Fushimi, Motofumi

写真a

Affiliation

Faculty of Science and Technology, Department of Applied Physics and Physico-Informatics ( Yagami )

Position

Research Associate/Assistant Professor/Instructor

Related Websites

Contact Address

3-14-1 Hiyoshi, Kohoku-ku, Yokohama-shi, Kanagawa
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Career 【 Display / hide 】

  • 2018.04
    -
    2021.03

    Japan Society for the Promotion of Science, Research Fellow (DC1)

  • 2019.04
    -
    2020.03

    Visiting Graduate Assistant, Department of Radiology, Weill Cornell Medicine

  • 2021.04
    -
    2025.03

    The University of Tokyo, The Graduate School of Engineering Department of Bioengineering, Project Assistant Professor

  • 2025.04
    -
    2026.03

    The University of Tokyo, The Graduate School of Information Science and Technology Department of Information Physics and Computing, 助教

  • 2026.04
    -
    Present

    Keio University, Faculty of Science and Technology Department of Applied Physics and Physico-Informatics, Assistant Professor

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Academic Background 【 Display / hide 】

  • 2014.04
    -
    2016.03

    The University of Tokyo, The Faculty of Engineering, 計数工学科

  • 2016.04
    -
    2018.03

    The University of Tokyo, The Graduate School of Information Science and Technology, Department of Information Physics and Computing

  • 2018.04
    -
    2021.03

    The University of Tokyo, The Graduate School of Information Science and Technology, Department of Information Physics and Computing

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Academic Degrees 【 Display / hide 】

  • 博士（情報理工学）, The University of Tokyo, Coursework, 2021.03

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Research Areas 【 Display / hide 】

  • Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Measurement engineering

  • Informatics / Perceptual information processing

  • Life Science / Biomedical engineering

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Research Keywords 【 Display / hide 】

  • medical imaging

  • biomagnetics

  • magnetic resonance imaging

  • magnetic particle imaging

  • magnetoencephalography

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Research Themes 【 Display / hide 】

  • Measurement and analysis methods for magnetic particle imaging, 

    2026.04
    -
    Present

  • Measurement and analysis methods for magnetoencephalograpgy, 

    2021.04
    -
    Present

  • Quantitative tissue-property imaging using MRI, 

    2018.04
    -
    Present

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Proposed Theme of Joint Research 【 Display / hide 】

  • Magnetic compensation system for naturalistic magnetoencephalography

    Interested in joint research with industry (including private organizations, etc.),  Desired form： Technical Consultation, Funded Research, Cooperative Research

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Papers 【 Display / hide 】

  • Enhancing Current-Source Imaging in Magnetocardiography: The Impact of Sensor Array Configuration

    Wenyu Shang, Motofumi Fushimi, Shinichi Chikaki, Masaki Sekino

    Annals of Biomedical Engineering (Springer Science and Business Media LLC)   2026.08

    Accepted,  ISSN  0090-6964

    　View Summary

    Abstract

    While magnetocardiography (MCG) is a non-invasive tool for assessing cardiac electrophysiology, its conventional planar sensor array often struggles to accurately estimate sources distant from the sensor. This limitation hinders the precise localization of deep cardiac activity. This study aims to overcome this challenge by investigating a novel cylindrical sensor array designed to improve source current estimation accuracy. We combined numerical simulations, phantom measurements, and in vivo rat experiments to compare a cylindrical sensor array with a conventional planar array. Single dipole localization was used in the simulation and phantom experiments under controlled focal source conditions, whereas both single-dipole fitting and minimum norm estimation (MNE)-based distributed source analyses were applied to the animal MCG data. The simulations and phantom measurements showed that the cylindrical array achieved more accurate single-dipole localization than the planar array under comparable sensor–source distance conditions. In the animal experiments, this advantage was not clearly observed using single-dipole fitting. The MNE-based distributed source analysis showed geometry-dependent reconstruction patterns, with the cylindrical array producing more posteriorly distributed activity and higher source map repeatability. The cylindrical sensor array provided complementary spatial information to anterior planar sampling, particularly for deeper or posterior cardiac activity. These findings suggest that surrounding sensor coverage may provide complementary information for MCG-based reconstruction, although further validation with realistic activation models remains necessary.

