KEIO RESEARCHERS INFORMATION SYSTEM

Other Affiliation 【 Display / hide 】

Other Affiliation 【 Display / hide 】

• School of Medicine, 衛生学公衆衛生学教室, 兼担教授

• Graduate School of Health Management, 教授

Career 【 Display / hide 】

Career 【 Display / hide 】

• 2003.06

  -

  2004.03

  神戸大学医学部附属病院, 医員（研修医）

• 2006.04

  -

  2009.09

  神戸大学医学部附属病院　　, 検査部, 医員

• 2009.10

  -

  2011.12

  神戸大学大学院医学研究科, 内科系講座 臨床検査・免疫学分野 立証検査医学部門, 特命助教

• 2010.05

  -

  2021.03

  先端医療センター研究所　, 先制・予防医療研究開発部 コホート研究チーム　, 客員研究員

• 2012.01

  -

  2014.03

  慶應義塾大学医学部, 衛生学公衆衛生学教室　, 助教

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Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 1997.04

  -

  2003.03

  神戸大学, 医学部医学科

  University, Graduated

• 2004.04

  -

  2005.03

  国立保健医療科学院　, 専門課程　生物統計分野

  Other, Completed

• 2005.04

  -

  2009.03

  神戸大学大学院, 医学系研究科　

  Graduate School, Completed

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• Master of Public Health in Biostatistics *現Certified Public Health Professionalに相当, 国立保健医療科学院, 2005.03

• 博士（医学）, 神戸大学, Coursework, 2009.03

Licenses and Qualifications 【 Display / hide 】

Licenses and Qualifications 【 Display / hide 】

• 日本医師会認定産業医

• 診療情報管理士

• 社会医学系専門医協会　専門医・指導医

• 医師免許, 2003.05

• 上級疫学専門家, 2020.04

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Life Science / Medical management and medical sociology

• Life Science / Hygiene and public health (laboratory)

• Life Science / Hygiene and public health (non-laboratory)

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• 健診の有効性

• 生活習慣病疫学

• 臨床検査医学

Books 【 Display / hide 】

Books 【 Display / hide 】

• Lipids and Cardiovascular Diseases: Epidemiologic Perspectives

  Nguyen X.M.T., Wilson P.W.F., Okamura T., Sugiyama D., Hirata T., Kuwabara K., Hirata A., Encyclopedia of Cardiovascular Research and Medicine, 2026.01

  　View Summary

  During the past 70 years, a relationship between low-density lipoprotein cholesterol (LDL-C) and coronary heart disease (CHD) incidence has been established in many countries. Evidence of causality has been provided by the reduction of CHD risk with pharmacologic lowering of LDL-C. These findings have made it possible to develop risk assessment charts for CHD and to detect high-risk individuals for early intervention. However, a causal relation between LDL-C concentration and stroke, remains controversial.

  • Access to Document (DOI)

• 疫学の辞典

  2023.01

• 健康教育マニュアル第2版

  2019.11

• 健康教育マニュアル

  Sugiyama Daisuke, 一般社団法人日本家族計画協会, 2014.07

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Independent and combined associations of body mass index and visceral fat area with kidney function decline in a healthy Japanese urban population: a longitudinal study

  Enami M.S., Hirata A., Kuwabara K., Miyazaki J., Kubota Y., Nishida Y., Kubo S., Hirata T., Uchida T., Kadota A., Higashiyama A., Sugiyama D., Nishikawa T., Miyamatsu N., Miyamoto Y., Okamura T.

