論文 - 広瀬　寛

Secular trends in blood pressure among university students in Japan over the last two decades

Adachi K., Azegami T., Sei N., Yamada-Goto N., Uchida K., Murai-Takeda A., Inokuchi M., Hayashi K., Mori M., Hirose H.

Hypertension Research 2024年

ISSN  09169636

　概要を見る

High blood pressure (BP) increases the risk of cardiovascular disease, not only among middle-aged and older adults, but also in young adults. Early interventions for high BP may prevent future organ damage. Therefore, it is essential to monitor BP trends in young adults to support this approach. During the COVID-19 pandemic, a trend of increasing BP was observed worldwide. However, young adults have not been fully evaluated. Therefore, this study examined BP trends among university students (n = 106,691) over two decades, every 5 years from 2003 to 2023, including the period before and after the COVID-19 pandemic. From 2003 to 2018, there were no notable changes in BP. However, following the COVID-19 pandemic, increased BP was observed in both men and women, with systolic BP increasing from 118.1 (SD, 14.2) mmHg in 2018 to 120.6 (SD, 12.5) mmHg in 2023 among men, and from 104.6 (SD, 11.8) mmHg to 105.1 (SD, 11.7) mmHg among women. These trends were particularly pronounced among students with normal and underweight somatotypes and among first- and second-year students. The results of the lifestyle survey showed a decrease in smoking and drinking habits, insufficient sleep, mental stress, consumption of fast food and snacks, and an increase in exercise habits. Although contributing factors to the recent increase in BP were not identified, there was an upward trend in BP among Japanese university students. It is important to carefully observe how BP trends change over the long term following the end of the COVID-19 pandemic. (Figure presented.)

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教職員健診における血清高分子量型アディポネクチン濃度の測定(CLEIA法)

広瀬 寛, 後藤 伸子, 森 正明

慶應保健研究 （慶應義塾大学保健管理センター）  39 （ 1 ） 71 - 76 2021年09月

ISSN  1340-9379

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アディポネクチン(ADPN)は脂肪細胞から分泌される善玉のホルモンで、細胞実験や動物実験で糖尿病や動脈硬化・腫瘍などを抑制し、百寿者では血中濃度が高いなど、抗加齢ホルモンとしての意義が注目されている。また、糖尿病マウスの脂肪細胞内でシステイン残基へのコハク酸結合により高分子量(HMW)型の産生が低下する機序が報告された。本研究では、40～65歳の教職員を対象に健診時に血清中のHMW-ADPN濃度を測定し、その意義を断面研究で検討した。当施設の定期健康診断を受診した40～65歳の教職員を対象に、血清HMW-ADPN濃度をCLEIA法で測定した(株式会社エスアールエルに委託)。解析対象の日本人は男性1,586名、女性1,019名(平均年齢は男性51歳、女性49歳)であった。(1)血清HMW-ADPN濃度の中央値は男性で2.6μg/mL、女性で4.9μg/mLであり、男女ともメタボリックシンドローム(MetS)群は非MetS群と比較して有意に低値であった。(2)男女とも、log[HMW-ADPN]はHDL-CやBNP、年齢とは正の相関が、BMI、腹囲、空腹時血糖、HbA1c、血清TG、赤血球数、ALT、γ-GTP、尿酸などと有意な負の相関が認められた。(3)男女ともに、運動習慣がある群の方がHMW-ADPNが高い傾向が認められた。(4)log[HMW-ADPN]を目的変数としたステップワイズ多重回帰分析では、HDL-C、尿酸、BMI、性別、BNP、γ-GTP、年齢、HbA1cの順に採択された(F≧10、P<0.0001、R2=0.417)。以上より、血清HMW-ADPN濃度はHDL-Cや女性、BNP、年齢とは正の、BMIや尿酸、γ-GTP、HbA1cとは負の、それぞれ独立して有意な関係を示した。(著者抄録)

Low birth weight is associated with decline in renal function in Japanese male and female adolescents

Murai-Takeda A., Kanda T., Azegami T., Hirose H., Inokuchi M., Tokuyama H., Wakino S., Tokumura M., Kawabe H., Mori M., Itoh H.

Clinical and Experimental Nephrology （Clinical and Experimental Nephrology）  23 （ 12 ） 1364 - 1372 2019年12月

ISSN  13421751

　概要を見る

© 2019, Japanese Society of Nephrology. Background: Low birth weight (LBW) is a risk factor for chronic kidney disease (CKD) in later life and is becoming increasingly common in developed countries, including Japan. Furthermore, a serial decrease in birth weight has been associated with an increasing prevalence of CKD stage 2 in male Japanese adolescents. Sex-specific differences affect CKD susceptibility, and the association between birth weight and CKD in women, has not been elucidated. In this study, we investigated the sex-specific effect of LBW on renal function. Methods: Annual cross-sectional data of 2417 Japanese adolescents (males 1736; females 681), aged 15–16 years, were evaluated over 8 years (2007–2014). Results: Over the study period, mean birth weights decreased significantly in males (p < 0.01) and females (p < 0.05). Furthermore, both sexes showed significant decrease in estimated glomerular filtration rates corresponding to the birth weight reduction. The prevalence of CKD stage 2 also increased in males (from 26.0 to 32.4%, p < 0.01) and females (from 6.3 to 18.5%, p < 0.05). The incidence of CKD stage 2 was significantly related to history of LBW (males: odds ratio 1.73; 95% confidence interval 1.06–2.80; p < 0.05; females: odds ratio 3.29; 95% confidence interval 1.25–8.02; p < 0.05). Conclusions: Our data revealed that renal function and birth weight have decreased over time, in healthy Japanese adolescents. In view of the recent declining trend demonstrated by birth weight in Japan, we speculate that the prevalence of CKD might increase in the future.

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中高一貫校における2018年度の熱中症発生状況とその対応

福富 千尋, 佐藤 幸美子, 西村 知泰, 井ノ口 美香子, 広瀬 寛, 内田 敬子, 康井 洋介, 有馬 ふじ代, 後藤 伸子, 山田 茉未子, 伴 英子, 徳村 光昭, 森 正明

慶應保健研究 （慶應義塾大学保健管理センター）  37 （ 1 ） 79 - 84 2019年08月

ISSN  1340-9379

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神奈川県内の中高一貫校(男女共学)では、2018年度夏季休業中の部活動において熱中症が、校内、校外合わせて30件発生し、2017年の8件に比べて大幅に増加した。2018年度の夏は、夏季休業開始早々から、保健室において熱中症と判断される運動部生徒への対応が多く、学校は熱中症の発生を減らすために熱中症予防策を設けた。この予防策は、熱中症発生状況に応じて、教員と保健室スタッフが相談し、2回の見直しが行われた。今後の熱中症予防策を検討するため、見直しした対策ごとの熱中症発生者数と暑さ指数(Wet Bulb Globe Temperature:WBGT、湿球黒球温度)の関係を解析した。また、熱中症罹患者を対象にアンケート調査を行った。2018年度からの熱中症予防策に従い、暑さ指数を基準とした活動制限を設けたことで熱中症発生の抑制につながった。熱中症罹患者アンケート調査では、大部分の者では、個人の身体面における熱中症発症リスクや、個人レベルの予防策における問題点は認められなかった。個人の予防対策のみで熱中症発生を防止することは難しく、学校全体で予防策に取り組む必要がある。(著者抄録)

Features of and preventive measures against hypertension in the young

Kawabe H., Azegami T., Takeda A., Kanda T., Saito I., Saruta T., Hirose H.

Hypertension Research （Hypertension Research）  42 （ 7 ） 935 - 948 2019年

ISSN  09169636

　概要を見る

© 2019, The Author(s). The Japanese hypertension guidelines report that essential hypertension is detected in 1–3% of upper elementary and high school students during blood pressure (BP) screenings. Hypertension in these age groups is an emerging public health concern mainly attributed to the rising rate of pediatric obesity. Considering the existence of BP tracking phenomenon, early preventive education and instruction are necessary, especially for male students with moderately elevated BP showing a tendency toward obesity, despite the low prevalence of hypertension in high school students. Students with a positive family history of hypertension and those born with low birth weight need the same measures. Lifestyle habits, such as increased alcohol intake, dramatically change once students begin university; thus, early education and instruction regarding the factors influencing BP are necessary. In particular, for male students with higher BP during high school, caution regarding increased body weight is required irrespective of their level of obesity. Young adults aged <40 years should be educated about the association between body weight and hypertension. Particular caution surrounding lifestyle habits, including drinking and smoking, is warranted in male hypertensive subjects because hypertension at a young age is strongly associated with obesity. BP monitoring and the management of obesity should be considered efficient approaches to the detection and treatment of hypertension. For the lifetime prevention of hypertension, it is essential to be aware of one’s health status and learn about healthy lifestyles beginning in childhood. BP measurement may be an appropriate means to achieve this goal.

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Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21

Tanikawa C., Kamatani Y., Toyoshima O., Sakamoto H., Ito H., Takahashi A., Momozawa Y., Hirata M., Fuse N., Takai-Igarashi T., Shimizu A., Sasaki M., Yamaji T., Sawada N., Iwasaki M., Tsugane S., Naito M., Hishida A., Wakai K., Furusyo N., Murakami Y., Nakamura Y., Imoto I., Inazawa J., Oze I., Sato N., Tanioka F., Sugimura H., Hirose H., Yoshida T., Matsuo K., Kubo M., Matsuda K.

Cancer Science （Cancer Science）  109 （ 12 ） 4015 - 4024 2018年12月

ISSN  13479032

　概要を見る

© 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. Gastric cancer is the third leading cause of cancer mortality in Japan and worldwide. Although previous studies identify various genetic variations associated with gastric cancer, host genetic factors are largely unidentified. To identify novel gastric cancer loci in the Japanese population, herein, we carried out a large-scale genome-wide association study using 6171 cases and 27 178 controls followed by three replication analyses. Analysis using a total of 11 507 cases and 38 904 controls identified two novel loci on 12q24.11-12 (rs6490061, P = 3.20 × 10 −8 with an odds ratio [OR] of 0.905) and 20q11.21 (rs2376549, P = 8.11 × 10 −10 with an OR of 1.109). rs6490061 is located at intron 19 of the CUX2 gene, and its expression was suppressed by Helicobacter pylori infection. rs2376549 is included within the gene cluster of DEFB families that encode antibacterial peptides. We also found a significant association of rs7849280 in the ABO gene locus on 9q34.2 (P = 2.64 × 10 −13 with an OR of 1.148). CUX2 and ABO expression in gastric mucosal tissues was significantly associated with rs6490061 and rs7849280 (P = 0.0153 and 8.00 × 10 −11 ), respectively. Our findings show the crucial roles of genetic variations in the pathogenesis of gastric cancer.

