論文 - 寺澤　悠理

Retrospective time estimation following damage to the prefrontal cortex

Kurosaki Y., Terasawa Y., Ibata Y., Hashimoto R., Umeda S.

Journal of Neuropsychology （Journal of Neuropsychology）  14 （ 1 ） 135 - 153 2018年01月

共著,  ISSN  1748-6645

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© 2018 The British Psychological Society Time estimation in patients with prefrontal cortex (PFC) damage is often inaccurate. The relationship between PFC and estimation of short time intervals has been examined. However, it remains unclear whether PFC damage affects estimation of longer time intervals. Here, we investigated the ability of patients and healthy subjects to verbally estimate a period of 30 min, using a method easily applied in clinical settings. In 99 patients with brain damage, we compared under and normal ranges of time in patients with PFC damage or damage to other brain areas with the chi-squared test. Subsequently, we conducted a discriminant analysis and a multiple linear regression analysis to identify specific brain areas affecting time estimation. We observed a significantly larger number of patients who overestimated 30 min in the group with bilateral PFC damage compared to patients with damage to other regions. Discriminant analysis revealed that damage of right lateral PFC and left medial PFC contributed to discrimination between the normal range and overestimation groups. Multiple linear regression analysis indicated that right lateral PFC damage strongly affected overestimation of a 30-min interval. Neuropsychological test results revealed lower general cognitive function scores and orientation scores in overestimation group. The length of estimated time and the score of delayed word recall were negatively correlated. We propose that these may require encoding, maintenance, and updating of memory and are indirectly related to contextual memory. We discuss hypotheses on contextual memory segmentation and reconstruction to clarify the mechanism of impaired time overestimation in PFC-damaged patients.

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Unrecognized Sleep Loss Accumulated in Daily Life Can Promote Brain Hyperreactivity to Food Cue

Katsunuma Ruri, Oba Kentaro, Kitamura Shingo, Motomura Yuki, Terasawa Yuri, Nakazaki Kyoko, Hida Akiko, Moriguchi Yoshiya, Mishima Kazuo

Sleep 40 （ 10 ）  2017年10月

ISSN  0161-8105

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<p>Epidemiological studies have shown that sleep debt increases the risk of obesity. Experimental total sleep deprivation (TSD) has been reported to activate the reward system in response to food stimuli, but food-related responses in everyday sleep habits, which could lead to obesity, have not been addressed. Here, we report that habitual sleep time at home among volunteers without any sleep concerns was shorter than their optimal sleep time estimated by the 9-day extended sleep intervention, which indicates that participants had already been in sleep debt in their usual sleep habits. The amygdala and anterior insula, which are responsible for both affective responses and reward prediction, were found to exhibit significantly lowered activity in the optimal sleep condition. Additionally, a subsequent one-night period of TSD reactivated the right anterior insula in response to food images; however, the activity level of amygdala remained lowered. These findings indicate that (1) our brain is at risk of hyperactivation to food triggers in everyday life, which could be a risk factor for obesity and lifestyle diseases, and (2) optimal sleep appears to reduce this hypersensitivity to food stimuli.</p>

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Recovery from unrecognized sleep loss accumulated in daily life improved mood regulation via prefrontal suppression of amygdala activity

Motomura Yuki, Kitamura Shingo, Nakazaki Kyoko, Oba Kentaro, Katsunuma Ruri, Terasawa Yuri, Hida Akiko, Moriguchi Yoshiya, Mishima Kazuo

Frontiers in Neurology 8 （ JUN ）  2017年06月

ISSN  1664-2295

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<p>Many modern people suffer from sleep debt that has accumulated in everyday life but is not subjectively noticed [potential sleep debt (PSD)]. Our hypothesis for this study was that resolution of PSD through sleep extension optimizes mood regulation by altering the functional connectivity between the amygdala and prefrontal cortex. Fifteen healthy male participants underwent an experiment consisting of a baseline (BL) evaluation followed by two successive interventions, namely, a 9-day sleep extension followed by one night of total sleep deprivation (TSD). Tests performed before and after the interventions included a questionnaire on negative mood and neuroimaging with arterial spin labeling MRI for evaluating regional cerebral blood flow (rCBF) and functional connectivity. Negative mood and amygdala rCBF were significantly reduced after sleep extension compared with BL. The amygdala had a significant negative functional connectivity with the medial prefrontal cortex (FC_amg-MPFC), and this negative connectivity was greater after sleep extension than at BL. After TSD, these indices reverted to the same level as at BL. An additional path analysis with structural equation modeling showed that the FCamg-MPFC significantly explained the amygdala rCBF and that the amygdala rCBF significantly explained the negative mood. These findings suggest that the use of our sleep extension protocol normalized amygdala activity via negative amygdala-MPFC functional connectivity. The resolution of unnoticed PSD may improve mood by enhancing frontal suppression of hyperactivity in the amygdala caused by PSD accumulating in everyday life.</p>