  • Real-Time Active Magnetic Compensation Based on Multipole Expansion for Magnetoencephalography under Arbitrary Motion

    Xinyu Cao, Tingyu Zhu, Shinichi Chikaki, Motofumi Fushimi, Masaki Sekino

    IEEE Transactions on Instrumentation and Measurement (Institute of Electrical and Electronics Engineers (IEEE))     1 - 1 2026.06

    Accepted,  ISSN  0018-9456

  • Magnetoencephalography measurement of somatosensory responses in optogenetic rats using optically pumped magnetometer

    Kanta Komuro, Motofumi Fushimi, Yuta Kainuma, Tingyu Zhu, Seiko Funatani, Shinichi Chikaki, Hiroshi Tomita, Hiromu Yawo, Masaki Sekino

    AIP Advances (AIP Publishing)  16 ( 3 )  2026.03

    Accepted

    　View Summary

    The aim of this study was to evaluate the effectiveness of optical stimulation in optogenetically modified rats for magnetoencephalographic (MEG) measurements in small animals. Inducing such responses through external stimulation and recording them with MEG is important for elucidating the fundamental brain mechanisms. Various stimulation methods, including electrical stimulation, have been proposed, but obtaining somatosensory responses in small animals with MEG remains difficult due to mechanical noise and electromagnetic interference. In this work, we employed optical stimulation of whiskers in channelrhodopsin-2 (ChR2)-expressing rats. Optical stimulation provides precise control, localized delivery via optical fibers, and nonmagnetic compatibility, making it well suited for MEG measurements. We used optically pumped magnetometers (OPMs), which offer the advantage of operating without a helium-based cryogenic cooling system, unlike conventional superconducting quantum interference device SQUID sensors. A custom jig was developed to construct a gradiometric measurement system with five OPM sensors inside a magnetic shield room. Whiskers of ChR2 rats were stimulated with blue light (473 nm), and brain magnetic fields were recorded at 64 locations with 6.25 mm spacing. Averaged responses revealed somatosensory-evoked magnetic fields of several hundred fT at 50 ms latency, yielding reliable dipolar field maps over a 5 × 5 cm2 area.

  • Magnetic Stimulation Counteracts the Progression of Immobilization‐Induced Muscle Atrophy in Rats

    Giyoung Kwoun, Imari Mimura, Hiroshi Nishi, Hironobu Takahashi, Karina Kouzaki, Jiawei Wan, Motofumi Fushimi, Takehito Sugasawa, Koichi Nakazato, Masaki Sekino, Masaomi Nangaku

    JCSM Communications (Wiley)  9 ( 1 )  2026.01

    Accepted,  ISSN  2996-1394

    　View Summary

    ABSTRACT

    Background

    Physical exercise is recommended for sarcopenia prevention and treatment. Patients with frailty often show poor tolerance. To achieve universal availability, electrical stimulation of skeletal muscles has been devised, but concerns remain regarding efficacy and safety. Alternatively, magnetic stimulation could theoretically induce skeletal muscle contractions by remotely inducing electric fields, which may be a promising noninvasive approach. Our objective is to examine the efficacy and underlying mechanisms of magnetic stimulation against disuse muscle atrophy in a rat model of wire hindlimb immobilization.

    Methods

    Rats were divided into the following three groups: control ( n  = 5), those with spiral wire immobilization (SWI)‐induced hindlimb muscle atrophy ( n  = 6) and those with SWI undergoing magnetic stimulation ( n  = 5). Magnetic stimulation was set at 30 Hz, intensity 25%, 800 trains and 12 000 pulses/day for 5 days. Rats were evaluated for muscle strength and harvested soleus and gastrocnemius muscles for transcriptome and metabolome analysis.

