研究者詳細 - 宮川　尚子

論文 - 宮川　尚子

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Inverse association of seafood intake with becoming overweight among survivors of the Great East Japan Earthquake

Tsuboyama-Kasaoka N., Ueda S., Miyagawa N., Nishi N., Shimoda H., Sakata K., Ogawa A., Kobayashi S.

International Journal of Disaster Risk Reduction （International Journal of Disaster Risk Reduction） 79 2022年09月

ISSN 22124209

Obesity is a major health issue after disaster. However, the types of food associated with obesity that increases in response to prolonged evacuation are unknown. Therefore, this study aimed to clarify the association between seafood intake following the Great East Japan Earthquake of 2011 and becoming overweight within 2 years after that baseline. We followed 4410 Japanese survivors aged ≥18 years (mean age 62.3 years) who were not overweight at baseline. In 2011, all participants completed a self-administered questionnaire regarding food intake and lifestyle and had a subsequent follow-up in 2013. Multiple logistic regression analysis was performed. During the 2-year follow-up, 296 participants became overweight. Frequency of fish and shellfish intake in men was significantly and inversely associated with becoming overweight after adjusting for confounding factors. The multivariable-adjusted odds ratios for becoming overweight in men was lower in the group with the highest intake of fish and shellfish (odds ratio 0.24; 95% confidence interval, 0.06–0.90) than in the group with the lowest intake in Model 1, and the trend was statistically significant in all models. This significant association was observed in temporary housing but not in non-temporary housing. We showed that consuming seafood may have an obesity-suppressing effect in men who suffered from disaster and lived in temporary housing. Seafood might be a key factor in reducing overweight/obesity not only after a disaster but also during a pandemic and in regions with low seafood intake.

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Effect of diabetes and prediabetes on the development of disability and mortality among middle-aged adult Japanese: a 22-year follow-up of NIPPON DATA90.

Tran Ngoc Hoang P, Kadota A, Yuichiro Y, Akiko H, Takehito H, Shohei O, Miyagawa N, Kondo K, Nagako O, Kita Y, Okayama A, Yukihiro F, Maegawa H, Miura K, Okamura T, Ueshima H, NIPPON DATA90 Research Group.

Journal of diabetes investigation （Journal of Diabetes Investigation） 13 （ 11 ） 1897 - 1904 2022年06月

ISSN 2040-1116

Aims/Introduction: To examine the association between diabetes and prediabetes at baseline, and disability, mortality over a 22-year period among middle-aged Japanese adults. Materials and Methods: Participants consisted of 1,788 adults aged 45–64 years at baseline from the cohort study National Integrated Project for Prospective Observation of Non-communicable Disease and its Trends in the Aged 1990 (NIPPON DATA90). Disability, defined as having a decline in activities of daily living (ADL), was assessed by a modified Katz questionnaire at four time points. Disability and death without disability for 22-year follow up were used as outcomes to test the association with a diagnosis of diabetes or prediabetes at baseline, using multinomial logistic regression. Adjusted odds ratios (ORs) were obtained from four models that contained appropriate adjustment factors, such as age, sex, smoking status, drinking status, body mass index and cardiovascular risk factors (hypertension, hypercholesterolemia, triglycerides, low serum high-density lipoprotein), at baseline. Results: In the present study, 334 participants (18.7%) reported at least one disability, and 350 (19.6%) were reported dead without observation of disability during follow up. Adjusting sex and other risk factors, participants with diabetes and prediabetes had a higher risk for disability (OR 1.43, 95% confidence interval [CI] 1.07–1.91 and OR 1.66, 95% CI 1.10–2.50, respectively) and for mortality (OR 1.56, 95% CI 1.16–2.08 and OR 1.77, 95% CI 1.18–2.65, respectively) than individuals with normal glucose tolerance. Conclusions: In middle-aged Japanese adults, individuals with diabetes and prediabetes were more likely to be associated with disability and mortality. Our findings suggest that prediabetes and diabetes in middle-aged adults should be paid more attention, and requires more intervention to prevent disability and mortality in later life.

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Association between C-Reactive Protein Levels and Functional Disability in the General Older-Population: The Takashima Study.

Takashima N, Nakamura Y, Miyagawa N, Kadota A, Saito Y, Matsui K, Miura K, Ueshima H, Kita Y

Journal of atherosclerosis and thrombosis （一般社団法人日本動脈硬化学会） advpub （ 0 ） 56 - 65 2022年03月