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VISCERAL FAT AREA, INSULIN RESISTANCE INDEX AND ALCOHOL INTAKE WERE RELATED TO BLOOD PRESSURE STATUS IN COMPREHENSIVE HEALTH CHECKUP

Hirose Hiroshi, Shimizu-Hirota Ryoko, Kawabe Hiroshi

JOURNAL OF HYPERTENSION 36   E100 - E101 2018年10月

ISSN  0263-6352

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高等学校における脳しんとうの管理

佐藤 幸美子, 西村 知泰, 藤 ひとみ, 牟田口 絵里, 中村 清美, 山岸 あや, 広瀬 寛, 徳村 光昭, 森 正明, 河邊 博史

慶應保健研究 （慶應義塾大学保健管理センター）  36 （ 1 ） 33 - 38 2018年08月

ISSN  1340-9379

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脳しんとうは、頭部への直接的な衝撃や頭部へ伝達する他の体の部位への衝撃で生じる頭部外傷である。脳しんとうの症状が完全に回復する前に運動を再開すると、脳しんとうを再発する危険性が高くなる。また、脳が発達途中である小児から青年期は、脳しんとうを起こしやすく、症状が完全に回復するまでに時間がかかり、脳しんとうを繰り返し起こすことで、致死的な病態や将来的な高次脳機能障害を引き起こす危険性が高くなる。以上のように、脳しんとうは学校において留意すべき頭部外傷であることから、脳しんとう後の学校における管理について、神奈川県内の2つの高等学校で検討した。フローチャートに則った脳しんとう後の対応を開始することで、教員および保健室での脳しんとうの発生状況、受傷した生徒等に関する正確な情報の収集ならびに共有が可能になった。2016年度に発生した36件の脳しんとうのうち、34件がコンタクトスポーツの部活動中の発生であった。受傷者31人のうち、過去5年以内に脳しんとうの既往がある生徒が7人(23%)おり、脳しんとうの再発の危険性が高いことが確認された。フローチャートに則った脳しんとう後の対応を通して、学校における脳しんとう発生予防の立案、脳しんとう後の生徒の慎重な健康管理が可能となった。このフローチャートに則った脳しんとう後の対応は、学校の安全配慮義務上、有用と考えられた。(著者抄録)

13年間における当大学での自動体外式除細動器の使用経験

清 奈帆美, 和井内 由充子, 山崎 花梨, 小原 慶子, 澁谷 麻由美, 松本 可愛, 齋藤 圭美, 當仲 香, 高橋 綾, 中園 春奈, 牧野 伸司, 広瀬 寛, 森 正明, 河邊 博史

CAMPUS HEALTH （(公社)全国大学保健管理協会）  55 （ 1 ） 195 - 197 2018年03月

ISSN  1341-4313

Temporal trends in renal function and birthweight in Japanese adolescent males (1998-2015)

Kanda T., Takeda A., Hirose H., Abe T., Urai H., Inokuchi M., Wakino S., Tokumura M., Itoh H., Kawabe H.

Nephrology Dialysis Transplantation （Nephrology Dialysis Transplantation）  33 （ 2 ） 304 - 310 2018年02月

ISSN  09310509

　概要を見る

© 2017 The Author . Published by Oxford University Press on behalf of ERA-EDTA. Background Low birthweight (LBW) is a worldwide public health problem, demonstrating an increasing incidence in developed countries, including Japan. LBW is also a risk factor for later development of chronic kidney disease (CKD). To date, studies have not evaluated the population impacts of increasing LBW rates on renal function. Methods Estimated glomerular filtration rate (EGFR) was evaluated in 3737 Japanese adolescent males (15-16 years old) using annual cross-sectional data over an 18-year period (1998-2015). Results Between the initial (1998-2003) and final (2010-15) periods of the study, the mean birthweight decreased from 3213.4 ± 383.8 to 3116.2 ± 382.3 g and the LBW rate increased from 2.5 to 5.5% (both P ≤ 0.01). Additionally, the mean EGFR decreased from 105.1 ± 15.9 to 97.4 ± 13.8 mL/min/1.73 m 2 and the prevalence of mildly reduced renal function (EGFR ≤ 60-<90 mL/min/1.73 m 2) increased from 16.4 to 30.0% (both P ≤ 0.01), most evident in the LBW group (from 10.3 to 41.7%, P ≤0.01). The prevalence of proteinuria also increased significantly. Mildly reduced renal function was significantly associated with LBW [odds ratio (LBW 3000-3999 g) 1.51; 95% confidence interval 1.00-2.55; P = 0.047]. Conclusions In this population of Japanese adolescents, the frequency of mildly reduced renal function increased as the LBW frequency increased. Our findings may have implications for the broader Japanese population as well as for other populations in which the prevalence of LBW is increasing.

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Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Demenais F., Margaritte-Jeannin P., Barnes K., Cookson W., Altmüller J., Ang W., Barr R., Beaty T., Becker A., Beilby J., Bisgaard H., Bjornsdottir U., Bleecker E., Bønnelykke K., Boomsma D., Bouzigon E., Brightling C., Brossard M., Brusselle G., Burchard E., Burkart K., Bush A., Chan-Yeung M., Chung K., Couto Alves A., Curtin J., Custovic A., Daley D., De Jongste J., Del-Rio-Navarro B., Donohue K., Duijts L., Eng C., Eriksson J., Farrall M., Fedorova Y., Feenstra B., Ferreira M., Freidin M., Gajdos Z., Gauderman J., Gehring U., Geller F., Genuneit J., Gharib S., Gilliland F., Granell R., Graves P., Gudbjartsson D., Haahtela T., Heckbert S., Heederik D., Heinrich J., Heliövaara M., Henderson J., Himes B., Hirose H., Hirschhorn J., Hofman A., Holt P., Hottenga J., Hudson T., Hui J., Imboden M., Ivanov V., Jaddoe V., James A., Janson C., Jarvelin M., Jarvis D., Jones G., Jonsdottir I., Jousilahti P., Kabesch M., Kähönen M., Kantor D., Karunas A., Khusnutdinova E., Koppelman G., Kozyrskyj A., Kreiner E., Kubo M., Kumar R., Kumar A., Kuokkanen M., Lahousse L., Laitinen T., Laprise C., Lathrop M., Lau S., Lee Y., Lehtimäki T., Letort S., Levin A., Li G., Liang L., Loehr L., London S., Loth D., Manichaikul A.

Nature Genetics （Nature Genetics）  50 （ 1 ） 42 - 50 2018年01月

ISSN  10614036

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© 2017 The Author(s). We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.

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Associations of Aging with Visceral Fat, HOMA-IR, and Beta-Cell Function in Humans

Hirose Hiroshi, Azuma Koichiro, Takayama Michiyo, Iwao Yasushi, Kawabe Hiroshi

DIABETES 66   A399 - A399 2017年06月

ISSN  0012-1797

Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in Japanese

広瀬 寛

JOURNAL OF DIABETES RESEARCH 2017 2017年

研究論文（学術雑誌）,  ISSN  2314-6745

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Investigation of Metabolic Factors Associated with eGFR Decline Over 1 Year in a Japanese Population without CKD

Hayashi Kaori, Takayama Michiyo, Abe Takayuki, Kanda Takeshi, Hirose Hiroshi, Shimizu-Hirota Ryoko, Shiomi Eisuke, Iwao Yasushi, Itoh Hiroshi

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 24 （ 8 ） 863 - 875 2017年

ISSN  1340-3478

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EGFR IN JAPANESE MALE ADOLESCENT HAS DECREASED BETWEEN 1998 AND 2015, AND LOW BIRTH WEIGHT IS CORRELATED WITH RENAL FUNCTION

Kanda T., Takeda A., Hirose H., Urai H., Wakino S., Itoh H., Kawabe H.

NEPHROLOGY 21   80 - 80 2016年09月

ISSN  1320-5358

RELATIONSHIPS OF VISCERAL FAT AREA AND INSULIN RESISTANCE INDEX WITH BLOOD PRESSURE STATUS

Hirose Hiroshi, Takayama Michiyo, Shimizu-Hirota Ryoko, Iwao Yasushi, Kawabe Hiroshi

JOURNAL OF HYPERTENSION 34   E393 - E393 2016年09月

ISSN  0263-6352

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Serum High-Molecular-Weight Adiponectin Levels Correlate with Various Metabolic Parameters in Special Health Checkup Programs

Hirose Hiroshi, Azuma Koichiro, Shimizu-Hirota Ryoko, Taka-Yama Michiyo, Iwao Yasushi, Kawabe Hiroshi

DIABETES 65   A626 - A627 2016年06月

ISSN  0012-1797

Replication Study in a Japanese Population of Six Susceptibility Loci for Type 2 Diabetes Originally Identified by a Transethnic Meta-Analysis of Genome-Wide Association Studies

Matsuba Ren, Imamura Minako, Tanaka Yasushi, Iwata Minoru, Hirose Hiroshi, Kaku Kohei, Maegawa Hiroshi, Watada Hirotaka, Tobe Kazuyuki, Kashiwagi Atsunori, Kawamori Ryuzo, Maeda Shiro

PLOS ONE 11 （ 4 ）  2016年04月

ISSN  1932-6203

　概要を見る

<p>Aim We performed a replication study in a Japanese population to evaluate the association between type 2 diabetes and six susceptibility loci (TMEM154, SSR1, FAF1, POU5F1, ARL15, and MPHOSPH9) originally identified by a transethnic meta-analysis of genomewide association studies (GWAS) in 2014. Methods We genotyped 7,620 Japanese participants (5,817 type 2 diabetes patients and 1,803 controls) for each of the single nucleotide polymorphisms (SNPs) using a multiplex polymerase chain reaction invader assay. The association of each SNP locus with the disease was evaluated using logistic regression analysis. Results Of the six SNPs examined in this study, four (rs6813195 near TMEM154, rs17106184 in FAF1, rs3130501 in POU5F1 and rs4275659 near MPHOSPH9) had the same direction of effect as in the original reports, but two (rs9505118 in SSR1 and rs702634 in ARL15) had the opposite direction of effect. Among these loci, rs3130501 and rs4275659 were nominally associated with type 2 diabetes (rs3130501; p = 0.017, odds ratio [OR] = 1.113, 95% confidence interval [CI] 1.019-1.215, rs4275659; p = 0.012, OR = 1.127, 95% CI 1.026-1.238, adjusted for sex, age and body mass index), but we did not observe a significant association with type 2 diabetes for any of the six evaluated SNP loci in our Japanese population. Conclusions Our results indicate that effects of the six SNP loci identified in the transethnic GWAS metaanalysis are not major among the Japanese, although SNPs in POU5F1 and MPHOSPH9 loci may have some effect on susceptibility to type 2 diabetes in this population.</p>

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Metabolic Factors in Addition to Aging and Current Smoking Are Independently Associated With the Prevalence of Colorectal Neoplasia in Japan: Analyses of Comprehensive Health Checkup Data

広瀬 寛

GASTROENTEROLOGY 150 （ 4 ） S767 - S768 2016年04月

研究論文（学術雑誌）,  ISSN  0016-5085

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Effects of Aging on Visceral and Subcutaneous Fat Areas and on Homeostasis Model Assessment of Insulin Resistance and Insulin Secretion Capacity in a Comprehensive Health Checkup

Hirose Hiroshi, Takayama Michiyo, Iwao Yasushi, Kawabe Hiroshi

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 23 （ 2 ） 207 - 215 2016年02月