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Time course and localization of brain activity in humor comprehension

Shibata Midori, Terasawa Yuri, Osumi Takahiro, Masui Keita, Ito Yuichi, Sato Arisa, Umeda Satoshi

Brain Research 1657   215 - 222 2017年02月

ISSN  0006-8993

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<p>Although a number of studies have investigated the incongruity-detection and resolution process in humor comprehension, it is difficult to functionally and anatomically dissociate these processes. We used event-related potentials (ERP) and standardized low resolution brain electromagnetic tomography analysis (sLORETA) to examine the time course and localization of brain activity during incongruity detection and resolution. We used the same materials as in our previous fMRI study. Eighteen participants read funny and unfunny scenarios and judged whether the target sentence was funny or not. Results indicated that ERPs elicited by a funny punch line showed a P2 component followed by a P600 component over the centro-parietal electrode sites. Our sLORETA analysis of the P2 ERPs revealed a stronger activation for the funny vs. unfunny condition in the superior frontal gyrus (SFG) and medial prefrontal cortex (mPFC). For the P600 ERPs, the funny punch line elicited greater activation in the temporal-parietal regions. These results indicate that incongruity-detection processes activate the SFG and mPFC in the P2 time window, while incongruity-resolution processes generate activation at the temporal-parietal regions in the P600 time window. These results provide the evidence that verbal humor comprehension is processed in steps which start with the incongruity detection in the early P2 time window and followed by a P600 component reflecting incongruity resolution.</p>

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Prospective memory mediated by interoceptive accuracy

Umeda Satoshi, Tochizawa Saiko, Shibata Midori, Terasawa Yuri

Philosophical Transactions of the Royal Society B: Biological Sciences 371 （ 1708 ）  2016年11月

ISSN  0962-8436

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<p>Previous studies on prospective memory (PM), defined as memory for future intentions, suggest that psychological stress enhances successful PM retrieval. However, the mechanisms underlying this notion remain poorly understood. We hypothesized that PM retrieval is achieved through interaction with autonomic nervous activity, which is mediated by the individual accuracy of interoceptive awareness, as measured by the heartbeat detection task. In this study, the relationship between cardiac reactivity and retrieval of delayed intentions was evaluated using the event-based PM task. Participants were required to detect PM target letters while engaged in an ongoing 2-back working memory task. The results demonstrated that individuals with higher PM task performance had a greater increase in heart rate on PM target presentation. Also, higher interoceptive perceivers showed better PM task performance. This pattern was not observed for working memory task performance. These findings suggest that cardiac afferent signals enhance PM retrieval, which is mediated by individual levels of interoceptive accuracy. This article is part of the themed issue ‘Interoception beyond homeostasis: affect, cognition and mental health’.</p>

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Estimating individual optimal sleep duration and potential sleep debt

Kitamura Shingo, Katayose Yasuko, Nakazaki Kyoko, Motomura Yuki, Oba Kentaro, Katsunuma Ruri, Terasawa Yuri, Enomoto Minori, Moriguchi Yoshiya, Hida Akiko, Mishima Kazuo

Scientific Reports 6 2016年10月

ISSN  2045-2322

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<p>In this study, we hypothesized that dynamics of sleep time obtained over consecutive days of extended sleep in a laboratory reflect an individual's optimal sleep duration (OSD) and that the difference between OSD and habitual sleep duration (HSD) at home represents potential sleep debt (PSD). We found that OSD varies among individuals and PSD showed stronger correlation with subjective/objective sleepiness than actual sleep time, interacting with individual's vulnerability of sleep loss. Furthermore, only 1 h of PSD takes four days to recover to their optimal level. Recovery from PSD was also associated with the improvement in glycometabolism, thyrotropic activity and hypothalamic-pituitary-adrenocortical axis. Additionally, the increase (rebound) in total sleep time from HSD at the first extended sleep would be a simple indicator of PSD. These findings confirmed self-evaluating the degree of sleep debt at home as a useful clinical marker. To establish appropriate sleep habits, it is necessary to evaluate OSD, vulnerability to sleep loss, and sleep homeostasis characteristics on an individual basis.</p>

