奥田　茂男 (オクダ　シゲオ)

Okuda, Shigeo

写真a

所属（所属キャンパス）

医学部 放射線科学教室（診断） （信濃町）

職名

講師

外部リンク
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  • 医学部, 准教授

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経歴 【 表示 ／ 非表示 】

  • 2008年04月
    -
    2015年08月

    慶應義塾大学医学部, 放射線科学教室（診断）, 学部内講師

  • 2015年09月
    -
    継続中

    慶應義塾大学医学部, 放射線科学教室（診断）, 准教授

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  • 医学博士, 慶應義塾大学, 論文

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  • ライフサイエンス / 放射線科学 (Radiation Science)

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研究キーワード 【 表示 ／ 非表示 】

  • 核磁気共鳴

  • 画像診断学

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著書 【 表示 ／ 非表示 】

  • 心臓・大血管 画像診断の勘ドコロNEO

    横山　健一　編, 奥田　茂男　他, メジカルビュー社, 2021年03月,  ページ数： 280

    担当範囲: 疾患編Ⅲ章 心筋症 4.左室緻密化障害(LVNC), 5. 不整脈原性右室心筋症(ARVC),  担当ページ： 84-87

  • MRI 応用自在

    高原　太郎　監修, 堀　正明, 本杉　宇太郎, 高橋　光幸 編, 奥田　茂男　他, メジカルビュー社, 2021年03月,  ページ数： 514

    担当範囲: VI. その他の臓器　9. 心筋虚血と梗塞の診断,  担当ページ： 489-498

  • ここから始める循環器疾患のCT・MRI

    似鳥　俊明, 横山　健一　編著, 奥田　茂男, 田村　全, 須山　陽介, 中塚　誠之, 陣崎　雅弘　他, 学研メディカル秀潤社, 2020年04月,  ページ数： 260

    担当範囲: 4章 腹部 腹部大動脈瘤、破裂腹部大動脈瘤、炎症性大動脈瘤、感染性大動脈瘤、腹部限局性大動脈解離、Leriche症候群,  担当ページ： 180-193

  • 循環器急性期診療

    伊藤大樹、松本直也、奥田 茂男, メディカル・サイエンス・インターナショナル, 2015年06月

    担当範囲: ５章　画像検査

  • 冠動脈疾患の非観血的イメージング

    奥田 茂男、谷本　伸弘、栗林　幸夫, 中山書店、東京, 2006年07月

    担当範囲: 92-98

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  • Diagnostic value of texture analysis of apparent diffusion coefficient maps for differentiating fat-poor angiomyolipoma from non-clear-cell renal cell carcinoma

    Arita Y., Yoshida S., Kwee T.C., Akita H., Okuda S., Iwaita Y., Mukai K., Matsumoto S., Ueda R., Ishii R., Mizuno R., Fujii Y., Oya M., Jinzaki M.

    European Journal of Radiology （European Journal of Radiology)  143 2021年10月

    ISSN  0720048X

    　概要を見る

    Purpose: To investigate the feasibility of texture analysis of apparent diffusion coefficient (ADC) maps for differentiating fat-poor angiomyolipomas (fpAMLs) from non-clear-cell renal cell carcinomas (non-ccRCCs). Methods: In this bi-institutional study, we included two consecutive cohorts from different institutions with pathologically confirmed solid renal masses: 67 patients (fpAML = 46; non-ccRCC = 21) for model development and 39 (fpAML = 24; non-ccRCC = 15) for validation. Patients underwent preoperative magnetic resonance imaging (MRI), including diffusion-weighted imaging. We extracted 45 texture features using a software with volumes of interest on ADC maps. Receiver operating characteristic curve analysis was performed to compare the diagnostic performance between the random forest (RF) model (derived from extracted texture features) and conventional subjective evaluation using computed tomography and MRI by radiologists. Results: RF analysis revealed that grey-level zone length matrix long-zone high grey-level emphasis was the dominant texture feature for diagnosing fpAML. The area under the curve (AUC) of the RF model to distinguish fpAMLs from non-ccRCCs was not significantly different between the validation and development cohorts (p = .19). In the validation cohort, the AUC of the RF model was similar to that of board-certified radiologists (p = .46) and significantly higher than that of radiology residents (p = .03). Conclusions: Texture analysis of ADC maps demonstrated similar diagnostic performance to that of board-certified radiologists for discriminating between fpAMLs and non-ccRCCs. Diagnostic performances in the development and validation cohorts were comparable despite using data from different imaging device manufacturers and institutions.

