研究者詳細 - 平田　あや

論文 - 平田　あや

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Metabolomics profiles alterations in cigarette smokers and heated tobacco product users

Harada, S; Ohmomo, H; Matsumoto, M; Sata, M; Iida, M; Hirata, A; Miyagawa, N; Kuwabara, K; Kato, S; Toki, R; Edagawa, S; Sugiyama, D; Sato, A; Hirayama, A; Sugimoto, M; Soga, T; Tomita, M; Shimizu, A; Okamura, T; Takebayashi, T

Ｊｏｕｒｎａｌ　ｏｆ　Ｅｐｉｄｅｍｉｏｌｏｇｙ（日本疫学会） 34 （ 9 ） 403 - 410 2024年09月

ISSN 09175040

Background: Heated tobacco products (HTPs) have gained global popularity, but their health risks remain unclear. Therefore, the current study aimed to identify plasma metabolites associated with smoking and HTP use in a large Japanese population to improve health risk assessment.Methods: Metabolomics data from 9,922 baseline participants of the Tsuruoka Metabolomics Cohort Study (TMCS) were analyzed to determine the association between smoking habits and plasma metabolites. Moreover, alterations in smoking-related metabolites among HTP users were examined based on data obtained from 3,334 participants involved from April 2018 to June 2019 in a follow-up survey.Results: Our study revealed that cigarette smokers had metabolomics profiles distinct from never smokers, with 22 polar metabolites identified as candidate biomarkers for smoking. These biomarker profiles of HTP users were closer to those of cigarette smokers than those of never smokers. The concentration of glutamate was higher in cigarette smokers, and biomarkers involved in glutamate metabolism were also associated with cigarette smoking and HTP use. Network pathway analysis showed that smoking was associated with the glutamate pathway, which could lead to endothelial dysfunction and atherosclerosis of the vessels.Conclusion: Our study showed that the glutamate pathway is affected by habitual smoking. These changes in the glutamate pathway may partly explain the mechanism by which cigarette smoking causes cardiovascular disease. HTP use was also associated with glutamate metabolism, indicating that HTP use may contribute to the development of cardiovascular disease through mechanisms similar to those in cigarette use.

Risk Factors for Heart Failure and Coronary Artery Disease Mortality Based on the National Vital Statistics During a 25-Year Follow-up in Japan　― NIPPON DATA90 ―

Kubo Kota, Hirata Aya, Kadota Aya, Harada Akiko, Nakamura Yasuyuki, Hayakawa Takehito, Takashima Naoyuki, Fujiyoshi Akira, Okami Yukiko, Kita Yoshikuni, Okayama Akira, Miura Katsuyuki, Ueshima Hirotsugu, Okamura Tomonori, for the NIPPON DATA90 Research Group

Circulation Journal （一般社団法人日本循環器学会） 88 （ 9 ） 1478 - 1487 2024年08月

ISSN 13469843

Background: Prevention of heart failure (HF) is a public health issue. Using the National Vital Statistics, we explored risk factors for HF and coronary artery disease (CAD) mortality.Methods and Results: Altogether, 7,556 Japanese individuals aged ≥30 years in 1990 were followed over 25 years; of these, 139 and 154 died from HF and CAD, respectively. In multivariable Cox proportional hazard analysis, common risk factors for CAD and HF mortality were hypertension (hazard ratio [HR] 1.48 [95% confidence interval {CI} 1.00–2.20] and 2.31 [95% CI 1.48–3.61], respectively), diabetes (HR 2.52 [95% CI 1.63–3.90] and 2.07 [95% CI 1.23–3.50], respectively), and current smoking (HR 2.05 [95% CI 1.27–3.31) and 1.86 [95% CI 1.10–3.15], respectively). Specific risk factors for CAD were male sex, chronic kidney disease, history of cardiovascular disease, and both abnormal T and Q waves, with HRs (95% CIs) of 1.75 (1.05–2.92), 1.78 (1.19–2.66), 2.50 (1.62–3.88), and 11.4 (3.64–36.0), respectively. Specific factors for HF were current drinking (HR 0.43; 95% CI 0.24–0.78) and non-high-density lipoprotein cholesterol (non-HDL-C; HR 0.81; 95% CI 0.67–0.98). There was an inverse association between non-HDL-C and HF in those aged ≥65 years (HR 0.71; 95% CI 0.56–0.90), but not in those aged <65 years.Conclusions: We identified common risk factors for HF and CAD deaths; a history of cardiovascular disease was a specific risk for CAD.

