Okuda, Shigeo



School of Medicine, Department of Radiology (Diagnostic Radiology) (Shinanomachi)


Associate Professor

E-mail Address

E-mail address

External Links

Other Affiliation 【 Display / hide

  • School of Medicine, Associate Professor

Career 【 Display / hide

  • 2008.04

    Senior Assistant Professor, Department of Diagnostic Radiology, Keio School of Medicine, 放射線科学教室(診断), 学部内講師

  • 2015.09

    慶應義塾大学医学部, 放射線科学教室(診断), 准教授

Academic Degrees 【 Display / hide

  • Medical Doctor, Keio University, Dissertation


Research Areas 【 Display / hide

  • Radiation science (Radiation Science)

Research Keywords 【 Display / hide

  • MRI

  • Diagnostic Radiology


Books 【 Display / hide

  • 心臓・大血管 画像診断の勘ドコロNEO

    横山 健一 編, 奥田 茂男 他, メジカルビュー社, 2021.03,  Page: 280

    Scope: 疾患編Ⅲ章 心筋症 4.左室緻密化障害(LVNC), 5. 不整脈原性右室心筋症(ARVC),  Contact page: 84-87

  • MRI 応用自在

    高原 太郎 監修, 堀 正明, 本杉 宇太郎, 高橋 光幸 編, 奥田 茂男 他, メジカルビュー社, 2021.03,  Page: 514

    Scope: VI. その他の臓器 9. 心筋虚血と梗塞の診断,  Contact page: 489-498

  • ここから始める循環器疾患のCT・MRI

    似鳥 俊明, 横山 健一 編著, 奥田 茂男, 田村 全, 須山 陽介, 中塚 誠之, 陣崎 雅弘 他, 学研メディカル秀潤社, 2020.04,  Page: 260

    Scope: 4章 腹部 腹部大動脈瘤、破裂腹部大動脈瘤、炎症性大動脈瘤、感染性大動脈瘤、腹部限局性大動脈解離、Leriche症候群,  Contact page: 180-193

  • Critical Care Cardiology

    ITOU DAIKI, MATSUMOTO NAOYA, OKUDA SHIGEO, メディカル・サイエンス・インターナショナル, 2015.06

    Scope: 5章 画像検査

  • Non invasive imaging of CAD


    Scope: 92-98

Papers 【 Display / hide

  • Diagnostic value of texture analysis of apparent diffusion coefficient maps for differentiating fat-poor angiomyolipoma from non-clear-cell renal cell carcinoma

    Arita Y., Yoshida S., Kwee T.C., Akita H., Okuda S., Iwaita Y., Mukai K., Matsumoto S., Ueda R., Ishii R., Mizuno R., Fujii Y., Oya M., Jinzaki M.

    European Journal of Radiology (European Journal of Radiology)  143 2021.10

    ISSN  0720048X

     View Summary

    Purpose: To investigate the feasibility of texture analysis of apparent diffusion coefficient (ADC) maps for differentiating fat-poor angiomyolipomas (fpAMLs) from non-clear-cell renal cell carcinomas (non-ccRCCs). Methods: In this bi-institutional study, we included two consecutive cohorts from different institutions with pathologically confirmed solid renal masses: 67 patients (fpAML = 46; non-ccRCC = 21) for model development and 39 (fpAML = 24; non-ccRCC = 15) for validation. Patients underwent preoperative magnetic resonance imaging (MRI), including diffusion-weighted imaging. We extracted 45 texture features using a software with volumes of interest on ADC maps. Receiver operating characteristic curve analysis was performed to compare the diagnostic performance between the random forest (RF) model (derived from extracted texture features) and conventional subjective evaluation using computed tomography and MRI by radiologists. Results: RF analysis revealed that grey-level zone length matrix long-zone high grey-level emphasis was the dominant texture feature for diagnosing fpAML. The area under the curve (AUC) of the RF model to distinguish fpAMLs from non-ccRCCs was not significantly different between the validation and development cohorts (p = .19). In the validation cohort, the AUC of the RF model was similar to that of board-certified radiologists (p = .46) and significantly higher than that of radiology residents (p = .03). Conclusions: Texture analysis of ADC maps demonstrated similar diagnostic performance to that of board-certified radiologists for discriminating between fpAMLs and non-ccRCCs. Diagnostic performances in the development and validation cohorts were comparable despite using data from different imaging device manufacturers and institutions.

  • Diagnostic value of computed high b-value whole-body diffusion-weighted imaging for primary prostate cancer

    Arita Y., Yoshida S., Waseda Y., Takahara T., Ishii C., Ueda R., Kwee T.C., Miyahira K., Ishii R., Okuda S., Jinzaki M., Fujii Y.