  BMC Nephrology 27 ( 1 ) 96 2026.12

  　View Summary

  Background: Obesity has been linked to progressive loss of kidney function, but the independent and combined associations of body mass index (BMI) and visceral fat accumulation remain uncertain in healthy individuals. This study aimed to clarify the longitudinal relationship between BMI, visceral fat area (VFA), and chronic kidney disease (CKD), defined as an estimated glomerular filtration rate based on serum cystatin C (eGFRcys) < 60 mL/min/1.73 m² among the Kobe Study participants targeting healthy urban residents in Japan. Methods: A total of 897 participants (267 men, 630 women) without CKD and with a mean age of 61.4 years were analyzed. VFA was measured using the impedance method, and participants were followed for a median of 8.3 years. Participants were classified into four groups based on baseline BMI (kg/m²) and VFA (cm²): G1 (VFA < 100 and BMI < 25), G2 (VFA < 100 and BMI ≥ 25), G3 (VFA ≥ 100 and BMI < 25), G4 (VFA ≥ 100 and BMI ≥ 25). Multivariable linear regression models were used to estimate adjusted mean annual changes in eGFRcys, and Cox proportional hazards models were applied to calculate hazard ratios (HRs) for incident CKD, adjusting for potential confounders (age, sex, smoking status, alcohol consumption, dyslipidemia, diabetes, hypertension and eGFRcys at baseline). Results: During follow-up, 85 participants (9.5%) developed CKD. The adjusted mean annual decline in eGFRcys was − 2.17% in G1, − 3.29% in G2, − 2.81% in G3, and − 3.81% in G4. Compared with G1, both G3 and G4 showed an elevated risks of CKD incidence (G3: HR 2.40, 95% CI 1.14–5.05; G4: HR 3.89, 95% CI 2.17–6.98), whereas the confidence interval crossed 1 for G2 (HR 0.88, 95% CI 0.12–6.47). Participants in G4 exhibited the steepest decline in kidney function and the highest CKD incidence rate (49.2 per 1,000 person-years). Conclusions: In healthy adults, the combination of elevated BMI and VFA was associated with accelerated kidney function decline. These findings underscore the importance of evaluating visceral fat in addition to BMI for early identification of individuals at increased risk of CKD and enable preventive strategies. Clinical trial number: Not applicable.

  • Access to Document (DOI)

• Development and validation of a dual-perspective competency scale for novice medical laboratory scientists in Japan

  Maekawa K., Sugiyama D., Imanishi T., Oki T., Ohnuma K., Carayannopoulos M.O., Satomi-Kobayashi S., Kawano S.

  BMC Medical Education 26 ( 1 )  2026.12

  　View Summary

  Background: Competency-based education defines competencies as educational outcomes and guiding instruction and assessment. In Japan, standardised competency frameworks for medical laboratory scientists in clinical settings are underdeveloped. This study aimed to develop and validate a competency scale for novice medical laboratory scientists with less than 3 years of clinical experience into an assessment tool. Methods: This study involved scale development and validation conducted in four phases: a preliminary study to test content validity for exploratory purposes, a pilot survey to examine the feasibility of the evaluation sheet under conditions similar to those of the main survey, a main survey to verify reliability and validity and a final phase to establish the completed scale. In the main survey, each novice medical and biomedical laboratory scientist (self-evaluator) was paired with two supervising evaluators from the same institution. The supervising evaluators, comprising educational supervisors, senior medical laboratory scientists or managers, were directly involved in the guidance and assessment of the corresponding novice. Results: Exploratory factor analysis of the self-evaluation dataset identified four factors with 51 items using a five-point Likert scale. The cumulative variance explained by the four factors was 52%, and Cronbach’s alpha ranged from 0.78 to 0.94 for each factor. The validity of the scale was confirmed through confirmatory factor analysis with the supervisory evaluation dataset. Conclusions: The Japan Medical Laboratory Scientists Competency Scale demonstrated robust psychometric properties, establishing it as an effective tool for assessing novice medical laboratory scientists in Japan through self- and supervisory evaluation. Those findings would support enhancements in workforce development and competency-based education in this field.

  • Access to Document (DOI)

• Longitudinal Study of Plasma Metabolites During Menopause and Their Associations With Later Onset of Metabolic Syndrome

  Miyake A., Iida M., Harada S., Sugiyama D., Matsumoto M., Miyagawa N., Toki R., Edagawa S., Hirata A., Kuwabara K., Okamura T., Sato A., Amano K., Hirayama A., Sugimoto M., Soga T., Tomita M., Arakawa K., Kisu I., Yamagami W., Takebayashi T.