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Temporal characteristics of thought orientation: an ERP study

Ito, Yuichi, Shibata, Midori, Tanaka, Yuto, Terasawa, Yuri, Umeda, Satoshi

INTERNATIONAL JOURNAL OF PSYCHOLOGY 51   883 - 884 2016年07月

研究論文（学術雑誌）,  ISSN  0020-7594

Attenuated sensitivity to the emotions of others by insular lesion

Terasawa, Yuri, Kurosaki, Yoshiko, Ibata, Yukio, Moriguchi, Yoshiya, Umeda, Satoshi

FRONTIERS IN PSYCHOLOGY 6 2015年09月

研究論文（学術雑誌）, 共著,  ISSN  1664-1078

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Neural networks for mindfulness and emotion suppression

Murakami Hiroki, Katsunuma Ruri, Oba Kentaro, Terasawa Yuri, Motomura Yuki, Mishima Kazuo, Moriguchi Yoshiya

PLoS One 10 （ 6 ）  2015年06月

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<p>Mindfulness, an attentive non-judgmental focus on "here and now" experiences, has been incorporated into various cognitive behavioral therapy approaches and beneficial effects have been demonstrated. Recently, mindfulness has also been identified as a potentially effective emotion regulation strategy. On the other hand, emotion suppression, which refers to trying to avoid or escape from experiencing and being aware of one's own emotions, has been identified as a potentially maladaptive strategy. Previous studies suggest that both strategies can decrease affective responses to emotional stimuli. They would, however, be expected to provide regulation through different top-down modulation systems. The present study was aimed at elucidating the different neural systems underlying emotion regulation via mindfulness and emotion suppression approaches. Twenty-one healthy participants used the two types of strategy in response to emotional visual stimuli while functional magnetic resonance imaging was conducted. Both strategies attenuated amygdala responses to emotional triggers, but the pathways to regulation differed across the two. A mindful approach appears to regulate amygdala functioning via functional connectivity from the medial prefrontal cortex, while suppression uses connectivity with other regions, including the dorsolateral prefrontal cortex. Thus, the two types of emotion regulation recruit different top-down modulation processes localized at prefrontal areas. These different pathways are discussed.</p>

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Fear conditioning induced by interpersonal conflicts in healthy individuals

Tada Mitsuhiro, Uchida Hiroyuki, Maeda Takaki, Konishi Mika, Umeda Satoshi, Terasawa Yuri, Nakajima Shinichiro, Mimura Masaru, Miyazaki Tomoyuki, Takahashi Takuya

PLoS One 10 （ 5 ）  2015年05月

　概要を見る

<p>Psychophysiological markers have been focused to investigate the psychopathology of psychiatric disorders and personality subtypes. In order to understand neurobiological mechanisms underlying these conditions, fear-conditioning model has been widely used. However, simple aversive stimuli are too simplistic to understand mechanisms because most patients with psychiatric disorders are affected by social stressors. The objective of this study was to test the feasibility of a newly-designed conditioning experiment using a stimulus to cause interpersonal conflicts and examine associations between personality traits and response to that stimulus. Twenty-nine healthy individuals underwent the fear conditioning and extinction experiments in response to three types of stimuli: a simple aversive sound, disgusting pictures, and pictures of an actors' face with unpleasant verbal messages that were designed to cause interpersonal conflicts. Conditioned response was quantified by the skin conductance response (SCR). Correlations between the SCR changes, and personality traits measured by the Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) and Revised NEO Personality Inventory were explored. The interpersonal conflict stimulus resulted in successful conditioning, which was subsequently extinguished, in a similar manner as the other two stimuli. Moreover, a greater degree of conditioned response to the interpersonal conflict stimulus correlated with a higher ZANBPD total score. Fear conditioning and extinction can be successfully achieved, using interpersonal conflicts as a stimulus. Given that conditioned fear caused by the interpersonal conflicts is likely associated with borderline personality traits, this paradigm could contribute to further understanding of underlying mechanisms of interpersonal fear implicated in borderline personality disorder.</p>

