KEIO RESEARCHERS INFORMATION SYSTEM

Career 【 Display / hide 】

Career 【 Display / hide 】

• 2017.04

  -

  2019.03

  Medical Hospital, Tokyo Medical and Dental University, Department of Pharmacy, pharmacist

• 2019.04

  -

  2023.03

  慶應義塾大学薬学部, 化学療法学講座, 助教

• 2023.04

  -

  2026.03

  慶應義塾大学薬学部, Social Pharmacy, 助教

• 2023.04

  -

  Present

  慶應義塾大学薬学部附属薬局, 非常勤薬剤師

• 2026.04

  -

  Present

  慶應義塾大学薬学部, 医療薬学・社会連携センター 社会薬学部門, 専任講師

Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 2013.04

  -

  2017.03

  Keio University

  Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• Doctor（Pharmacy）, Keio University, Coursework, 2017.03

Licenses and Qualifications 【 Display / hide 】

Licenses and Qualifications 【 Display / hide 】

• Pharmacist license, 2013.07

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Low rate of pharmacists accessing renal function laboratory values: A cross-sectional study using electronic medical records of a Japanese community pharmacy.

  Kondo S., Ito N., Maese M., Okamoto Y., Iwata H., Kobayashi N., Yamaura K.

  Drug discoveries & therapeutics (International Research and Cooperation Association for Bio & Socio-Sciences Advancement)  advpub ( 0 )  2026.06

  ISSN  1881-7831

  　View Summary

  <p>This study aimed to assess the availability of renal function laboratory values in Japanese community pharmacies and examine their association with the prescription of drugs requiring dosage adjustment. In this cross-sectional observational study, data were obtained from the electronic medical records of a community pharmacy in Japan. A total of 389 eligible patients (aged ≥ 18 years) who visited the pharmacy in April 2024 were included. The primary outcome measures were the proportion of participants with available renal function laboratory values and those prescribed medications requiring dosage adjustment. A total of 128 patients (32.9%) were prescribed at least one medication requiring dosage adjustment, most commonly vitamin A and D preparations (32 cases) and antidiabetic agents (31 cases). Renal function laboratory values were available for 40 patients (10.3%). Compared to those not prescribed such drugs, patients receiving medications requiring renal-based dosage adjustments included a significantly higher proportion of older adults (70/128, 54.7% <i>vs</i> 98/261, 37.5%, <i>p</i> = 0.001) and patients with available laboratory values (20/128, 15.6% <i>vs</i> 20/261, 7.7%, <i>p</i> = 0.015). No patients were identified with the "Triple Whammy," which is known to significantly increase the risk of renal function deterioration. Community pharmacists endeavor to obtain renal function laboratory values for older adults, who are more likely to be prescribed medications requiring dosage adjustment. However, the proportion of cases with obtained laboratory values remains low. Pharmacists are expected to actively recommend renal function testing to physicians. Furthermore, they should contribute to safe pharmacotherapy by utilizing comprehensive patient information.</p>

  • Access to Document (DOI)
  • CiNii Research

• Association of Loneliness and Health Literacy with Overuse of Over-the-counter Drugs in Patients with COVID-19 in Japan.

  Fujimoto T., Iwata H., Kobayashi N., Kondo S., Yamaura K.

  The Keio journal of medicine  2026.06

  ISSN  0022-9717

  • Access to Document (DOI)

• Diagnostic Labeling Patterns of Malnutrition and Undernutrition in Japan: A Nationwide Patient Estimation Database Study.

  Maese M., Kondo S., Saito T., Okamoto Y., Iwata H., Kobayashi N., Yamaura K.

  Nutrients 18 ( 9 )  2026.04

  　View Summary

  Background/Objectives: Malnutrition and undernutrition are critical health concerns associated with increased mortality and costs. Although these are distinct clinical concepts, they are often used interchangeably in clinical practice and are inconsistent with the diagnostic frameworks. This diagnostic ambiguity may obscure true patient profiles. This study aimed to clarify the real-world diagnostic patterns of malnutrition and undernutrition and identify associated drug prescription trends using a patient estimation database in Japan. Methods: We analyzed the AHI partners database of 2024. Patients were identified using the International Statistical Classification of Diseases and Related Health Problems, 10th Revision, code E46. Sex differences were analyzed and stratified according to age group: older adults (≥65 years) and younger adults (15–39 years). Odds ratios (ORs) were used to identify associated drugs. Results: Of 96,673,453 patients, 216,652 were diagnosed with malnutrition and 77,100 with undernutrition. In both categories, older adults accounted for more than half of the patients. Notably, distinct diagnostic labeling patterns were observed by sex. Malnutrition predominated in women (58.8%), whereas undernutrition was more prevalent in men (70.6%). This male predominance of undernutrition was reversed in younger adults, where women showed higher proportions in both categories. Prescription analysis identified 31 drugs frequently prescribed to the study population. Enteral elemental formulas had the highest OR (89.7). Some psychotropic drugs were frequently prescribed to women. Conclusions: Diagnostic patterns varied by sex and age, potentially reflecting distinct practices in diagnostic labeling. These findings highlight the need for standardized frameworks to ensure consistent assessments and effective nutritional interventions.