    European Journal of Radiology (European Journal of Radiology)  137 2021.04

    ISSN  0720048X

     View Summary

    © 2021 Elsevier B.V. Purpose: To investigate the utility of post-acquisition computed diffusion-weighted imaging (cDWI) for primary prostate cancer (PCa) evaluation in biparametric whole-body MRI (bpWB-MRI). Methods: Patients who underwent pelvic MRI for PCa screening and subsequent bpWB-MRI for staging were included. Two radiologists assessed the diagnostic performance of the following datasets for clinically significant PCa diagnosis (grade group ≥2 according to the Prostate Imaging-Reporting and Data System, version 2.1): bpMRI2000 (axial DWI scans with a b-value of 2,000 s/mm2 + axial T2WI scans from pre-biopsy pelvic MRI), computed bpWB-MRI2000 (computed WB-DWI scans with a b-value of 2,000 s/mm2 + axial WB-T2WI scans), and native bpWB-MRI1000 (native axial WB-DWI scans with a b-value of 1,000 s/mm2 + axial WB-T2WI scans). Systemic biopsy was used as reference standard. Results: Fifty-one patients with PCa were included. The areas under the curve (AUCs) of bpMRI2000 (0.89 for reader 1 and 0.86 for reader 2) and computed bpWB-MRI2000 (0.86 for reader 1 and 0.83 for reader 2) were significantly higher (p < 0.001) than those of native bpWB-MRI1000 (0.67 for both readers). No significant difference was observed between the AUCs of bpMRI2000 and computed bpWB-MRI2000 (p = 0.10 for reader 1 and p = 0.25 for reader 2). Conclusions: The diagnostic performance of computed bpWB-MRI2000 was similar to that of dedicated pelvic bpMRI2000 for primary PCa evaluation. cDWI can be recommended for implementation in standard WB-MRI protocols to facilitate a one-step evaluation for concurrent detection of primary and metastatic PCa.

  • Radiologic features of mixed epithelial and stromal tumors of the kidney: Hyperattenuating on unenhanced computed tomography and T2-hypointensity on magnetic resonance imaging

    Tatsuya S., Hirotaka A., Yuki A., Akiko T., Masahiro H., Shigeo O., Shuji M., Ryuichi M., Mototsugu O., Masahiro J.

    Radiology Case Reports (Radiology Case Reports)  16 ( 4 ) 858 - 862 2021.04

     View Summary

    In the 2016 World Health Organization renal tumor classification, the mixed epithelial and stromal tumor family was introduced as a new entity. This family encompasses a spectrum of tumors, ranging from predominantly cystic tumors (adult cystic nephromas) to tumors that are variably solid (mixed epithelial and stromal tumors). The majority of previous studies incorporating “mixed epithelial and stromal tumor” in the titles were actually reports of imaging findings of adult cystic nephroma. Thus, the solid component of mixed epithelial and stromal tumors has not been well evaluated. In this study, we present 2 cases of mixed epithelial and stromal tumors, as defined by the 2016 World Health Organization classification, showing a predominantly solid component. The characteristic findings of the solid component of these tumors were T2-hypointensity on magnetic resonance imaging and hyperattenuation on unenhanced computed tomography. Angiomyolipoma with epithelial cysts and epithelioid angiomyolipoma should be considered in the differential diagnosis of mixed epithelial and stromal tumors.

  • Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals

    Kawaguchi S., Soma Y., Nakajima K., Kanazawa H., Tohyama S., Tabei R., Hirano A., Handa N., Yamada Y., Okuda S., Hishikawa S., Teratani T., Kunita S., Kishino Y., Okada M., Tanosaki S., Someya S., Morita Y., Tani H., Kawai Y., Yamazaki M., Ito A., Shibata R., Murohara T., Tabata Y., Kobayashi E., Shimizu H., Fukuda K., Fujita J.

    JACC: Basic to Translational Science (JACC: Basic to Translational Science)  6 ( 3 ) 239 - 254 2021.03

    ISSN  2452302X

     View Summary

    The severe shortage of donor hearts hampered the cardiac transplantation to patients with advanced heart failure. Therefore, cardiac regenerative therapies are eagerly awaited as a substitution. Human induced pluripotent stem cells (hiPSCs) are realistic cell source for regenerative cardiomyocytes. The hiPSC-derived cardiomyocytes are highly expected to help the recovery of heart. Avoidance of teratoma formation and large-scale culture of cardiomyocytes are definitely necessary for clinical setting. The combination of pure cardiac spheroids and gelatin hydrogel succeeded to recover reduced ejection fraction. The feasible transplantation strategy including transplantation device for regenerative cardiomyocytes are established in this study.