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Integration of cognitive and affective networks in humor comprehension

Shibata Midori, Terasawa Yuri, Umeda Satoshi

Neuropsychologia 65   137 - 145 2014年12月

ISSN  0028-3932

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<p>Humor comprehension is a complex process that requires the detection and resolution of the incongruity, eliciting a positive feeling of mirth or reward. We conducted a functional magnetic resonance imaging (fMRI) study to identify the key factors involved in this complex process. To reduce the influence of other factors, we utilized a group of sentences that were nearly identical across conditions (i.e., the first two sentences and the punch line were identical, but the third sentence was different). We found that the punch line (target sentence) in the funny condition induced a perception of funniness and elicited greater activation in language and semantic neural networks, which have been implicated in comprehension processing (i.e., incongruity detection and resolution). We also found increased activation in the mesolimbic reward regions, which have been implicated in the experience of positive rewards in the funny condition. Psycho-physiological interaction analyses revealed that language and semantic regions, such as inferior frontal gyrus (IFG), middle temporal gyrus (MTG), superior temporal gyrus (STG), superior frontal gyrus (SFG), and inferior parietal lobule (IPL) are simultaneously activated during humor comprehension processing. These analyses also revealed that the right MTG, the left IPL, and IFG showed enhanced connectivity with the midbrain. Our findings suggest that these networks play a central role in incongruity detection and resolution, as well as in positive emotional response.</p>

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Sleepiness induced by sleep-debt enhanced amygdala activity for subliminal signals of fear

Motomura Yuki, Kitamura Shingo, Oba Kentaro, Terasawa Yuri, Enomoto Minori, Katayose Yasuko, Hida Akiko, Moriguchi Yoshiya, Higuchi Shigekazu, Mishima Kazuo

BMC Neuroscience 15 （ 1 ）  2014年08月

　概要を見る

<p>Background: Emotional information is frequently processed below the level of consciousness, where subcortical regions of the brain are thought to play an important role. In the absence of conscious visual experience, patients with visual cortex damage discriminate the valence of emotional expression. Even in healthy individuals, a subliminal mechanism can be utilized to compensate for a functional decline in visual cognition of various causes such as strong sleepiness. In this study, sleep deprivation was simulated in healthy individuals to investigate functional alterations in the subliminal processing of emotional information caused by reduced conscious visual cognition and attention due to an increase in subjective sleepiness. Fourteen healthy adult men participated in a within-subject crossover study consisting of a 5-day session of sleep debt (SD, 4-h sleep) and a 5-day session of sleep control (SC, 8-h sleep). On the last day of each session, participants performed an emotional face-viewing task that included backward masking of nonconscious presentations during magnetic resonance scanning. Results: Finally, data from eleven participants who were unaware of nonconscious face presentations were analyzed. In fear contrasts, subjective sleepiness was significantly positively correlated with activity in the amygdala, ventromedial prefrontal cortex, hippocampus, and insular cortex, and was significantly negatively correlated with the secondary and tertiary visual areas and the fusiform face area. In fear-neutral contrasts, subjective sleepiness was significantly positively correlated with activity of the bilateral amygdala. Further, changes in subjective sleepiness (the difference between the SC and SD sessions) were correlated with both changes in amygdala activity and functional connectivity between the amygdala and superior colliculus in response to subliminal fearful faces.Conclusion: Sleepiness induced functional decline in the brain areas involved in conscious visual cognition of facial expressions, but also enhanced subliminal emotional processing via superior colliculus as represented by activity in the amygdala. These findings suggest that an evolutionally old and auxiliary subliminal hazard perception system is activated as a compensatory mechanism when conscious visual cognition is impaired. In addition, enhancement of subliminal emotional processing might cause involuntary emotional instability during sleep debt through changes in emotional response to or emotional evaluation of external stimuli.</p>

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Sleepiness induced by sleep-debt enhanced amygdala activity for subliminal signals of fear

Motomura, Yuki, Kitamura, Shingo, Oba, Kentaro, Terasawa, Yuri, Enomoto, Minori, Katayose, Yasuko, Hida, Akiko, Moriguchi, Yoshiya, Higuchi, Shigekazu, Mishima, Kazuo