ISSN 1340-3478

Aims: High-sensitivity C-reactive protein (hsCRP) associates with atherosclerotic diseases such as stroke. However, previous results on the association between hsCRP levels and functional disability were controversial. Methods: We analyzed 2,610 men and women who did not exhibit functional disability or death within the first 3 years of the baseline survey and those aged 65 years or older at the end of follow-up. The levels of hsCRP were assessed using latex agglutination assay at baseline survey from 2006 to 2014. Functional disability was followed up using the long-term care insurance (LTCI) program until November 1, 2019. Functional disability was defined as a new LTCI program certification. Cox proportional hazards model with competing risk analysis for death was used to evaluate the association between hsCRP levels and future functional disability. Results: During a 9-year follow-up period, we observed 328 cases of functional disability and 67 deaths without prior functional disability incidence. The multivariable-adjusted hazard ratio (HR, 95% confidence interval [CI]) of functional disability in log-transferred hsCRP levels was 1.43 (1.22–1.67) in men and 0.97 (0.81–1.15) in women. When hsCRP level was analyzed as a categorical variable, low hsCRP levels (＜1.0 mg/l) as the reference, the multivariable-adjusted HR (95% CI) of functional disability in high hsCRP levels (≥ 3.0 mg/l) was 2.37 (1.56–3.62). Similar results were observed when stratified by sex, but it was not significant in women. Conclusions: This study demonstrates that low-grade systemic inflammation to assess hsCRP might predict the future incidence of functional disability, especially in men.

Dietary Patterns and Their Associations with Intermediate Age-Related Macular Degeneration in a Japanese Population

Sasaki M., Miyagawa N., Harada S., Tsubota K., Takebayashi T., Nishiwaki Y., Kawasaki R.

Journal of Clinical Medicine （Journal of Clinical Medicine） 11 （ 6 ） 2022年03月

ISSN 2077-0383

This population-based cross-sectional study investigated the influence of dietary patterns on age-related macular degeneration (AMD) in a Japanese population. The Tsuruoka Metabolomics Cohort Study enrolled a general population aged 35–74 years from among participants in annual health check-up programs in Tsuruoka City, Japan. Eating habits were assessed using a food frequency questionnaire. Principal component analysis was used to identify dietary patterns among food items. The association between quartiles of scores for each dietary pattern and intermediate AMD was assessed using multivariate logistic regression models. Of 3433 participants, 415 had intermediate AMD. We identified four principal components comprising the Vegetable-rich pattern, Varied staple food pattern, Animal-rich pattern, and Seafood-rich pattern. After adjusting for potential confounders, higher Varied staple food diet scores were associated with a lower prevalence of intermediate AMD (fourth vs. first quartile) (OR, 0.63; 95% confidence interval [CI], 0.46–0.86). A significant trend of decreasing ORs for intermediate AMD associated with increasing Varied staple food diet scores was noted (p for trend = 0.002). There was no significant association between the other dietary patterns and intermediate AMD. In a Japanese population, individuals with a dietary pattern score high in the Varied staple food pattern had a lower prevalence of intermediate AMD.

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高血圧の指摘や治療の継続状況と野菜摂取量の関連　NIPPON DATA2010

中川夕美, 由田克士, 荒井裕介, 尾島俊之, 藤吉朗, 中川秀昭, 奥田奈賀子, 宮川尚子, 門田文, 近藤慶子, 岡村智教, 大久保孝義, 西信雄, 上島弘嗣, 岡山明, 三浦克之

日本循環器病予防学会誌（(一社)日本循環器病予防学会） 57 （ 1 ） 42 - 54 2022年03月

ISSN 1346-6267

【目的】高血圧者に対する食事指導等の介入によって野菜摂取量の増加が認められたとする報告はこれまでにもあるが、高血圧を指摘されることそれ自体や治療の継続状況と野菜摂取量の関連を検討した報告はない。そこで本研究では、高血圧の指摘や治療の継続状況が、実際の野菜摂取量に影響を与えるのか検討した。【方法】平成22年国民健康・栄養調査及びNIPPON DATA2010の20歳以上の参加者を対象とした。このうち、これまでに医療機関や健康診査で脳卒中、心筋梗塞、腎臓病または腎機能低下と指摘されたことはないが、高血圧の指摘を受けている者もしくは高血圧、糖尿病、脂質異常症のいずれの指摘も受けたことはないが、国民健康・栄養調査の血圧測定値が高血圧(収縮期血圧140mmHg以上または拡張期血圧90mmHg以上の者と定義)であった高値血圧者の男女1,004人を解析対象とした。野菜摂取量が多いこと(1日350g以上)をアウトカムとして、高血圧を指摘されることやその後の治療の継続状況(治療継続、治療中断、未治療)との関連をロジスティック回帰分析にて検討した。【結果】野菜摂取量が多いことと高血圧を指摘されることは男女とも有意な関連はなく、野菜を積極的に摂取しようと心がけることとのオッズ比が男性1.72(95%CI:1.17-2.53)、女性1.51(95%CI:1.04-2.21)と有意な正の関連が認められた。野菜摂取量が多いことと高血圧者における治療の継続状況では、野菜を積極的に摂取しようと心がけることとのオッズ比が男性1.69(95%CI:1.07-2.68)と有意な正の関連、「治療中断」の女性でオッズ比0.37(95%CI:0.15-0.90)と有意な負の関連がみられた。【結論】男女とも野菜の摂取量と高血圧の指摘自体との関連は認められなかったが、女性では治療中断と負の関連が示唆された。(著者抄録)

A genome-wide association study on adherence to low-carbohydrate diets in Japanese.