  • Diagnostic value of computed high b-value whole-body diffusion-weighted imaging for primary prostate cancer

    Arita Y., Yoshida S., Waseda Y., Takahara T., Ishii C., Ueda R., Kwee T.C., Miyahira K., Ishii R., Okuda S., Jinzaki M., Fujii Y.

    European Journal of Radiology （European Journal of Radiology)  137 2021年04月

    ISSN  0720048X

    　概要を見る

    © 2021 Elsevier B.V. Purpose: To investigate the utility of post-acquisition computed diffusion-weighted imaging (cDWI) for primary prostate cancer (PCa) evaluation in biparametric whole-body MRI (bpWB-MRI). Methods: Patients who underwent pelvic MRI for PCa screening and subsequent bpWB-MRI for staging were included. Two radiologists assessed the diagnostic performance of the following datasets for clinically significant PCa diagnosis (grade group ≥2 according to the Prostate Imaging-Reporting and Data System, version 2.1): bpMRI2000 (axial DWI scans with a b-value of 2,000 s/mm2 + axial T2WI scans from pre-biopsy pelvic MRI), computed bpWB-MRI2000 (computed WB-DWI scans with a b-value of 2,000 s/mm2 + axial WB-T2WI scans), and native bpWB-MRI1000 (native axial WB-DWI scans with a b-value of 1,000 s/mm2 + axial WB-T2WI scans). Systemic biopsy was used as reference standard. Results: Fifty-one patients with PCa were included. The areas under the curve (AUCs) of bpMRI2000 (0.89 for reader 1 and 0.86 for reader 2) and computed bpWB-MRI2000 (0.86 for reader 1 and 0.83 for reader 2) were significantly higher (p < 0.001) than those of native bpWB-MRI1000 (0.67 for both readers). No significant difference was observed between the AUCs of bpMRI2000 and computed bpWB-MRI2000 (p = 0.10 for reader 1 and p = 0.25 for reader 2). Conclusions: The diagnostic performance of computed bpWB-MRI2000 was similar to that of dedicated pelvic bpMRI2000 for primary PCa evaluation. cDWI can be recommended for implementation in standard WB-MRI protocols to facilitate a one-step evaluation for concurrent detection of primary and metastatic PCa.

  • Radiologic features of mixed epithelial and stromal tumors of the kidney: Hyperattenuating on unenhanced computed tomography and T2-hypointensity on magnetic resonance imaging

    Tatsuya S., Hirotaka A., Yuki A., Akiko T., Masahiro H., Shigeo O., Shuji M., Ryuichi M., Mototsugu O., Masahiro J.

    Radiology Case Reports （Radiology Case Reports)  16 （ 4 ） 858 - 862 2021年04月

    　概要を見る

    In the 2016 World Health Organization renal tumor classification, the mixed epithelial and stromal tumor family was introduced as a new entity. This family encompasses a spectrum of tumors, ranging from predominantly cystic tumors (adult cystic nephromas) to tumors that are variably solid (mixed epithelial and stromal tumors). The majority of previous studies incorporating “mixed epithelial and stromal tumor” in the titles were actually reports of imaging findings of adult cystic nephroma. Thus, the solid component of mixed epithelial and stromal tumors has not been well evaluated. In this study, we present 2 cases of mixed epithelial and stromal tumors, as defined by the 2016 World Health Organization classification, showing a predominantly solid component. The characteristic findings of the solid component of these tumors were T2-hypointensity on magnetic resonance imaging and hyperattenuation on unenhanced computed tomography. Angiomyolipoma with epithelial cysts and epithelioid angiomyolipoma should be considered in the differential diagnosis of mixed epithelial and stromal tumors.

  • Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals

    Kawaguchi S., Soma Y., Nakajima K., Kanazawa H., Tohyama S., Tabei R., Hirano A., Handa N., Yamada Y., Okuda S., Hishikawa S., Teratani T., Kunita S., Kishino Y., Okada M., Tanosaki S., Someya S., Morita Y., Tani H., Kawai Y., Yamazaki M., Ito A., Shibata R., Murohara T., Tabata Y., Kobayashi E., Shimizu H., Fukuda K., Fujita J.

    JACC: Basic to Translational Science （JACC: Basic to Translational Science)  6 （ 3 ） 239 - 254 2021年03月

    ISSN  2452302X

    　概要を見る

    The severe shortage of donor hearts hampered the cardiac transplantation to patients with advanced heart failure. Therefore, cardiac regenerative therapies are eagerly awaited as a substitution. Human induced pluripotent stem cells (hiPSCs) are realistic cell source for regenerative cardiomyocytes. The hiPSC-derived cardiomyocytes are highly expected to help the recovery of heart. Avoidance of teratoma formation and large-scale culture of cardiomyocytes are definitely necessary for clinical setting. The combination of pure cardiac spheroids and gelatin hydrogel succeeded to recover reduced ejection fraction. The feasible transplantation strategy including transplantation device for regenerative cardiomyocytes are established in this study.

  • Peritoneal dissemination of pancreatic cancer caused by endoscopic ultrasound-guided fine needle aspiration: A case report and literature review

    Kojima H., Kitago M., Iwasaki E., Masugi Y., Matsusaka Y., Yagi H., Abe Y., Hasegawa Y., Hori S., Tanaka M., Nakano Y., Takemura Y., Fukuhara S., Ohara Y., Sakamoto M., Okuda S., Kitagawa Y.

    World Journal of Gastroenterology （World Journal of Gastroenterology)  27 （ 3 ） 294 - 304 2021年01月

    研究論文（学術雑誌）, 共著, 査読有り,  ISSN  1007-9327

    　概要を見る

    © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. BACKGROUND Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is a biopsy technique widely used to diagnose pancreatic tumors because of its high sensitivity and specificity. Although needle-tract seeding caused by EUS-FNA has been recently reported, dissemination of pancreatic cancer cells is generally considered to be a rare complication that does not affect patient prognosis. However, the frequency of dissemination and needle-tract seeding appears to have been underestimated. We present a case of peritoneal dissemination of pancreatic cancer due to preoperative EUS-FNA. CASE SUMMARY An 81-year-old man was referred to the Department of Surgery of our hospital in Japan owing to the detection of a pancreatic mass on computed tomography during medical screening. Trans-gastric EUS-FNA revealed that the mass was an adenocarcinoma; hence laparoscopic distal pancreatectomy with lymphadenectomy was performed. No intraoperative peritoneal dissemination and liver metastasis were visually detected, and pelvic lavage cytology was negative for carcinoma cells. The postoperative surgical specimen was negative for carcinoma cells at the dissected margin and the cut end margin; however, pathological findings revealed adenocarcinoma cells on the peritoneal surface proximal to the needle puncture site, and the cells were suspected to be disseminated via EUS-FNA. Hence, the patient received adjuvant therapy with S-1 (tegafur, gimeracil, and oteracil potassium); however, computed tomography performed 5 mo after surgery revealed liver metastasis and cancerous peritonitis. The patient received palliative therapy and died 8 mo after the operation. CONCLUSION The indications of EUS-FNA should be carefully considered to avoid iatrogenic dissemination, especially for cancers in the pancreatic body or tail.

