杉山 大典 (スギヤマ ダイスケ)

Sugiyama, Daisuke

写真a

所属(所属キャンパス)

看護医療学部 (湘南藤沢)

職名

教授

HP

その他の所属・職名 【 表示 / 非表示

  • 医学部, 衛生学公衆衛生学教室, 兼担教授

  • 大学院健康マネジメント研究科, 教授

経歴 【 表示 / 非表示

  • 2003年06月
    -
    2004年03月

    神戸大学医学部附属病院, 医員(研修医)

  • 2006年04月
    -
    2009年09月

    神戸大学医学部附属病院  , 検査部, 医員

  • 2009年10月
    -
    2011年12月

    神戸大学大学院医学研究科, 内科系講座 臨床検査・免疫学分野 立証検査医学部門, 特命助教

  • 2010年05月
    -
    継続中

    先端医療センター研究所 , 先制・予防医療研究開発部 コホート研究チーム , 客員研究員

  • 2012年01月
    -
    2014年03月

    慶應義塾大学医学部, 衛生学公衆衛生学教室 , 助教

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学歴 【 表示 / 非表示

  • 1997年04月
    -
    2003年03月

    神戸大学, 医学部医学科

    大学, 卒業

  • 2004年04月
    -
    2005年03月

    国立保健医療科学院 , 専門課程 生物統計分野

    その他, 修了

  • 2005年04月
    -
    2009年03月

    神戸大学大学院, 医学系研究科 

    大学院, 修了

学位 【 表示 / 非表示

  • Master of Public Health in Biostatistics *現Certified Public Health Professionalに相当, 国立保健医療科学院, 2005年03月

  • 博士(医学), 神戸大学, 課程, 2009年03月

免許・資格 【 表示 / 非表示

  • 日本医師会認定産業医

  • 診療情報管理士

  • 社会医学系専門医協会 専門医・指導医

  • 医師免許, 2003年05月

  • 上級疫学専門家, 2020年04月

 

研究分野 【 表示 / 非表示

  • ライフサイエンス / 医療管理学、医療系社会学

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含む

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含まない

研究キーワード 【 表示 / 非表示

  • 健診の有効性

  • 生活習慣病疫学

  • 臨床検査医学

 

著書 【 表示 / 非表示

  • 健康教育マニュアル

    岡山 明編著(分担執筆), 一般社団法人日本家族計画協会, 2014年07月

論文 【 表示 / 非表示

  • Physique at Birth and Cardiovascular Disease Risk Factors in Japanese Urban Residents: the KOBE Study

    Umemoto K., Kubo S., Nishida Y., Higashiyama A., Kawamura K., Kubota Y., Hirata T., Hirata A., Sata M., Kuwabara K., Miyazaki J., Kadota A., Iida M., Sugiyama D., Miyamatsu N., Miyamoto Y., Okamura T.

    Journal of Atherosclerosis and Thrombosis (Journal of Atherosclerosis and Thrombosis)  29 ( 2 ) 188 - 199 2022年

    ISSN  13403478

     概要を見る

    Aim: This study investigated the relationship between birth physique and cardiovascular risk factors in Japanese urban residents aged 40 years and more. Methods: A self-administered questionnaire on birth physique was performed among 624 individuals (165 men and 459 women) who participated in the KOBE study. We examined whether self-reported birth physique and available recorded birth weights matched for 72 participants. Then the association between birth physique and risk factors for all participants was examined by gender. Body size at birth in the questionnaire (large, medium, small) was set as an exposure and laboratory values from the baseline survey (2010-2011) were used as outcomes. Results: Mean (standard deviation) recorded birth weight of 72 participants was 3665 (318), 3051 (300), and 2653 (199) g, in the large, medium, and small group, respectively. In the analysis for all participants, odds ratio for having both hypertension and impaired glucose tolerance were significantly higher in the small versus large birth weight group, which was 7.42 (95% CI 1.75–31.50) for men and 4.44 (95% CI 1.14–17.30) for women after adjusting for age, body mass index, smoking/alcohol/exercise habits, and menstrual status in women. Similar results were observed in participants with recorded birth weight. Conclusions: The present study indicates that individuals with small physique at birth might be at higher risk for hypertension and impaired glucose tolerance in middle age compared to those with large birth weight.