お薬手帳と比較した自記式質問紙による服薬情報の妥当性研究

矢嶋里菜, 松元美奈子, 飯田美穂, 原田成, 澁木琢磨, 平田あや, 桑原和代, 宮川尚子, 中村智徳, 岡村智教, 武林亨

日本公衆衛生雑誌（日本公衆衛生学会） 71 （ 8 ） 430 - 437 2024年08月

ISSN 05461766

目的　疫学研究において服薬情報は自記式質問紙を用いて得ることが多いが，高齢者を対象に妥当性を検討した報告は希少である。本研究の目的は自己申告による服薬情報の妥当性をお薬手帳と比較して検討することである。方法　2019–2020年度に山形県鶴岡市の一般地域在住高齢者を対象として実施されたコホート研究の参加者370人において，自記式質問紙による薬剤情報をお薬手帳の薬剤情報と比較した。解析対象薬剤は降圧薬，脂質異常症用薬，抗心筋梗塞・抗狭心症薬，糖尿病用薬，抗リウマチ薬，骨粗鬆症・骨代謝改善薬，便秘薬，胃薬，抗不安・抗うつ薬，抗認知症薬，喘息治療薬，アレルギー治療薬，抗血栓薬，ステロイド，甲状腺疾患治療薬，解熱・鎮痛・抗炎症薬である。お薬手帳の薬剤情報を基準とし，調査日より前90日以内に服薬中で，28日以上処方されている内服薬，骨粗鬆症・骨代謝改善薬は注射薬も対象とした。ATCコード（解剖治療化学分類法）に基づいて薬効分類を行い，各薬剤の感度，特異度，カッパ係数を計算した。お薬手帳の持参がなかった者は「解析対象薬剤の使用なし」と定義し解析に組み込んだ。結果　男性146人，女性224人，平均年齢（標準偏差）は73.3（4.0）歳であった。各薬剤の感度と特異度は，降圧薬（0.97, 0.97），脂質異常症用薬（0.93, 0.98），抗心筋梗塞・抗狭心症薬（0.24, 0.99），糖尿病用薬（0.94, 1.00），抗リウマチ薬（1.00, 1.00），骨粗鬆症・骨代謝改善薬（0.82, 0.99），便秘薬（0.71, 0.98），胃薬（0.63, 0.97），抗不安薬・抗うつ薬（0.36, 1.00），抗認知症薬（0.67, 1.00），喘息治療薬（0.67, 0.98），アレルギー治療薬（0.57, 0.99），抗血栓薬（0.88, 0.98），副腎皮質ホルモン製剤（0.80, 0.99），甲状腺疾患治療薬（1.00, 1.00），解熱・鎮痛・抗炎症薬（0.75, 0.96）であった。結論　薬剤の種類により感度，特異度が異なっていた。とくに感度が8割を超える薬剤（降圧薬，脂質異常症用薬，糖尿病用薬，抗リウマチ薬，骨粗鬆症・骨代謝改善薬，抗血栓薬，副腎皮質ホルモン製剤，甲状腺疾患治療薬）では，高齢者においても自己申告による服薬情報の収集は有用であることが示唆された。

Study Profile of the Tsuruoka Metabolomics Cohort Study (TMCS)