  • Access to Document (DOI)

• Analysis of drug-induced adverse reactions affecting appetite and taste using the Japanese Adverse Drug Event Report Database

  Maese M, Kondo S, Sakatsume Y, Takagi M, Yokoyama Y, Iwata H, Kobayashi N, Yamaura K

  BMC Research Notes 19 ( 1 )  2026

  Research paper (scientific journal), Accepted

  　View Summary

  Objective: Pharmacotherapy is a potential risk factor for undernutrition; however, the association between individual drugs and nutrition-related adverse reactions remains unknown. We aimed to explore drugs affecting appetite and taste using the Japanese Adverse Drug Event Report (JADER) database. Methods: JADER reports (April 2004–January 2025) were analyzed for drug safety signals across seven Preferred Terms (PTs): “Appetite disorder,” “Decreased appetite,” “Abnormal loss of weight,” “Ageusia,” “Dysgeusia,” “Hypogeusia,” and “Taste disorder.” Signal detected drugs were classified by therapeutic category, and their package insert information was reviewed. Results: Among 20,638 nutrition-related adverse reaction reports, signals were detected for 54, 14, 24, and 13 drugs for “Decreased appetite,” “Ageusia,” “Dysgeusia,” and “Taste disorder”, respectively. No signals were detected for the other three PTs. Regarding therapeutic category, other hormone preparations were common for “Decreased appetite,” while anti-viral agents were common for “Dysgeusia” and “Taste disorder.” Of these, five and 15 drugs lacked descriptions in the package inserts regarding decreased appetite and taste-related adverse reactions, respectively. Conclusions: This study clarified drugs that may affect appetite and taste, providing a focused list for early detection. These findings may enhance pharmacovigilance practices and inform clinical approaches for managing drug-induced nutritional concerns.

  • Access to Document (DOI)

• A blended learning program sustains pharmacists' oral health support competency for 15 months: A longitudinal study

  Hayashi N, Goto T, Shiga Y, Okazaki M, Sano A, Maida N, Iwata H, Matsui H, Kondo S, Kobayashi N, Yamaura K

  Drug discoveries & therapeutics (International Research and Cooperation Association for Bio & Socio-Sciences Advancement)  advpub ( 0 ) 56 - 62 2026

  Research paper (scientific journal), Accepted,  ISSN  1881-7831

  　View Summary

  <p>The importance of oral health has gained increasing recognition in the recent years owing to its association with numerous systemic diseases such as diabetes and cardiovascular disease. Dental checkups are crucial for maintaining and promoting oral health; however, in Japan, a relatively low uptake of dental checkups remains a challenge. Community pharmacists are expected to play a vital role in supporting the health and well-being of local residents; however, they have been observed to be reluctant to provide support in the oral health domain. This study aimed to develop and evaluate a blended learning training program on oral health support aimed at educating pharmacists working in health support pharmacies. The training, which involved online learning and on-site training, covered topics such as the importance of oral health, methods of oral health assessment, and the mechanisms of eating and swallowing. The participants, including a total of 39 pharmacists from across the country, completed surveys before and after the training, as well as at 9 months and 15 months posttraining. The results demonstrated a significant improvement in the pharmacists' knowledge, explanatory abilities, and confidence in providing oral health support, and these effects were observed to persist for up to 15 months after the training had ended. In addition, the variety of oral health-related products in pharmacies increased. This blended learning program demonstrates the potential to redefine the role of pharmacists in promoting oral health and contribute to the improvement of oral health among local residents.</p>

  • Access to Document (DOI)
  • CiNii Research

display all >>

Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• Analysis of real-world data on drugs related to renal impairment and the development of a renal function testing system in community pharmacies

  Kondo, Shingo

  福澤諭吉記念慶應義塾学事振興基金事業報告集 (福澤基金運営委員会)  2024

• Overcoming drug resistance and cell cycle alteration to cancer molecular target drugs

  Kondo, Shingo

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2021

• Clarification of the mechanism of resistance to cancer molecular target drugs

  Kondo, Shingo

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2020

• ABCB5/Abcb5発現細胞の薬剤耐性機構に関する研究(審査報告)

  Kondo, Shingo

  (慶應義塾大学大学院薬学研究科)  2016

Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• ヒスチジン異化はメトトレキサート感受性の主要な決定因子である

