Simizu, Siro

写真a

Affiliation

Faculty of Science and Technology, Department of Applied Chemistry (Yagami)

Position

Professor

Related Websites

External Links
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Profile Summary 【 Display / hide 】

  • My research interests are glycoscience, cancer cell biology and chemical biology.

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Academic Background 【 Display / hide 】

  • 1993.03

    Keio University, Faculty of Science and Engineering, Department of Applied Chemistry

    University, Graduated

  • 1998.03

    Keio University, Graduate School, Division of Science and Engineering

    Graduate School, Completed, Doctoral course

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Academic Degrees 【 Display / hide 】

  • Ph.D., Keio University, Coursework, 1998.03

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Research Areas 【 Display / hide 】

  • Nanotechnology/Materials / Bio chemistry

  • Life Science / Molecular biology

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Research Keywords 【 Display / hide 】

  • Cancer cell biology

  • Chemical Biology

  • Glycoscience

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Books 【 Display / hide 】

  • 実験医学

    宮崎 功、奥村 英夫、清水 史郎、長田 裕之, 2011

    Scope: 79-83

  • 化学と工業

    叶 直樹、清水 史郎, 2011

    Scope: 37-39

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Papers 【 Display / hide 】

  • Involvement of DNA binding domain in the cellular stability and importin affinity of NF-kappaB component RelB

    Takeiri M, Horie K, Takahashi D, Watanabe M, Horie R, Simizu S & Umezawa K.

    Org. Biomol. Chem. 10   3053 - 3059 2012

    Research paper (scientific journal), Joint Work

  • Determination of cathepsin V activity and intracellular trafficking by N-glycosylation

    Niwa Y, Suzuki T, Dohmae N, Umezawa K & Simizu S.

    FEBS Lett. 586   3601 - 3607 2012

    Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

  • Inhibition of lysenin-induced hemolysis by all-E-lutein derived from the plant Dalbergia latifolia

    Niwa Y, Matsui C, Sukumwang N, Iinuma H, Ikeda Y, Koyano T, Kovitayakorn T, Simizu S & Umezawa K.

    Planta Med. 78   957 - 961 2012

    Research paper (scientific journal), Joint Work, Accepted

  • Suppression of cellular invasion by glybenclamide through inhibited secretion of platelet-derived growth factor in ovarian clear cell carcinoma ES-2 cells

    Yasukagawa T, Niwa Y, Simizu S & Umezawa K.

    FEBS Lett. 586   1504 - 1509 2012

    Research paper (scientific journal), Joint Work, Accepted

  • Involvement of NF-kappaB-mediated expression of galectin-3-binding protein in tumor necrosis factor-alpha-induced breast cancer cell adhesion

    Noma N, Simizu S, Kambayashi Y, Kabe Y, Suematsu M & Umezawa K.

    Oncol. Rep. 27   2080 - 2084 2012

    Research paper (scientific journal), Joint Work, Accepted

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • Presence of microfibril associated glycoprotein 4 and type V collagen and the possible absence of fibrillin-1 in bead-like structures in elastofibroma

    Nishida H., Sasaki T., Taga Y., Murasawa Y., Simizu S., Matsushita S., Isogai Z., Hattori S., Daa T., Nagamine N., Sekine A., Fujiwara S.

    Journal of Dermatological Science 112 ( 2 ) 112 - 116 2023.11

    ISSN  09231811

  • Vasculogenic mimicry: A dynamic event of malignancy

    Simizu S.

    Biochimica et Biophysica Acta - General Subjects (Biochimica et Biophysica Acta - General Subjects)  1866 ( 3 )  2022.03

    ISSN  03044165

  • C-Mannosylation: Previous studies and future research perspectives

    Niwa Y., Simizu S.

    Trends in Glycoscience and Glycotechnology (Trends in Glycoscience and Glycotechnology)  30 ( 177 ) E231 - E238 2018.11

    ISSN  09157352

    　View Summary

    © 2018 FCCA (Forum: Carbohydrates Coming of Age). C-linked glycosylation, one of the protein glycosylations, is a unique type of glycosylation in which an α-mannose is attached to the indole C2 carbon of a tryptophan residue via a C–C linkage and is so named C-mannosylation. C-mannosylation is enzymati-cally catalyzed in the endoplasmic reticulum (ER) lumen, and the N-terminal side Trp residue of the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys (Xaa represents any amino acid) is often C-mannosylated. It has been reported that about 30 proteins are C-mannosylated, and the functions of C-mannosylation are becoming clear. In 2013, C. elegans dumpy-19 (dpy-19) was identified as a C-mannosyltransferase, and we revealed that DPY19L3, one of the human homologs of dpy-19, has similar activity in 2016. In this review, we describe previous studies about C-mannosylation, including our results and future research perspectives.