  • Validity assessment of self-reported medication use for hypertension, diabetes, and dyslipidemia in a pharmacoepidemiologic study by comparison with health insurance claims

    Matsumoto M., Harada S., Iida M., Kato S., Sata M., Hirata A., Kuwabara K., Takeuchi A., Sugiyama D., Okamura T., Takebayashi T.

    Journal of Epidemiology (Journal of Epidemiology)  31 ( 9 ) 495 - 502 2021年

    ISSN  09175040

     概要を見る

    Background: Although self-reported questionnaires are widely employed in epidemiologic studies, their validity has not been sufficiently assessed. The aim of this study was to evaluate the validity of a self-reported questionnaire on medication use by comparison with health insurance claims and to identify individual determinants of discordance in the Tsuruoka Metabolomics Cohort Study. Methods: Participants were 2,472 community-dwellers aged 37 to 78 years from the Tsuruoka Metabolomics Cohort Study. Information on lifestyle and medications was collected through a questionnaire. Sensitivity and specificity were determined using health insurance claims from November 2014 to March 2016, which were used as a standard. Potential determinants of discordance were assessed using multivariable logistic regression. Results: The self-reported questionnaire on medication use showed high validity. Sensitivity and specificity were 0.95 (95% CI, 0.93–0.96) and 0.97 (95% CI, 0.96–0.98) for antihypertensive medications, 0.94 (95% CI, 0.91–0.97) and 0.98 (95% CI, 0.98–0.99) for diabetes medications, and 0.84 (95% CI, 0.82–0.87) and 0.98 (95% CI, 0.97–0.99) for dyslipidemia medications, respectively. Males without high education and those who currently smoke cigarettes were found to be associated with discordant reporting which affected sensitivity, especially those with medication use for dyslipidemia. Conclusions: In this population-based cohort study, we found that the self-reported questionnaire on medication use was a valid measure to capture regular medication users. Sensitivity for dyslipidemia medications was lower than those for the other medications. Type of medication, sex, education years, and smoking status influenced discordance, which affected sensitivity in self-reporting.

  • Association of the estimated coronary artery incidence risk according to the japan atherosclerosis society guidelines 2017 with cardio-ankle vascular index

    Sata M., Okamura T., Harada S., Sugiyama D., Kuwabara K., Hirata A., Takeuchi A., Iida M., Kato S., Matsumoto M., Kurihara A., Takebayashi T.

    Journal of Atherosclerosis and Thrombosis (Journal of Atherosclerosis and Thrombosis)  28 ( 12 ) 1266 - 1274 2021年

    ISSN  13403478

     概要を見る

    Aims: The categories in the comprehensive lipid and risk management guidelines were proposed by the Japan Atherosclerosis Society (JAS Guidelines 2017), which adopted the estimated 10 year absolute risk of coronary artery disease (CAD) incidence in the Suita score. We examined whether those categories were concordant with the degree of arterial stiffness. Methods: In 2014, the cardio-ankle vascular index (CAVI), an arterial stiffness parameter, was measured in 1,972 Japanese participants aged 35–74 years in Tsuruoka City, Yamagata Prefecture, Japan. We examined the mean CAVI and the proportion and odds ratios (ORs) of CAVI ≥ 9.0 on the basis of the following three management classifications using the analysis of variance and logistic regression: “Category I (Low risk),” “Category II (Middle risk),” and “Category III (High risk).” Results: The mean CAVI and proportion of CAVI ≥ 9.0 were 8.6 and 34.8% among males and 8.1 and 18.3% among females, respectively. The mean CAVI and proportion of CAVI ≥ 9.0 were associated with an estimated 10 year absolute risk for CAD among males and females, excluding High risk for females. These results were similar to the management classification by the guideline: the multivariable-adjusted ORs (95% confidence intervals) of CAVI ≥ 9.0 among Category II and Category III compared with those among Category I were 2.96 (1.61–5.43) and 7.33 (4.03–13.3) for males and 3.99 (2.55–6.24) and 3.34 (2.16–5.16) for females, respectively. Conclusions: The risk stratification, which was proposed in the JAS Guidelines 2017, is concordant with the arterial stiffness parameter.