    Results

    The body weight (144.8 ± 6.5 g vs. 175.2 ± 5.6 g) and the weight of the soleus (0.037 ± 0.01 g vs. 0.065 ± 0.01 g) and gastrocnemius muscles (0.599 ± 0.02 g vs. 0.966 ± 0.05 g) were lower in the SWI than the controls ( p  < 0.05). Intriguingly, the weight of gastrocnemius muscle (0.654 ± 0.024 g vs. 0.599 ± 0.01 g, p  < 0.05) and maximal knee extension twitch torque (110.49 ± 8.57 mNm vs. 84.57 ± 6.61 mNm, p  < 0.05) were greater in rats with SWI and magnetic stimulation than in rats with SWI alone. RNA‐seq identified 469 genes that were downregulated by SWI, 190 genes that were upregulated by magnetic stimulation. Metabolome profiling indicated altered glutathione metabolism in SWI muscles (−Log10(P‐value) = 3.2, −Log10(false discovery rate, FDR) = 1.6), whereas magnetic stimulation influenced purine metabolism (−Log10(P‐value) = 2.8, −Log10(FDR) = 0.9), partially supported by RNA‐seq differentially expressed gene list. In engineered human muscle tissues, treatment with 1 μM L‐alanosine, a purine metabolism inhibitor, negatively affected the maintenance of the electric pulse stimulation‐induced contractile function; twitch forces were 0.12 ± 0.09 mN with 0.69 ± 0.14 mN as control ( p  < 0.05) and tetanic forces were 0.28 ± 0.23 mN with 1.55 ± 0.33 mN as control ( p  < 0.05).

    Conclusions

    Magnetic stimulation counteracted the loss of weight and function of murine gastrocnemius muscle induced by immobilization and may have the potential to halt the progression of sarcopenia via alteration of the metabolic pathway in the muscle.

  • Potential of Deeper Brain Stimulation using Magnetic Fields

    Masaki Sekino, Anna Iino, Motofumi Fushimi

    IEEJ Transactions on Fundamentals and Materials (Institute of Electrical Engineers of Japan (IEE Japan))  145 ( 11 ) 348 - 353 2025.11

    Accepted,  ISSN  0385-4205

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Reviews, Commentaries, etc. 【 Display / hide 】

  • 多重極モデルに基づく脳磁図の計測・解析技術

    伏見幹史

    計測と制御 65 ( 2 ) 111 - 116 2026.02

    Article, review, commentary, editorial, etc. (scientific journal), Single Work, Lead author, Corresponding author

  • 脳疾患治療のための磁気刺激

    伏見幹史, 飯野杏菜

    まぐね 20 ( 2 )  2025.04

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Lead author, Corresponding author

  • MRIを用いた人体内部の電気特性の画像化

    奈良高明, 伏見幹史

    Medical Imaging Technology 38 ( 3 ) 85 - 90 2020.03

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work

  • MR画像の撮像原理

    伏見幹史

    計測と制御 58 ( 7 ) 520 - 524 2019.07

    Article, review, commentary, editorial, etc. (scientific journal), Single Work, Lead author, Corresponding author

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Presentations 【 Display / hide 】

  • 多点多重極展開に基づく運動時脳磁図計測のための磁気補償法

    金鶴怜央, 伏見幹史

    計測自動制御学会 第43回センシングフォーラム, 

    2026.09
    , 

    Oral presentation (general)

  • Forward Equations and Inversion Methods in Moment Domain For focally Extended Source Identification in MEG

    Motofumi Fushimi

    The 24th International Conference on Biomagnetism, 

    2026.08
    , 

    Poster presentation

  • Investigation of the Effects of Sensor Array Geometry on Magnetocardiographic Measurements

    Wenyu Shang, Shinichi Chikaki, Motofumi Fushimi, Masaki Sekino

    The 24th International Conference on Biomagnetism, 

    2026.08
    , 

    Poster presentation

  • 多重極展開の座標変換に基づくウェアラブルMEG用磁気補償システム

    伏見幹史, 藤井暉大, 関野正樹, 奈良高明

    第41回日本生体磁気学会大会, 

    2026.06
    , 

    Poster presentation

  • 磁場・温度のマルチモーダル計測可能な 高感度ダイヤモンド量子磁力計

    小室幹太,貝沼雄太,伏見幹史,関口直太,眞榮力,宮川仁,谷口尚,寺地徳之,阿部浩之,小野田忍,大島武,波多野睦子,岩﨑孝之,関野正樹

    第73回応用物理学会春季学術講演会, 

    2026.03
    , 

    Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 磁場と電流源の多重極モデルに基づく脳磁図計測システムの開発