  • C-Mannosylation: Previous studies and future research perspectives

    Niwa Y., Simizu S.

    Trends in Glycoscience and Glycotechnology (Trends in Glycoscience and Glycotechnology)  30 ( 177 )  2018.11

    ISSN  09157352

    　View Summary

    © 2018 FCCA (Forum: Carbohydrates Coming of Age). C-linked glycosylation, one of the protein glycosylations, is a unique type of glycosylation in which an α-mannose is attached to the indole C2 carbon of a tryptophan residue via a C–C linkage and is so named C-mannosylation. C-mannosylation is enzymati-cally catalyzed in the endoplasmic reticulum (ER) lumen, and the N-terminal side Trp residue of the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys (Xaa represents any amino acid) is often C-mannosylated. It has been reported that about 30 proteins are C-mannosylated, and the functions of C-mannosylation are becoming clear. In 2013, C. elegans dumpy-19 (dpy-19) was identified as a C-mannosyltransferase, and we revealed that DPY19L3, one of the human homologs of dpy-19, has similar activity in 2016. In this review, we describe previous studies about C-mannosylation, including our results and future research perspectives.

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Presentations 【 Display / hide 】

  • R-spondin1 におけるリン酸化の機能解析

    西谷 拓海, 鈴木 健裕, 丹羽 祐貴, 三浦 一輝, 堂前 直, 清水 史郎

    日本農芸化学会関東支部会2018年度大会 (千葉) , 

    2018.10
    , 

    Poster presentation

  • Vibsanin A誘導体の生物活性評価および標的分子の同定

    三浦 一輝、松木 渉、高尾 賢一、清水 史郎

    日本農芸化学会関東支部会2018年度大会　 (千葉) , 

    2018.10
    , 

    Poster presentation

  • ヒトC型糖転移酵素DPY19L3のプロモーター解析

    吉本 哲、三浦 一輝、清水 史郎

    日本農芸化学会関東支部会2018年度大会　 (千葉) , 

    2018.10
    , 

    Poster presentation

  • トポロジー解析によるDPY19L1のC-mannosyltransferase活性中心の探索

    横山 典弘, 柳原 凌太郎, 三浦 一輝, 丹羽 祐貴, 清水 史郎

    日本農芸化学会関東支部会2018年度大会 (千葉) , 

    2018.10
    , 

    Poster presentation

  • C-mannosylation－基質と酵素の探索

    清水 史郎

    日本農芸化学会中部支部 第183回例会 (名古屋) , 

    2018.09
    , 

    Symposium, workshop panel (nominated)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Role of C-mannosylation in zebrafish and development of inhibitors for C-mannosylation

    2024.04
    -
    2027.03

    基盤研究(C), Principal investigator

  • 新たなC型糖修飾責任酵素の同定と基質タンパク質の解析

    2018.04
    -
    2021.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

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Awards 【 Display / hide 】

  • 日本がん転移学会　研究奨励賞

    SIMIZU Siro, 2012.07, 日本がん転移学会, ケミカルバイオロジーによる転移関連分子の理解と制御

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • B.B.B.論文賞

    MIYAZAKI Isao, SIMIZU Siro, ICHIMIYA Harumi, KAWATANI Makoto, OSADA Hiroyuki, 2009.03, 日本農芸化学会, Robust and systematic drug screening method using chemical arrays and the protein library: identification of novel inhibitors of carbonic anhydrase II

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 日本癌学会奨励賞

    SIMIZU Siro, 2004.10, 日本癌学会, 薬剤耐性・転移に関与するがん分子標的の機能解析

    Type of Award： Award from Japanese society, conference, symposium, etc.

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Courses Taught 【 Display / hide 】

  • ADVANCED BIOLOGICAL CHEMISTRY

    2025

  • SEMINAR IN APPLIED CHEMISTRY

    2025

  • MICROBIOLOGY

    2025

  • LABORATORIES IN APPLIED CHEMISTRY D

    2025

  • INDEPENDENT STUDY ON FUNDAMENTAL SCIENCE AND TECHNOLOGY

    2025

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Memberships in Academic Societies 【 Display / hide 】

  • The Japanese Society of Carbohydrate Research, 

    2015
    -
    Present

  • 日本がん分子標的治療学会, 

    2009
    -
    Present

  • 日本ケミカルバイオロジー学会, 

    2008
    -
    Present

  • 日本がん転移学会, 

    2006
    -
    Present

  • 日本癌学会, 

    1992
    -
    Present
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Committee Experiences 【 Display / hide 】

  • 2015
    -
    Present

    Member, 日本がん転移学会

  • 2009
    -
    Present

    Board of Councillors, 日本がん分子標的治療学会

  • 2008
    -
    Present

    Member, 日本ケミカルバイオロジー学会

  • 1992
    -
    Present

    Member, 日本癌学会

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