ISSN  1340-3478

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<p>Aim:The association between aging and insulin resistance has been unclear. We evaluated the effects of aging on visceral fat area (VFA) and subcutaneous fat area (SFA) measured by computed tomography, homeostasis model assessment of insulin resistance (HOMA-IR), and homeostasis model assessment of β-cell function (HOMA-β) among participants in a comprehensive health checkup. Methods: This study included 1,050 male and 700 female Japanese participants aged 35-84 years in our comprehensive health checkup program during a 2-year period. Participants who were on medication for diabetes mellitus or those who met the pre-determined exclusion criteria were excluded. The participants were divided into five groups according to age. Results: As age increased from Group 1 to Group 5, both VFA and VFA/SFA ratio significantly increased in both male and female participants, whereas log[HOMA-IR] linearly and significantly decreased (p＜0.0001 for each). Body mass index (BMI), waist circumference (WC), and SFA increased with age in female participants but decreased in male participants. Although age was not or only weakly correlated with log[glucose] and log[HbA1c] in both male and female participants, age showed significant negative correlations with log[insulin], log[HOMA-IR], and log[HOMA-β] even after adjusting for BMI and WC (p＜0.0001 for each). Serum high-molecular-weight adiponectin (HMW-ADPN) levels were measured in 114 male and 87 female participants, and log[HMW-ADPN] was negatively correlated with log[HOMA-IR] and positively correlated with age in both male and female participants. Conclusions: In the present study, both male and female participants showed increases in VFA and VFA/SFA ratio and decreases in insulin, HOMA-IR, and HOMA-β with age.</p>

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Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

Imamura Minako, Takahashi Atsushi, Yamauchi Toshimasa, Hara Kazuo, Yasuda Kazuki, Grarup Niels, Zhao Wei, Wang Xu, Huerta-Chagoya Alicia, Hu Cheng, Moon Sanghoon, Long Jirong, Kwak Soo Heon, Rasheed Asif, Saxena Richa, Ma Ronald C. W., Okada Yukinori, Iwata Minoru, Hosoe Jun, Shojima Nobuhiro, Iwasaki Minaka, Fujita Hayato, Suzuki Ken, Danesh John, Jorgensen Torben, Jorgensen Marit E., Witte Daniel R., Brandslund Ivan, Christensen Cramer, Hansen Torben, Mercader Josep M., Flannick Jason, Moreno-Macias Hortensia, Burtt Noel P., Zhang Rong, Kim Young Jin, Zheng Wei, Singh Jai Rup, Tam Claudia H. T., Hirose Hiroshi, Maegawa Hiroshi, Ito Chikako, Kaku Kohei, Watada Hirotaka, Tanaka Yasushi, Tobe Kazuyuki, Kawamori Ryuzo, Kubo Michiaki, Cho Yoon Shin, Chan Juliana C. N., Sanghera Dharambir, Frossard Philippe, Park Kyong Soo, Shu Xiao-Ou, Kim Bong-Jo, Florez Jose C., Tusie-Luna Teresa, Jia Weiping, Tai E. Shyong, Pedersen Oluf, Saleheen Danish, Maeda Shiro, Kadowaki Takashi

NATURE COMMUNICATIONS 7 2016年01月

ISSN  2041-1723

　概要を見る

<p>Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P-8), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P</p>

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Vitamin D deficiency with high intact PTH levels is more common in younger than in older women

Miyamoto Takeshi, Katsuyama Eri, Kanagawa Hiroya, Fujie Atsuhiro, Miyamoto Hiroya, Yoshida Shigeyuki, Mori Tomoaki, Miyamoto Kana, Sato Yuiko, Kobayashi Tami, Nakamura Masaya, Matsumoto Morio, Nishiwaki Yuji, Hirose Hiroshi, Kanda Takeshi, Saito Ikuo, Toyama Yoshiaki

Keio Journal of Medicine 65 （ 2 ） 33 - 38 2016年

ISSN  0022-9717

　概要を見る

<p>Low serum 25-hydroxyvitamin D (25(OH)D) levels are implicated as a risk factor for hip and spine fractures. Studies of the relation between 25(OH)D levels and fractures have primarily involved elderly osteoporosis patients or patients with fractures; however, the serum 25(OH)D and parathyroid hormone (PTH) status in younger adult populations remains largely unknown. We evaluated serum 25(OH)D and intact PTH levels in 411 women aged 39–64 years who were not receiving medication for osteoporosis or other bone diseases. Serum 25(OH)D levels were positively correlated with age (P = 0.019), whereas intact PTH levels were inversely correlated with 25(OH)D levels (P &lt;0.001). Thus, low vitamin D levels with high intact PTH levels were more common in younger than in older women. Our data show that serum 25(OH)D insufficiency could be a more serious concern in the younger population than had been previously anticipated. Because serum 25(OH)D insufficiency is reportedly a risk factor for hip and spine fracture, the number of fracture patients could increase in the future, suggesting that we may need to correct the serum vitamin D/intact PTH status to prevent future osteoporosis.</p>

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Replication study of the association of rs7578597 in THADA, rs10886471 in GRK5, and rs7403531 in RASGRP1 with susceptibility to type 2 diabetes among a Japanese population

Sakai Kensuke, Imamura Minako, Tanaka Yasushi, Iwata Minoru, Hirose Hiroshi, Kaku Kohei, Maegawa Hiroshi, Watada Hirotaka, Tobe Kazuyuki, Kashiwagi Atsunori, Kawamori Ryuzo, Maeda Shiro

DIABETOLOGY INTERNATIONAL 6 （ 4 ） 306 - 312 2015年12月

ISSN  2190-1678

　概要を見る

<p>Aims: To evaluate the association of rs7578597 in THADA, rs10886471 in GRK5, rs7403531 in RASGRP1, and rs6723108 in TMEM163 with type 2 diabetes among the Japanese we performed a replication study of the association of these single nucleotide polymorphism (SNP) loci. Methods: We genotyped these 4 SNPs for 10,287 Japanese participants (7,478 type 2 diabetes, 2,809 controls) and used logistic regression analysis to examine the association of these SNPs with type 2 diabetes. Results: Rs6723108 was not polymorphic in our control group, and was excluded from the analysis. Rs7578597 was nominally associated with type 2 diabetes (p = 0.0186, odds ratio = 0.55, 95 % confidence interval = 0.33–0.90 adjusted for age, sex, and body mass index); however this association was not significant after Bonferroni correction (p ≥ 0.0125) and the effect direction was not consistent with that in the original report. There was significant heterogeneity in the allele frequency of rs7578597 among our control groups, and the nominal association was no longer observed (p = 0.58) after excluding a control collection in which the risk allele frequency was significantly higher than those in the other control collections. The remaining 2 SNP loci were not associated with type 2 diabetes in this Japanese population (p ≥ 0.05). We did not observe a significant association between the 3 SNPs and glycemic traits. Conclusions: The 4 loci have no significant effect on susceptibility to type 2 diabetes among the Japanese, although further evaluation with larger cohorts is necessary, especially for rs7578597 in THADA.</p>

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Aging, Smoking, Dyslipidemia, and Obesity Are Independently Associated With the Prevalence of Colorectal Neoplasia in Japan: Analyses of Comprehensive Health Checkup Data

Inoue Nagamu, Takayama Michiyo, Makino Kanako, Matsuzaki Juntaro, Shiomi Eisuke, Shimizu Ryoko, Yoshida Toshifumi, Kashiwagi Kazuhiro, Hirose Hiroshi, Momoshima Suketaka, Sugino Yoshinori, Iwao Yasushi

AMERICAN JOURNAL OF GASTROENTEROLOGY 110   S601 - S601 2015年10月

ISSN  0002-9270

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Palmitic acid-rich diet suppresses glucose-stimulated insulin secretion (GSIS) and induces endoplasmic reticulum (ER) stress in pancreatic islets in mice

Hirata Takumi, Kawai Toshihide, Hirose Hiroshi, Tanaka Kumiko, Kurosawa Hideaki, Fujii Chikako, Fujita Haruhisa, Seto Yoshiko, Matsumoto Hideo, Itoh Hiroshi

ENDOCRINE RESEARCH 41 （ 1 ） 8 - 15 2015年07月

ISSN  0743-5800

　概要を見る

<p>The objective was to clarify whether dietary palmitic acid supplementation affects glucose-stimulated insulin secretion (GSIS) and the endoplasmic reticulum (ER) stress pathway in pancreatic islets in mice. Eight-week-old male C57BL/6J mice were randomly divided into three treatment diet groups: control diet, palmitic acid-supplemented diet (PAL) and oleic acid-supplemented diet (OLE). After 2 weeks of treatment, intraperitoneal glucose tolerance test and intraperitoneal insulin tolerance test were performed. GSIS was assessed by pancreatic perfusion in situ with basal (100 mg/dL) glucose followed by a high (300 mg/dL) glucose concentration. We measured mRNA levels of ER stress markers such as C/EBP homologous protein (CHOP), immunoglobulin heavy-chain binding protein (BIP) and X-box binding protein (XBP)-1 using real-time polymerase chain reaction (PCR) analyses in isolated islets. Immunohistochemical staining was also performed. Mice fed PAL showed significantly decreased glucose tolerance (p &lt; 0.05). In the perfusion study, GSIS was significantly suppressed in the PAL group (p &lt; 0.05). Semi-quantitative RT-PCR revealed that islet CHOP, BIP, and XBP-1 mRNA expression were significantly increased in the PAL group (p &lt; 0.05). TUNEL-positive β-cells were not detected in all groups. Dietary palmitic acid-supplementation for 2 weeks might suppress GSIS and induce ER stress in pancreatic islets in mice, in the early stage of lipotoxicity.</p>

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A Meta-analysis of Japanese Genome-Wide Association Studies Identified Seven Novel Susceptibility Loci to Type 2 Diabetes

Imamura Minako, Maeda Shiro, Yamauchi Toshimasa, Hara Kazuo, Takahashi Atsushi, Kubo Michiaki, Iwata Minoru, Hirose Hiroshi, Yasuda Kazuki, Watada Hirotaka, Maegawa Hiroshi, Ito Chikako, Tanaka Yasushi, Tobe Kazuyuki, Kaku Kohei, Kawamori Ryuzo, Kadowaki Takashi

DIABETES 64   A6 - A6 2015年06月

ISSN  0012-1797

Replication Study in a Japanese Population to Evaluate the Association between 10 SNP Loci, Identified in European Genome-Wide Association Studies, and Type 2 Diabetes

Matsuba Ren, Sakai Kensuke, Imamura Minako, Tanaka Yasushi, Iwata Minoru, Hirose Hiroshi, Kaku Kohei, Maegawa Hiroshi, Watada Hirotaka, Tobe Kazuyuki, Kashiwagi Atsunori, Kawamori Ryuzo, Maeda Shiro

PLOS ONE 10 （ 5 ）  2015年05月

ISSN  1932-6203

　概要を見る

<p>Aim: We performed a replication study in a Japanese population to evaluate the association between type 2 diabetes and 7 susceptibility loci originally identified by European genomewide association study (GWAS) in 2012: ZMIZ1, KLHDC5, TLE1, ANKRD55, CILP2, MC4R, and BCAR1. We also examined the association of 3 additional loci: CCND2 and GIPR, identified in sex-differentiated analyses, and LAMA1, which was shown to be associated with non-obese European type 2 diabetes. Methods: We genotyped 6,972 Japanese participants (4,280 type 2 diabetes patients and 2,692 controls) for each of the 10 single nucleotide polymorphisms (SNPs): rs12571751 in ZMIZ1, rs10842994 near KLHDC5, rs2796441 near TLE1, rs459193 near ANKRD55, rs10401969 in CILP2, rs12970134 near MC4R, rs7202877 near BCAR1, rs11063069 near CCND2, rs8108269 near GIPR, and rs8090011 in LAMA1 using a multiplex polymerase chain reaction invader assay. The association of each SNP locus with the disease was evaluated using a logistic regression analysis. Results: All SNPs examined in this study had the same direction of effect (odds ratio &gt; 1.0, p = 9.77 × 10&lt;sup&gt;-4&lt;/sup&gt;, binomial test), as in the original reports. Among them, rs12571751 in ZMIZ1 was significantly associated with type 2 diabetes [p = 0.0041, odds ratio = 1.123, 95% confidence interval 1.037-1.215, adjusted for sex, age and body mass index (BMI)], but we did not observe significant association of the remaining 9 SNP loci with type 2 diabetes in the present Japanese population (p ≥ 0.005). A genetic risk score, constructed from the sum of risk alleles for the 7 SNP loci identified by un-stratified analyses in the European GWAS meta-analysis were associated with type 2 diabetes in the present Japanese population (p = 2.3 × 10 &lt;sup&gt;-4&lt;/sup&gt;, adjusted for sex, age and BMI). Conclusions: ZMIZ1 locus has a significant effect on conferring susceptibility to type 2 diabetes also in the Japanese population.</p>