Nakamura Y, Tamura T, Narita A, Shimizu A, Sutoh Y, Takashima N, Matsui K, Miyagawa N, Kadota A, Miura K, Otonari J, Ikezaki H, Hishida A, Nagayoshi M, Okada R, Kubo Y, Tanaka K, Shimanoe C, Ibusuki R, Nishimoto D, Oze I, Ito H, Ozaki E, Matsui D, Mikami H, Kusakabe M, Suzuki S, Watanabe M, Arisawa K, Katsuura-Kamano S, Kuriki K, Nakatochi M, Momozawa Y, Kubo M, Takeuchi K, Wakai K, J-MICC Research Group Consortium.

European journal of clinical nutrition （European Journal of Clinical Nutrition） 76 （ 8 ） 1103 - 1110 2022年02月

研究論文（学術雑誌）, 共著, ISSN 0954-3007

Background/objectives: Low-carbohydrate diets (LCD) are useful for weight reduction, and 50–55% carbohydrate consumption is associated with minimal risk. Genetic differences were related to nutritional consumption, food preferences, and dietary patterns, but whether particular genetic differences in individuals influence LCD adherence is unknown. Subjects/methods: We conducted a GWAS on adherence to LCD utilizing 14,076 participants from the Japan Multi-Institutional Collaborative Cohort study. We used a previously validated semiquantitative food frequency questionnaire to estimate food consumption. Association of the imputed variants with the LCD score by Halton et al. we used linear regression analysis adjusting for sex, age, total dietary energy consumption, and components 1 to 10 by principal component analysis. We repeated the analysis with adjustment for alcohol consumption (g/day) in addition to the above-described variables. Results: Men and women combined analysis without adjustment for alcohol consumption; we found 395 variants on chromosome 12 associated with the LCD score having P values <5 × 10−8. A conditional analysis with the addition of the dosage data of rs671 on chromosome 12 as a covariate, P values for all 395 SNPs on chromosome 12 turned out to be insignificant. In the analysis with additional adjustment for alcohol consumption, we did not identify any SNPs associated with the LCD score. Conclusion: We found rs671 was inversely associated with adherence to LCD, but that was strongly confounded by alcohol consumption.

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Predictors of lower limb fractures in general Japanese: NIPPON DATA90

Saito Y., Miura K., Arima H., Hayakawa T., Takashima N., Kita Y., Okuda N., Fujiyoshi A., Iwahori T., Miyagawa N., Kondo K., Torii S., Kadota A., Ohkubo T., Okayama A., Okamura T., Ueshima H.

PLoS ONE （PLoS ONE） 17 （ 2 February ） e0261716 2022年02月

ISSN 1932-6203

Objective This study aimed to investigate the incidence rates and predictors of lower limb fractures in a general Japanese population. Methods NIPPON DATA is a nationwide, long-term, prospective cohort study of individuals who participated in the National Cardiovascular Survey Japan and the National Nutrition Survey in 1990. Overall, 3,134 individuals (1,827 women, 1,307 men) who participated in follow-up assessments in 1995, 2000, and/or 2006 were included in the present analysis. The outcomes of this study were lower limb fractures (including proximal femur fractures). Results The mean age at baseline was 63.8 years in women and 63.1 years in men. The average body mass index (BMI) was 23.3 kg/m2 in women and 22.9 kg/m2 in men. During a mean follow- up of 12.1 years, 271 total lower limb fractures were observed. In women, older age, lower BMI, and less intake of vegetables were associated with increased risks of proximal femur fractures. With regard to the outcome of total lower limb fractures, less intake of vegetables and regular exercise were significant predictors in women. Calcium intake was not significantly associated with proximal femur or total lower limb fractures. There were no significant predictors of proximal femur or total lower limb fractures in men, except for age. Conclusions Aging was a significant risk factor for proximal femur and total lower limb fractures in both men and women. With regard to modifiable risk factors, low BMI and low intake of vegetables were associated with increased risks of proximal femur and/or total lower limb fractures in the general population of Japanese women.

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Seven-year incidence of new-onset hypertension by frequency of dairy intake among survivors of the Great East Japan Earthquake

Miyagawa N., Tsubota-Utsugi M., Tsuboyama-Kasaoka N., Nishi N., Shimoda H., Sakata K., Ogawa A., Kobayashi S.