Harada, S; Iida, M; Miyagawa, N; Hirata, A; Kuwabara, K; Matsumoto, M; Okamura, T; Edagawa, S; Kawada, Y; Miyake, A; Toki, R; Akiyama, M; Kawai, A; Sugiyama, D; Sato, Y; Takemura, R; Fukai, K; Ishibashi, Y; Kato, S; Kurihara, A; Sata, M; Shibuki, T; Takeuchi, A; Kohsaka, S; Sawano, M; Shoji, S; Izawa, Y; Katsumata, M; Oki, K; Takahashi, S; Takizawa, T; Maruya, H; Nishiwaki, Y; Kawasaki, R; Hirayama, A; Ishikawa, T; Saito, R; Sato, A; Soga, T; Sugimoto, M; Tomita, M; Komaki, S; Ohmomo, H; Ono, K; Otsuka-Yamasaki, Y; Shimizu, A; Sutoh, Y; Hozawa, A; Kinoshita, K; Koshiba, S; Kumada, K; Ogishima, S; Sakurai-Yageta, M; Tamiya, G; Takebayashi, T

Ｊｏｕｒｎａｌ　ｏｆ　Ｅｐｉｄｅｍｉｏｌｏｇｙ（日本疫学会） 34 （ 8 ） 393 - 401 2024年08月

ISSN 09175040

The Tsuruoka Metabolomics Cohort Study (TMCS) is an ongoing population-based cohort study being conducted in the rural area of Yamagata Prefecture, Japan. This study aimed to enhance the precision prevention of multi-factorial, complex diseases, including non-communicable and aging-associated diseases, by improving risk stratification and prediction measures. At baseline, 11,002 participants aged 35–74 years were recruited in Tsuruoka City, Yamagata Prefecture, Japan, between 2012 and 2015, with an ongoing follow-up survey. Participants underwent various measurements, examinations, tests, and questionnaires on their health, lifestyle, and social factors. This study uses an integrative approach with deep molecular profiling to identify potential biomarkers linked to phenotypes that underpin disease pathophysiology and provide better mechanistic insights into social health determinants. The TMCS incorporates multi-omics data, including genetic and metabolomic analyses of 10,933 participants, and comprehensive data collection ranging from physical, psychological, behavioral, and social to biological data. The metabolome is used as a phenotypic probe because it is sensitive to changes in physiological and external conditions. The TMCS focuses on collecting outcomes for cardiovascular disease, cancer incidence and mortality, disability and functional decline due to aging and disease sequelae, and the variation in health status within the body represented by omics analysis that lies between exposure and disease. It contains several sub-studies on aging, heated tobacco products, and women’s health. This study is notable for its robust design, high participation rate (89%), and long-term repeated surveys. Moreover, it contributes to precision prevention in Japan and East Asia as a well-established multi-omics platform.

Evaluation of Medication Adherence Among Prevalent Users in Hypertension, Dyslipidemia, and Diabetes Using Health Insurance Claims: A Population-Based Cohort Study in Japan

Matsumoto, M; Harada, S; Ikuta, H; Iida, M; Kato, S; Sata, M; Shibuki, T; Ishibashi, Y; Miyagawa, N; Hisamatsu, M; Hirata, A; Kuwabara, K; Takeuchi, A; Sugiyama, D; Suzuki, S; Nakamura, T; Okamura, T; Takebayashi, T

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY 33 （ 8 ） 2024年08月

ISSN 1053-8569

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Clinical Practice for Acute Heart Failure in Japan From the Nationwide Registry

Hirata, A; Hirata, T

CIRCULATION JOURNAL （一般社団法人日本循環器学会） 88 （ 8 ） 1274 - 1275 2024年07月

ISSN 13469843

Association of Nonalcoholic Fatty Liver Disease with Arterial Stiffness and its Metabolomic Profiling in Japanese Community-Dwellers

Hirata, A; Harada, S; Iida, M; Kurihara, A; Fukai, K; Kuwabara, K; Kato, S; Matsumoto, M; Sata, M; Miyagawa, N; Toki, R; Edagawa, S; Sugiyama, D; Sato, A; Hirayama, A; Sugimoto, M; Soga, T; Tomita, M; Okamura, T; Takebayashi, T

Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ（一般社団法人日本動脈硬化学会） 31 （ 7 ） 1031 - 1047 2024年07月

ISSN 13403478

Aims: Nonalcoholic fatty liver disease (NAFLD) is known to be associated with atherosclerosis. This study focused on upstream changes in the process by which NAFLD leads to atherosclerosis. The study aimed to confirm the association between NAFLD and the cardio-ankle vascular index (CAVI), an indicator of subclinical atherosclerosis, and explore metabolites involved in both by assessing 94 plasma polar metabolites.Methods: A total of 928 Japanese community-dwellers (306 men and 622 women) were included in this study. The association between NAFLD and CAVI was examined using a multivariable regression model adjusted for confounders. Metabolites commonly associated with NAFLD and CAVI were investigated using linear mixed-effects models in which batch numbers of metabolite measurements were used as a random-effects variable, and false discovery rate-adjusted p-values were calculated. To determine the extent to which these metabolites mediated the association between NAFLD and CAVI, mediation analysis was conducted.Results: NAFLD was positively associated with CAVI (coefficients [95% Confidence intervals (CI)]=0.23 [0.09–0.37]; p=0.001). A total of 10 metabolites were involved in NAFLD and CAVI, namely, branched-chain amino acids (BCAAs; valine, leucine, and isoleucine), aromatic amino acids (AAAs; tyrosine and tryptophan), alanine, proline, glutamic acid, glycerophosphorylcholine, and 4-methyl-2-oxopentanoate. Mediation analysis showed that BCAAs mediated more than 20% of the total effect in the association between NAFLD and CAVI.Conclusions: NAFLD was associated with a marker of atherosclerosis, and several metabolites related to insulin resistance, including BCAAs and AAAs, could be involved in the process by which NAFLD leads to atherosclerosis.

Is renal function the key to disease risk management in elevated homocysteine levels?

Hirata, A

HYPERTENSION RESEARCH 47 （ 7 ） 1976 - 1977 2024年07月

ISSN 0916-9636

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Smoking is associated with impaired long-term quality of life in elderly people: a 22-year cohort study in NIPPON-DATA 90.

Liu, YW; Okamura, T; Hirata, A; Sato, Y; Hayakawa, T; Kadota, A; Kondo, K; Ohkubo, T; Miura, K; Okayama, A; Ueshima, H

Ｊｏｕｒｎａｌ　ｏｆ　Ｅｐｉｄｅｍｉｏｌｏｇｙ（日本疫学会） 34 （ 6 ） 265 - 269 2024年06月

ISSN 09175040

Background: Whether smoking is associated with worse quality of life (QoL) or not is relatively controversial. The current study is to investigate the relationship between smoking and subjective QoL in a long cohort study.Methods: The NIPPON DATA 90 project collected 8,383 community residents in 300 randomly selected areas as baseline data in 1990, administered four follow-up QoL surveys, and evaluated mortality statistics. We conducted multinomial logistic regression analysis to compare past smokers and current smokers to never smokers, with impaired QoL and mortality as outcomes.Results: In four follow-ups, QoL data was collected from 2,035, 2,252, 2,522, and 3,280 participants in 1995, 2000, 2005, and 2012, respectively. In the 1995 follow-up, current smoking at baseline was not associated with worse QoL. In 2000 and 2005 follow-ups, smoking was significantly associated with worse QoL (odds ratio [OR] 2.1; 95% confidence interval [CI], 1.33–3.36 and OR 2.29; 95% CI, 1.38–3.80, respectively). In the 2012 follow-up, smoking was not associated with QoL. Sensitivity analysis did not change the result significantly.Conclusion: In this study we found that baseline smoking was associated with worse QoL in long-follow-up.