  Journal of Clinical Endocrinology and Metabolism 111 ( 6 ) e1672 - e1680 2026.06

  ISSN  0021972X

  　View Summary

  Context: Previous metabolomics studies suggest potential associations between menopausal changes in lipids and an increased risk of metabolic syndrome (MetS). However, longitudinal data on other key metabolites, such as branched-chain amino acids (BCAAs) and homocysteine, remain limited, and most studies lack long-term follow-up across the menopause transition. Objective: This study aimed to investigate longitudinal changes in circulating metabolites during menopause over a mean follow-up of 5 years and assess their associations with subsequent MetS development. Methods: Premenopausal women from the Tsuruoka Metabolomics Cohort Study who participated in at least one follow-up survey were included. Menopausal status, data on MetS, and plasma metabolites profiled using capillary electrophoresis mass spectrometry were assessed at each visit. Thirty-one metabolites were examined for associations with menopausal status using mixed-effects models. The association of these menopause-related metabolites with MetS development was examined via logistic regression analysis adjusted for follow-up duration. Results: Among 953 women (aged 43.8 ± 5.4 years), 316 (33.2%) reached menopause during follow-up (5.0 ± 1.1 years). Eighteen metabolites changed significantly with menopause, particularly those related to BCAA metabolism, urea cycle, and homocysteine metabolism. Of 695 women without MetS at baseline, 65 (9.4%) developed MetS. Glutamate (odds ratio [95% CI]: 1.95 [1.49-2.57]) was associated with higher MetS risk. Higher levels of glutamate, valine, leucine, and cystine were significantly associated with the development of hyperglycemia. Conclusion: Longitudinal changes in charged metabolites occur across the menopausal transition, with specific metabolites such as glutamate possibly contributing to the metabolic alterations underlying increased MetS risk.

  • Access to Document (DOI)

• Are changes in the urinary sodium-to-potassium ratio associated with changes in blood pressure in a healthy population with low urinary sodium-to-potassium ratios? Eight-year follow-up results from the KOBE Study

  Kawahara M., Tsukinoki R., Miyamatsu N., Kuwabara K., Kubo S., Kubota Y., Higashiyama A., Hirata A., Hirata T., Miyazaki J., Sugiyama D., Miyamoto Y., Okamura T.

  Hypertension Research 49 ( 6 ) 1878 - 1887 2026.06

  ISSN  09169636

  　View Summary

  Little is known about the associations between changes in the urinary sodium-to-potassium (Na/K) ratio and blood pressure (BP) in healthy individuals. Using survey data, urinary data, and BP data from the KOBE Study, this longitudinal study aimed to assess the associations between changes in the urinary Na/K ratio and BP in a healthy Japanese population over an 8-year follow-up period. We analyzed 567 participants aged 40–74 years who did not initiate antihypertensive or cardiovascular disease treatment during follow-up. Changes in the spot urinary Na/K ratio and BP were calculated by subtracting the baseline values from the follow-up measurements, and their associations were examined using a multivariable linear regression analysis that adjusted for sex, age, body mass index, baseline Na/K ratio and BP, low-density lipoprotein, hemoglobin A1c, ethanol intake, smoking status, salt taste sensitivity, years of education, employment status, baseline survey season, and 8-year follow-up survey season. The study cohort had a mean spot urinary Na/K ratio of 2.1 at baseline. While BP increased significantly over the 8-year follow-up period, the urinary Na/K ratio remained unchanged. However, urinary Na/K ratio changes were positively associated with changes in systolic BP (β = 1.48, p = 0.001) and diastolic BP (β = 0.76, p = 0.004). In conclusion, increases in spot urinary Na/K ratios were predictive of long-term BP elevation in a healthy, normotensive population with near-optimal urinary Na/K ratios at baseline. These findings indicate that maintaining a low urinary Na/K ratio is important for BP control, even among healthy individuals. (Figure presented.)

  • Access to Document (DOI)

• Changes in rheumatoid arthritis medication in pregnancy: a retrospective observational study using a Japanese claims database

  Shiotsuki Y., Iida M., Tsuchiya S., Matsumoto M., Sugiyama D.

