慶應義塾研究者情報データベース

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• 2017年04月

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  2019年03月

  慶應義塾大学病院　地域-大学循環プログラム, 初期臨床研修医

• 2019年04月

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  2020年03月

  慶應義塾大学医学部, 救急医学, 専攻医

• 2020年04月

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  2021年03月

  済生会宇都宮病院, 救急集中治療科, 専攻医

• 2021年04月

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  2021年12月

  慶應義塾大学医学部, 救急医学, 専攻医

• 2022年01月

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  2022年03月

  国立病院機構東京医療センター, 救急科, 専攻医

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• 2011年04月

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  2017年03月

  慶應義塾大学　医学部

  大学, 卒業

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• 医師免許, 2017年03月

• 救急科専門医, 2023年01月

• 集中治療科専門医, 2026年04月

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• ライフサイエンス / 救急医学

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• Optimal route of supplementary protein delivery for physical recovery in critically ill patients: Protocol for a multicenter randomized clinical trial

  Yoshida M., Yamamoto R., Sagawa M., Toshima G., Ukita S., Higashibeppu N., Tatsumi H., Matsuo Y., Yoneda R., Ishihara E., Ogawa H., Kuronuma N., Yoshida T., Tampo A., Ishii K., Katsura Y., Inoue K., Takatani Y., Suzuki T., Tampo A., Araki S., Minoura A., Suzuki G., Morinaga K., Kaku M., Suganuma S., Yamanaka T., Ota Y., Ookawa R., Iino M., Nakamura K.

  Clinical Nutrition Espen 73 2026年06月

  ISSN  2405-4577

  　概要を見る

  Background and aims Approximately 50% of critically ill patients develop physical impairment following intensive care. To overcome this impairment, major international guidelines for nutrition therapy recommend a higher protein intake than the standard dose. However, the optimal delivery route of additional protein supplementation to achieve protein target intake remains unclear. Therefore, this trial aims to identify the optimal route for supplementary protein delivery, either enteral nutrition (EN) alone or EN combined with parenteral amino acid supplementation, on physical outcomes. Methods This is a nationwide multicenter open-label randomized parallel-group trial. This study will encompass adult patients admitted to intensive care units in which EN can be initiated within 48 h of admission. Participants will be assigned to either the EN-only group (all protein provided enterally using high-protein EN formulas) or the EN + PN group (protein provided via EN combined with supplementary intravenous amino acids using standard-protein EN formulas) to achieve the target dose. The nutritional targets are 20–30 kcal/kg/day for energy and 1.5–1.8 g/kg/day for protein within 3–5 days post-EN initiation. The primary outcome is functional independence, defined as a Barthel Index score of ≥ 85, at 90 days following randomization. Ethics and dissemination The Ethics Committee of Keio University School of Medicine approved this study (approval number: 20251054). Written informed consent will be obtained from all participants or their legal representatives. Trial registration This protocol was registered at the University Hospital Medical Information Network Clinical Trials Registry on July 12, 2025 (UMIN000058441: https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000066822 )

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• Potential return of spontaneous circulation in Japanese out-of-hospital cardiac arrest patients with pseudo–pulseless electrical activity: a post hoc analysis of a prospective multicentric study

  Horikoshi Y., Hamaguchi J., Ishizawa R., Yamanaka T., Shimizu K., Kitamura N., Homma Y., Funakoshi H., Tagami T., Yasunaga H., Takeda M., Aso S., Yamanaka T., Shimizu K., Kitamura N., Funakoshi H., Yasunaga H., Aso S.

  Resuscitation Plus 29 2026年05月

  ISSN  2666-5204

  　概要を見る

  Introduction As of yet, there are few studies of Asian patients with pseudo-pulseless electrical activity (PEA). Japanese patients with out-of-hospital cardiac arrest (OHCA) tend to be elderly, experience cardiac arrest while at home, and present with severe illness. The present study evaluated the prognostic implications of pseudo-PEA in a Japanese cohort with a high risk of OHCA. Methods The present study is a post hoc analysis of SOS-KANTO 2017, a prospective, multicentric study which included OHCA patients with PEA on hospital arrival who underwent echocardiographic assessment during resuscitation. The patients were categorized into a pseudo-PEA and a true PEA group. The primary outcome was the return of spontaneous circulation (ROSC). The secondary outcomes included survival to hospital admission, 30-day survival, and a favorable neurological status at discharge. Logistic regression was performed with cardiac activity as the primary predictor after adjusting for covariates. Results Of 894 eligible patients, 345 had pseudo-PEA, and 549 had true PEA. In total, 49.3% achieved ROSC. The pseudo-PEA group had a significantly higher rate of ROSC (87.2% vs. 25.5%; p < 0.01). On multivariable logistic regression, the pseudo-PEA group was independently associated with a high ROSC rate (odds ratio [OR]: 22.1; 95% confidence interval [CI]: 14.2–34.3), survival to hospital admission (OR: 17.8; 95% CI: 11.2–28.2), 30-day survival (OR: 51.9; 95% CI: 7.33–367), and favorable neurological outcome at discharge (OR: 14.3; 95% CI: 1.62–125). Conclusion Pseudo-PEA may be associated with a higher rate of ROSC and favorable, short and middle-term outcomes in Japanese patients with OHCA. Early echocardiographic assessment of cardiac activity may help prognostication and guide resuscitation even in high-risk populations.