Reliability of Time-Series Plasma Metabolome Data over 6 Years in a Large-Scale Cohort Study

Miyake, A; Harada, S; Sugiyama, D; Matsumoto, M; Hirata, A; Miyagawa, N; Toki, R; Edagawa, S; Kuwabara, K; Okamura, T; Sato, A; Amano, K; Hirayama, A; Sugimoto, M; Soga, T; Tomita, M; Arakawa, K; Takebayashi, T; Iida, M

METABOLITES 14 （ 1 ） 2024年01月

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A population-based urinary and plasma metabolomics study of environmental exposure to cadmium

Ishibashi, Y; Harada, S; Eitaki, Y; Kurihara, A; Kato, S; Kuwabara, K; Iida, M; Hirata, A; Sata, M; Matsumoto, M; Shibuki, T; Okamura, T; Sugiyama, D; Sato, A; Amano, K; Hirayama, A; Sugimoto, M; Soga, T; Tomita, M; Takebayashi, T

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE （一般社団法人日本衛生学会） 29 （ 0 ） 22 - 22 2024年

ISSN 1342078X

Background: The application of metabolomics-based profiles in environmental epidemiological studies is a promising approach to refine the process of health risk assessment. We aimed to identify potential metabolomics-based profiles in urine and plasma for the detection of relatively low-level cadmium (Cd) exposure in large population-based studies.Method: We analyzed 123 urinary metabolites and 94 plasma metabolites detected in fasting urine and plasma samples collected from 1,412 men and 2,022 women involved in the Tsuruoka Metabolomics Cohort Study. Regression analysis was performed for urinary N-acetyl-beta-D-glucosaminidase (NAG), plasma, and urinary metabolites as dependent variables, and urinary Cd (U-Cd, quartile) as an independent variable. The multivariable regression model included age, gender, systolic blood pressure, smoking, rice intake, BMI, glycated hemoglobin, low-density lipoprotein cholesterol, alcohol consumption, physical activity, educational history, dietary energy intake, urinary Na/K ratio, and uric acid. Pathway-network analysis was carried out to visualize the metabolite networks linked to Cd exposure.Result: Urinary NAG was positively associated with U-Cd, but not at lower concentrations (Q2). Among urinary metabolites in the total population, 45 metabolites showed associations with U-Cd in the unadjusted and adjusted models after adjusting for the multiplicity of comparison with FDR. There were 12 urinary metabolites which showed consistent associations between Cd exposure from Q2 to Q4. Among plasma metabolites, six cations and one anion were positively associated with U-Cd, whereas alanine, creatinine, and isoleucine were negatively associated with U-Cd. Our results were robust by statistical adjustment of various confounders. Pathway-network analysis revealed metabolites and upstream regulator changes associated with mitochondria (ACACB, UCP2, and metabolites related to the TCA cycle).Conclusion: These results suggested that U-Cd was associated with metabolites related to upstream mitochondrial dysfunction in a dose-dependent manner. Our data will help develop environmental Cd exposure profiles for human populations.

The association between sleep parameters and sarcopenia in Japanese community-dwelling older adults

Shibuki Takuma, Iida Miho, Harada Sei, Kato Suzuka, Kuwabara Kazuyo, Hirata Aya, Sata Mizuki, Matsumoto Minako, Osawa Yusuke, Okamura Tomonori, Sugiyama Daisuke, Takebayashi Toru

ARCHIVES OF GERONTOLOGY AND GERIATRICS 109 2023年06月

ISSN 0167-4943

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Quality Control of Targeted Plasma Lipids in a Large-Scale Cohort Study Using Liquid Chromatography-Tandem Mass Spectrometry

Hirayama, A; Ishikawa, T; Takahashi, H; Yamanaka, S; Ikeda, S; Hirata, A; Harada, S; Sugimoto, M; Soga, T; Tomita, M; Takebayashi, T

METABOLITES 13 （ 4 ） 2023年04月

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Optimal Cut-off Points of Triglycerides for Cardiovascular Disease Prediction in Japanese Population

Hirata Aya

Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ（一般社団法人日本動脈硬化学会） 30 （ 2 ） 105 - 106 2023年02月

ISSN 13403478

Fatty liver index predicts the development of hypertension in a Japanese general population with and without dysglycemia

