KEIO RESEARCHERS INFORMATION SYSTEM

Career 【 Display / hide 】

Career 【 Display / hide 】

• 2018.04

  -

  2021.03

  Japan Society for the Promotion of Science, Research Fellow (DC1)

• 2019.04

  -

  2020.03

  Visiting Graduate Assistant, Department of Radiology, Weill Cornell Medicine

• 2021.04

  -

  2025.03

  The University of Tokyo, The Graduate School of Engineering Department of Bioengineering, Project Assistant Professor

• 2025.04

  -

  2026.03

  The University of Tokyo, The Graduate School of Information Science and Technology Department of Information Physics and Computing, 助教

• 2026.04

  -

  Present

  Keio University, Faculty of Science and Technology Department of Applied Physics and Physico-Informatics, Assistant Professor

Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 2014.04

  -

  2016.03

  The University of Tokyo, The Faculty of Engineering, 計数工学科

• 2016.04

  -

  2018.03

  The University of Tokyo, The Graduate School of Information Science and Technology, Department of Information Physics and Computing

• 2018.04

  -

  2021.03

  The University of Tokyo, The Graduate School of Information Science and Technology, Department of Information Physics and Computing

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• 博士（情報理工学）, The University of Tokyo, Coursework, 2021.03

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Measurement engineering

• Informatics / Perceptual information processing

• Life Science / Biomedical engineering

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• medical imaging

• biomagnetics

• magnetic resonance imaging

• transcranial magnetic stimulation

• magnetoencephalography

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Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Magnetoencephalography measurement of somatosensory responses in optogenetic rats using optically pumped magnetometer

  Kanta Komuro, Motofumi Fushimi, Yuta Kainuma, Tingyu Zhu, Seiko Funatani, Shinichi Chikaki, Hiroshi Tomita, Hiromu Yawo, Masaki Sekino

  AIP Advances (AIP Publishing)  16 ( 3 )  2026.03

  Accepted

  　View Summary

  The aim of this study was to evaluate the effectiveness of optical stimulation in optogenetically modified rats for magnetoencephalographic (MEG) measurements in small animals. Inducing such responses through external stimulation and recording them with MEG is important for elucidating the fundamental brain mechanisms. Various stimulation methods, including electrical stimulation, have been proposed, but obtaining somatosensory responses in small animals with MEG remains difficult due to mechanical noise and electromagnetic interference. In this work, we employed optical stimulation of whiskers in channelrhodopsin-2 (ChR2)-expressing rats. Optical stimulation provides precise control, localized delivery via optical fibers, and nonmagnetic compatibility, making it well suited for MEG measurements. We used optically pumped magnetometers (OPMs), which offer the advantage of operating without a helium-based cryogenic cooling system, unlike conventional superconducting quantum interference device SQUID sensors. A custom jig was developed to construct a gradiometric measurement system with five OPM sensors inside a magnetic shield room. Whiskers of ChR2 rats were stimulated with blue light (473 nm), and brain magnetic fields were recorded at 64 locations with 6.25 mm spacing. Averaged responses revealed somatosensory-evoked magnetic fields of several hundred fT at 50 ms latency, yielding reliable dipolar field maps over a 5 × 5 cm2 area.

  • Access to Document (DOI)

• Magnetic Stimulation Counteracts the Progression of Immobilization‐Induced Muscle Atrophy in Rats

  Giyoung Kwoun, Imari Mimura, Hiroshi Nishi, Hironobu Takahashi, Karina Kouzaki, Jiawei Wan, Motofumi Fushimi, Takehito Sugasawa, Koichi Nakazato, Masaki Sekino, Masaomi Nangaku

  JCSM Communications (Wiley)  9 ( 1 )  2026.01

  Accepted,  ISSN  2996-1394

  　View Summary

  ABSTRACT
  
  Background
  
  Physical exercise is recommended for sarcopenia prevention and treatment. Patients with frailty often show poor tolerance. To achieve universal availability, electrical stimulation of skeletal muscles has been devised, but concerns remain regarding efficacy and safety. Alternatively, magnetic stimulation could theoretically induce skeletal muscle contractions by remotely inducing electric fields, which may be a promising noninvasive approach. Our objective is to examine the efficacy and underlying mechanisms of magnetic stimulation against disuse muscle atrophy in a rat model of wire hindlimb immobilization.
  
  Methods
  
  Rats were divided into the following three groups: control ( n  = 5), those with spiral wire immobilization (SWI)‐induced hindlimb muscle atrophy ( n  = 6) and those with SWI undergoing magnetic stimulation ( n  = 5). Magnetic stimulation was set at 30 Hz, intensity 25%, 800 trains and 12 000 pulses/day for 5 days. Rats were evaluated for muscle strength and harvested soleus and gastrocnemius muscles for transcriptome and metabolome analysis.
  
