), Joint Work, Accepted

Nitric oxide induces chemotaxis of neutrophil-likeL-60 cells and traslocation of cofilin to plasma membranes.

Adachi R, Matsui S, Kinoshita M, Nagaishi K, Sasaki H, Kasahara T, Suzuki K.

Int J Immunopharmcol 22(11)   855-864 2000.11

Research paper (conference, symposium, etc.), Joint Work, Accepted

Suppression of apoptosis by the overexpression of focal adhesion kinases in a human leukemic cell line, HL-60.

Sonoda Y, Matumoto Y, Watanabe S, Funakoshi M, Hanks S K, Kasahara T*.

J Biol Chem 275   16309-16315 2000.11

Research paper (conference, symposium, etc.), Single Work, Accepted

サイトカインレセプター, CCR1?CCR5.

'笠原 忠, 船越めぐみ.'

臨床免疫. (/科学評論社)  34(7)   p570-576 2000.07

Research paper (scientific journal), Joint Work, Accepted

Differential induction of JE/MCP-1 in subclones from a murine macrophage cell line, RAW264.7: Role of kB-3 binding protein.

Ueno M,, Sonoda Y,, Funakoshi M,, Mukaida N,, Nose K,, Kasahara T*.

Cytokine 12(3)   207-219 2000.07

Research paper (conference, symposium, etc.), Single Work, Accepted

Establishment and usefulness of an anti-human CD57 IgG1 monoclonal antibody.

Tajima J, Heike Y, Kato K, Ikarashi Y, Asada-Mikami R, Yoshida M, Kasahara T, Wakasugi H*.

Immunol Lett 72(3)   159-162 2000.06

Research paper (conference, symposium, etc.), Joint Work, Accepted

Anti-apoptotic role of focal adhesion kinase (FAK): Induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60.

Sonoda Y, Matsumoto Y, Funakoshi M, Yamamoto D, Hanks SK, Kasahara T.

J Biol Chem 275 (21)   16309-16315 2000.05

Research paper (conference, symposium, etc.), Joint Work, Accepted

炎症細胞に働くサイトカイン：最近の知見.

笠原 忠.

炎症と免疫 (/先端医学社)  8(4)   376-383 2000.04

Research paper (scientific journal), Single Work, Accepted

Differential induction of JE/MCP-1 in subclones from a murine macrophage cell line, RAW264.7: Role of kB-3 binding protein.

Ueno M, Sonoda Y, Funakoshi M, Mukaida N, Nose K, Kasahara T.

Cytokine 12(3)   207-219 2000.04

Research paper (conference, symposium, etc.), Joint Work, Accepted

Interleukin-8 levels and granulocyte counts in cervical mucus during pregnancy.

Luo L, Ibaragi T, Maeda M, Nozawa M, Kasahara T, Sakai M, Sasaki Y, Tanebe K, Saito S*.

Am J Reprod Immunol 43(2)   78-84 2000.02

Research paper (conference, symposium, etc.), Joint Work, Accepted

Interleukin-8 levels and granulocyte counts in cervial mucus during pregnancy.

Luo L, Ibaragi T, Maeda M, Nozawa M, Kasahara T, Sakai M, Sasaki Y, Nanebe K, Saito S*.

Amer J Reprod Immunol 43(2)   78-84 2000.02

Research paper (conference, symposium, etc.), Joint Work, Accepted

NH2-terminal pentapeptide of endothelial IL-8 is responsible for the induction of apoptosis and has an antitumor effect in vivo.

Terui Y,Tomizuka H,Mishima Y,Ikeda M, Kasahara T, Uwai M, Mori M, Itoh T,Tanaka M, Yamada M, Shimamura S , Ishizaka Y, Ozawa K , Hatake K.

Cancer Res 59(22)   5651-5655 1999.11

Research paper (conference, symposium, etc.), Joint Work, Accepted

Dermal fibroblasts represent a potent major source of human eotaxin: In vitro production and cytokine-mediated regulation.

Miyamasu M, Nakajima T, Misaki Y, Izumi S, Tsuno N, KasaharaT, Morita Y, H, Hirai K*.

Cytokine 11(10)   751-758 1999.10

Research paper (conference, symposium, etc.), Joint Work, Accepted

b2-microglobulin identified as an apoptosis-inducing factor and its characterization.

Mori M,Terui Y, Ikeda M, Tomizuka H, Uwai M, Kasahara T, Kubota N, Itoh T, Tanaka M, Yamada M, Shimamura S, Ishizaka Y, Ikeda K, Ozawa K, Miura Y, Hatake K:.

Blood 94(8)   2744-2753 1999.10

Research paper (conference, symposium, etc.), Joint Work, Accepted

Herbimycin A inhibits both dephosphorylataion and translocation of Coffilin induced by opsonized zymosan in macrophage-like U937 cells.

Nagaishi K, Sasaki H, Adachi R, Matsui S,, Mogami T, Yamaguchi T, KasaharaT, Hayakawa T, Suzuki K*.

J Cell Physiol 180(3)   345-354 1999.09

Research paper (conference, symposium, etc.), Joint Work, Accepted

The participation of IL-8 in the synovial lesions at an early stage of rheumatoid arthritis.

Takahashi Y, Kasahara T, Sawai T, Rikimaru A, Mukaida N, Matsushima K, Sasaki T,*.

Tohoku J Exp Med 188 (1)   75-87 1999.05

Research paper (conference, symposium, etc.), Joint Work, Accepted

bFGF inhibits the activation of caspase-3 and apoptosis of P19 embryonal carcinoma cells during neuronal differentiation.

Miho Y, Kouroku Y, Fujita E, Mukasa T, Urase K, Kasahara T, Momoi M, Momoi T.

Cell Death Differentiation 6(5)   463-470 1999.05

Research paper (conference, symposium, etc.), Joint Work, Accepted

Participation of cofilin in opsonized zymosan-triggered activation of neutrophil-like HL-60 cells through rapid dephophorylation and translocation to plasma membranes.

Nagaishi K, Adachi R, Sasaki H, Kawanishi T, Yamaguchi T, Mogami T, Kasahara T, Hayakawa T, Suzuki K*.

J Biochem 125(5)   891-898 1999.05

Research paper (conference, symposium, etc.), Joint Work, Accepted

FAK is the upstreatm signal protein of the PI3-kinase-Akt survaival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line.

Sonoda Y, Watanabe S, Matsumoto Y, Yokota-Aizu E, Kasahara T*.

J Biol Chem 274:   10566-10570 1999.04

Research paper (conference, symposium, etc.), Joint Work, Accepted

Selective expression of eotaxin contributes to renal interstitial eosinophilia.

Wada T, Furuichi K, Sakai N, Shimizu M, Segawa C, Kobayashi K, Mukaida N, Kasahara T, Matushima K, Yokoyama, H.

Nephrology Dialysis Transplantation 14   76-80 1999.01

Research paper (conference, symposium, etc.), Joint Work, Accepted