  • Peritoneal dissemination of pancreatic cancer caused by endoscopic ultrasound-guided fine needle aspiration: A case report and literature review

    Hideaki Kojima, Minoru Kitago, Eisuke Iwasaki, Yohei Masugi, Yohji Matsusaka, Hiroshi Yagi, Yuta Abe, Yasushi Hasegawa, Shutaro Hori, Masayuki Tanaka, Yutaka Nakano, Yusuke Takemura, Seiichiro Fukuhara, Yoshiyuki Ohara, Michiie Sakamoto, Shigeo Okuda, Yuko Kitagawa

    World Journal of Gastroenterology (World Journal of Gastroenterology)  27 ( 3 ) 294 - 304 2021.01

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  1007-9327

     View Summary

    © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. BACKGROUND Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is a biopsy technique widely used to diagnose pancreatic tumors because of its high sensitivity and specificity. Although needle-tract seeding caused by EUS-FNA has been recently reported, dissemination of pancreatic cancer cells is generally considered to be a rare complication that does not affect patient prognosis. However, the frequency of dissemination and needle-tract seeding appears to have been underestimated. We present a case of peritoneal dissemination of pancreatic cancer due to preoperative EUS-FNA. CASE SUMMARY An 81-year-old man was referred to the Department of Surgery of our hospital in Japan owing to the detection of a pancreatic mass on computed tomography during medical screening. Trans-gastric EUS-FNA revealed that the mass was an adenocarcinoma; hence laparoscopic distal pancreatectomy with lymphadenectomy was performed. No intraoperative peritoneal dissemination and liver metastasis were visually detected, and pelvic lavage cytology was negative for carcinoma cells. The postoperative surgical specimen was negative for carcinoma cells at the dissected margin and the cut end margin; however, pathological findings revealed adenocarcinoma cells on the peritoneal surface proximal to the needle puncture site, and the cells were suspected to be disseminated via EUS-FNA. Hence, the patient received adjuvant therapy with S-1 (tegafur, gimeracil, and oteracil potassium); however, computed tomography performed 5 mo after surgery revealed liver metastasis and cancerous peritonitis. The patient received palliative therapy and died 8 mo after the operation. CONCLUSION The indications of EUS-FNA should be carefully considered to avoid iatrogenic dissemination, especially for cancers in the pancreatic body or tail.

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • Q&Aでまとめる 予後予測・治療効果予測の画像検査

    臨床画像編集委員会 編, 奥田 茂男 他

    臨床放射線 (金原出版)  65 ( 8 ) 847 - 858 2020.08

    Introduction and explanation (scientific journal), Joint Work

  • 循環器疾患の画像診断 - 現状と進歩

    陣崎 雅弘 編, 奥田 茂男 他

    循環器ジャーナル (医学書院)  67 ( 3 ) 420 - 427 2019.07

    Introduction and explanation (scientific journal), Joint Work

Presentations 【 Display / hide

  • 問題症例検討

    三浦 瑛祐、尾島 英知、久保田 直人、遠山 兼史、松坂 陽至、阿部 紘大、遠藤 泰、辻川 華子、上野 彰久、真杉 洋平、北郷 実、奥田 茂男、坂元 亨宇

    第56回日本肝癌研究会 (大阪) , 2020.12, Oral Presentation(general)

  • 子宮頸部腺癌診療の問題点を探る : 画像、特にMRIの立場から

    Shigeo Okuda

    第59回日本臨床細胞学会秋季大会 (Yokohama) , 2020.11, Oral Presentation(guest/special)

  • 非層流の速度計測におけるパラドックス1-拡張した肺動脈における血流評価-

    奥田 茂男, 松本 俊亮, 鈴木 達也, 田村 全, 山田 祥岳, 藤代 力也, 川上 崇, 陣崎 雅弘

    第2回 4D Flow 研究会, 2020.10, Oral Presentation(general)

  • Improvement of silent navigator signal combination

    Yuji Iwadate, Atsushi Nozaki, Yoshinobu Nunokawa, Shigeo Okuda, Tetsuya Wakayama, Masahiro Jinzaki

    第48回日本磁気共鳴医学会大会, 2020.09, Oral Presentation(general)

  • A novel technique for determining evaluation area on elastogram with coherentwave auto-selection (CHASE)

    Daiki Ito, Tomokazu Numano, Tetsushi Habe, Toshiki Maeno, Kazuyuki Mizuhara, Koshi Okabe, Shigeo Okuda, Masahiro Jinzaki

    第48回日本磁気共鳴医学会大会, 2020.09, Oral Presentation(general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • The value of 4D flow with dual VENC for evaluating blood flow


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 奥田 茂男, Grant-in-Aid for Scientific Research (C), Principal Investigator

  • 大動脈および肺動脈の低侵襲治療における 4D flow MRI を用いた血流評価


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 奥田 茂男, Grant-in-Aid for Scientific Research (C), Principal Investigator


Courses Taught 【 Display / hide











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Courses Previously Taught 【 Display / hide

  • Imaging of hepatobiliary system

    Keio University, 2015, Full academic year, Major subject, Lecture, Within own faculty, 100people


  • Guidance to Diagnostic Radiology

    Keio University, 2015, Full academic year, Major subject, Lecture, Within own faculty, 100people


  • Diagnostic Radiology

    Keio University, 2015, Full academic year, Major subject, Seminar, Within own faculty, 1h