  近藤 慎吾

  ファルマシア (公益社団法人日本薬学会)  55 ( 7 ) 702 2019.07

  Book review, literature introduction, etc., Single Work

Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• 新型コロナウイルス感染症第7波自宅療養者における一般用医薬品の適正使用の実態と課題

  藤本卓磨, 岩田紘樹, 小林典子, 近藤慎吾, 中村友紀, 山浦克典

  [Domestic presentation] 

  2023.11

  , 

  Oral presentation (general)

• 頭痛およびヘルスリテラシーの評価スコアを用いた頭痛患者の特性分析

  近藤 慎吾, 藤本 卓磨, 岩田 紘樹, 小林 典子, 中村 友紀, 山浦 克典

  [Domestic presentation] 

  2023.09

  , 

  Oral presentation (general)

• ヒト結腸がん細胞株の上皮間葉転換に伴うグルタミナーゼ阻害剤高感受性とATF4の発現低下

  加藤 優, 近藤 慎吾, 杉本 芳一

  [Domestic presentation]  第27回日本がん分子標的治療学会学術集会 (佐賀市文化会館) , 

  2023.06

  , 

  Oral presentation (general), 日本がん分子標的治療学会

• EMTを誘導したヒト大腸がんHCT116細胞に対するglutaminase阻害剤の効果

  奥村光遥, 加藤優, 近藤慎吾, 杉本芳一

  [Domestic presentation]  日本薬学会第142年会, 

  2023.03

  , 

  Poster presentation

• BET阻害剤dBET6はSLUG導入EMT細胞のフェロトーシス感受性を増大させる

  加藤優, 深澤ゆかり, 近藤慎吾, 杉本芳一

  [Domestic presentation]  日本薬学会第142年会, 

  2023.03

  , 

  Oral presentation (general)

display all >>

Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• 口腔乾燥を誘導する薬剤の同定と薬剤師による臨床的介入の効果の検討

  2025.04

  -

  2028.03

  Grants-in-Aid for Scientific Research, 近藤 慎吾, Grant-in-Aid for Scientific Research (C), No Setting

  　View Summary

  口腔乾燥は医療用医薬品の添付文書中の「その他の副作用」に記載があるが、その危険度に関するデータは不足している。
  本研究ではエムスリー株式会社が保有する診療データベースを用いて、実際に口腔乾燥の訴えがある患者の服用薬を解析して、副作用症状を起こす可能性の高いハイリスク薬を同定することを目的とする。さらに、それらハイリスク薬に対する代替薬リストを作成する。口腔乾燥を感じる患者の処方に対して薬剤情報提供文書で医師に変更提案し、薬剤変更による口腔乾燥の改善効果を検証する。

• がん分子標的薬に対する細胞周期の変化と薬剤耐性の克服

  2021.04

  -

  2022.03

  学事振興資金（個人研究）, No Setting, Principal investigator

• がん分子標的薬に対する耐性機構の解明

  2020.04

  -

  2021.03

  学事振興資金（個人研究）, No Setting, Principal investigator

Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• CLINICAL PHARMACY AND PHARMACOTHERAPY

  2026

• PRIOR LEARNING FOR CLINICAL PRACTICE 5

  2026

• EARLY EXPOSURE TO HOSPITAL & COMMUNITY PHARMACY

  2026

• PRACTICAL LEARNING ON SUPPORTING THE INTELLECTUALLY DISABLED PERSON'S ACTIVITIES

  2026

• SEMINAR: (SOCIAL PHARMACY)

  2026

display all >>

Courses Previously Taught 【 Display / hide 】

Courses Previously Taught 【 Display / hide 】

• COMMUNITY PHARMACY

  Keio University

  2025.04

  -

  2026.03

• STUDY OF MAJOR FIELD: (SOCIAL PHARMACY)

  Keio University

  2025.04

  -

  2026.03

• CLINICAL PHARMACY AND PHARMACOTHERAPY

  Keio University

  2025.04

  -

  2026.03

• PRACTICAL LEARNING ON SUPPORTING THE INTELLECTUALLY DISABLED PERSON'S ACTIVITIES

  Keio University

  2025.04

  -

  2026.03

• ADVANCED MOLECULAR BIOLOGY OF DISEASE

  Keio University

  2025.04

  -

  2026.03

display all >>

Memberships in Academic Societies 【 Display / hide 】

Memberships in Academic Societies 【 Display / hide 】

• 日本性差医学・医療学会, 

  2024.01

  -

  Present

• 日本医療薬学会, 

  2023.08

  -

  Present

• 日本がん分子標的治療学会, 

  2019.04

  -

  Present

• 日本癌学会, 

  2012.04

  -

  Present

• 日本薬学会, 

  2011.04

  -

  Present