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Effects of Oral Propranolol on a Juxtapapillary Capillary Hemangioma: A Single-Subject Pilot Study

Tanabe, H; Sahashi, K; Kitano, T; Tomita, Y; Saito, AM; Hirose, H

OPHTHALMIC SURGERY LASERS & IMAGING RETINA 46 （ 3 ） 380 - 383 2015年03月

ISSN  2325-8160

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Genome-wide association study identifies three novel loci for type 2 diabetes

Hara Kazuo, Fujita Hayato, Johnson Todd A., Yamauchi Toshimasa, Yasuda Kazuki, Horikoshi Momoko, Peng Chen, Hu Cheng, Ma Ronald C. W., Imamura Minako, Iwata Minoru, Tsunoda Tatsuhiko, Morizono Takashi, Shojima Nobuhiro, So Wing Yee, Leung Ting Fan, Kwan Patrick, Zhang Rong, Wang Jie, Yu Weihui, Maegawa Hiroshi, Hirose Hiroshi, Kaku Kohei, Ito Chikako, Watada Hirotaka, Tanaka Yasushi, Tobe Kazuyuki, Kashiwagi Atsunori, Kawamori Ryuzo, Jia Weiping, Chan Juliana C. N., Teo Yik Ying, Shyong Tai E., Kamatani Naoyuki, Kubo Michiaki, Maeda Shiro, Kadowaki Takashi

HUMAN MOLECULAR GENETICS 23 （ 1 ） 239 - 246 2014年01月

ISSN  0964-6906

　概要を見る

<p>Although over 60loci for type 2 diabetes (T2D) havebeenidentified, there still remains a large geneticcomponent to be clarified. To explore unidentified loci for T2D, we performed a genome-wide association study (GWAS) of 6 209 637 single-nucleotide polymorphisms (SNPs), which were directly genotyped or imputed using East Asian references from the 1000 Genomes Project (June 2011 release) in 5976 Japanese patients with T2D and 20 829 nondiabetic individuals. Nineteen unreported loci were selected and taken forward to follow-up analyses. Combined discovery and follow-up analyses (30 392 cases and 34 814 controls) identified three new loci with genome-wide significance, which were MIR129-LEP [rs791595; risk allele 5 A; risk allele frequency (RAF) 5 0.080; P 5 2.55 × 10^-13; odds ratio (OR) 5 1.17], GPSM1 [rs11787792; risk allele 5 A; RAF 5 0.874; P 5 1.74 × 10^-10; OR 5 1.15] and SLC16A13 (rs312457; risk allele 5 G; RAF 5 0.078; P 5 7.69 × 10^-13; OR 5 1.20). This study demonstrates that GWASs based on the imputation of genotypes using modern reference haplotypes such as that from the 1000 Genomes Project data can assist in identification of new loci for common diseases. © The Author 2013. Published by Oxford University Press. All rights reserved.</p>

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Disturbed tumor necrosis factor system is linked with lower eGFR and chronic inflammation in hypertension

Eguchi Takashi, Maruyama Tatsuya, Ohno Yoichi, Morii Toshiyuki, Hirose Hiroshi, Takenaka Tsuneo, Suzuki Hiromichi, Kawabe Hiroshi, Saito Ikuo, Hayashi Matsuhiko, Itoh Hiroshi

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS 29 （ 1 ） E69 - E77 2014年

ISSN  0393-6155

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<p>Background: The relationship between tumor necrosis factor (TNF)-related parameters and cardiorenal metabolic factors is still controversial in clinical hypertension. Methods: Normotensive men (NT, n=60) and treated stage 2 and 3 essential hypertensive men (HT, n=89) were enrolled in this study. The relationship between TNF-related parameters and cardiorenal metabolic factors was examined in NT and HT, separately. Results: HT showed higher rates of insulin resistance and enhanced chronic inflammation compared with NT. The levels of soluble TNF receptor 1 and 2 were significantly higher in HT than in NT, although TNF-a levels were unexpectedly lower in HT than in NT. Regression analysis indicated that the TNF-related parameters were closely linked with mild renal dysfunction both in NT and HT, and moderately related to chronic inflammation only in HT. HT taking inhibitors of the renin-angiotensin system showed improved insulin resistance, but no difference in the TNF-related parameters. Conclusion: These results suggest that the disturbed TNF system is closely linked with chronic inflammation rather than with insulin resistance in HT. © 2014 Wichtig Editore.</p>

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Effects of Oral Propranolol on Circumscribed Choroidal Hemangioma A Pilot Study

Tanabe, H; Sahashi, K; Kitano, T; Tomita, Y; Saito, AM; Hirose, H

JAMA OPHTHALMOLOGY 131 （ 12 ） 1617 - 1622 2013年12月

ISSN  2168-6165

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Assessing the Clinical Utility of a Genetic Risk Score Constructed Using 49 Susceptibility Alleles for Type 2 Diabetes in a Japanese Population

広瀬 寛

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 98 （ 10 ） E1667 - E1673 2013年10月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  0021-972X

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A Novel, Rapid, Effective, Tolerable, and Safe Preparation Using Mosapride Citrate as an Adjunct to Low-volume Polyethylene Glycol Solution for Colonoscopy

広瀬 寛

AMERICAN JOURNAL OF GASTROENTEROLOGY 108   S577 - S577 2013年10月

研究論文（学術雑誌）,  ISSN  0002-9270

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Replication Study for the Association of 9 East Asian GWAS-Derived Loci with Susceptibility to Type 2 Diabetes in a Japanese Population

Sakai Kensuke, Imamura Minako, Tanaka Yasushi, Iwata Minoru, Hirose Hiroshi, Kaku Kohei, Maegawa Hiroshi, Watada Hirotaka, Tobe Kazuyuki, Kashiwagi Atsunori, Kawamori Ryuzo, Maeda Shiro

PLOS ONE 8 （ 9 ）  2013年09月

ISSN  1932-6203

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C-Reactive Protein, High-Molecular-Weight Adiponectin and Development of Metabolic Syndrome in the Japanese General Population: A Longitudinal Cohort Study

Saisho Yoshifumi, Hirose Hiroshi, Roberts Rachel, Abe Takayuki, Kawabe Hiroshi, Itoh Hiroshi

PLOS ONE 8 （ 9 ）  2013年09月

ISSN  1932-6203

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Effect of Telmisartan or Losartan for Treatment of Nonalcoholic Fatty Liver Disease: Fatty Liver Protection Trial by Telmisartan or Losartan Study (FANTASY) (vol 2013, 587140, 2013)

広瀬 寛

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY    587140 - 587140 2013年08月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  1687-8337

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Replication study for the association of a single-nucleotide polymorphism, rs3746876, within KCNJ15, with susceptibility to type 2 diabetes in a Japanese population

広瀬 寛

JOURNAL OF HUMAN GENETICS 58 （ 7 ） 490 - 493 2013年07月

研究論文（学術雑誌）,  ISSN  1434-5161

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Usefulness of Genetic Risk Score Constructed from 47 Loci for Type 2 Diabetes in Non-Obese, Older Japanese Individuals

Imamura Minako, Iwata Minoru, Maegawa Hiroshi, Watada Hirotaka, Hirose Hiroshi, Tanaka Yasushi, Tobe Kazuyuki, Kaku Kohei, Kashiwagi Atsunori, Kawamori Ryuzo, Maeda Shiro

DIABETES 62   A433 - A433 2013年07月

ISSN  0012-1797

Cost-utility analysis of cataract surgery in Japan: a probabilistic Markov modeling study

Hiratsuka, Y; Yamada, M; Akune, Y; Murakami, A; Okada, AA; Yamashita, H; Ohashi, Y; Yamagishi, N; Tamura, H; Fukuhara, S; Takura, T; Eguchi, S; Akune, Y; Yamada, M; Kurosaka, D; Takahashi, K; Miyake, S; Hirose, H; Otori, Y

JAPANESE JOURNAL OF OPHTHALMOLOGY 57 （ 4 ） 391 - 401 2013年07月

ISSN  0021-5155

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Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India

広瀬 寛

DIABETES 62 （ 5 ） 1746 - 1755 2013年05月

研究論文（学術雑誌）,  ISSN  0012-1797

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Replication study for the association of rs391300 in SRR and rs17584499 in PTPRD with susceptibility to type 2 diabetes in a Japanese population

広瀬 寛

JOURNAL OF DIABETES INVESTIGATION 4 （ 2 ） 168 - 173 2013年03月

研究論文（学術雑誌）,  ISSN  2040-1116

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Effect of Telmisartan or Losartan for Treatment of Nonalcoholic Fatty Liver Disease: Fatty Liver Protection Trial by Telmisartan or Losartan Study (FANTASY)

Hirata Takumi, Tomita Kengo, Kawai Toshihide, Yokoyama Hirokazu, Shimada Akira, Kikuchi Masahiro, Hirose Hiroshi, Ebinuma Hirotoshi, Irie Junichiro, Ojiro Keisuke, Oikawa Yoichi, Saito Hidetsugu, Itoh Hiroshi, Hibi Toshifumi

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY 2013 2013年

ISSN  1687-8337

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A Single Nucleotide Polymorphism within DUSP9 Is Associated with Susceptibility to Type 2 Diabetes in a Japanese Population

Fukuda Hisashi, Imamura Minako, Tanaka Yasushi, Iwata Minoru, Hirose Hiroshi, Kaku Kohei, Maegawa Hiroshi, Watada Hirotaka, Tobe Kazuyuki, Kashiwagi Atsunori, Kawamori Ryuzo, Maeda Shiro

PLOS ONE 7 （ 9 ）  2012年09月

ISSN  1932-6203

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A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations

Imamura Minako, Maeda Shiro, Yamauchi Toshimasa, Hara Kazuo, Yasuda Kazuki, Morizono Takashi, Takahashi Atsushi, Horikoshi Momoko, Nakamura Masahiro, Fujita Hayato, Tsunoda Tatsuhiko, Kubo Michiaki, Watada Hirotaka, Maegawa Hiroshi, Okada-Iwabu Miki, Iwabu Masato, Shojima Nobuhiro, Ohshige Toshihiko, Omori Shintaro, Iwata Minoru, Hirose Hiroshi, Kaku Kohei, Ito Chikako, Tanaka Yasushi, Tobe Kazuyuki, Kashiwagi Atsunori, Kawamori Ryuzo, Kasuga Masato, Kamatani Naoyuki, Nakamura Yusuke, Kadowaki Takashi

HUMAN MOLECULAR GENETICS 21 （ 13 ） 3042 - 3049 2012年07月

ISSN  0964-6906

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Low Serum High-Molecular-Weight Adiponectin Level Predicts Worsening of Glucose Tolerance in Non-Diabetic Japanese Men

Hirose Hiroshi, Kawabe Hiroshi, Saito Ikuo

DIABETES 61   A647 - A647 2012年06月

ISSN  0012-1797

Variability of Home Blood Pressure Measurements Between First and Second Measurements on One Occasion, and Factors Related to Variability

Kawabe Hiroshi, Kanda Takeshi, Hirose Hiroshi, Saito Ikuo

CLINICAL AND EXPERIMENTAL HYPERTENSION 34 （ 4 ） 237 - 242 2012年

ISSN  1064-1963

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Genetic variants at CDC123/CAMK1D and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese population

Imamura M., Iwata M., Maegawa H., Watada H., Hirose H., Tanaka Y., Tobe K., Kaku K., Kashiwagi A., Kawamori R., Nakamura Y., Maeda S.

