Papers - Watanabe, Koota

The Unfolded Protein Response Mediated by PERK is casually related to the Pathogenesis of Intervertebral Disc Degeneration

Fujii T, Fujita N, Suzuki S, Tsuji T, Takaki T, Umezawa K, Watanabe K, Miyamoto T, Horiuchi K, Matsumoto M, Nakamura M

Journal of orthopaedic research (Journal of Orthopaedic Research)  36 ( 5 ) 1334 - 1345 2017

Research paper (scientific journal),  ISSN  07360266

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© 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. Although the number of patients with intervertebral disc (IVD) degeneration is increasing in aging societies, its etiology and pathogenesis remain elusive and there is currently no effective treatment to prevent this undesirable condition. The unfolded protein response (UPR) is a cellular machinery that plays critical roles in handling endoplasmic reticulum (ER) stress, a condition caused by the accumulation of unfolded proteins in the ER lumen. This study aimed to elucidate the potential role of the UPR mediated by pancreatic endoplasmic reticulum kinase (PERK), one of the major ER stress sensors in mammalian cells, in the development of IVD degeneration. IVD degeneration was artificially induced in Wister rats by percutaneously puncturing the coccyx IVDs and human IVDs were collected from patients who underwent spinal surgery. Expression of the UPR target genes was elevated in degenerative IVDs in both humans and rats. The induction of ER stress in annulus fibrosus cells significantly increased the transcripts for tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) in a nuclear factor (NF)-κB pathway-dependent manner. The expression of TNF-α and IL-6 was significantly reduced by treatment with a selective PERK inhibitor, GSK2606414, and by gene silencing against PERK and activating transcription factor 4 (ATF4) transcripts. Our findings indicate that the UPR mediated by the PERK pathway is causally related to the development of IVD degeneration, suggesting that PERK may be a potential molecular target for suppressing the degenerative changes in IVDs. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1334–1345, 2018.

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Epithelioid Hemangioma of the Thoracic Spine : A case Report and Review of the Literature.

Okada E, Matsumoto M, Nishida M, Iga T, Morishita M, Tazuka M, Mukai K, Kobayashi E, Watanabe k

The journal of Spine Cord Medicine (Journal of Spinal Cord Medicine)  42 ( 6 ) 1 - 6 2017

Research paper (scientific journal),  ISSN  10790268

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Context: Osseous epithelioid hemangioma is uncommon, and reports of epithelioid hemangiomas of the spine are especially rare. Study Design: Case report. Findings: A 43-year-old male was referred to our department with progressive gait disturbance. CT scans showed a lucent mass in the vertebral body at the T3 level. MRI of the thoracic spine showed a strongly enhanced mass compressing the spinal cord. The patient underwent laminectomy from T2 to T4, debulking of the tumor, and posterior fusion from T1 to T5. After the operation, the patient's neurological status improved significantly, and he was able walk without assistance. Histological examination determined that the tumor was an epithelioid hemangioma. The patient was treated with 40 Gy radiation for local control of the tumor. The patient could walk without difficulty 12 months after the surgery. Conclusion: This is a rare example of an epithelioid hemangioma that developed in the thoracic spine and compressed the spinal cord, and was treated successfully.

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Surgical Correction of Severe Kyphoscoliosis Associated with Crouzon Syndrome with Serious Postoperative Respiratory Problems

Umezu T, Fujita N, Yagi M, Tsuji O, Nagoshi N, Ishii K, Nakamura M, Matsumoto M, Watanabe K

JBJS case connector 7 ( 4 ) e98 2017

Research paper (scientific journal)

Spinal arteriovenous fistula coexisting within a spinal lipoma: report of two cases

Horiuchi Y, Iwanami A, Akiyama T, Hikata T, Watanabe K, Yagi M, Fujita N, Okada E, Nagoshi N, Tsuji O, Ishii K, Yoshida K, Nakamura M, Matsumoto M

Spinal cord series and cases 3   17079 2017

Research paper (scientific journal)

Response to Lefebvre et al

Takeda K, Kou I, Kawakami N, Yasuhiko Y, Ogura Y, Imagawa E, Miyake N, Matsumoto N, Sudo H, Kotani T, Japan Early Onset Scoliosis Research Group, Nakamura M, Matsumoto M, Watanabe K, Ikegawa S

Clinical genetics 92 ( 5 ) 563 - 564 2017

Research paper (scientific journal)

Physical Activities and Lifestyle Factors Related to Adolescent Idiopathic Scoliosis.