  Modern Rheumatology 36 ( 3 ) 345 - 352 2026.05

  ISSN  14397595

  　View Summary

  Objectives: To examine changes in rheumatoid arthritis (RA) medication prescriptions during the peri-delivery period, and to explore recent RA prescription trends using a Japanese claims database. Methods: This retrospective observational cohort study used an insurance claims database provided by JMDC Inc. We identified pregnant women with RA who delivered between April 2018 and October 2023. The outcome was the initiation or resumption of intensive treatment after delivery, defined as new or restarting of biologic disease modifying anti-rheumatic drugs (DMARDs), targeted synthetic DMARDs, oral corticosteroids (OCS), or methotrexate. Results: We identified 229 mothers with RA and 246 deliveries. Intensive treatment was initiated in 55 (22.4%) deliveries. Continuation of the same prescription from before delivery was observed in 106 (43.1%) deliveries. The most frequent new prescription postpartum was methotrexate in 18 (7.3%) deliveries. OCS were the most commonly prescribed medications throughout the observation period. Tumour necrosis factor alpha inhibitors were prescribed at similar rates as OCS before pregnancy and in the first trimester, but declined during the second and third trimesters, and returned postpartum. Conclusions: The number of deliveries that required intensive treatment postpartum was lower than in previous studies. Our results suggest that the latest guidelines for pregnant women with RA help control disease activity.

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• Associations between fatigue, fatigue management barriers, and social support among patients with breast cancer undergoing endocrine therapy

  Sugiyama, Daisuke

  Keio SFC journal (慶應SFC学会)  24 ( 1 ) 14 - 22 2024

  ISSN  13472828

• The association between the mild cognitive impairment and the risk factors for arteriosclerotic disease based upon the cohort study of urban population.

  Sugiyama, Daisuke

  科学研究費補助金研究成果報告書 2022

• Research on risk factors contributing to arteriosclerosis using CAVI in urban and remote islands

  Sugiyama, Daisuke

  科学研究費補助金研究成果報告書 2018

• Investigation of obesity-related metabolic markers in plasma and urine using metabolome profiling

  Sugiyama, Daisuke

  科学研究費補助金研究成果報告書 2017

• A systematic review and meta-analysis of the effects of probiotics on children with atopic dermatitis

  Sugiyama, Daisuke

  Keio SFC journal (慶應義塾大学湘南藤沢学会)  16 ( 2 ) 140 - 155 2016

  ISSN  13472828

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Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• 循環器病予防と喫煙・飲酒対策　わが国のコホート研究から見える喫煙・飲酒の健康リスク

  杉山 大典

  日本循環器病予防学会誌 ((一社)日本循環器病予防学会)  61 ( 2 ) 104 - 104 2026.05

  ISSN  1346-6267

• 関節リウマチ免疫抑制治療開始前に実施が推奨される感染症スクリーニング検査の実態　JMDC後期高齢者データベースによる検討

  汐月 雄一, 土屋 志織, 杉山 大典

  薬剤疫学 ((一社)日本薬剤疫学会)  30 ( Suppl. ) S146 - S147 2025.10

  ISSN  1342-0445

• 特定保健指導に2クール連続該当するリピーターへの保健指導効果　男女別記述統計

  吉田 裕美, 田口 敦子, 杉山 大典, 石井 香織, 岡村 智教

  日本公衆衛生学会総会抄録集 ((一社)日本公衆衛生学会)  84回   582 - 582 2025.10

  ISSN  1347-8060

• 業種別にみた特定保健指導効果　全国健康保険協会東京支部における男女別記述統計

  石井 香織, 大須賀 秀夫, 吉田 裕美, 田口 敦子, 杉山 大典, 岡村 智教

  日本公衆衛生学会総会抄録集 ((一社)日本公衆衛生学会)  84回   582 - 582 2025.10

  ISSN  1347-8060

• 保健師活動のICT活用・デジタル化研究(第3報)　活動マネジメントツールの有用性と課題

  泰地 可南子, 田口 敦子, 加藤 由希子, 吉田 裕美, 赤塚 永貴, 石川 志麻, 平野 優子, 村嶋 幸代, 春山 早苗, 高山 公子, 吉田 知可, 高橋 勇太, 杉山 大典, 宮川 祥子, 水流 聡子

  日本公衆衛生学会総会抄録集 ((一社)日本公衆衛生学会)  84回   648 - 648 2025.10

  ISSN  1347-8060

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Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• 酒状況が精神的健康状態に与える影響：神戸研究

  Sugiyama Daisuke

  第52回日本アルコール・アディクション医学会, 

  2017.09

  , 

  Oral presentation (general)

