Papers - Watanabe, Koota

【椎間板変性の病態と治療】 椎間板の微小環境 低酸素、酸化ストレスの観点から

藤田順之, 鈴木悟士, 渡辺航太, 石井 賢, 松本守雄, 中村雅也

整形・災害外科 60 ( 3 ) 273 - 277 2017

Research paper (scientific journal)

【LATERAL INTERBODY FUSION(LIF)-我が国における現況と展望-】 EXTREME LATERAL INTERBODY FUSION(XLIF) 適応と手術手技

石井 賢, 塩野雄太, 磯貝宜広, 船尾陽生, 細金直文, 八木 満, 日方智宏, 渡辺航太, 松本守雄

整形外科最小侵襲手術ジャーナル  ( 82 ) 2 - 12 2017

Research paper (scientific journal)

【脊椎・脊髄疾患と筋萎縮】 脊柱矢状面バランスと筋萎縮

八木 満, 藤田順之, 石井 賢, 中村雅也, 松本守雄, 渡辺航太

脊椎脊髄ジャーナル 30 ( 5 ) 579 - 584 2017

Research paper (scientific journal)

二期的手術により全摘できた頸胸髄上衣腫の1例

鈴木悟士, 岩波明生, 安田明正, 藤田順之, 日方智宏, 渡辺航太, 中村雅也, 松本守雄, 石井 賢

臨床整形外科 52 ( 3 ) 303 - 309 2017

Research paper (scientific journal)

腰椎変性疾患に対する２椎間の後方経路腰椎椎体間固定術後の椎体間ケージ沈み込みの危険因子

磯貝宜広, 渡邉航太, 日方智宏, 藤田順之, 八木　満, 辻 収彦, 名越慈人, 中村雅也, 松本守雄, 石井　賢

臨床整形外科 52 ( 7 ) 685 - 690 2017

Research paper (scientific journal)

Myelopathy due to Spinal Extramedullary Hematopoiesis in a Patient with Polycythemia Vera

Ito S, Fujita N, Hosogane N, Nagoshi N, Yagi M, Iwanami A, Watanabe K, Tsuji T, Nakamura M, Matsumoto M, Ishii K

Journal of sports medicine    2416365 2017

Research paper (scientific journal)

Compound heterozygosity for null mutations and a common hypomorphic risk haplotype in TBX6 causes congenital scoliosis

Takeda K, Kou I, Kawakami N, Iida A, Nakajima M, Ogura Y, Imagawa E, Miyake N, Matsumoto N, Yasuhiko Y, Sudo H, Kotani T, Japan Early Onset Scoliosis Research Group, Nakamura M, Matsumoto M, Watanabe K, Ikegawa S

Human mutation 38 ( 3 ) 317 - 323 2017

Asymmetrical pedicle subtraction osteotomy for progressive kyphoscoliosis caused by a pediatric Chance fracture: acase report

Suzuki S, Fujita N, Hikata T, Iwanami A, Ishii K, Nakamura M, Matsumoto M, Watanabe K

Scoliosis and Spinal Disorders 12   8 2017

Research paper (scientific journal)

Response to Lefebvre et al

Takeda K, Kou I, Kawakami N, Yasuhiko Y, Ogura Y, Imagawa E, Miyake N, Matsumoto N, Sudo H, Kotani T, Japan Early Onset Scoliosis Research Group, Nakamura M, Matsumoto M, Watanabe K, Ikegawa S

Clinical genetics 92 ( 5 ) 563 - 564 2017

Research paper (scientific journal)

A functional variant in MIR4300HG, the host gene of microRNA MIR4300 is associated with progression of adolescent idiopathic scoliosis

Ogura Y, Kou I, Takahashi Y, Takeda K, Minami S, Kawakami N, Uno K, Ito M, Yonezawa I, Kaito T, Yanagida H, Watanabe K, Taneichi H, Harimaya K, Taniguchi Y, Kotani T, Tsuji T, Suzuki T, Sudo H, Fujita N, Yagi M, Chiba K, Kubo M, Kamatani Y, Nakamura M, Matsumoto M, Japan Scoliosis Clinical Research Group, Watanabe K, Ikegawa S, Japan Scoliosis Clinical Research Group