Hypertension Research （Hypertension Research） 45 （ 9 ） 1459 - 1467 2022年

研究論文（学術雑誌）, 共著, 筆頭著者, 査読有り, ISSN 09169636

Survivors of natural disasters are at a high risk of cardiovascular disease. Behavioral risk factors, including modifiable diet, need to be identified. Thus far, the association between dairy intake and new-onset hypertension among these survivors is unknown. Therefore, we investigated this relationship. We conducted a longitudinal cohort study of 4475 survivors of the Great East Japan Earthquake in 2011 who participated in a 7-year follow-up survey. New-onset hypertension was assessed using annual health checkup data. Information on the frequency of dairy intake was obtained using a self-report questionnaire. The hazard ratio for developing hypertension according to the frequency of dairy intake was calculated using Cox proportional hazards regression models. The total number of person-years observed was 20,042, with a median follow-up of 5.4 years. During the observation period, 1554 individuals developed hypertension. The multivariable-adjusted hazard ratios of new-onset hypertension were significantly lower in those who consumed dairy products once per day (0.82, 95% confidence interval 0.71–0.94) and twice or more times per day (0.84, 95% confidence interval 0.71–0.99) than in nonconsumers; the inverse linear trend was marginally significant (P = 0.083). This association was not affected by lipid metabolism and was consistent across subgroups by sex, age, behavioral factors, cardiometabolic factors, and housing type due to the disaster. A higher frequency of dairy intake was associated with a lower risk of new-onset hypertension in community-dwelling survivors of earthquakes and tsunamis. Dietary guidance involving dairy intake could reduce the risk of developing hypertension among these survivors.

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Differential Association of Serum n-3 Polyunsaturated Fatty Acids with Various Cerebrovascular Lesions in Japanese Men

Kondo K., Arima H., Fujiyoshi A., Sekikawa A., Kadota A., Hisamatsu T., Torii S., Shiino A., Morino K., Miyagawa N., Segawa H., Watanabe Y., Maegawa H., Nozaki K., Miura K., Ueshima H.

Cerebrovascular Diseases （Cerebrovascular Diseases） 51 （ 6 ） 1 - 7 2022年

ISSN 10159770

Background: An association between a high intake of marine-derived n-3 polyunsaturated fatty acids (n-3 PUFAs) with a lower risk of coronary heart disease was previously reported. However, the association between n-3 PUFAs and cerebrovascular lesions remains unclear. We evaluated this association in a general-population-based sample of Japanese men. Methods: Participants were community-dwelling men (40-79 years old) living in Kusatsu City, Shiga, Japan. Serum concentrations of n-3 PUFAs, defined as the sum of eicosapentaenoic and docosahexaenoic acids, were measured via gas-liquid chromatography between 2006 and 2008. Magnetic resonance imaging was used to assess cerebrovascular lesions (including intracerebral large-artery stenosis, lacunar infarction, and microbleeds) and white matter lesions between 2012 and 2015. Logistic regression adjusting for conventional cardiovascular risk factors was used to estimate the odds ratio of prevalent cerebrovascular lesions per 1 standard deviation higher serum concentration of n-3 PUFAs. Results: Of a total of 739 men, the numbers (crude prevalence in %) of prevalent cerebral large-artery stenoses, lacunar infarctions, microbleeds, and white matter lesions were 222 (30.0), 162 (21.9), 103 (13.9), and 164 (22.2), respectively. A 1 standard deviation higher concentration of n-3 PUFAs (30.5 μmol/L) was independently associated with lower odds of cerebral large-artery stenosis (multivariable-adjusted odds ratio, 0.80; 95% confidential interval, 0.67-0.97). There were no significant associations of n-3 PUFAs with the other types of lesions. Conclusions: n-3 PUFAs may have protective effects against large-artery stenosis, but not small vessel lesions, in the brain.

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Reproducibility and validity of food group intake in a short food frequency questionnaire for the middle-aged Japanese population

Imaeda N., Goto C., Sasakabe T., Mikami H., Oze I., Hosono A., Naito M., Miyagawa N., Ozaki E., Ikezaki H., Nanri H., Nakahata N.T., Kamano S.K., Kuriki K., Yaguchi Y.T., Kayama T., Kurihara A., Harada S., Wakai K.

Environmental Health and Preventive Medicine （Environmental Health and Preventive Medicine） 26 （ 1 ） 28 - 28 2021年12月

研究論文（学術雑誌）, 共著, ISSN 1342078X

Purpose: The purpose of this study was to evaluate the reproducibility and validity of a short food frequency questionnaire (FFQ) for food group intake in Japan, the reproducibility and partial validity of which were previously confirmed for nutrients. Methods: A total of 288 middle-aged healthy volunteers from 11 different areas of Japan provided nonconsecutive 3-day weighed dietary records (DRs) at 3-month intervals over four seasons. We evaluated reproducibility based on the first (FFQ1) and second (FFQ2) questionnaires and their validity against the DRs by comparing the intake of 20 food groups. Spearman’s rank correlation coefficients (SRs) were calculated between energy-adjusted intake from the FFQs and that from the DRs. Results: The intake of 20 food groups estimated from the two FFQs was mostly equivalent. The median energy-adjusted SRs between the FFQ1 and FFQ2 were 0.61 (range 0.38–0.86) for men and 0.66 (0.45–0.84) for women. For validity, the median de-attenuated SRs between DRs and the FFQ1 were 0.51 (0.17–0.76) for men and 0.47 (0.23–0.77) for women. Compared with the DRs, the proportion of cross-classification into exact plus adjacent quintiles with the FFQ1 ranged from 58 to 86% in men and from 57 to 86% in women. According to the robust Z scores and the Bland–Altman plot graphs, the underestimation errors in the FFQ1 tended to be greater in individuals with high mean levels of consumption for meat for men and for other vegetables for both men and women. Conclusion: The FFQ demonstrated high reproducibility and reasonable validity for food group intake. This questionnaire is short and remains appropriate for identifying associations between diet and health/disease among adults in Japan.