DIABETOLOGIA 54 （ 12 ） 3071 - 3077 2011年12月

ISSN  0012-186X

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Prediction of metabolic syndrome using artificial neural network system based on clinical data including insulin resistance index and serum adiponectin

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COMPUTERS IN BIOLOGY AND MEDICINE 41 （ 11 ） 1051 - 1056 2011年11月

研究論文（学術雑誌）,  ISSN  0010-4825

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Association of New Loci Identified in European Genome-Wide Association Studies with Susceptibility to Type 2 Diabetes in the Japanese

広瀬 寛

PLOS ONE 6 （ 10 ）  2011年10月

研究論文（学術雑誌）,  ISSN  1932-6203

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Relationships between Composition of Major Free Fatty Acids (FFA) and Fat Distribution, and Insulin Resistance in Japanese

Kawai Toshihide, Oguma Yuko, Katsukawa Fuminori, Hirose Hiroshi, Tanaka Kumiko, Azuma Koichiro, Meguro Shu, Matsumoto Hideo, Itoh Hiroshi

DIABETES 60   A192 - A193 2011年07月

ISSN  0012-1797

Genome-Wide Association Study Identifies HLA-DP as a Susceptibility Gene for Pediatric Asthma in Asian Populations

広瀬 寛

PLOS GENETICS 7 （ 7 ） 735 - 743 2011年07月

研究論文（学術雑誌）,  ISSN  1553-7390

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A Functional Single Nucleotide Polymorphism in Mucin 1, at Chromosome 1q22, Determines Susceptibility to Diffuse-Type Gastric Cancer

Saeki Norihisa, Saito Akira, Choi Il Ju, Matsuo Keitaro, Ohnami Sumiko, Totsuka Hirohiko, Chiku Suenori, Kuchiba Aya, Lee Yeon-Su, Yoon Kyong-Ah, Kook Myeong-Cherl, Park Sook Ryun, Kim Young-Woo, Tanaka Hideo, Tajima Kazuo, Hirose Hiroshi, Tanioka Fumihiko, Matsuno Yoshihiro, Sugimura Haruhiko, Kato Shunji, Nakamura Tsuneya, Nishina Tomohiro, Yasui Wataru, Aoyagi Kazuhiko, Sasaki Hiroki, Yanagihara Kazuyoshi, Katai Hitoshi, Shimoda Tadakazu, Yoshida Teruhiko, Nakamura Yusuke, Hirohashi Setsuo, Sakamoto Hiromi

GASTROENTEROLOGY 140 （ 3 ） 892 - 902 2011年03月

ISSN  0016-5085

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Effects of Losartan/Hydrochlorothiazide Treatment, After Change from ARB at Usual Dosage, on Blood Pressure and Various Metabolic Parameters Including High-Molecular Weight Adiponectin in Japanese Male Hypertensive Subjects

広瀬 寛

CLINICAL AND EXPERIMENTAL HYPERTENSION 33 （ 1 ） 41 - 46 2011年

研究論文（学術雑誌）,  ISSN  1064-1963

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Relationship between Waist Circumferences Measured at the Umbilical Level and Midway between the Ribs and Iliac Crest - A Solution to the Debate on Optimal Waist Circumference Standards in the Diagnostic Criteria of Metabolic Syndrome in Japan

Yokoyama Hirokazu, Hirose Hiroshi, Kanda Takeshi, Kawabe Hiroshi, Saito Ikuo

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 18 （ 9 ） 735 - 743 2011年

ISSN  1340-3478

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A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

広瀬 寛

NATURE GENETICS 42 （ 10 ） 864 - + 2010年10月

研究論文（学術雑誌）,  ISSN  1061-4036

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Genome-Wide Association Study of Pancreatic Cancer in Japanese Population

Low Siew-Kee, Kuchiba Aya, Zembutsu Hitoshi, Saito Akira, Takahashi Atsushi, Kubo Michiaki, Daigo Yataro, Kamatani Naoyuki, Chiku Suenori, Totsuka Hirohiko, Ohnami Sumiko, Hirose Hiroshi, Shimada Kazuaki, Okusaka Takuji, Yoshida Teruhiko, Nakamura Yusuke, Sakamoto Hiromi

PLOS ONE 5 （ 7 ）  2010年07月

ISSN  1932-6203

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Replication Study for the Association of 23 Susceptibility Loci for Type 2 Diabetes in the Japanese

Ohshige Toshihiko, Omori Shintaro, Tanaka Yasushi, Kashiwagi Atsunori, Kaku Kohei, Hirose Hiroshi, Kawamori Ryuzo, Nakamura Yusuke, Maeda Shiro

DIABETES 59   A37 - A37 2010年06月

ISSN  0012-1797

Individuals susceptible to lung adenocarcinoma defined by combined HLA-DQA1 and TERT genotypes

Kohno Takashi, Kunitoh Hideo, Shimada Yoko, Shiraishi Kouya, Ishii Yuko, Goto Koichi, Ohe Yuichiro, Nishiwaki Yutaka, Kuchiba Aya, Yamamoto Seiichiro, Hirose Hiroshi, Oka Akira, Yanagitani Noriko, Saito Ryusei, Inoko Hidetoshi, Yokota Jun

CARCINOGENESIS 31 （ 5 ） 834 - 841 2010年05月

ISSN  0143-3334

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Effects of 6-month treatment with losartan/hydrochlorothiazide (HCTZ), when changed from ARBs of usual dosage, on various metabolic parameters including blood pressures and high molecular weight (HMW)-adiponectin levels in Japanese male hypertensive subjects

Hirose Hiroshi, Kawabe Hiroshi, Saito Ikuo

ENDOCRINE JOURNAL 57   S425 - S425 2010年03月

ISSN  0918-8959

Serum high-molecular-weight adiponectin as a marker for the evaluation and care of subjects with metabolic syndrome and related disorders

広瀬 寛

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 17 （ 12 ） 1201 - 1211 2010年

研究論文（学術雑誌）,  ISSN  1340-3478

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Elevated Serum Adiponectin Level in Patients with Mycobacterium avium-intracellulare Complex Pulmonary Disease

広瀬 寛

RESPIRATION 79 （ 5 ） 383 - 387 2010年

研究論文（学術雑誌）,  ISSN  0025-7931

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Use of Home Blood Pressure Monitoring and Exercise, Diet and Medication Compliance in Japan

Saito Ikuo, Nomura Motoko, Hirose Hiroshi, Kawabe Hiroshi

CLINICAL AND EXPERIMENTAL HYPERTENSION 32 （ 4 ） 210 - 213 2010年

ISSN  1064-1963

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Usefulness of C-Reactive Protein to High-Molecular-Weight Adiponectin Ratio to Predict Insulin Resistance and Metabolic Syndrome in Japanese Men

Saisho Yoshifumi, Hirose Hiroshi, Seino Yoshie, Saito Ikuo, Itoh Hiroshi

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 17 （ 9 ） 944 - 952 2010年

ISSN  1340-3478

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MCP-1 gene A-2518G polymorphism and carotid artery atherosclerosis in patients with type 2 diabetes

Yuasa Sachiko, Maruyama Taro, Yamamoto Yukihiro, Hirose Hiroshi, Kawai Toshihide, Matsunaga-Irie Seiko, Itoh Hiroshi

DIABETES RESEARCH AND CLINICAL PRACTICE 86 （ 3 ） 193 - 198 2009年12月

ISSN  0168-8227

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Serum bile acid along with plasma incretins and serum high-molecular weight adiponectin levels are increased after bariatric surgery

Nakatani Hiroshi, Kasama Kazunori, Oshiro Takashi, Watanabe Mitsuhiro, Hirose Hiroshi, Itoh Hiroshi

METABOLISM-CLINICAL AND EXPERIMENTAL 58 （ 10 ） 1400 - 1407 2009年10月

ISSN  0026-0495

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Possible association of tumor necrosis factor receptor 2 gene polymorphism with severe hypertension using the extreme discordant phenotype design

広瀬 寛

HYPERTENSION RESEARCH 32 （ 9 ） 775 - 779 2009年09月

研究論文（学術雑誌）,  ISSN  0916-9636

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Replication study for the association of new meta-analysis-derived risk loci with susceptibility to type 2 diabetes in 6,244 Japanese individuals

Omori S., Tanaka Y., Horikoshi M., Takahashi A., Hara K., Hirose H., Kashiwagi A., Kaku K., Kawamori R., Kadowaki T., Nakamura Y., Maeda S.

DIABETOLOGIA 52 （ 8 ） 1554 - 1560 2009年08月

ISSN  0012-186X

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HMW-Adiponectin Associates with Triglyceride Concentrations in Type 1 Diabetic Patients

Maruyama Chizuko, Ishibashi Rieko, Araki Risa, Koike Shino, Hirose Hiroshi, Maruyama Taro

J. Atheroscler. Thromb. 16 （ 3 ） 207-216 - 216 2009年06月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  1340-3478

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Two types of unsafe drinker judged to have metabolic syndrome: Typical metabolic syndrome or alcohol-related syndrome?