Watanabe K, Michikawa T, Yonezawa I, Takaso M, Minami S, Soshi S, Tsuji T, Okada E, Abe K, Takahashi M, Asakura K, Nishiwaki Y, Matsumoto M

The Journal of bone and joint surgery 99 ( 4 ) 284 - 294 2017

Research paper (scientific journal)

Increased sorbitol levels in the hypertrophic ligamentumflavum of diabetic patients with lumbar spinal canal stenosis

Luo J, Huang L, Chen Z, Zeng Z, Miyamoto T, Wu H, Zhang Z, Pan Z, Fujita N, Hikata T, Iwanami A, Tsuji T, Ishii K, Nakamura M, Matsumoto M, Watanabe K, Cao K

Journal of orthopaedic research 35 ( 5 ) 1058 - 1066 2017

Research paper (scientific journal)

Compound Heterozygosity for Null Mutations and a Common Hypomorphic Risk Haplotype in TBX6 Causes Congenital Scoliosis

Takeda K, Kou I, Kawakami N, Iida A, Nakajima M, Ogura Y, Imagawa E, Miyake N, Matsumoto N, Yasuhiko Y, Sudo H, Kotani T, Japan Early Onset Scoliosis Research Group, Nakamura M, Matsumoto M, Watanabe K, Ikegawa S

Human mutation 38 ( 3 ) 317 - 323 2017

Research paper (scientific journal)

Scoliosis is a Risk Factor for Gastroesophageal Reflux Disease in Adult Spinal Deformity

Hosogane N, Watanabe K, Yagi M, Kaneko S, Toyama Y, Matsumoto M

Clinical spine surgery 30 ( 4 ) E480 - E484 2017

Research paper (scientific journal)

Onset and remodeling of coronal imbalance after selective posterior thoracic fusion for Lenke 1C and 2C adolescent idiopathic scoliosis (a pilot study)

Ishikawa M, Cao K, Pang L, Fujita N, Yagi M, Hosogane N, Tsuji T, Machida M, Ishihara S, Nishiyama M, Fukui Y, Nakamura M, Matsumoto M, Watanabe K

Scoliosis and Spinal Disorders 12   16 2017

Research paper (scientific journal)

Histomorphometric analysis of minimodeling in the vertebrae in postmenopausal patients treated with anti-osteoporotic agents

Hikata T, Hasegawa T, Horiuchi K, Fujita N, Iwanami A, Watanabe K, Ishii K, Nakamura M, Amizuka N, Matsumoto M

Bone reports 5   286 - 291 2017

Research paper (scientific journal)

Effect of the upper instrumented vertebral level (upper vs. lower thoracic spine) on gait ability after corrective surgery for adult spinal deformity

Yagi M, Fujita N, Tsuji O, Nagoshi N, Yato Y, Asazuma T, Ishii K, Nakamura M, Matsumoto M, Watanabe K

The Spine Journal (Spine Journal)  18 ( 1 ) 130 - 138 2017

Research paper (scientific journal),  ISSN  15299430

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© 2017 Elsevier Inc. Background Context The relationship between gait pattern and the level of upper instrumented vertebra (UIV) in surgically treated patients with adult spinal deformity (ASD) has not been fully documented. Purpose This study aimed to assess the effect of UIV level for the gait pattern in ASD. Study Design/Setting A prospective case series was carried out. Patient Sample Thirty surgically treated consecutive female ASD with lumbosacral fusion (age 67.0±8.4 years; body mass index 22.7±2.4 kg/m 2 ; Cobb angle 49.9°±21.3°; coronal vertical axis 1.5±3.6 cm; C7 sagittal vertical axis [C7SVA] 9.3±5.3 cm; pelvic incidence-lumbar lordosis 35.4°±25.8°; and lean volume of the lower leg 5.5±0.9 kg) were categorized into upper thoracic [UT] group or lower thoracic [LT] group based on the level of UIV (UT; UIV T2–T5, LT; UIV T9–T11), and the gait pattern were compared before and after corrective spine surgery. Outcome Measures Scoliosis Research Society Patient Questionnaire, Oswestry Disability Index, and force plate analysis were the outcome measures. Methods All subjects underwent gait analysis on a custom-built force plate. Dual-energy X-ray absorptiometry. Subjects were followed-up for at least 2 years postoperation. Results The UT group had larger baseline Cobb angle, whereas the LT group had larger C7SVA (UT vs. LT; Cobb angle: 59.2±22.9 vs. 44.6±17.4° p=.03, C7SVA: 10.9±8.7 vs. 12.0±7.1 cm, p=.03). Preoperatively, no difference was found in gait velocity and stride between UT and LT group, whereas the right and left difference of step length was significantly large in UT group (velocity: 55.0±12.5 vs. 53.6±9.0 m/min, stride: 99.7±13.0 vs. 97.8±13.6 cm, step length; 10.4±4.9 vs. 5.6%±3.3%). Coronal and sagittal alignments were significantly improved in both groups (total; Cobb angle: 19.4°±10.6° C7SVA: 5.3±2.9 cm, PI–LL: 12.1°±5.1°). Gait pattern, stride, and velocity all improved significantly after surgery (total; velocity: 62.3±8.9m/min, stride: 106.8±12.3 cm, p=.01). The knee angle at the heel contact phase and hip range of motion (ROM) were also significantly improved at postoperation (total; hip ROM: preoperation: 29.2°±9.1° postoperation: 36.2°±4.8° knee angle; preoperation: 10.6°±6.6° postoperation: 4.4°±2.8°). No difference was observed for the pelvis and shoulder rotation on the horizontal plane at postoperation in both groups (total; pelvis rotation; preoperation: 7.4°±3.4° postoperation: 7.9°±2.4° shoulder rotation; preoperation: 7.4°±2.9° postoperation: 8.7°±3.6°). The head vertical deviation was also not changed postoperatively in both groups (preoperation: 3.1±0.9 cm, postoperation: 3.1±0.8 cm). Conclusions Both UT and LT groups achieved similar improvement of gait ability and pattern after surgery. Additional studies will be needed to further define the effect of UIV for the activity of daily living such as fast walking, stepping the stairs, or standing from the chair in ASDs.