Human molecular genetics 26 ( 20 ) 4086 - 4092 2017

Research paper (scientific journal)

Exploration for reliable radiographic assessment method for hinge-like hypermobility at atlanto-occipital joint

Kaneko S, Ishii K, Watanabe K, Tsuji T, Nakamura M, Matsumoto M, Yato Y, Asazuma T

European spine journal (European Spine Journal)  27 ( 6 ) 1303 - 1308 2017

Research paper (scientific journal),  ISSN  09406719

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© 2017, The Author(s). Purpose: Hinge-like hyper-mobility is occasionally observed at the atlanto-occipital (O-C1) joint. However, it has not been clear if this kind of hinge-like hyper-mobility at the O-C1 joint should be regarded as “pathologic”, or referred to as “instability”. To solve this issue, we aimed to establish a reliable radiographic assessment method for this specific type of O-C1 instability and figure out the “standard value” for the range of motion (ROM) of the O-C1 joint. Methods: To figure out the standard range of the O-C1 angle, we acquired magnetic resonance imaging (MRI) sagittal views of the cervical spine for 157 healthy volunteers [average: 37.4 year-old (yo)] without spine diseases, at neutral, maximum flexion and maximum extension positions. Results: The average value (AVE) for ROM of O-C1 angle was 9.91°. The standard value for ROM of O-C1 angle was calculated as 0°–21°. There was no statistically significant gender difference. We also found that the older population (≧ 40 yo) significantly had a larger ROM of O-C1 angle (AVE: 11.72°) compared to the younger population (< 40 yo) (AVE: 8.99°). Conclusions: We consider that hinge-like instability at O-C1 joint, which cannot be assessed by measuring Powers ratio, can be assessed by measuring the range of O-C1 angles using dynamic-MRI. Evaluation of O-C1 instability is important especially when we perform surgical treatment for diseases with upper cervical instability (such as retro-odontoid pseudotumor). We consider that the current study provides important information in such a case.

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The Unfolded Protein Response Mediated by PERK is casually related to the Pathogenesis of Intervertebral Disc Degeneration

Fujii T, Fujita N, Suzuki S, Tsuji T, Takaki T, Umezawa K, Watanabe K, Miyamoto T, Horiuchi K, Matsumoto M, Nakamura M

Journal of orthopaedic research (Journal of Orthopaedic Research)  36 ( 5 ) 1334 - 1345 2017

Research paper (scientific journal),  ISSN  07360266

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© 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. Although the number of patients with intervertebral disc (IVD) degeneration is increasing in aging societies, its etiology and pathogenesis remain elusive and there is currently no effective treatment to prevent this undesirable condition. The unfolded protein response (UPR) is a cellular machinery that plays critical roles in handling endoplasmic reticulum (ER) stress, a condition caused by the accumulation of unfolded proteins in the ER lumen. This study aimed to elucidate the potential role of the UPR mediated by pancreatic endoplasmic reticulum kinase (PERK), one of the major ER stress sensors in mammalian cells, in the development of IVD degeneration. IVD degeneration was artificially induced in Wister rats by percutaneously puncturing the coccyx IVDs and human IVDs were collected from patients who underwent spinal surgery. Expression of the UPR target genes was elevated in degenerative IVDs in both humans and rats. The induction of ER stress in annulus fibrosus cells significantly increased the transcripts for tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) in a nuclear factor (NF)-κB pathway-dependent manner. The expression of TNF-α and IL-6 was significantly reduced by treatment with a selective PERK inhibitor, GSK2606414, and by gene silencing against PERK and activating transcription factor 4 (ATF4) transcripts. Our findings indicate that the UPR mediated by the PERK pathway is causally related to the development of IVD degeneration, suggesting that PERK may be a potential molecular target for suppressing the degenerative changes in IVDs. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1334–1345, 2018.