Wu Dan, Hirata Aya, Hirata Takumi, Imai Yukiko, Kuwabara Kazuyo, Funamoto Mika, Sugiyama Daisuke, Okamura Tomonori

HYPERTENSION RESEARCH 2023年01月

ISSN 0916-9636

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都市部住民における塩味味覚閾値の規定要因に関する検討：神戸研究

若子みな美, 佐田みずき, 久保田芳美, 西田陽子, 久保佐智美, 東山綾, 平田匠, 門田文, 平田あや, 宮嵜潤二, 川原瑞希, 桑原和代, 杉山大典, 宮松直美, 宮本恵宏, 岡村智教

日本公衆衛生雑誌（日本公衆衛生学会） advpub （ 0 ） 2023年

ISSN 05461766

目的　塩味味覚閾値の高値は高血圧との関連が指摘されているが，その規定要因は明らかではない。都市部地域住民集団で塩味味覚閾値の規定要因を明らかにするとともに，複数の規定要因が同時に存在した場合の塩味味覚閾値との関連を明らかにすることを目的とした。方法　がんや循環器疾患の既往歴がなく，高血圧，糖尿病，脂質異常症の治療中ではない40～74歳の健康な都市部住民を対象としたコホート研究である神戸研究のベースライン調査参加者1,117人のうち，塩味味覚閾値検査を実施し，尿検査から推定一日食塩摂取量の結果が把握できる1,116人を対象者とした。塩味味覚閾値調査はソルセイブ®を用いて塩味味覚閾値0.6%を正常群，0.8%以上を高値群と定義した。塩味味覚閾値高値を目的変数，問診票から得られた生活状況，家族状況，教育歴，喫煙状況，飲酒状況，塩干物摂取状況，ストレス指標，推定一日食塩摂取量を説明変数として，二項ロジスティック回帰モデルにて検討した。さらに，説明変数を塩味味覚閾値に影響を与える要因，目的変数を塩味味覚閾値（正常/高値）として強制投入法を用いた多変量解析にて二項ロジスティック回帰分析を実施した。この分析では，推定一日食塩摂取量との多重共線性を考慮して，尿中ナトカリ比を除いて実施した。結果　平均年齢は男性60.9±9.0歳，女性58.0±8.7歳であった。塩味味覚閾値の正常群は80.9%（903人）（男性73.6%（251人），女性84.1%（652人）），高値群は19.1%（213人）（男性26.3%（90人），女性15.9%（123人））であった。多変量解析の結果，全対象者において現在喫煙習慣がある群は喫煙習慣が無い群と比較し，塩味味覚閾値高値となるオッズ比（95%信頼区間）が2.51（1.33-4.74）と有意な関連が認められた。また，推定一日食塩摂取量上位25%群では下位75%群と比較してオッズ比（95%信頼区間）が1.45（1.03-2.03）と塩味味覚閾値高値との有意な関連を認めた。男女別の解析では，男女ともに現在喫煙習慣と塩味味覚閾値高値との関連を認め，推定一日食塩摂取量は男性のみ関連を認めた。結論　健康な都市住民において，喫煙習慣と推定一日食塩摂取量の多さが塩味味覚閾値高値と関連していた。

Association between visceral fat accumulation and decline in the estimated glomerular filtration rate based on cystatin C in the Japanese urban population: the KOBE study

Tanabe Ayumi, Hirata Aya, Kuwabara Kazuyo, Kubo Sachimi, Higashiyama Aya, Hirata Takumi, Sugiyama Daisuke, Nishida Yoko, Kubota Yoshimi, Kadota Aya, Nishikawa Tomofumi, Miyamatsu Naomi, Miyamoto Yoshihiro, Okamura Tomonori