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Association between socioeconomic status and prolonged television viewing time in a general Japanese population: NIPPON DATA2010

Sumimoto Y., Yanagita M., Miyamatsu N., Okuda N., Nishi N., Nakamura Y., Nakamura K., Miyagawa N., Miyachi M., Kadota A., Ohkubo T., Okamura T., Ueshima H., Okayama A., Miura K.

Environmental Health and Preventive Medicine （Environmental Health and Preventive Medicine） 26 （ 1 ） 57 - 57 2021年12月

研究論文（学術雑誌）, 共著, ISSN 1342078X

Background: It has been pointed out that prolonged television (TV) viewing is one of the sedentary behaviors that is harmful to health; however, the association between socioeconomic status (SES) and prolonged TV viewing time has not been sufficiently investigated in Japan. Methods: The study population are the participants of NIPPON DATA2010, which is a prospective cohort study of the National Health and Nutrition Survey 2010 in Japan. They were residents in 300 randomly selected areas across Japan. This study included 2752 adults. SES was classified according to the employment status, educational attainment, living status, and equivalent household expenditure (EHE). Prolonged TV viewing time was defined as more than or equal to 4 h of TV viewing per day. Multivariable logistic regression analyses were conducted to examine the association of SES with prolonged TV viewing time. Results: The mean TV viewing time was 2.92 h in all participants. Of 2752 participants, 809 (29.4%) prolonged TV viewing, and the mean TV viewing time of them was 5.61 h. The mean TV viewing time in participants without prolonged TV viewing time was 1.81 h. The mean TV viewing time was prolonged as age classes increased and significantly longer in aged ≥60 years. Prolonged TV viewing time was associated with not working for all age classes and sexes. Only among women, education attainment and living status were also associated with prolonged TV viewing time. For education attainment, the lower the received years of education, the higher odds ratios (OR) of prolonged TV viewing time. For living status, in women aged <60 years, living with others had a significantly higher OR compared to living with spouse. On the other hand, in women aged ≥60 years, living alone had a significantly higher OR. EHE did not have any significant associations with prolonged TV viewing time. Conclusions: In a general Japanese population, it should be noted that the association between SES and prolonged TV viewing time differed by age and sex. Particularly, it must draw attention to the prolonged TV viewing in elderly. The intervention in order to shorten TV viewing time needs to consider these attributes.

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Association of skipping breakfast and short sleep duration with the prevalence of metabolic syndrome in the general Japanese population: Baseline data from the Japan Multi-Institutional Collaborative cohort study

Katsuura-Kamano S., Arisawa K., Uemura H., Van Nguyen T., Takezaki T., Ibusuki R., Suzuki S., Otani T., Okada R., Kubo Y., Tamura T., Hishida A., Koyama T., Matsui D., Kuriki K., Takashima N., Miyagawa N., Ikezaki H., Matsumoto Y., Nishida Y., Shimanoe C., Oze I., Matsuo K., Mikami H., Kusakabe M., Takeuchi K., Wakai K.

Preventive Medicine Reports （Preventive Medicine Reports） 24 101613 - 101613 2021年12月

ISSN 2211-3355

The purpose of the study was to investigate sex-specific associations of skipping breakfast and short sleep duration with metabolic syndrome (MetS) and their interaction. We analyzed baseline data of 14,907 men and 14,873 women aged 35–69 years, who participated in the Japan Multi-Institutional Collaborative Cohort Study from 2005. MetS was diagnosed using a modification of the National Cholesterol Education Program Adult Treatment Panel III revised definition (NCEP-R 2005), using body mass index instead of waist circumference. Breakfast consumption was classified into two categories: ≥6 days/week (consumers) or <6 days/week (skippers). Sleep duration was classified into three categories: <6h, 6 to <8 h, and ≥8 h/day. Multivariate logistic regression analysis was performed to estimate odds ratios (ORs) and 95 % confidence intervals (CIs) and examine the presence of interaction. In men, skipping breakfast and short sleep duration were independently associated with an increased prevalence of MetS (OR 1.26, 95%CI 1.12–1.42 and OR 1.28, 95%CI 1.12–1.45, respectively), obesity, and components of MetS. However, no significant interaction was observed between skipping breakfast and short sleep duration. In women, skipping breakfast and short sleep duration were associated with an increased prevalence of obesity, but not with MetS. These findings indicate that breakfast consumption and moderate sleep duration may be associated with a lower risk of MetS, particularly in men.

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Association between Stress-Coping Strategy and Functional Disability in the General Older Adult Population: The Takashima Study.

Takashima N, Nakamura Y, Miyagawa N, Kadota A, Tanaka-Mizuno S, Matsui K, Miura K, Ueshima H, Kita Y, Takashima Study Group.