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Epithelioid Hemangioma of the Thoracic Spine : A case Report and Review of the Literature.

Okada E, Matsumoto M, Nishida M, Iga T, Morishita M, Tazuka M, Mukai K, Kobayashi E, Watanabe k

The journal of Spine Cord Medicine (Journal of Spinal Cord Medicine)  42 ( 6 ) 1 - 6 2017

Research paper (scientific journal),  ISSN  10790268

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Context: Osseous epithelioid hemangioma is uncommon, and reports of epithelioid hemangiomas of the spine are especially rare. Study Design: Case report. Findings: A 43-year-old male was referred to our department with progressive gait disturbance. CT scans showed a lucent mass in the vertebral body at the T3 level. MRI of the thoracic spine showed a strongly enhanced mass compressing the spinal cord. The patient underwent laminectomy from T2 to T4, debulking of the tumor, and posterior fusion from T1 to T5. After the operation, the patient's neurological status improved significantly, and he was able walk without assistance. Histological examination determined that the tumor was an epithelioid hemangioma. The patient was treated with 40 Gy radiation for local control of the tumor. The patient could walk without difficulty 12 months after the surgery. Conclusion: This is a rare example of an epithelioid hemangioma that developed in the thoracic spine and compressed the spinal cord, and was treated successfully.

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Surgical Correction of Severe Kyphoscoliosis Associated with Crouzon Syndrome with Serious Postoperative Respiratory Problems

Umezu T, Fujita N, Yagi M, Tsuji O, Nagoshi N, Ishii K, Nakamura M, Matsumoto M, Watanabe K

JBJS case connector 7 ( 4 ) e98 2017

Research paper (scientific journal)

脊髄離断術後に脊髄摘出を２回施行した胸髄発生Glioblastomaの1例．

櫻井孝紀, 岩波明生, 藤田順之, 日方智宏, 渡辺航太, 石井　賢, 松本守雄, 中村雅也

日本脊髄障害医学会雑誌　 29 ( 1 ) 132-134 2016.05

Research paper (scientific journal)

Genome-wide association study for adolescent idiopathic scoliosis.

Ogura Y, Kou I, Scoliosis J, Matsumoto M, Watanabe K, Ikegawa S

Clincal Calcium 26 ( 4 ) 553-00 2016.04

Research paper (scientific journal)

A chordoma-derived cell line U-CH1-N recapitulates the biological of notochordal nucleus pulposus cells

Fujita N, Suzuki S, Watanabe K, Ishii K, Watanabe R, Shimoda M, Takubo K, Tsuji T, Toyama Y, Miyamoto T, Horiuchi K, Nakamura M, Matsumoto M

Journal of Orthopaedic Research 34 ( 8 ) 1341-50 2016

Research paper (scientific journal)

Risk Factors of radiological adjacent disc degeneration with lumbar interbody fusion for degenerative spondylolisthesis.

Tsuji T, Watanabe K, Hosogane N, Fujita N, Ishi K, Chiba K, Toyama Y, Nakamura M, Matsumoto M

Journal of Orthopaedic Science 21 ( 2 ) 133 - 137 2016

Research paper (scientific journal)

Automatic Screening System for Scoliosis Utilizing Moire Pattern.

Choi R, Watanabe K, Nakamura M, Matsumoto M, Fujita N, Ogura Y, Tuji T, Wata K, Kotani T, Miyazaki M, Shigematsu H, Demura S, Takahashi M, Abe K, Yoshimtsu A.

FCV2016, Gifu  2016

Research paper (scientific journal)

Epidemiological survey of ossification of the posterior longitudinal ligament by using clinical investigation registration forms .

Tuji T, Chiba K, Hosogane N, Fujita N, Hikata T, Iwanami A, Watanabe K, Ishii K, Toyama Y, Nakamura M, Matsumoto M.

Journal of Orthopaedic Science 21   291-4 2016

Research paper (scientific journal)