  • Estimated 24 h urinary sodium-to-potassium ratio is related to renal function decline: A 6-year cohort study of japanese urban residents

    Hattori H., Hirata A., Kubo S., Nishida Y., Nozawa M., Kawamura K., Hirata T., Kubota Y., Sata M., Kuwabara K., Higashiyama A., Kadota A., Sugiyama D., Miyamatsu N., Miyamoto Y., Okamura T.

    International Journal of Environmental Research and Public Health (International Journal of Environmental Research and Public Health)  17 ( 16 ) 1 - 12 2020年08月

    ISSN  16617827

     概要を見る

    The effect of the sodium-to-potassium ratio (Na/K) on renal function within the clinically normal range of renal function are limited. We investigated the effects of an estimated 24 h urinary Na/K (e24hUNa/K) on a 6-year renal function decline among 927 urban Japanese community dwellers with no history of cardiovascular diseases and medication for hypertension, diabetes, or dyslipidemia. We partitioned the subjects into quartiles according to the e24hUNa/K. The estimated glomerular filtration rate (eGFR) was calculated using the chronic kidney disease epidemiology collaboration (CKD/EPI) formula and renal function decline was defined as an absolute value at or above the third quartile of the eGFR decline rate. A multivariable logistic regression model was used for estimation. Compared with the first quartile of the e24hUNa/K, multivariable-adjusted odds ratios (ORs) for eGFR decline in the second, third, and fourth quartiles were 0.96 (95% confidence interval: 0.61–1.51), 1.06 (0.67–1.66), and 1.65 (1.06–2.57), respectively. These results were similar when the simple spot urine Na/K ratio was used in place of the e24hUNa/K. Apparently healthy urban residents with an almost within normal range mean baseline eGFR and high e24hUNa/K ratios had an increased risk for a future decline in renal function. Reducing the Na/K ratio may be important in the prevention of chronic kidney disease in its early stage.

  • US detection of medial meniscus extrusion can predict the risk of developing radiographic knee osteoarthritis: a 5-year cohort study

    Chiba D., Sasaki E., Ota S., Maeda S., Sugiyama D., Nakaji S., Ishibashi Y.

    European Radiology (European Radiology)  30 ( 7 ) 3996 - 4004 2020年07月

    ISSN  09387994

     概要を見る

    Objectives: To clarify the relationship between the baseline value of medial meniscus extrusion (MME) and the radiographic change of knee osteoarthritis (KOA) through a 5-year follow-up. Methods: Overall, 472 participants and 944 knees were eligible. MME (mm) was measured at the baseline, and KOA was radiographically evaluated at both baseline and 5-year follow-up by Kellgren-Lawrence grade (KLG). Radiographic KOA (ROA) was defined as the knee showing KLG ≥ 2. Incident ROA (iROA) was defined if the baseline KLG of 0–1 increased to KLG ≥ 2 in 5 years. Progressive ROA (pROA) was defined if the baseline KLG of 2–3 worsened to a higher grade in 5 years. Receiver operating characteristic (ROC) curve and generalized estimating equations were used for analysis. Results: Of 574 non-ROA knees at the baseline, 43 knees (7.5%) developed iROA; of 370 ROA knees, 47 knees (12.7%) developed pROA. Based on the ROC curves, 4 mm was the optimal cutoff to detect the risk of iROA (area under curve [AUC] 0.639 [right knee]; AUC 0.641 [left knee]) and that of pROA (AUC 0.750 [right knee]; AUC 0.863 [left knee]). Multiple regression analysis showed that the 4-mm cutoff of MME was significantly associated with both the prevalence of iROA (regression coefficient [B] 1.909; p ≤ 0.001; adjusted odds ratio [aOR] 6.746) and that of pROA (B 1.791; p ≤ 0.001; aOR 5.993). Conclusions: On ultrasonography, the participants with more extruded medial meniscus showed a higher prevalence of both iROA and pROA. Ultrasonography could identify patients who had a risk of developing KOA. Key Points: • Through a 5-year follow-up, the current cohort study was conducted to clarify the relationship between the baseline value of medial meniscus extrusion (MME) and the radiographic change of knee osteoarthritis (KOA). • More extruded medial meniscus evaluated by ultrasonography was associated with the development of radiographic KOA. • Ultrasonography could identify the patients who had a risk of developing KOA, and the 4-mm cutoff of MME was optimal to detect this risk.