Gerontology （Gerontology） 68 （ 6 ） 1 - 8 2021年09月

研究論文（学術雑誌）, 共著, ISSN 0304-324X

Background: Both physical and psychological factors have been associated with functional disability. However, the associations between stress-coping strategies and future functional disability remain unclear. Methods: We analyzed 2,924 participants who did not have incidence of functional disability or death within the first 3 years of the baseline survey and were aged 65 years or more at the end of follow-up. Stress-coping strategies were assessed via a self-administered questionnaire (emotional expression, emotional support seeking, positive thought, problem-solving, and disengagement) in a baseline survey from 2006 to 2014. Levels of coping strategies were classified as low, middle, and high based of frequency. Functional disability decline was followed up using the long-term-care insurance program until November 1, 2019. Functional disability decline was defined as a new long-term-care insurance program certification. Cox proportional hazards model with competing risk analysis for death was used to evaluate associations between coping strategy levels and functional disability. Results: During the follow-up period, we observed 341 cases of functional disability and 73 deaths without previous incidence of functional disability. A significant inverse association between "positive thought"and "problem-solving"and future functional disability was observed. Multivariable adjusted hazard ratios (95% confidence interval) for functional disability were 0.68 (0.51-0.92) for high levels of "positive thought"and 0.73 (0.55-0.95) for high levels of "problem-solving,"compared with low levels of the coping strategies. The inverse association was stronger in men. Conclusions: Some subcomponents of stress-coping strategies might be associated with future incidence of functional disability among older adults.

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Population-Based Impact of Smoking, Drinking, and Genetic Factors on HDL-Cholesterol Levels in J-MICC Study Participants.

Nindita Y, Nakatochi M, Ibusuki R, Shimoshikiryo I, Nishimoto D, Shimatani K, Takezaki T, Ikezaki H, Murata M, Hara M, Nishida Y, Tamura T, Hishida A, Nagayoshi M, Okada R, Matsuo K, Ito H, Mikami H, Nakamura Y, Otani T, Suzuki S, Koyama T, Ozaki E, Kuriki K, Takashima N, Miyagawa N, Arisawa K, Katsuura-Kamao S, Momozawa Y, Kubo M, Takeuchi K, Wakai K

Journal of epidemiology （日本疫学会） advpub （ 0 ） 193 - 200 2021年08月

研究論文（学術雑誌）, 共著, ISSN 0917-5040

BACKGROUND: Environmental and genetic factors are suggested to exhibit factor-based association with HDL-cholesterol (HDL-C) levels. However, the population-based effects of environmental and genetic factors have not been compared clearly. We conducted a cross-sectional study using data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study to evaluate the population-based impact of smoking, drinking, and genetic factors on low HDL-C. METHODS: Data from 11,498 men and women aged 35-69 years were collected for a genome-wide association study (GWAS). Sixty-five HDL-C-related SNPs with genome-wide significance (P < 5 × 10-8) were selected from the GWAS catalog, and seven representative SNPs were defined, and the population-based impact was estimated using population attributable fraction (PAF). RESULTS: We found that smoking, drinking, daily activity, habitual exercise, egg intake, BMI, age, sex and the SNPs CETP rs3764261, APOA5 rs662799, LIPC rs1800588, LPL rs328, ABCA1 rs2575876, LIPG rs3786247, and APOE rs429358 were associated with HDL-C levels. The gene-environmental interactions on smoking and drinking were not statistically significant. The PAF for low HDL-C was the highest in men (63.2%) and in rs3764261 (31.5%) of the genetic factors, and the PAFs of smoking and drinking were 23.1% and 41.8%, respectively. CONCLUSIONS: The present study showed that the population-based impact of genomic factor CETP rs3764261 for low HDL-C was higher than that of smoking and lower than that of drinking.

Association between lifestyle changes and at-home hours during and after the state of emergency due to the COVID-19 pandemic in Japan

Nishijima C., Miyagawa N., Tsuboyama-Kasaoka N., Chiba T., Miyachi M.

Nutrients （Nutrients） 13 （ 8 ） 2021年08月

研究論文（学術雑誌）, 共著

Lifestyle changes during the coronavirus disease (COVID-19) lockdown have been previously examined, but there is limited understanding about changes after such restrictions were lifted. This study examines changes in lifestyle habits and body weight among the Japanese population with regard to the length of at-home hours both during (April to May) and after (September) the na-tionwide stay-at-home request compared to those before the COVID-19 pandemic (January 2020). An online survey was conducted in September 2020 involving 10,000 Japanese survey monitors, selected according to population distribution. During the stay-at-home request, 34% participants extended their at-home hours. More respondents in the group with extended at-home hours experienced an increase or decrease in total physical activity, snacking, food intake, alcohol drinking, and body weight than those in the group with nonextended at-home hours. Some of these changes had a trend according to age. The prevalence of most of these changes decreased when at-home hours returned to normal after the stay-at-home request period; however, increased alcohol consumption and increased or decreased body weight persisted. Our findings suggest that close monitoring for further health outcomes and age-appropriate measures to encourage favorable health behaviors is needed.