広瀬 寛

MEDICAL SCIENCE MONITOR 15 （ 6 ） PH57 - PH64 2009年06月

研究論文（学術雑誌）,  ISSN  1234-1010

CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men

広瀬 寛

BIOMARKERS 14 （ 4 ） 207 - 212 2009年06月

研究論文（学術雑誌）,  ISSN  1354-750X

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Association of a SNP in JAZF1 with Susceptibility to Type 2 Diabetes in a Japanese Population

Omori Shintaro, Tanaka Yasushi, Horikoshi Momoko, Hara Kazuo, Hirose Hiroshi, Kashiwagi Atsunori, Kaku Kohei, Kawamori Ryuzo, Kadowaki Takashi, Nakamura Yusuke, Maeda Shiro

DIABETES 58   A302 - A302 2009年06月

ISSN  0012-1797

Palmitate Rich Diet Suppresses Glucose-Stimulated Insulin Secretion (GSIS) Via Endoplasmic Reticulum (ER) Stress in Mice

Hirata Takumi, Kawai Toshihide, Hirose Hiroshi, Fujita Haruhisa, Seto Yoshiko, Itoh Hiroshi

DIABETES 58   A624 - A624 2009年06月

ISSN  0012-1797

FOXP3/Scurfin Gene Polymorphism Is Associated with Female Japanese Type 1 Diabetic Patients

Yamada Yoshifumi, Iwase Kyoko, Shimada Akira, Okubo Yoshiaki, Kanazawa Yasuhiko, Irie Junichiro, Oikawa Yoichi, Kawai Toshihide, Hirose Hiroshi, Maruyama Taro, Itoh Hiroshi

DIABETES 58   A590 - A590 2009年06月

ISSN  0012-1797

Effects of Telmisartan Therapy on Metabolic Profiles and Serum High Molecular Weight (HMW)-Adiponectin Level in Japanese Male Hypertensive Subjects with Abdominal Obesity

Komiya Naoko, Hirose Hiroshi, Kawabe Hiroshi, Itoh Hiroshi, Saito Ikuo

J. Atheroscler. Thromb. 16 （ 2 ） 137-142 - U6 2009年04月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  1340-3478

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Relations between Serum Reactive Oxygen Metabolites (ROMs) and Various Inflammatory and Metabolic Parameters in a Japanese Population

Hirose Hiroshi, Kawabe Hiroshi, Komiya Naoko, Saito Ikuo

J. Atheroscler. Thromb. 16 （ 2 ） 77-82 - 82 2009年04月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  1340-3478

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Characteristics of Reference Intervals of Metabolic Factors in Healthy Japanese: A Proposal to Set Generation- and Gender-Specific Diagnostic Criteria for Metabolic Syndrome

Yokoyama Hirokazu, Hirose Hiroshi, Kawabe Hiroshi, Saito Ikuo

J. Atheroscler. Thromb. 16 （ 2 ） 113-120 - 120 2009年04月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  1340-3478

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High-molecular-weight adiponectin is a predictor of progression to metabolic syndrome: a population-based 6-year follow-up study in Japanese men

Seino Yoshie, Hirose Hiroshi, Saito Ikuo, Itoh Hiroshi

METABOLISM-CLINICAL AND EXPERIMENTAL 58 （ 3 ） 355-360 - 360 2009年03月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  0026-0495

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FOXP3/Scurfin gene polymorphism is associated with adult onset type 1 diabetes in Japanese, especially in women and slowly progressive type patient

Iwase K, Shimada A, Kawai T, Ohkubo Y, Kanazawa Y, Irie J, Oikawa Y, Hirose H, Maruyama T, Itoh H

Autoimmunity 42 （ 2 ） 159-167 2009年02月

研究論文（学術雑誌）, 共著, 査読有り

Contribution of nicotine acetylcholine receptor polymorphisms to lung cancer risk in a smoking-independent manner in the Japanese

広瀬 寛

CARCINOGENESIS 30 （ 1 ） 65 - 70 2009年01月

研究論文（学術雑誌）,  ISSN  0143-3334

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FOXP3/Scurfin gene polymorphism is associated with adult onset type 1 diabetes in Japanese, especially in women and slowly progressive-type patients

広瀬 寛

AUTOIMMUNITY 42 （ 2 ） 159 - 167 2009年

研究論文（学術雑誌）,  ISSN  0891-6934

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Effect on the Atherogenic Marker Plasminogen Activator Inhibitor Type-1 of Addition of the ACE Inhibitor Imidapril to Angiotensin II Type 1 Receptor Antagonist Therapy in Hypertensive Patients with Abnormal Glucose Metabolism A Prospective Cohort Study in Primary Care

Yajima Ken, Shimada Akira, Hirose Hiroshi, Oikawa Yoichi, Yamada Satoru, Meguro Shu, Irie Junichiro, Irie Seiko

CLINICAL DRUG INVESTIGATION 29 （ 12 ） 811 - 819 2009年

ISSN  1173-2563

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Effects of 12-Month Valsartan Therapy on Glycation and Oxidative Stress Markers in Type 2 Diabetic Subjects With Hypertension

Komiya Naoko, Hirose Hiroshi, Saisho Yoshifumi, Saito Ikuo, Itoh Hiroshi

INTERNATIONAL HEART JOURNAL 49 （ 6 ） 681-689 - 689 2008年11月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  1349-2365

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SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

Unoki Hiroyuki, Takahashi Atsushi, Kawaguchi Takahisa, Hara Kazuo, Horikoshi Momoko, Andersen Gitte, Ng Daniel P. K., Holmkvist Johan, Borch-Johnsen Knut, Jorgensen Torben, Sandbaek Annelli, Lauritzen Torsten, Hansen Torben, Nurbaya Siti, Tsunoda Tatsuhiko, Kubo Michiaki, Babazono Tetsuya, Hirose Hiroshi, Hayashi Matsuhiko, Iwamoto Yasuhiko, Kashiwagi Atsunori, Kaku Kohei, Kawamori Ryuzo, Tai E. Shyong, Pedersen Oluf, Kamatani Naoyuki, Kadowaki Takashi, Kikkawa Ryuichi, Nakamura Yusuke, Maeda Shiro

NATURE GENETICS 40 （ 9 ） 1098-2102 - 1102 2008年09月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  1061-4036

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His595Tyr polymorphism in the methionine synthase reductase (MTRR) gene is associated with pancreatic cancer risk

Ohnami Shumpei, Sato Yasunori, Yoshimura Kimio, Ohnami Sumiko, Sakamoto Hiromi, Aoki Kazunori, Ueno Hideki, Ikeda Masafumi, Morizane Chigusa, Shimada Kazuaki, Sakamoto Yoshihiro, Esaki Minoru, Saito Ikuo, Hirose Hiroshi, Saito Daizo, Sugimura Haruhiko, Kosuge Tomoo, Okusaka Takuji, Yoshida Teruhiko

GASTROENTEROLOGY 135 （ 2 ） 477-488 - 488 2008年08月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  0016-5085

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Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer

Sakamoto Hiromi, Yoshimura Kimio, Saeki Norihisa, Katai Hitoshi, Shimoda Tadakazu, Matsuno Yoshihiro, Saito Daizo, Sugimura Haruhiko, Tanioka Fumihiko, Kato Shunji, Matsukura Norio, Matsuda Noriko, Nakamura Tsuneya, Hyodo Ichinosuke, Nishina Tomohiro, Yasui Wataru, Hirose Hiroshi, Hayashi Matsuhiko, Toshiro Emi, Ohnami Sumiko, Sekine Akihiro, Sato Yasunori, Totsuka Hirohiko, Ando Masataka, Takemura Ryo, Takahashi Yoriko, Ohdaira Minoru, Aoki Kenichi, Honmyo Izumi, Chiku Suenori, Aoyagi Kazuhiko, Sasaki Hiroki, Ohnami Shumpei, Yanagihara Kazuyoshi, Yoon Kyong-Ah, Kook Myeong-Cherl, Lee Yeon-Su, Park Sook Ryun, Kim Chan Gyoo, Choi Il Ju, Yoshida Teruhiko, Nakamura Yusuke, Hirohashi Setsuo

NATURE GENETICS 40 （ 6 ） 730-740 - 740 2008年06月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  1061-4036

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Polymorphisms within CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8 and KCNJ11 are associated with susceptibility to type 2 diabetes in a Japanese population

Omori Shintaro, Tanaka Yasushi, Hirose Hiroshi, Kashiwagi Atsunori, Kaku Kohei, Kawamori Ryuzo, Nakamura Yusuke, Maeda Shiro

DIABETES 57   A331 - A331 2008年06月

ISSN  0012-1797

Combination of C-reactive protein and high molecular weight (HMW)-adiponectin reflects further metabolic abnormalities compared with each of them alone in Japanese type 2 diabetic subjects

Saisho Y, Hirose H, Horimai C, Miyashita K, Takei I, Umezawa K, Itoh H

Endocrine Journal 55 （ 2 ） 433-438 2008年05月

研究論文（学術雑誌）, 共著, 査読有り

Effects of DHMEQ, a novel nuclear factor-κB inhibitor, on beta cell dysfunction in INS-1 cells

Saisho Y, Hirose H, Horimai C, Miyashita K, Takei I, Umezawa K, Itoh H

Endocrine Journal 55 （ 2 ） 433-438 2008年05月

研究論文（学術雑誌）, 共著, 査読有り

Combination of C-reactive protein and high molecular weight (HMW)-adiponectin reflects further metabolic abnormalities compared with each of them alone in Japanese type 2 diabetic subjects

広瀬 寛

ENDOCRINE JOURNAL 55 （ 2 ） 331 - 338 2008年04月

研究論文（学術雑誌）,  ISSN  0918-8959

Effects of DHMEQ, a novel nuclear factor-kappa B inhibitor, on beta cell dysfunction in INS-1 cells

Saisho Yoshifumi, Hirose Hiroshi, Horimai Chihiro, Miyashita Kiichi, Takei Izumi, Umezawa Kazuo, Itoh Hiroshi

ENDOCRINE JOURNAL 55 （ 2 ） 433 - 438 2008年04月

ISSN  0918-8959

Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population

広瀬 寛

DIABETES 57 （ 3 ） 791-795 - 795 2008年03月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  0012-1797

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Significance of leptin and high-molecular weight adiponectin in the general population of Japanese male adolescents

広瀬 寛

METABOLISM-CLINICAL AND EXPERIMENTAL 57 （ 2 ） 157 - 162 2008年02月

研究論文（学術雑誌）,  ISSN  0026-0495

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Association of a missense single nucleotide polymorphism, Cys1367Arg of the WRN gene, with the risk of bone and soft tissue sarcomas in Japan

広瀬 寛

CANCER SCIENCE 99 （ 2 ） 333 - 339 2008年02月

研究論文（学術雑誌）,  ISSN  1347-9032

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Lifestyle factors, and the radial artery augmentation index in post-menopausal women

広瀬 寛

ANNALS OF NUTRITION AND METABOLISM 53 （ 1 ） 61 - 61 2008年

研究論文（学術雑誌）,  ISSN  0250-6807

Relationship between proinsulin-to-insulin ratio and advanced glycation endproducts in Japanese type 2 diabetic subjects

広瀬 寛

DIABETES RESEARCH AND CLINICAL PRACTICE 78 （ 2 ） 182 - 188 2007年11月

研究論文（学術雑誌）,  ISSN  0168-8227

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High molecular weight multimer form of adiponectin as a useful marker to evaluate insulin resistance and metabolic syndrome in Japanese men

広瀬 寛

METABOLISM-CLINICAL AND EXPERIMENTAL 56 （ 11 ） 1493-1499 - 1499 2007年11月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  0026-0495

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Common variants of the TCF7L2 are associated with susceptibility to type 2 diabetes, but not with the expression of TCF7L2 in the adipose or plasma GLP-1 concentrations in a Japanese population

Hayashi Toshihide, Maegawa Hiroshi, Baba-Zono Tetsuya, Yamamoto Hiroshi, Hirose Hiroshi, Naito Hiroyuki, Tani Toru, Kawamori Ryuzo, Kaku Kohei, Kashiwagi Atsunori, Iwamoto Yasuhiko, Maeda Shiro

DIABETES 56   A295 - A296 2007年06月

ISSN  0012-1797

Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population

広瀬 寛

DIABETOLOGIA 50 （ 5 ） 980-984 - 984 2007年05月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  0012-186X

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Blood pressure-independent effects of valsartan on oxidative and glycation markers in type 2 diabetic subjects

広瀬 寛

JOURNAL OF HYPERTENSION 24   391 - 391 2006年12月

研究論文（学術雑誌）,  ISSN  0263-6352

Association of polymorphisms in the MTH1 gene with small cell lung carcinoma risk

Kohno Takashi, Sakiyama Tokuki, Kunitoh Hideo, Goto Koichi, Nishiwaki Yutaka, Saito Daizo, Hirose Hiroshi, Eguchi Takashi, Yanagitani Noriko, Saito Ryusei, Sasaki-Matsumura Rumie, Mimaki Sachiyo, Toyama Kaoru, Yamamoto Seiichiro, Kuchiba Aya, Sobue Tomotaka, Ohta Tsutomu, Ohki Misao, Yokota Jun

CARCINOGENESIS 27 （ 12 ） 2448 - 2454 2006年12月

ISSN  0143-3334

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No association of TNFRSF1B microsatellite polymorphism with blood pressure in Japanese health checkup examinees.