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Response to Lefebvre et al

Takeda K, Kou I, kawakami N, Yasuhiko Y, Ogura Y, Imagawa E, Miyake N, Matsumoto N, Sudo H, Kotani T, Japan Early Onset Scoliosis Research Group, Nakamura M, Matsumoto M, Watanabe K, Ikegawa S

Clinical Genetics  2017

Research paper (scientific journal)

Factors associated with postoperative C5 palsy after expansive open-door laminoplasty: retrospective cohort study using multivariable analysis

Tsuji T, Matsumoto M, Nakamura M, Ishii K, Fujita N, Chiba K, Watanabe K

European Spine Journal 26   2410 - 2416 2017

Research paper (scientific journal)

Presence of Modic type 1 change increases risk of postoperative pyogenic discitis following decompression surgery for lumbar canal stenosis

Ninomiya K, Fujita N, Hosogane N, Hikata T, Watanabe K, Tsuji O, Nagoshi N, Yagi M, Kaneko S, Fukui Y, Koyanagi T, Shiraishi T, Tsuji T, Nakamura M, Matsumoto M, Ishii K

Journal of Orthopaedic Science  2017

Research paper (scientific journal)

Correlation between preoperative physical signs and functional outcomes after laminoplasty for ossification of the posterior longitudinal ligament

Tsuji T, Fujita N, Watanabe K, Nakamura M, Matsumoto M, Ishii K

Journal of orthopaedic science 22 ( 2 ) 266 - 269 2017

Research paper (scientific journal)

Low Bone-Mineral Density Is a Significan Risk for Proximal Junctional failure After Surgical correction of Adult Spinal Deformity

Yagi M, Fujita N, Tsuji O, Nagoshi N, Asazuma T, Ishii K, Nakamura M, Matsumoto M, Watanabe K

Spine 42 2017

Research paper (scientific journal)

Idiopathic Spinal epidural fat accumulation is associated with hyperlipidemia

Ishihara S, Fujita N, Yagi M, Tsuji T, Michikawa T, Nishiwaki Y, Fukui Y, Horiuchi K, Ishii K, Nakamura M, Matsumoto M, Watanabe K

Spine (Spine)  43 ( 8 ) E468 - E473 2017

Research paper (scientific journal),  ISSN  03622436

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© 2018 Wolters Kluwer Health, Inc. Study Design. Single-center retrospective analysis of consecutively collected data. Objective. To determine the clinical characteristics of idiopathic spinal epidural lipomatosis (SEL). Summary of Background Data. SEL is associated with the overt accumulation of nonencapsulated adipose tissue in the epidural space, leading to spinal cord or nerve root compression. The etiology of this condition is currently not completely understood. Methods. Data of 166 male patients who underwent primary surgery for lumbar spinal canal stenosis (LSS) from May 2013 to February 2016 were retrospectively reviewed. Participants were divided into three groups based on the degree of epidural lipomatous lesion. Patient data of age at surgery, body mass index, prevalence of common noncommunicable diseases, blood tests, arteriosclerotic index, and preoperative clinical scores (assessed using the Japanese Orthopedic Association Back Pain Evaluation Questionnaire) were evaluated. Multivariate analysis was performed to assess the potential associated factors for idiopathic SEL. Results. Patients with LSS with severe SEL had a significantly higher body mass index and elevated serum levels of total cholesterol and triglyceride compared with those without SEL. Analysis of preoperative clinical scores revealed that patients with SEL experienced pain more frequently and showed less walking ability than did those without SEL. Multivariate analysis revealed that hyperlipidemia was significantly associated with idiopathic SEL (odds ratio =3.74, 95% confidence interval =1.31-10.64). Conclusion. Our data suggest that aberrant lipid metabolism is related to the pathogenesis of idiopathic SEL and that patients with LSS with idiopathic SEL have more severe pain than do those without SEL.

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A cost -effectiveness comparisons of adult spinal deformity surgry in the United States and Japan

Yagi M, Ames CP, Keefe M, Hosogane N, Smith JS, Shaffrey CI, Schwab F, Lafage V, Bess RS, Matsumoto M, Watanabe K, International Spine Study Group

European Spine Journal  2017

Research paper (scientific journal)

Risk factor analysis of kyphotic malalignment after cervical intramedullary tumor resection in adults

Nori S, Iwanami A, Yasuda A, Nagoshi N, Fujita N, Hikata T, Yagi M, Tsuji T, Watanabe K, Momoshima S, Matsumoto M, Nakamura M, Ishii K

Journal of neurosurgery    1 - 10 2017

Research paper (scientific journal)