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KOARA(リポジトリ)収録論文等 【 表示 / 非表示

総説・解説等 【 表示 / 非表示

研究発表 【 表示 / 非表示

  • 能動喫煙・受動喫煙が精神的健康状態に与える影響

    杉山 大典

    第52回日本アルコール・アディクション医学会, 

    2017年09月

    ポスター発表

  • 地域住民における耐糖能異常の有無による飲酒習慣の糖尿病発症リスクに関する検討

    杉山 大典

    第52回日本アルコール・アディクション医学会, 

    2017年09月

    ポスター発表

  • 酒状況が精神的健康状態に与える影響:神戸研究

    杉山 大典

    第52回日本アルコール・アディクション医学会, 

    2017年09月

    口頭発表(一般)

  • 男性の飲酒とCVD死亡の関連における脂質異常症およびγ-GTP値の影響:NIPPON DATA90

    杉山 大典

    第52回日本アルコール・アディクション医学会, 

    2017年09月

  • 非メタボリック症候群対象者における飲酒と正常高値以上血圧の新規発症の関連 羽曳野市特定健診での検討

    杉山 大典

    第52回日本アルコール・アディクション医学会, 

    2017年09月

    口頭発表(一般)

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競争的研究費の研究課題 【 表示 / 非表示

  • 一般地域住民における自己抗体陽性率の評価及びその臨床的意義の解明

    2020年04月
    -
    2025年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 杉山 大典, 基盤研究(C), 補助金,  研究代表者

  • 軽度認知機能障害と動脈硬化性疾患リスクファクターの関連:都市部住民における検討

    2017年
    -
    2019年

    科学研究費補助金(文部科学省・日本学術振興会), 補助金,  研究代表者

  • メタボリック症候群と投薬加療が必要な糖尿病の新規発症の関連について:一般市民集団を対象とした研究

    2016年04月
    -
    2017年03月

    一般財団法人日本健康増進財団, 生活習慣病予防に関する研究助成, その他,  研究代表者

  • 都市部住民における自己抗体の発現と生活習慣病との関係性の解明

    2013年
    -
    2015年

    科学研究費補助金(文部科学省・日本学術振興会), 補助金,  研究代表者

受賞 【 表示 / 非表示

  • Thrombosis Research awarded Outstanding Reviewer Status

    2017年03月

    受賞区分: その他

  • Thrombosis Research awarded Outstanding Reviewer Status

    2017年03月

  • 第75回日本公衆衛生学会 示説(ポスター)賞

    2016年10月

  • 示説(ポスター)賞

    2016年10月, 第75回日本公衆衛生学会

    受賞区分: 国内学会・会議・シンポジウム等の賞

  • 日本動脈硬化学会 第8回JAT賞受賞

    2016年07月

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担当授業科目 【 表示 / 非表示

  • 疫学研究の統計的方法

    2022年度

  • 疫学研究の統計的方法

    2022年度

  • プロジェクトⅡ(応用)

    2022年度

  • プロジェクトⅠ(基礎)

    2022年度

  • 公衆衛生学

    2022年度

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担当経験のある授業科目 【 表示 / 非表示

  • 臨床疫学

    慶應義塾

    2018年04月
    -
    2019年03月

    春学期, 講義, 兼担

  • 基礎生物統計学II

    慶應義塾

    2018年04月
    -
    2019年03月

    春学期, 講義, 兼担

    健康マネジメント研究科・医学研究科共通科目

  • 基礎生物統計学I

    慶應義塾

    2018年04月
    -
    2019年03月

    春学期, 講義, 兼担

    健康マネジメント研究科・医学研究科共通科目

  • 公衆衛生学

    慶應義塾

    2017年04月
    -
    2018年03月

    秋学期, 実習・実験, 兼担

  • 疫学研究の統計的手法

    慶應義塾

    2017年04月
    -
    2018年03月

    秋学期, 兼担

    健康マネジメント研究科・医学研究科共通科目

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社会活動 【 表示 / 非表示

  • 日本動脈硬化学会

    2017年07月
    -
    継続中

     概要を見る

    評議員

  • 日本疫学会

    2017年06月
    -
    継続中

     概要を見る

    代議員

  • 日本循環器病予防学会

    2017年06月
    -
    継続中

     概要を見る

    評議員