Eguchi Takashi, Maruyama Tatsuya, Ohno Yoichi, Hirao Keiichi, Morii Toshiyuki, Hirose Hiroshi, Hayashi Matsuhiko, Kawabe Hiroshi, Saito Ikuo, Saruta Takao

JOURNAL OF HYPERTENSION 24   242 - 243 2006年12月

ISSN  0263-6352

Implication of antibodies to oxidized low-density lipoprotein(ox-LDL) and polymorphisms in hypertension with diabetes

Hirao Keiichi, Maruyama Tatsuya, Ohno Yoichi, Hirose Hiroshi, Shimada Akira, Takei Izumi, Murata Mitsuru, Morii Toshiyuki, Eguchi Takashi, Hayashi Matsuhiko, Saruta Takao

JOURNAL OF HYPERTENSION 24   225 - 225 2006年12月

ISSN  0263-6352

Gap between patients' and physicians' attitudes and awareness toward hypertension and its complication, cardiovascular diseases

Saito Ikuo, Hirose Hiroshi

JOURNAL OF HYPERTENSION 24   219 - 219 2006年12月

ISSN  0263-6352

Cellular insulin resistance in Epstein-Barr virus-transformed lymphoblasts from young insulin-resistant Japanese men

Morii T, HIROSE HIROSHI, et al.

Metabolism 54 （ 3 ） 370-375 2005年03月

研究論文（学術雑誌）, 単著, 査読有り

GPR40 gene Arg211His polymorphism may contribute to the variation of insulin secretory capacity in Japanese men

Ogawa T, HIROSE HIROSHI, et al.

Metabolism 54 （ 3 ） 296-299 2005年03月

研究論文（学術雑誌）, 単著, 査読有り

FABP2遺伝子多型

石井達哉、広瀬 寛

日本臨床 63 （ 増刊2 ） 185-188 2005年02月

研究論文（学術雑誌）, 共著, 査読有り

Associations between serum leptin levels and transaminase acitivities and the status of lifestyle in Japanese workers

横山裕一、広瀬 寛、他

Alcohol. Clin. Exp. Res. 28 （ 8 ） 159S-162S 2004年08月

研究論文（学術雑誌）, 共著, 査読有り

"Low dose" metformin improves hyperglycemia better than acarbose in type 2 diabetes

矢島　賢、広瀬 寛、他

Rev. Diab. Stud. 1 （ 2 ） 89-94 2004年08月

研究論文（学術雑誌）, 共著, 査読有り

Inverse association between serum adiponectin level and transaminase activities in Japanese male workers

横山裕一、広瀬 寛、他

J. Hepatol. 41 （ 1 ） 19-24 2004年07月

研究論文（学術雑誌）, 共著, 査読有り

Relationships between serum soluble leptin receptor level and serum leptin and adiponectin levels, insulin resistance index, lipid profile and LEPR gene polymorphisms in Japanese population

小川健夫、広瀬 寛、他

Metabolism 53 （ 7 ） 879-885 2004年07月

研究論文（学術雑誌）, 共著, 査読有り

Associations among lifestyle status, serum adiponectin level and insulin resistance

Yokoyama H, HIROSE HIROSHI

Intern. Med. 43 （ 6 ） 453-457 2004年06月

研究論文（学術雑誌）, 共著, 査読有り

座談会: 糖尿病治療におけるピオグリタゾンの位置付けを考える

小田原雅人、林 晃一、広瀬 寛、細川和弘

Diabetes Frontier 15 （ 3 ） 391-397 2004年06月

研究論文（学術雑誌）, 共著

Effects of leptin receptor gene 3'-untranslated region polymorphism on metabolic profiles in young Japanese men

Nishikai K, Hirose H, Ishii T, Hayashi M, Saito I, Saruta T

J. Atheroscler. Thromb. 11 （ 2 ） 74-79 2004年04月

研究論文（学術雑誌）, 共著, 査読有り

Relation between development of nephropathy and p22phox C242T and receptor for advanced glycation end product G1704T gene polymorphisms in type 2 diabetic patients

Matsunaga-Irie S, Maruyama T, Yamamoto Y, Motohashi Y, Hirose H, Shimada A, Murata M, Saruta T

Diabetes Care 27 （ 2 ） 303-307 2004年02月

研究論文（学術雑誌）, 共著, 査読有り

Adiponectin, an adipocyte-derived protein, predicts future insulin resistance: two-year follow-up study in Japanese population

Yamamoto Y, Hirose H, Saito I, Nishikai K, Saruta T

J. Clin. Endocr. Metab. 89 （ 1 ） 87-90 2004年01月

研究論文（学術雑誌）, 共著, 査読有り

Relation between blood pressure and rhinitis in a Japanese adolescent population

Saito I, Mori M, Shibata H, Hirose H, Tsujioka M, Kawabe H

Hypertens. Res. 26 （ 12 ） 961-963 2003年12月

研究論文（学術雑誌）, 共著, 査読有り

Stromal cell-derived factor-1 chemokine gene polymorphism is not associated with onset age of Japanese type 1 diabetes

Shigihara T, Shimada A, Yamada S, Maruyama T, Hirose H, Saruta T

Ann. N.Y. Acad. Sci. 1005   328-331 2003年11月

研究論文（学術雑誌）, 共著, 査読有り

Insulin resistance index, HOMA-IR, and hypertension: seven-year follow-up study in middle-aged Japanese men (the KEIO study)

Hirose H, Saito I, Kawabe H, Saruta T

Hypertens. Res. 26 （ 10 ） 795-800 2003年10月

研究論文（学術雑誌）, 共著, 査読有り

Trends in blood pressure control in hypertensive patients with diabetes mellitus in Japan

Hirose H, Saito I

Hypertens. Res. 26 （ 9 ） 717-722 2003年09月

研究論文（学術雑誌）, 共著, 査読有り

Relation between blood pressure control, body mass index, and intensity of medical treatment

Saito I, Murata K, Hirose H, Tsujioka M, Kawabe H

Hypertens. Res. 26 （ 9 ） 711-715 2003年09月

研究論文（学術雑誌）, 共著, 査読有り

Vitamin D receptor gene polymorphism affects onset pattern of type 1 diabetes

Motohashi Y, Yamada S, Yanagawa T, Maruyama T, Suzuki R, Niino M, Fukazawa T, Kasuga A, Hirose H, Matsubara K, Shimada A, Saruta T

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 88 （ 7 ） 3137-3140 - 3140 2003年07月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  0021-972X

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血清アディポネクチン濃度測定の臨床的意義

広瀬 寛、山本幸宏、宮下紀一、齊藤郁夫

内分泌・糖尿病科 16 （ 6 ） 541-547 2003年06月

研究論文（学術雑誌）, 共著

Combination therapy with PPARγ and PPARα agonists increases glucose-stimulated insulin secretion in db/db mice

Yajima K, Hirose H, Fujita H, Seto Y, Fujita H, Ukeda K, Miyashita K, Kawai T, Yamamoto Y, Ogawa T, Yamada T, Saruta T

Am. J. Physiol. - Endoc. M. 284 （ 5 ） 966-971 2003年05月

研究論文（学術雑誌）, 共著, 査読有り

Correlation of adipocyte-derived protein, adiponectin with insulin resistance index and serum HDL-Cholesterol, independent of body mass index in the Japanese population

Yamamoto Y, Hirose H, Saito I, Saruta T

DIABETES 51   A307 - A307 2002年06月

ISSN  0012-1797

Effects of pioglitazone on metabolic parameters, body fat distribution and serum GBP28/adiponectin level in Japanese male patients with type 2 diabetes

Hirose H, Kawai T, Yamamoto Y, Taniyama M, Tomita M, Matsubara K, Okazaki Y, Ishii T, Oguma Y, Takei I, Saruta T

Metabolism 51 （ 3 ） 314-317 2002年03月

研究論文（学術雑誌）, 共著, 査読有り

Effects of intestinal fatty acid-binding protein gene Ala54Thr polymorphism and s3-adrenergic receptor gene Trp64Arg polymorphism on insulin resistance and fasting plasma glucose levels in young to older Japanese men

Ishii T, Hirose H, Kawai T, Hayashi K, Maruyama H, Saito I, Saruta T

Metabolism 50 （ 11 ） 1301-1307 2001年11月

研究論文（学術雑誌）, 共著

インスリン抵抗性とサイトカイン

広瀬 寛、矢島 賢、山本幸宏、河合俊英、石井達哉、藤田晴久、瀬戸淑子、宮下紀一、西海奏子、林啓介、河邊博史、齊藤郁夫、猿田享男

Diabetes Frontier 12 （ 5 ）  2001年10月

研究論文（学術雑誌）, 共著

NeuroD/BETA2 gene G→A polymorphism may affect onset pattern of type 1 diabetes in Japanese

Yamada S、Motohashi Y、Yanagawa T、Maruyama T、Kasuga A、Hirose H、Matsubara K、Shimada A、Saruta T

Diabetes Care 24 （ 8 ） 1438-1441 2001年07月

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糖尿病における脂質代謝異常と細胞障害性

細胞 33 （ 8 ） 302-305 2001年07月

単著

肥満・インスリン抵抗性と高血圧

広瀬 寛、齊藤郁夫

慶應保健研究 19 （ 1 ） 9-13 2001年06月

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肥満、高中性脂肪血症とインスリン抵抗性の関係

齊藤郁夫、広瀬寛、和井内英樹、竹下栄子

慶應保健研究 19 （ 1 ） 15-17 2001年06月

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血中γGTP活性とインスリン抵抗性および血中インスリン値

横山裕一、広瀬 寛、柴田洋孝、森 正明、和井内由充子、辻岡三南子、吉田正、河邊博史、齊藤郁夫

慶應保健研究 19 （ 1 ） 33-36 2001年06月

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生活習慣病に関連する因子群の遺伝子多型に関する検討

森木隆典、柴田洋孝、広瀬 寛、横山裕一、村田満、渡辺清明、齊藤郁夫

慶應保健研究 19 （ 1 ） 37-45 2001年06月

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SUBIを用いた理工学部大学教員の心理的健康感の評価

藤井香、広瀬 寛、大野裕、齊藤郁夫、勝川史憲

慶應保健研究 19 （ 1 ） 55-59 2001年06月

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Cholesteryl eser transfer protein polymorphism associated with macroangiopathy in Japanese patients with type 2 diabetes

Meguro S、Takei I、Murata M、Hirose H、Takei N、Mitsuyoshi Y、Ishii K、Oguchi S、Shinohara J、Takeshita E、Watanabe K、Saruta T