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総説・解説等 【 表示 ／ 非表示 】

  • Q&Aでまとめる　予後予測・治療効果予測の画像検査

    臨床画像編集委員会　編, 奥田　茂男　他

    臨床放射線 (金原出版)  65 ( 8 ) 847 - 858 2020年08月

    記事・総説・解説・論説等（学術雑誌）, 共著

  • 循環器疾患の画像診断 - 現状と進歩

    陣崎　雅弘　編, 奥田　茂男　他

    循環器ジャーナル (医学書院)  67 ( 3 ) 420 - 427 2019年07月

    記事・総説・解説・論説等（学術雑誌）, 共著

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研究発表 【 表示 ／ 非表示 】

  • 問題症例検討

    三浦 瑛祐、尾島 英知、久保田 直人、遠山 兼史、松坂 陽至、阿部 紘大、遠藤 泰、辻川 華子、上野 彰久、真杉 洋平、北郷 実、奥田 茂男、坂元 亨宇

    第56回日本肝癌研究会 (大阪) , 

    2020年12月
    , 

    口頭発表（一般）

  • 子宮頸部腺癌診療の問題点を探る ： 画像、特にMRIの立場から

    奥田茂男

    第59回日本臨床細胞学会秋季大会 (横浜) , 

    2020年11月
    , 

    口頭発表（招待・特別）

  • 非層流の速度計測におけるパラドックス１-拡張した肺動脈における血流評価-

    奥田 茂男, 松本 俊亮, 鈴木 達也, 田村 全, 山田 祥岳, 藤代 力也, 川上 崇, 陣崎 雅弘

    第２回 4D Flow 研究会, 

    2020年10月
    , 

    口頭発表（一般）

  • 静音ナビゲータ信号合成法の改善

    Yuji Iwadate, Atsushi Nozaki, Yoshinobu Nunokawa, Shigeo Okuda, Tetsuya Wakayama, Masahiro Jinzaki

    第48回日本磁気共鳴医学会大会, 

    2020年09月
    , 

    口頭発表（一般）

  • MR エラストグラフィにおける弾性率評価領域の自動抽出 (CHASE)

    Daiki Ito, Tomokazu Numano, Tetsushi Habe, Toshiki Maeno, Kazuyuki Mizuhara, Koshi Okabe, Shigeo Okuda, Masahiro Jinzaki

    第48回日本磁気共鳴医学会大会, 

    2020年09月
    , 

    口頭発表（一般）

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競争的研究費の研究課題 【 表示 ／ 非表示 】

  • 低速血流にも対応する 4D flow 法による血流評価

    2018年04月
    -
    2021年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 奥田　茂男, 基盤研究(C), 補助金,  研究代表者

  • 大動脈および肺動脈の低侵襲治療における 4D flow MRI を用いた血流評価

    2015年04月
    -
    2019年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 奥田　茂男, 基盤研究(C), 補助金,  研究代表者

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担当授業科目 【 表示 ／ 非表示 】

  • 先端医療技術

    2022年度

  • 放射線医学講義

    2022年度

  • 内科学（消化器）講義

    2022年度

  • 内科学（循環器）講義

    2022年度

  • 臨床実習入門

    2022年度

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  • 消化器内科系統講義 肝胆画像診断

    慶應義塾

    2015年04月
    -
    2016年03月
    , 

    通年, 講義, 専任, 100人

    肝臓、胆嚢、画像診断

  • 放射線診断学系統講義

    慶應義塾

    2015年04月
    -
    2016年03月
    , 

    通年, 講義, 専任, 100人

    MR基礎

  • 放射線診断学

    慶應義塾

    2015年04月
    -
    2016年03月
    , 

    通年, 演習, 専任, 1時間

    消化管造影、心大血管画像診断

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