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• Hydrogen Molecule Delivery System to Ischemic Intestine Using Resuscitative Endovascular Balloon Occlusion of Aorta in Hemorrhagic Shock—A Proof-of-Concept Study

  Yamanaka T., Matsuoka T., Homma K., Tamura T., Suzuki S., Suzuki S., Kaito D., Yoshizawa J., Yajima K., Ono S., Maeshima K., Kobayashi E., Sano M., Sasaki J.

  Biomedicines 14 （ 2 ）  2026年02月

  ISSN  2227-9059

  　概要を見る

  Background: The use of resuscitative endovascular balloon occlusion of the aorta (REBOA) for hemorrhagic shock in the torso has become increasingly common as a bridge to definitive hemostasis. Hydrogen molecules, distributed throughout the bloodstream, alleviate ischemic injury but cannot reach ischemic organs during REBOA use. This study investigates whether intra-aortic irrigation with hydrogen-dissolved saline under REBOA use delivers hydrogen to the intestine in a swine hemorrhagic shock model. Methods: We induced volume-regulated hemorrhagic shock in a 40 kg female swine. Following this, hydrogen-dissolved saline irrigation was initiated through an intra-aortic catheter positioned distal to the REBOA balloon. Hydrogen concentration in the portal vein was determined in four models: controlled hemorrhagic shock with full REBOA inflation during the standard occlusion time, uncontrolled hemorrhagic shock with liver injury and full REBOA inflation during the extended occlusion time, uncontrolled hemorrhagic shock with liver injury and partial REBOA inflation during the extended occlusion time, and as the control model, controlled hemorrhagic shock with full REBOA inflation during the standard occlusion time with normal saline irrigation without hydrogen. Results: Hydrogen concentration in the portal vein was found to be 0.224 mg/L (13.998%) in the controlled hemorrhagic shock model with full REBOA inflation, 0.049 mg/L (3.063%) in the uncontrolled hemorrhagic shock model with liver injury and full REBOA inflation, 0.018 mg/L (1.125%) in the uncontrolled hemorrhagic shock model with liver injury and partial REBOA inflation, and 0.002 mg/L (0.015%) in the control model. These results demonstrate the presence of hydrogen in the portal vein under different REBOA applications. Conclusions: Increased hydrogen concentration in the portal vein indicated that hydrogen was delivered to the intestine. These findings suggest an approach for drug administration during REBOA use. However, further investigations are required to establish its application in clinical settings.

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• Postintensive Care Frailty of Older Patients With Septic Shock: A Post Hoc Analysis of a Multicenter Randomized Controlled Trial

  Yamamoto R., Yamanaka T., Kaito D., Endo A., Yamakawa K., Tagami T., Umemura Y., Sasaki J.

  Critical Care Medicine 2026年

  ISSN  00903493

  　概要を見る

  Objectives: – Postintensive care frailty impairs quality of life in survivors of severe illness. While anabolic hormone deficiency and prolonged inflammation are considered key physiologic mechanisms, specific features associated with frailty progression remain unclear. This study aimed to elucidate clinical characteristics associated with frailty deterioration following recovery from septic shock in older adults. Design: – Post hoc analysis of a randomized controlled trial. Setting: – ICUs in Japan. Patients: – Adults of 65 years or older with septic shock. Measurements and Main Results: – Data were analyzed from a randomized controlled trial investigating optimal blood pressure targets in patients of 65 years or older with septic shock. Frailty at 90 days after intensive care was classified as no-to-mild, moderate, and severe based on the Clinical Frailty Scale (CFS) scores of less than or equal to 4, 5–6, and greater than or equal to 7, respectively. Baseline characteristics, treatments, and outcomes were compared across these frailty categories. Factors associated with postintensive care frailty were identified using ordinal logistic regression fitted with a generalized estimating equation model. Among 513 eligible patients, 339 patients survived to 90 days; 103 patients (30.4%) had no-to-mild frailty, 114 patients (33.6%) had moderate frailty, and 122 patients (36.0%) had severe frailty, respectively. Higher presepsis CFS scores (adjusted odds ratio [aOR], 2.03 [1.72–2.40] per 1-point increase; p < 0.001), higher sequential organ failure assessment (SOFA) scores (aOR, 1.16 [1.06–1.26] per 1-point increase; p < 0.001), and corticosteroid use (aOR, 1.72 [1.14–2.61]; p < 0.001) were independently associated with frailty. Subgroup analyses revealed that corticosteroid use was associated with frailty deterioration in patients with baseline frailty (CFS ≥ 5), whereas SOFA scores were associated with frailty in patients with tissue hypoperfusion (lactate, ≥ 2 mmol/L). Conclusions: – Baseline frailty before sepsis, organ dysfunction severity, and corticosteroid therapy independently predict severe postintensive care frailty in older adults with septic shock.