Atherosclerosis 156 （ 1 ） 151-156 2001年04月

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Relationships between baseline serum leptin levels and two-year changes in body mass index, blood pressure, and metabolic parameters in Japanese male adolescents and middle-aged men

Clinical Science 100 （ 2 ） 145-150 2001年02月

研究論文（学術雑誌）, 共著, 査読有り

インスリン抵抗性を有する高血圧の治療

広瀬寛,齊藤郁夫,猿田享男

ホルモンと臨床 49 （ 3 ）  2000年12月

研究論文（学術雑誌）, 共著

Effects of body weight control on changes in blood pressure: three-year follow-up study in young Japanese individuals

Hypertension Research 23 （ 5 ） 421-426 2000年09月

研究論文（学術雑誌）, 共著, 査読有り

減量―長続きさせるには―

広瀬寛,齊藤郁夫

今日の高血圧治療 4(2) 2000年07月

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若年・中高年男性の血圧・体重と血清レプチン濃度の関係ー2年間の追跡調査ー

広瀬寛,河邊博史,辻岡三南子,齊藤郁夫,他

慶應保健研究 18（1） 2000年06月

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肥満に伴う高血圧の発症機序

広瀬寛,齊藤郁夫

Mebio 17 (4月別冊) 2000年04月

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高血圧を合併する２型糖尿病

広瀬寛,齊藤郁夫

治療薬 4 （ 4 ）  1999年10月

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若年軽度肥満者の血圧におよぼす体重コントロールの影響－３年間の追跡調査－

広瀬寛,辻岡三南子,河邊博史,齊藤郁夫

慶應保健研究 17 （ 1 ）  1999年06月

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Molecular cloning of a novel interferon regulatory factor in Japanese flounder, Paralichthys olivaceus

Yabu, T; Hirose, H; Hirono, I; Katagiri, T; Aoki, T

MOLECULAR MARINE BIOLOGY AND BIOTECHNOLOGY 7 （ 2 ） 138 - 144 1998年06月

ISSN  1053-6426

Eradication of Helicobacter pylori in patients with end-stage renal disease under dialysis treatment

Tamura, H; Tokushima, H; Murakawa, M; Matsumura, O; Itoyama, S; Sekine, S; Hirose, H; Mitarai, T; Isoda, K

AMERICAN JOURNAL OF KIDNEY DISEASES 29 （ 1 ） 86 - 90 1997年01月

ISSN  0272-6386

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S-Cone pathway sensitivity in diabetes measured with threshold versus intensity curves on flashed backgrounds

Terasaki, H; Hirose, H; Miyake, Y

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 37 （ 4 ） 680 - 684 1996年03月

ISSN  0146-0404

Hyperacuity test to evaluate vision through dense cataracts; Research preliminary to a clinical study .4. Data on patients with macular degeneration and minimal media disorders obtained with and without a pseudo-nuclear cataract 6/60 (20/200) at the Aravind Eye Hospital, Madurai, India

Singh, S; Aravind, S; Hirose, H; Enoch, JM; Azens, SP

OPTOMETRY AND VISION SCIENCE 73 （ 2 ） 125 - 126 1996年02月

ISSN  1040-5488

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Hyperacuity test to evaluate vision through dense cataracts; Research preliminary to a clinical study .3. Data on normal subjects obtained with and without a pseudo-nuclear cataract 6/60 (20/200) at the Aravind Eye Hospital, Madurai, India

Singh, S; Aravind, S; Hirose, H; Enoch, JM

OPTOMETRY AND VISION SCIENCE 73 （ 1 ） 62 - 64 1996年01月

ISSN  1040-5488

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ANISEIKONIA, METAMORPHOPSIA AND PERCEIVED ENTOPTIC PATTERN - SOME EFFECTS OF A MACULAR EPIRETINAL MEMBRANE, AND THE SUBSEQUENT SPONTANEOUS SEPARATION OF THE MEMBRANE

ENOCH, JM; SCHWARTZ, A; CHANG, D; HIROSE, H

OPHTHALMIC AND PHYSIOLOGICAL OPTICS 15 （ 4 ） 339 - 343 1995年07月

ISSN  0275-5408

QUANTIFICATION OF PRISM INDUCED METAMORPHOPSIA AS A MODEL FOR CLINICAL RETINAL (AND OTHER) DISTORTIONS

HIROSE, H; ENOCH, JM

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 36 （ 4 ） S938 - S938 1995年03月

ISSN  0146-0404

VISION ASSESSMENT BEHIND DENSE CATARACTS IN DEVELOPING NATIONS

ENOCH, JM; GIRALDEZ, M; HUANG, D; HIROSE, H; KNOWLES, R; NAMPERUMALSAMY, P; LABREE, L; AZEN, SP

PERIMETRY UPDATE 1994/1995    319 - 327 1995年

SHORT-WAVELENGTH-SENSITIVE MECHANISM IN DIABETIC-PATIENTS BY MEASURES OF THE THRESHOLD VERSUS INTENSITY CURVES ON FLASHED BACKGROUNDS

TERASAKI, H; HIROSE, H

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 35 （ 4 ） 1594 - 1594 1994年03月

ISSN  0146-0404

IDENTIFYING THE CILIARY SULCUS FOR SUTURING A POSTERIOR CHAMBER INTRAOCULAR-LENS BY TRANSILLUMINATION

HORIGUCHI, M; HIROSE, H; KOURA, T; SATOU, M

ARCHIVES OF OPHTHALMOLOGY 111 （ 12 ） 1693 - 1695 1993年12月

ISSN  0003-9950

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INSULIN AND GLUCAGON-SECRETION FROM ISOLATED-PERFUSED PANCREASES OF ZUCKER FATTY RATS

HIROSE H, MARUYAMA H, KIDO K, ITO K, KOYAMA K, KATAOKA K, SARUTA T

DIABETOLOGIA 36   A87 - A87 1993年08月

ISSN  0012-186X

ALPHA-2 ADRENERGIC AGONISM STIMULATES ISLET GLUCAGON-RELEASE FROM PERFUSED RAT PANCREAS - POSSIBLE INVOLVEMENT OF ALPHA-2A ADRENERGIC-RECEPTOR SUBTYPE

HIROSE H, MARUYAMA H, ITOH K, KOYAMA K, KIDO K, SARUTA T

ACTA ENDOCRINOLOGICA 127 （ 3 ） 279 - 283 1992年09月

ISSN  0001-5598

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EFFECTS OF ALPHA-2 AND BETA-ADRENERGIC AGONISM ON PANCREATIC A-CELLS IN RATS

HIROSE H, ITOH K, KIDO K, KOYAMA K, MARUYAMA H, SARUTA T

DIABETOLOGIA 35   A123 - A123 1992年08月

ISSN  0012-186X

ARACHIDONIC-ACID METABOLITES AND ALPHA-2-ADRENOCEPTOR-MEDIATED GLUCAGON-SECRETION IN RATS

KOYAMA K, HIROSE H, MARUYAMA H, ITOH K, KIDO K, SARUTA T

DIABETES RESEARCH AND CLINICAL PRACTICE 16 （ 3 ） 229 - 232 1992年06月

ISSN  0168-8227

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EXAMINATION OF LUNG-CANCER USING A HUMAN MONOCLONAL-ANTIBODY HB4C5-CLONE-3

SATO, S; HIROSE, H; TAI, H; OKANO, H; YASUMOTO, K; MURAKAMI, H; NOMOTO, K; MATSUYAMA, M; TAMAKI, S; HASHIZUME, S

ANIMAL CELL TECHNOLOGY : BASIC & APPLIED ASPECTS, VOL 4    541 - 545 1992年

EXTRACTION OF A VANADIUM-BINDING SUBSTANCE (VANADOBIN) FROM THE BLOOD-CELLS OF SEVERAL ASCIDIAN SPECIES

MICHIBATA, H; HIROSE, H; SUGIYAMA, K; OOKUBO, Y; KANAMORI, K

BIOLOGICAL BULLETIN 179 （ 1 ） 140 - 147 1990年08月

ISSN  0006-3185

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SUPPRESSOR LYMPHOCYTE-T DYSFUNCTION IN MCNS - ROLE OF THE H-2 HISTAMINE RECEPTOR-BEARING SUPPRESSOR LYMPHOCYTES-T

INAGE, Z; WADA, N; KIKKAWA, Y; INAMI, M; HIROSE, H; KITAGAWA, T

CLINICAL NEPHROLOGY 33 （ 1 ） 20 - 24 1990年01月

ISSN  0301-0430

STUDIES ON SWS CONE MECHANISM BY MEASURES OF THE PROBE-FLASH THRESHOLD

TERASAKI, H; HIROSE, H; OKADA, Y

COLOR VISION DEFICIENCIES    121 - 126 1990年

ANALYSIS OF EDB RESIDUE IN THE IMPORTED FRUITS

NAKAMURA, Y; HASEGAWA, Y; TONOGAI, Y; HANAFUSA, M; HIROSE, H; TAHARASAKO, Y; ITO, Y

JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI 36 （ 2 ） 142 - 147 1989年

ISSN  1341-027X

DETERMINATION OF ETHYLENE DIBROMIDE IN TROPICAL FRESH FRUITS USING DEAN-STARK APPARATUS AND ECD-GAS CHROMATOGRAPHY

NAKAMURA, Y; HASEGAWA, Y; TONOGAI, Y; HANAFUSA, M; HIROSE, H; TAHARASAKO, Y; ITO, Y

JOURNAL OF FOOD PROTECTION 51 （ 9 ） 727 - 730 1988年09月

ISSN  0362-028X

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EFFECTS OF INDOMETHACIN AND COLD-STRESS ON GASTRIC-ACID SECRETION AND ULCERATION - THE EFFECTS OF ANTI-ACID SECRETORY AGENTS IN RATS

ARAI, I; HIROSE, H; USUKI, C; MURAMATSU, M; AIHARA, H

RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY 57 （ 3 ） 313 - 327 1987年09月

ISSN  0034-5164

EFFECTS OF RESTRAINT AND WATER-IMMERSION STRESS AND INSULIN ON GASTRIC-ACID SECRETION IN RATS

ARAI, I; HIROSE, H; MURAMATSU, M; AIHARA, H

PHYSIOLOGY & BEHAVIOR 40 （ 3 ） 357 - 361 1987年

ISSN  0031-9384

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EFFECT OF SOFALCONE ON ACUTE GASTRIC-MUCOSAL LESIONS INDUCED BY ASPIRIN AND ETHANOL IN REFERENCE TO THE BIOSYNTHESIS OF GASTRIC-MUCOSAL GLYCOPROTEIN

MURAMATSU, M; MURAKAMI, S; ARAI, I; ISOBE, Y; HIROSE, H; USUKI, C; AIHARA, H

RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY 54 （ 3 ） 321 - 337 1986年12月

ISSN  0034-5164

INFERIOR VENA-CAVA THROMBUS AFTER RETROPERITONEAL LYMPHADENECTOMY FOR TESTICULAR-TUMOR

MAEDA, O; YOKOKAWA, K; OKA, T; NAMIKI, M; FUJIOKA, H; MATSUDA, M; NISHIYAMA, M; SHIRAKURA, R; HIROSE, H; SONODA, T

UROLOGIA INTERNATIONALIS 41 （ 4 ） 318 - 320 1986年

ISSN  0042-1138

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