Endocrinologia Japonica （一般社団法人日本内分泌学会） 70 （ 1 ） 97 - 106 2023年

ISSN 09188959

Although metabolic syndrome, including visceral fat accumulation, causes kidney and cardiovascular diseases, the impact of visceral fat accumulation on mild decreased renal function remains unclear. This study examines the association between visceral fat area (VFA) measured by bioimpedance methods and the estimated glomerular filtration rate based on serum cystatin C (eGFRcys) in the Japanese urban population. This community-based cross-sectional study enrolled 952 individuals (287 men, 665 women) who participated in the second follow-up survey of the Kobe Orthopedic and Biomedical Epidemiological (KOBE) study. We compared the multivariate-adjusted means of eGFRcys among VFA quartile groups by gender using the analysis of covariance. Models were adjusted for age, high blood pressure, hypercholesterolemia, glucose intolerance, smoking, and alcohol use, and further adjusted for body mass index (BMI). The highest VFA quartile group had lower eGFRcys than the lowest VFA quartile group after adjusted for cardiometabolic risk factors, except for BMI (93.1 [95% confidence interval (CI), 90.1–96.2] vs. 82.1 [95% CI, 79.1–85.0] in men and 95.8 [95% CI, 94.1–97.5] vs. 89.4 [95% CI, 87.8–90.9] in women). Moreover, further adjustment for BMI revealed a similar result in men (93.5 [95% CI, 89.8–97.2] vs. 81.6 [95% CI, 77.9–85.3]), while no significant association was found in women. This study suggests a significant association between increased VFA levels and lower eGFRcys levels independent of cardiometabolic risk factors, such as glucose intolerance and hypercholesterolemia in men and women, as well as independent of BMI in men.

Determinants of double product: a cross-sectional study of urban residents in Japan

Nakagoshi, N; Kubo, S; Nishida, Y; Kuwabara, K; Hirata, A; Sata, M; Higashiyama, A; Kubota, Y; Hirata, T; Tatsumi, Y; Kawamura, K; Miyazaki, J; Miyamatsu, N; Sugiyama, D; Miyamoto, Y; Okamura, T

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE （一般社団法人日本衛生学会） 28 （ 0 ） 37 - 37 2023年

ISSN 1342078X

Background: The current study aimed to investigate the determinants of high double product (DP) by evaluating the association between resting DP, which is calculated as systolic blood pressure (SBP) multiplied by heart rate (HR), and blood test results and lifestyle factors.Methods: This research included 973 participants in the baseline survey of the KOBE study, which included a cohort of urban residents. The possible DP determinants were identified by examining the association between lifestyle factors and laboratory findings and DP by analyzing covariance adjusted for sex and age. Logistic regression analysis was performed with high DP (SBP × HR ≥ 9145 mmHg beats/min or quintile according to sex) as outcome and DP determinants as independent variables.Results: Age, hematocrit, and gamma-glutamyl transferase (log) level were positively associated with a high DP in both men and women. In addition, a high DP was positively associated with Homeostatic Model Assessment for Insulin Resistance score in women alone. Meanwhile, the amount of exercise was negatively associated with a high DP in men alone.Conclusions: High DP values at rest were associated with insulin resistance, gamma-glutamyl transferase, and the amount of exercise in participants without underlying disease.

Predicting habitual water intake from lifestyle questions

Tanaka, H; Mizuma, K; Nakamura, Y; Hirata, A; Miyazaki, J; Suzuki, K; Seta, H; Watanabe, H; Suzuki, T; Watanabe, R; Murayama, N; Okamura, T; Nakamura, S

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES 27 （ 18 ） 8829 - 8841 2023年

ISSN 1128-3602

Effect of Chronic Kidney Disease or Anemia or Both on Cardiovascular Mortality in a 25-Year Follow-Up Study of Japanese General Population (From NIPPON DATA90)

Kubo Kota, Okamura Tomonori, Sugiyama Daisuke, Hisamatsu Takashi, Hirata Aya, Kadota Aya, Kondo Keiko, Hirata Takumi, Higashiyama Aya, Hayakawa Takehito, Miyamoto Yoshihiro, Okayama Akira, Miura Katsuyuki, Ueshima Hirotsugu

AMERICAN JOURNAL OF CARDIOLOGY 184 1 - 6 2022年12月

ISSN 0002-9149

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