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Association between socioeconomic status and physical inactivity in a general Japanese population: NIPPON DATA2010

Sumimoto Y., Yanagita M., Miyamatsu N., Okuda N., Nishi N., Nakamura Y., Nakamura K., Miyagawa N., Miyachi M., Kadota A., Ohkubo T., Okamura T., Ueshima H., Okayama A., Miura K.

PLoS ONE （PLoS ONE） 16 （ 7 July ） e0254706 2021年07月

研究論文（学術雑誌）, 共著, ISSN 1932-6203

Background: Lower socioeconomic status (SES) may be related to inactivity lifestyle; however, the association between SES and physical inactivity has not been sufficiently investigated in Japan. Methods: The study population is the participants of NIPPON DATA2010, which is a prospective cohort study of the National Health and Nutrition Survey 2010 in Japan. They were residents in 300 randomly selected areas across Japan. This study included 2,609 adults. Physical activity was assessed by physical activity index (PAI) calculated from activity intensity and time. The lowest tertile of PAI for each 10-year age class and sex was defined as physical inactivity. Multivariable logistic regression analyses were conducted to examine the association of SES (employment status, educational attainment, living status, and equivalent household expenditure (EHE)) with physical inactivity. Results: In the distribution of PAI by age classes and sex, the highest median PAI was aged 30-39 years among men (median 38.6), aged 40-49 years among women (38.0), and median PAI was decreased with increasing age. Multivariable-adjusted model shows that not working was significantly associated with physical inactivity after adjustment for age in all age groups and sexes. Not living with spouse for adult women and elderly men was significantly associated with physical inactivity compared to those who living with spouse. However, neither educational attainment nor EHE had any significant associations with physical inactivity. Conclusions: The result indicated that physical inactivity was associated with SES in a general Japanese population. SES of individuals need to be considered in order to prevent inactivity lifestyle.

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Alcohol drinking and brain morphometry in apparently healthy community-dwelling Japanese men

Syaifullah A.H., Shiino A., Fujiyoshi A., Kadota A., Kondo K., Ito T., Segawa H., Moniruzzaman M., Waki T., Miyagawa N., Tooyama I., Ueshima H., Miura K., Horie M., Nakagawa Y., Yamamoto T., Nakano Y., Ogawa E., Maegawa H., Morino K., Miyazawa I., Watanabe Y., Nozaki K., Andoh A., Tsuru T., Ogita H., Miyamatsu N., Nakamura Y., Torii S., Kadowaki T., Kadowaki S., Suzuki S., Kunimura A., Higashiyama A., Okamura T., Azuma K., Sawamura T., Igase M., Tabara Y., Sekikawa A., Barinas-Mitchell E.J.M., Edmundowicz D., Ohkubo T., Hozawa A., Murakami Y., Okuda N., Arima H., Satoh A., Kita Y., Hisamatsu T., Yanagita M., Abbott R.D., Ohno S., Takashima N., Zaid M., Saito Y.

Alcohol （Alcohol） 90 57 - 65 2021年02月

研究論文（学術雑誌）, 共著, ISSN 07418329

The clinical implications of alcohol consumption have been extensively examined; however, its effects on brain structures in apparently healthy community-dwellers remain unclear. Therefore, we investigated the relationship between alcohol consumption and brain gray matter volume (GMV) in community-dwelling Japanese men using voxel-based morphometry (VBM). We recruited cognitively intact Japanese men, aged 40–79 years, from a population-based cohort in Shiga, Japan. Brain magnetic resonance imaging was performed, on average, 2 years after demographic and medical information was obtained in 2010–2014. A multivariable linear regression analysis of 639 men was conducted to elucidate the relationship between the amount of alcohol consumed and GMV. VBM statistics were analyzed by threshold-free cluster enhancement with a family-wise error rate of <0.05. The results obtained demonstrated that the amount of alcohol consumed was associated with lower GMV. The VBM analysis showed lower GMV within the parahippocampal, entorhinal, cingulate, insular, temporal, and frontal cortices and cerebellum in very heavy drinkers (≥42 ethanol g/day) than in non-drinkers. Furthermore, alcohol consumption was associated with a higher white matter lesion volume. These results suggest subclinical structural changes similar to alcohol-related neurological diseases.

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Seven-Day Pedometer-Assessed Step Counts and Brain Volume: A Population-Based Observational Study

Moniruzzaman M., Kadota A., Shiino A., Fujiyoshi A., Ito T., Syaifullah A.H., Miyagawa N., Kondo K., Hisamatsu T., Segawa H., Tooyama I., Ueshima H., Miura K.