  Results
  
  The body weight (144.8 ± 6.5 g vs. 175.2 ± 5.6 g) and the weight of the soleus (0.037 ± 0.01 g vs. 0.065 ± 0.01 g) and gastrocnemius muscles (0.599 ± 0.02 g vs. 0.966 ± 0.05 g) were lower in the SWI than the controls ( p  < 0.05). Intriguingly, the weight of gastrocnemius muscle (0.654 ± 0.024 g vs. 0.599 ± 0.01 g, p  < 0.05) and maximal knee extension twitch torque (110.49 ± 8.57 mNm vs. 84.57 ± 6.61 mNm, p  < 0.05) were greater in rats with SWI and magnetic stimulation than in rats with SWI alone. RNA‐seq identified 469 genes that were downregulated by SWI, 190 genes that were upregulated by magnetic stimulation. Metabolome profiling indicated altered glutathione metabolism in SWI muscles (−Log10(P‐value) = 3.2, −Log10(false discovery rate, FDR) = 1.6), whereas magnetic stimulation influenced purine metabolism (−Log10(P‐value) = 2.8, −Log10(FDR) = 0.9), partially supported by RNA‐seq differentially expressed gene list. In engineered human muscle tissues, treatment with 1 μM L‐alanosine, a purine metabolism inhibitor, negatively affected the maintenance of the electric pulse stimulation‐induced contractile function; twitch forces were 0.12 ± 0.09 mN with 0.69 ± 0.14 mN as control ( p  < 0.05) and tetanic forces were 0.28 ± 0.23 mN with 1.55 ± 0.33 mN as control ( p  < 0.05).
  
  Conclusions
  
  Magnetic stimulation counteracted the loss of weight and function of murine gastrocnemius muscle induced by immobilization and may have the potential to halt the progression of sarcopenia via alteration of the metabolic pathway in the muscle.

  • Access to Document (DOI)

• Potential of Deeper Brain Stimulation using Magnetic Fields

  Masaki Sekino, Anna Iino, Motofumi Fushimi

  IEEJ Transactions on Fundamentals and Materials (Institute of Electrical Engineers of Japan (IEE Japan))  145 ( 11 ) 348 - 353 2025.11

  Accepted,  ISSN  0385-4205

  • Access to Document (DOI)

• Volume current coupling—remote direct neural coupling across the extracellular space

  Ayumu Matani, Yusuke Takeda, Motofumi Fushimi, Akira Tsukamura

  Brain Research (Elsevier BV)  1871 ( 15 ) 150066 - 150066 2025.11

  Accepted,  ISSN  0006-8993

  • Access to Document (DOI)

• Development of Size-Tunable Superparamagnetic Iron Oxide/Fluorescent Conjugated Polymer Composite Nanoparticles for Sentinel Lymph Node Biopsy

  Huanyu Zhang, Haruka Ono, Koya Chubachi, Noriko Nakamura, Junichi Tabata, Motofumi Fushimi, Masaki Sekino, Seiichi Ohta

  ACS Applied Materials & Interfaces (American Chemical Society (ACS))  17 ( 44 )  2025.10

  Accepted,  ISSN  1944-8244

  • Access to Document (DOI)

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Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• 多重極モデルに基づく脳磁図の計測・解析技術

  伏見幹史

  計測と制御 65 ( 2 ) 111 - 116 2026.02

  Lead author, Corresponding author

• 脳疾患治療のための磁気刺激

  伏見幹史, 飯野杏菜

  まぐね 20 ( 2 )  2025.04

  Lead author, Corresponding author

• MRIを用いた人体内部の電気特性の画像化

  奈良高明, 伏見幹史

  Medical Imaging Technology 38 ( 3 ) 85 - 90 2020.03

• MR画像の撮像原理

  伏見幹史

  計測と制御 58 ( 7 ) 520 - 524 2019.07

  Lead author, Corresponding author

Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• 磁場・温度のマルチモーダル計測可能な 高感度ダイヤモンド量子磁力計

  小室幹太,貝沼雄太,伏見幹史,関口直太,眞榮力,宮川仁,谷口尚,寺地徳之,阿部浩之,小野田忍,大島武,波多野睦子,岩﨑孝之,関野正樹

  第73回応用物理学会春季学術講演会, 

  2026.03

  , 

  Oral presentation (general)

• Magnetoencephalographic mapping by optical stimulation of optogenetic rats using Optically pumped magnetometers

  Kanta Komuro,Motofumi Fushimi,Yuta Kainuma,Tingyu Zhu,Seiko Funatani,Shinichi Chikaki,Masaki Sekino

  The 70th Annual Conference on Magnetism and Magnetic Materials, 

  2025.10

  , 

  Oral presentation (general)

• 無限次多重極展開に基づく脳磁図の干渉信号分離

  伏見 幹史,奈良 高明

  計測自動制御学会 第42回センシングフォーラム, 

  2025.09

  , 

  Oral presentation (general)

• 電気特性イメージングに向けたマルチエコーBloch–Siegertシフト法による複素B1マッピング

  伏見幹史,草将澄秋,関野正樹

  第53回日本磁気共鳴医学会大会, 

  2025.08

  , 

  Oral presentation (general)

