Osawa, Yusuke



Graduate School of Health Management (Shonan Fujisawa)


Associate Professor

Other Affiliation 【 Display / hide

  • Sports Medicine Research Center, 兼担所員

Academic Degrees 【 Display / hide

  • Master of Science in Health Management, Keio University, Coursework, 2007.03

  • 博士(健康マネジメント学), Keio University, Coursework, 2011.08

    Effects of resistance training with whole-body vibration on muscle fitness and program design for untrained healthy adults


Research Areas 【 Display / hide

  • Life Science / Medical management and medical sociology (Aging Exercise)

  • Life Science / Sports sciences

Research Keywords 【 Display / hide

  • Aging; Epidemiology; Proteomics; Sarcopenia


Papers 【 Display / hide

  • Plasma amino acid signature for sarcopenic phenotypes in community-dwelling octogenarians: Results from the Kawasaki Aging Wellbeing Project

    Y Osawa, J Candia, Y Abe, T Tajima, Y Oguma, Y Arai

    Experimental Gerontology 178, 112230 (Experimental Gerontology)  178   112230 2023.07

    Single Work,  ISSN  0531-5565

     View Summary

    Sarcopenia is one of the primary risk factors for various adverse health events in later life. However, its pathophysiology in the very old population remains unclear. Hence, this study aimed to examine whether plasma free amino acids (PFAAs) correlate with major sarcopenic phenotypes (i.e., muscle mass, muscle strength, and physical performance) in community-dwelling adults aged 85–89 years living in Japan. Cross-sectional data from the Kawasaki Aging Well-being Project were used. We included 133 adults aged 85–89 years. In this study, fasting blood was collected to measure 20 plasma PFAAs. Measures for the three major sarcopenic phenotypes included appendicular lean mass assessed by multifrequency bioimpedance, isometric handgrip strength, and gait speed from a 5 m walk at a usual pace. Furthermore, we used phenotype–specific elastic net regression models adjusted for age centered at 85 years, sex, body mass index, education level, smoking status, and drinking habit to identify significant PFAAs for each sarcopenic phenotype. Higher histidine and lower alanine levels were associated with poor gait speed, but no PFAAs correlated with muscle strength or mass. In conclusion, PFAAs such as plasma histidine and alanine are novel blood biomarkers associated with physical performance in community-dwelling adults aged 85 years or older.

  • The association between sleep parameters and sarcopenia in Japanese community-dwelling older adults

    T Shibuki, M Iida, S Harada, S Kato, K Kuwabara, A Hirata, M Sata, ...

    Archives of Gerontology and Geriatrics 109, 104948 (Archives of Gerontology and Geriatrics)  109   104948 2023.06

    Single Work,  ISSN  0167-4943

     View Summary

    Purpose: This study aimed to examine the association between sleep duration and quality and sarcopenia, assessed by factors such as low muscle mass (LMM), low muscle strength (LMS), and low physical performance (LPP) among older community-dwellers in Japan. Methods: In this cross-sectional study, a total of 2,069 (men, 902; women, 1,167) participants aged 65 to 80 years were included. Sarcopenia and each low physical function were defined using the definitions of the Asian Working Groups of Sarcopenia 2019. Sleep duration was stratified into three categories: short sleep (<6 h), normal sleep (6-8 h), and long sleep (>8 h). Sleep quality was classified into two groups based on 8-item Athens Insomnia Scale score: insomnia (≥6), and non-insomnia (<6). We analyzed the association between sleep parameters and sarcopenia, including low physical functions, by logistic regression analysis. Results: Compared to normal sleepers, long sleepers had a positive association with sarcopenia (odds ratio [OR] 2.11, 95% confidence interval [CI] 1.25-3.58). In particular, long sleep was strongly associated with LMS (OR 1.77, 95%CI 1.07-2.94) and LPP (OR 1.90, 95%CI 1.25-2.88). On the other hand, poor sleep quality was not associated with sarcopenia in long sleepers, but in normal sleepers. Conclusions: Long sleep was associated with sarcopenia, including LMS and LPP. However, in long sleepers, insomnia was not associated with sarcopenia or any of its components.

  • Plasma growth and differentiation factor 15 predict longitudinal changes in bone parameters in women, but not in men

    Y Osawa, T Tanaka, RD Semba, G Fantoni, R Moaddel, J Candia, ...