BMC NEUROSCIENCE 15 2014年08月

研究論文（学術雑誌）, 共著,  ISSN  1471-2202

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Learning Process in Association with Interpersonal Conflict in Healthy Individuals, Using Fear Conditioning Paradigm

Tada, Mitsuhiro, Uchida, Hiroyuki, Maeda, Takaki, Konishi, Mika, Umeda, Satoshi, Terasawa, Yuri, Nakajima, Shinichiro, Mimura, Masaru, Takahashi, Takuya

BIOLOGICAL PSYCHIATRY 75 （ 9 ） 124S - 124S 2014年05月

研究論文（学術雑誌）,  ISSN  0006-3223

Interoceptive sensitivity predicts sensitivity to the emotions of others

Terasawa, Yuri, Moriguchi, Yoshiya, Tochizawa, Saiko, Umeda, Satoshi

COGNITION & EMOTION 28 （ 8 ） 1435 - 1448 2014年

研究論文（学術雑誌）, 共著,  ISSN  0269-9931

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Altered brain activity for phonological manipulation in dyslexic Japanese children

Kita Yosuke, Yamamoto Hisako, Oba Kentaro, Terasawa Yuri, Moriguchi Yoshiya, Uchiyama Hitoshi, Seki Ayumi, Koeda Tatsuya, Inagaki Masumi

Brain 136 （ 12 ） 3696 - 3708 2013年12月

ISSN  0006-8950

　概要を見る

<p>Because of unique linguistic characteristics, the prevalence rate of developmental dyslexia is relatively low in the Japanese language. Paradoxically, Japanese children have serious difficulty analysing phonological processes when they have dyslexia. Neurobiological deficits in Japanese dyslexia remain unclear and need to be identified, and may lead to better understanding of the commonality and diversity in the disorder among different linguistic systems. The present study investigated brain activity that underlies deficits in phonological awareness in Japanese dyslexic children using functional magnetic resonance imaging. We developed and conducted a phonological manipulation task to extract phonological processing skills and to minimize the influence of auditory working memory on healthy adults, typically developing children, and dyslexic children. Current experiments revealed that several brain regions participated in manipulating the phonological information including left inferior and middle frontal gyrus, left superior temporal gyrus, and bilateral basal ganglia. Moreover, dyslexic children showed altered activity in two brain regions. They showed hyperactivity in the basal ganglia compared with the two other groups, which reflects inefficient phonological processing. Hypoactivity in the left superior temporal gyrus was also found, suggesting difficulty in composing and processing phonological information. The altered brain activity shares similarity with those of dyslexic children in countries speaking alphabetical languages, but disparity also occurs between these two populations. These are initial findings concerning the neurobiological impairments in dyslexic Japanese children.</p>

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Altered brain activity for phonological manipulation in dyslexic Japanese children

Kita, Yosuke, Yamamoto, Hisako, Oba, Kentaro, Terasawa, Yuri, Moriguchi, Yoshiya, Uchiyama, Hitoshi, Seki, Ayumi, Koeda, Tatsuya, Inagaki, Masumi

BRAIN 136   3696 - 3708 2013年12月

研究論文（学術雑誌）, 査読有り,  ISSN  0006-8950

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AUTISTIC TRAITS AFFECT NEURAL CORRELATES OF VISUOSPATIAL PERSPECTIVE TAKING

Kanayama, Yusuke, Moriguchi, Yoshiya, Oba, Kentaro, Terasawa, Yuri, Murakami, Hiroki, Mishima, Kazuo, Kumano, Hiroaki

PSYCHOSOMATIC MEDICINE 75 （ 3 ） A165 - A165 2013年04月

研究論文（学術雑誌）,  ISSN  0033-3174

How does interoceptive awareness interact with the subjective experience of emotion? An fMRI Study

Terasawa, Yuri, Fukushima, Hirokata, Umeda, Satoshi

HUMAN BRAIN MAPPING 34 （ 3 ） 598 - 612 2013年03月

研究論文（学術雑誌）, 査読有り,  ISSN  1065-9471

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Anterior insular cortex mediates bodily sensibility and social anxiety

Terasawa, Yuri, Shibata, Midori, Moriguchi, Yoshiya, Umeda, Satoshi

SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE 8 （ 3 ） 259 - 266 2013年03月

研究論文（学術雑誌）, 査読有り,  ISSN  1749-5016

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