• Design of Magnetic Flux Concentrators for NV-Diamond Magnetoencephalography

  Tingyu Zhu,Naota Sekiguchi,Yuta Kainuma,Motofumi Fushimi,Takayuki Iwasaki,Mutsuko Hatano,Masaki Sekino

  The 47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 

  2025.07

  , 

  Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• 磁場と電流源の多重極モデルに基づく脳磁図計測システムの開発

  2025.04

  -

  2028.03

  日本学術振興会, 科学研究費助成事業, 若手研究, No Setting

• 頭部導体形状を考慮した脳磁図逆問題解析による高分解能脳活動領域マッピング

  2025.04

  -

  2027.03

  みずほ学術振興財団, Research grant, Principal investigator

• ウェアラブル脳磁図計測のための磁気式トラッキングおよび神経電流源マッピング

  2025.04

  -

  2027.03

  旭硝子財団, Research grant, Principal investigator

• 単一MRI撮像に基づく生体組織の電磁気特性イメージング

  2025.04

  -

  2027.03

  中谷財団, Research grant, Principal investigator

• MRIを用いた波動場計測に基づく生体内物性値分布の再構成

  2025.04

  -

  2027.03

  栢森情報科学振興財団, Research grant, No Setting

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Intellectual Property Rights, etc. 【 Display / hide 】

Intellectual Property Rights, etc. 【 Display / hide 】

• 電流源推定システム、方法、およびプログラム

  Date applied： 特願2024-143253  2024.08 

  Patent

• 経頭蓋磁気刺激コイル

  Date applied： 特願2024-016984  2024.02 

  Patent

• INFORMATION PROCESSING APPARATUS AND INFORMATION PROCESSING METHOD

  Date applied： 特願US 17/585742  2022.01 

  Date announced： 特開US 2022/0236352  2022.07 

  Patent

Awards 【 Display / hide 】

Awards 【 Display / hide 】

• 2025年優秀論文発表賞（A部門研究会）

  2026.03, 電気学会, 運動時脳磁図のための適応的磁気補償システム

• 2025年度計測自動制御学会学術奨励賞

  伏見幹史, 2026.03, 計測自動制御学会, 無限次多重極展開に基づく脳磁図の干渉信号分離

• Podium in permittivity reconstruction, The first MR Electrical Properties Tomography (MR-EPT) Reconstruction Challenge

  Motofumi Fushimi, 2024.09, EMTP Study Group, International Society for Magnetic Resonance in Medicine

• 研究奨励賞

  伏見幹史, 2023.12, 電気学会マグネティックス技術委員会, 磁場の多重極展開に基づく磁性ナノ粒子制御のための磁気力場最適化

• 第13回医用生体電磁気学シンポジウム 若手優秀賞

  伏見幹史, 2021.04, 医用生体電磁気学研究会, MRI計測に基づく生体組織の電気特性イメージング

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Other 【 Display / hide 】

Other 【 Display / hide 】

• Contributor of MNE-Python

  2024年

  　View Details

  Open-source Python package for exploring, visualizing, and analyzing human neurophysiological data: MEG, EEG, sEEG, ECoG, NIRS, and more.
  https://mne.tools/1.7/changes/v1.7.html

Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• LABORATORIES IN SCIENCE AND TECHNOLOGY

  2026

• LABORATORY IN SCIENCE

  2026

Courses Previously Taught 【 Display / hide 】

Courses Previously Taught 【 Display / hide 】

• システム情報工学設計演習（プロジェクト演習）

  東京大学

  2025.04

  -

  2026.03

• システム情報工学実験第一（演算増幅器の基礎とセンサ回路への応用）

  東京大学

  2025.04

  -

  2026.03

• バイオエンジニアリング夏季実験（MRIの基礎）

  東京大学

  2021.04

  -

  2025.03

Social Activities 【 Display / hide 】

Social Activities 【 Display / hide 】

• 量子現象に基づく生体イメージング

  QST量子生命科学研究所, 量子生命科学サマーセミナー2023 スピンが描く生命科学の世界, 

  , 

  2023.09

Memberships in Academic Societies 【 Display / hide 】

Memberships in Academic Societies 【 Display / hide 】

• 電気学会, 

  2024.10

  -

  Present

• Japanese Society for Magnetic Resonance in Medicine, 

  2024.07

  -

  Present

• Institute of Electrical and Electronics Engineers, 

  2024.04

  -

  Present

• Japan Biomagnetism and Bioelectromagnetics Society, 

  2024.04

  -

  Present

• International Society for Magnetic Resonance in Medicine, 

  2018.06

  -

  Present

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Committee Experiences 【 Display / hide 】

Committee Experiences 【 Display / hide 】

• 2024.10

  -

  2027.09

  バイオ・医療分野における磁気関連技術に関する調査専門委員会 委員, 電気学会