    The Journals of Gerontology: Series A  2022.04

    Single Work,  ISSN  1079-5006

  • Proteins in the pathway from high red blood cell width distribution to all-cause mortality

    Y Osawa, T Tanaka, RD Semba, G Fantoni, R Moaddel, J Candia, ...

    EBioMedicine 76, 103816 (eBioMedicine)  76   103816 2022.01

    Research paper (scientific journal), Single Work, Accepted

     View Summary

    Background: The pathophysiological mechanisms underlying the association between red blood cell distribution width (RDW) and all-cause mortality are unknown. We conducted a data-driven discovery investigation to identify plasma proteins that mediate the association between RDW and time to death in community-dwelling adults. Methods: At baseline, 962 adults (women, 54·4%; age range, 21–98 years) participated in the InCHIANTI, “Aging in the Chianti Area” study, and proteomics data were generated from their plasma specimens. Of these, 623 participants had proteomics data available at the 9-year follow-up. For each visit, a total of 1301 plasma proteins were measured using SOMAscan technology. Complete data on vital status were available up to the 15-year follow-up period. Protein-specific exponential distribution accelerated failure time, and linear regression analyses adjusted for possible covariates were used for mortality and mediation analyses, respectively (survival data analysis). Findings: Baseline values of EGFR, GHR, NTRK3, SOD2, KLRF1, THBS2, TIMP1, IGFBP2, C9, APOB, and LRP1B mediated the association between baseline RDW and all-cause mortality. Changes in IGFBP2 and C7 over 9 years mediated the association between changes in RDW and 6-year all-cause mortality. Interpretation: Cellular senescence may contribute to the association between RDW and mortality. Funding: This study was funded by grants from the National Institutes of Health (NIH) and the National Institute on Aging (NIA) contract and was supported by the Intramural Research Program of the NIA, NIH. The InCHIANTI study was supported as a ‘targeted project’ by the Italian Ministry of Health and in part by the U.S. NIA.

  • Physical activity and all-cause mortality and mediators of the association in the very old

    Y Osawa, Y Abe, M Takayama, Y Oguma, Y Arai

    Experimental Gerontology 150, 111374 (Experimental Gerontology)  150   111374 2021.07

    Research paper (scientific journal), Single Work, Accepted,  ISSN  0531-5565

     View Summary

    Background and objective: Physical activity (PA) confers protection to individuals from the risk of death. However, in the very old, the dose-response relationship between PA and all-cause mortality and the possible biological mediators of this association are less known. We investigated whether PA predicts 6-year all-cause mortality and what biomarkers mediate the association. Design: Prospective cohort data from the Tokyo Oldest Old Survey on Total Health study. Setting: Community-dwelling population. Participants: A total of 441 women and men aged over 85 years. Measurements: Questionnaire-based PA was assessed at baseline and 3-year and 6-year follow-up visits. Survival status was confirmed up to the 6-year follow-up visit (153 deaths, 34.7%). Data of plasma albumin, cholinesterase, NT-proBNP, interleukin-6, cystatin C, and HbA1c levels were collected. For mediation analysis for survival analysis, we used the baseline PA and biomarkers with Weibull distribution accelerated failure time model and linear regression model adjusted for age, sex, body mass index, smoking, education level, and Mini-Mental State Examination. Results: A curvilinear relationship was observed in the association between baseline PA and all-cause mortality. Compared to the inactive (0 METs*h/week), light amount of PA was associated with a lower risk of mortality. Compared to the highest tertile of PA (11.2 METs*h/week), higher PA did not reduce the risk of death. Circulation levels of albumin and cholinesterase mediated the association between baseline PA and all-cause mortality (proportion mediated, 54%, both; p < 0.05). Conclusions: Compared to completely inactive, light PA reduces the risk of all-cause mortality in the very old population. Mediation analysis suggests that protein synthesis in the liver may mediate the association between PA and all-cause mortality. Further studies are needed to understand the underlying association between PA, nutrition, and death.

display all >>

Papers, etc., Registered in KOARA 【 Display / hide

Research Projects of Competitive Funds, etc. 【 Display / hide

  • 身体活動推進のための地域介入 多世代複合コホート研究の活用と政策展開


    日本学術振興会 , 科学研究費助成事業 基盤研究(B), Research grant, Coinvestigator(s)

  • Proteomic Signatures for Osteosarcopenia


    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator


Courses Taught 【 Display / hide











display all >>