• 能動喫煙・受動喫煙が精神的健康状態に与える影響

  Sugiyama Daisuke

  第52回日本アルコール・アディクション医学会, 

  2017.09

  , 

  Poster presentation

• 地域住民における耐糖能異常の有無による飲酒習慣の糖尿病発症リスクに関する検討

  Sugiyama Daisuke

  第52回日本アルコール・アディクション医学会, 

  2017.09

  , 

  Poster presentation

• 職域健診受診者における喫煙と動脈硬化性疾患発症リスクの検討　cardio-ankle vascular index(CAVI)

  Sugiyama Daisuke

  第52回日本アルコール・アディクション医学会, 

  2017.09

• 男性の飲酒とCVD死亡の関連における脂質異常症およびγ-GTP値の影響：NIPPON DATA90

  Sugiyama Daisuke

  第52回日本アルコール・アディクション医学会, 

  2017.09

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• 一般地域住民における自己抗体陽性率の評価及びその臨床的意義の解明

  2020.04

  -

  2025.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

• 軽度認知機能障害と動脈硬化性疾患リスクファクターの関連：都市部住民における検討

  2017

  -

  2019

  Grant-in-Aid for Scientific Research, Research grant, Principal investigator

• メタボリック症候群と投薬加療が必要な糖尿病の新規発症の関連について：一般市民集団を対象とした研究

  2016.04

  -

  2017.03

  一般財団法人日本健康増進財団, 生活習慣病予防に関する研究助成, Other, Principal investigator

• 都市部住民における自己抗体の発現と生活習慣病との関係性の解明

  2013

  -

  2015

  Grant-in-Aid for Scientific Research, Research grant, Principal investigator

Awards 【 Display / hide 】

Awards 【 Display / hide 】

• Thrombosis Research awarded Outstanding Reviewer Status

  2017.03

  Type of Award： Other

• Thrombosis Research awarded Outstanding Reviewer Status

  2017.03

• 第75回日本公衆衛生学会　示説（ポスター）賞

  2016.10

• 示説（ポスター）賞

  2016.10, 第75回日本公衆衛生学会

  Type of Award： Award from Japanese society, conference, symposium, etc.

• 日本動脈硬化学会　第8回JAT賞受賞

  2016.07

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Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• ENVIRONMENT AND HEALTH

  2026

• HEALTH SCIENCE

  2026

• PHARMACOLOGY FOR NURSING AND HEALTH CARE

  2026

• DATA SCIENCE AND ARTIFICIAL INTELLIGENCE

  2026

• BIOCHEMISTRY AND PHYSIOLOGY FOR NURSING AND HEALTH CARE

  2026

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Courses Previously Taught 【 Display / hide 】

Courses Previously Taught 【 Display / hide 】

• 基礎生物統計学I

  Keio University

  2018.04

  -

  2019.03

  , 

  Spring Semester, Lecture, Lecturer outside of Keio

  健康マネジメント研究科・医学研究科共通科目

• 臨床疫学

  Keio University

  2018.04

  -

  2019.03

  , 

  Spring Semester, Lecture, Lecturer outside of Keio

• 基礎生物統計学II

  Keio University

  2018.04

  -

  2019.03

  , 

  Spring Semester, Lecture, Lecturer outside of Keio

  健康マネジメント研究科・医学研究科共通科目

• 基礎生物統計学I

  Keio University

  2017.04

  -

  2018.03

  , 

  Spring Semester, Lecture, Lecturer outside of Keio

  健康マネジメント研究科・医学研究科共通科目

• 公衆衛生学

  Keio University

  2017.04

  -

  2018.03

  , 

  Autumn Semester, Laboratory work/practical work/exercise, Lecturer outside of Keio

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Social Activities 【 Display / hide 】

Social Activities 【 Display / hide 】

• 日本動脈硬化学会

  2017.07

  -

  Present

  　View Summary

  評議員

• 日本疫学会

  2017.06

  -

  Present

  　View Summary

  代議員

• 日本循環器病予防学会

  2017.06

  -

  Present

  　View Summary

  評議員

Committee Experiences 【 Display / hide 】

Committee Experiences 【 Display / hide 】

• 2023.07

  -

  2025.06

  Judging committee of Research Fellowship for Young Scientists, 独立行政法人日本学術振興会