    2025.04
    -
    2028.03

    日本学術振興会, 科学研究費助成事業, 若手研究, No Setting

  • 頭部導体形状を考慮した脳磁図逆問題解析による高分解能脳活動領域マッピング

    2025.04
    -
    2027.03

    みずほ学術振興財団, Research grant, Principal investigator

  • 単一MRI撮像に基づく生体組織の電磁気特性イメージング

    2025.04
    -
    2027.03

    中谷財団, Research grant, Principal investigator

  • MRIを用いた波動場計測に基づく生体内物性値分布の再構成

    2025.04
    -
    2027.03

    栢森情報科学振興財団, Research grant, No Setting

  • ウェアラブル脳磁図計測のための磁気式トラッキングおよび神経電流源マッピング

    2025.04
    -
    2027.03

    旭硝子財団, Research grant, Principal investigator

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Intellectual Property Rights, etc. 【 Display / hide 】

  • 電流源推定システム、方法、およびプログラム

    Date applied： 特願2024-143253  2024.08 

    Patent

  • 経頭蓋磁気刺激コイル

    Date applied： 特願2024-016984  2024.02 

    Patent

  • INFORMATION PROCESSING APPARATUS AND INFORMATION PROCESSING METHOD

    Date applied： 特願US 17/585742  2022.01 

    Date announced： 特開US 2022/0236352  2022.07 

    Patent

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Awards 【 Display / hide 】

  • 第41回日本生体磁気大会 U35奨励賞

    伏見幹史, 2026.06, 日本生体磁気大会, 多重極展開の座標変換に基づくウェアラブルMEG用磁気補償システム

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 2025年優秀論文発表賞（A部門研究会）

    伏見幹史, 2026.03, 電気学会, 運動時脳磁図のための適応的磁気補償システム

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 2025年度計測自動制御学会学術奨励賞

    伏見幹史, 2026.03, 計測自動制御学会, 無限次多重極展開に基づく脳磁図の干渉信号分離

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • Podium in permittivity reconstruction, The first MR Electrical Properties Tomography (MR-EPT) Reconstruction Challenge

    Motofumi Fushimi, 2024.09, EMTP Study Group, International Society for Magnetic Resonance in Medicine

    Type of Award： Award from international society, conference, symposium, etc.

  • 研究奨励賞

    伏見幹史, 2023.12, 電気学会マグネティックス技術委員会, 磁場の多重極展開に基づく磁性ナノ粒子制御のための磁気力場最適化

    Type of Award： Award from Japanese society, conference, symposium, etc.

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Other 【 Display / hide 】

  • Contributor of MNE-Python

    2024年

    　View Details

    Open-source Python package for exploring, visualizing, and analyzing human neurophysiological data: MEG, EEG, sEEG, ECoG, NIRS, and more.
    https://mne.tools/1.7/changes/v1.7.html

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Courses Taught 【 Display / hide 】

  • LABORATORIES IN SCIENCE AND TECHNOLOGY

    2026

  • LABORATORY IN SCIENCE

    2026

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Courses Previously Taught 【 Display / hide 】

  • 理工学基礎実験（ニューラルネットワークの基礎）

    慶應義塾大学

    2026.04
    -
    Present

  • 自然科学実験（弾性率）

    慶應義塾大学

    2026.04
    -
    Present

  • システム情報工学設計演習（プロジェクト演習）

    東京大学

    2025.04
    -
    2026.03

  • システム情報工学実験第一（演算増幅器の基礎とセンサ回路への応用）

    東京大学

    2025.04
    -
    2026.03

  • バイオエンジニアリング夏季実験（MRIの基礎）

    東京大学

    2021.04
    -
    2025.03

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Social Activities 【 Display / hide 】

  • 量子現象に基づく生体イメージング

    QST量子生命科学研究所, 量子生命科学サマーセミナー2023 スピンが描く生命科学の世界, 

    , 
    2023.09
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Memberships in Academic Societies 【 Display / hide 】

  • 電気学会, 

    2024.10
    -
    Present

  • Japanese Society for Magnetic Resonance in Medicine, 

    2024.07
    -
    Present

  • Institute of Electrical and Electronics Engineers, 

    2024.04
    -
    Present

  • Japan Biomagnetism and Bioelectromagnetics Society, 

    2024.04
    -
    Present

  • International Society for Magnetic Resonance in Medicine, 

    2018.06
    -
    Present

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Committee Experiences 【 Display / hide 】

  • 2024.10
    -
    2027.09

    バイオ・医療分野における磁気関連技術に関する調査専門委員会 委員, 電気学会

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