Journal of Physical Activity and Health （Journal of Physical Activity and Health） 18 （ 2 ） 157 - 164 2021年

研究論文（学術雑誌）, 共著, ISSN 15433080

Background: To investigate the association between step counts and brain volumes (BVs)—global and 6 a priori selected cognition-related regions of interest—in Japanese men aged 40–79 years. Methods: The authors analyzed data from 680 cognitively intact participants of the Shiga Epidemiological Study of Subclinical Atherosclerosis—a population-based observational study. Using multivariable linear regression, the authors assessed cross-sectional associations between 7-day step counts at baseline (2006–2008) and BVs at follow-up (2012–2015) for age-stratified groups (<60 y and ≥60 y). Results: In the older adults ≥60 years, step counts at baseline (per 1000 steps) were associated with total BV at follow-up (β = 1.42, P = .022) while adjusted for potential covariates. Regions of interest-based analyses yielded an association of step counts with both prefrontal cortexes (P < .05) in older adults, while the left entorhinal cortex showed marginally significant association (P = .05). No association was observed with hippocampus, parahippocampal, cingulum, and cerebellum. No association was observed in younger adults (<60 y). Conclusions: The authors found a positive association between 7-day step counts and BVs, including prefrontal cortexes, and left entorhinal cortex in apparently healthy Japanese men.

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Association between the prevalence of hypertension and dairy consumption by housing type among survivors of the Great East Japan Earthquake

Miyagawa N., Tsuboyama-Kasaoka N., Nishi N., Tsubota-Utsugi M., Shimoda H., Sakata K., Ogawa A., Kobayashi S.

Journal of Human Hypertension （Journal of Human Hypertension） 36 （ 3 ） 299 - 307 2021年

研究論文（学術雑誌）, 共著, 筆頭著者, 査読有り, ISSN 09509240

Survivors of the Great East Japan Earthquake in 2011 had higher risks of cardiovascular diseases and hypertension, particularly residents of heavy flooding areas and evacuees. Thus far, the association between the prevalence of hypertension and dairy consumption remains unknown among these evacuees. We investigated this association by housing type after the Great East Japan Earthquake. In this cross-sectional study, we conducted a baseline survey among 9569 survivors of the earthquake, aged ≥18 years, between September 2011 and February 2012. Hypertension was defined as a systolic/diastolic blood pressure ≥140/90 mmHg or as persons undergoing treatment for high blood pressure. The frequency of dairy consumption was determined using a questionnaire. Participants living in prefabricated housing and emergency shelters were regarded as residents of temporary housing. Hypertension was prevalent among 43.8% and 44.7% of the participants in temporary and non-temporary housing, respectively. A logistic regression analysis of the prevalence of hypertension by daily dairy consumption showed that the magnitude of multivariable-adjusted odds ratios differed according to housing type (odds ratio, 0.64; 95% confidence interval, 0.51–0.80 in temporary housing; odds ratio, 0.85; 95% confidence interval, 0.73–0.995 in non-temporary housing; P for interaction = 0.0501). These associations were consistent across subgroups according to sex, age, behavioral factors, obesity, disorders of lipid metabolism, and economic status. A higher frequency of dairy consumption was associated with a lower prevalence of hypertension among community-dwelling survivors of earthquakes and tsunamis, particularly those living in temporary housing. Therefore, dietary therapy involving dairy consumption could help prevent hypertension among evacuees.

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Factors Associated with Lower Cognitive Performance Scores among Older Japanese Men in Hawaii and Japan

Miyagawa N., Ohkubo T., Fujiyoshi A., Shiino A., Chen R., Ross G.W., Willcox B., Miura K., Ueshima H., Masaki K., Polidori M.C.

Journal of Alzheimer's Disease （Journal of Alzheimer's Disease） 81 （ 1 ） 403 - 412 2021年

研究論文（学術雑誌）, 共著, 筆頭著者, 査読有り, ISSN 13872877

Background: Few studies have compared factors related to cognitive function among people with similar genetic backgrounds but different lifestyles. Objective: We aimed to identify factors related to lower cognitive scores among older Japanese men in two genetically similar cohorts exposed to different lifestyle factors. Methods: This cross-sectional study of community-dwelling Japanese men aged 71-81 years included 2,628 men enrolled in the Kuakini Honolulu-Asia Aging Study based in Hawaii and 349 men in the Shiga Epidemiological Study of Subclinical Atherosclerosis based in Japan. We compared participant performance through Cognitive Abilities Screening Instrument (CASI) assessment in Hawaii (1991-1993) and Japan (2009-2014). Factors related to low cognitive scores (history of cardiovascular disease, cardiometabolic factors, and lifestyle factors) were identified with questionnaires and measurements. Multivariable logistic regression analysis was used to calculate the adjusted odds ratios (ORs) of a low (<82) CASI score based on different factors. Results: CASI scores were lower in Hawaii than in Japan [21.2%(n=556) versus 12.3%(n=43), p<0.001], though this was not significant when adjusted for age and educational attainment (Hawaii 20.3%versus Japan 17.9%, p=0.328). History of stroke (OR=1.65, 95%confidence interval=1.19-2.29) was positively associated with low cognitive scores in Hawaii. Body mass index =25kg/m2 tended to be associated with low cognitive scores in Japan; there was a significant interaction between the cohorts. Conclusion: Cognitive scores differences between cohorts were mostly explained by differences in educational attainment. Conversely, cardiovascular diseases and cardiometabolic factors differentially impacted cognitive scores among genetically similar older men exposed to different lifestyle factors.

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