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• Bacterial contamination of ultrasound probes in emergency departments: a multi-centre observational study

  Yamanaka T., Yamamoto R., Yajima K., Yamashita I., Kurihara T., Kujirai D., Moritani K., Kamikura H., Koh H., Sasaki J.

  Journal of Hospital Infection 163   23 - 29 2025年09月

  ISSN  01956701

  　概要を見る

  Background: Ultrasound is frequently used in emergency departments (EDs) for patient evaluation and diagnosis. Despite the risk of probe contamination from body fluids and blood, the rate of such contamination remains unclear. Aim: This study aimed to evaluate bacterial contamination of ultrasound probes in EDs, focusing on hospital types and reprocessing methods. Methods: A multi-centre prospective observational study was conducted at a university hospital, a non-academic tertiary hospital, and a regional hospital in 2023. Samples were collected from probes used on ED patients. Reprocessing methods included water-moistened wipes alone, water-moistened wipes with ethanol wipes, quaternary ammonium wipes alone, and quaternary ammonium wipes with ethanol or hypochlorite wipes. Outcomes included the level of bacterial contamination, measured by colony-forming units (cfu) per total surface area of each probe, and resistant bacterial strains. Findings: The median cfu was 10 (IQR: 0–50) at the university hospital, 40 (10–135) at the non-academic tertiary hospital, and 30 (1–95) at the regional hospital. By reprocessing method, the median cfu was 20 (1–90) for water-moistened wipes alone, 10 (0–20) for water-moistened wipes and additional ethanol wipe, 90 (40–180) for quaternary ammonium wipes alone, and 20 (1–50) for quaternary ammonium wipe and additional ethanol or hypochlorite wipe. Resistant bacterial strains were found on 18.2% of probes. Conclusion: High levels of bacterial contamination, including resistant strains, were observed on ultrasound probes in EDs, regardless of facility type and reprocessing method.

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• 当院におけるAdvance Care Planningの検討

  高橋 亜実, 堀越 雄一郎, 山中 隆広, 小川 広晃, 山元 良, 佐々木 淳一

  日本救急医学会雑誌 （(一社)日本救急医学会）  36 （ 11 ） 881 - 881 2025年11月

  ISSN  0915-924X

• 二重管気管切開カニューレの使用により院内心停止を防ぐための取り組み

  山中 隆広, 堀越 佑一, 松吉 健夫, 金子 仁, 清水 敬樹

  安全医学 （(一社)日本臨床医学リスクマネジメント学会）  22 （ 増刊号 ） 79 - 79 2025年09月

  ISSN  1349-5224

• 非透視下でECPRを行った心停止症例における大腿動脈穿刺位置と合併症の関連性

  山中 隆広, 堀越 佑一, 清水 敬樹, 佐々木 淳一

  日本集中治療医学会雑誌 （(一社)日本集中治療医学会）  32 （ Suppl.2 ） S687 - S687 2025年09月

  ISSN  1340-7988

• ARDS患者のV-V ECMO中のPEEP設定におけるEITの可能性

  松村 一希, 濱口 純, 山中 隆広, 石澤 嶺, 笠原 道, 佐々木 淳一, 清水 敬樹

  日本救急医学会雑誌 （(一社)日本救急医学会）  35 （ 11 ） 663 - 663 2024年11月

  ISSN  0915-924X

• 非透視下でECPRを行った心停止症例における大腿動脈穿刺位置の特徴

  山中 隆広, 堀越 佑一, 清水 敬樹

  蘇生 （日本蘇生学会）  43 （ 3 ） 183 - 183 2024年11月

  ISSN  0288-4348

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所属学協会 【 表示 ／ 非表示 】

所属学協会 【 表示 ／ 非表示 】

• 日本心肺補助学会, 

  2024年

  -

  継続中

• 日本救急医学会, 

  2019年

  -

  継続中

• 日本熱傷学会, 

  2019年

  -

  継続中

• 日本集中治療医学会, 

  2019年

  -

  継続中