Arita, Makoto

写真a

Affiliation

Faculty of Pharmacy, Department of Pharmacy 代謝生理化学講座 (Shiba-Kyoritsu)

Position

Professor

E-mail Address

E-mail address

Related Websites

Profile Summary 【 Display / hide

  • Lipids are recognized as extremely diverse molecules. Precise determination of molecular lipid species becomes a prerequisite not only to understand their biological functions in physiology and disease, but also to discover novel bioactive lipids that may link between lipid metabolisms and biological phenotypes. A powerful method for the analysis of lipids is liquid chromatography tandem mass spectrometry (LC-MS/MS). Our research is aimed at elucidating structure and function of endogenous lipid mediators that regulate inflammation and tissue homeostasis. Polyunsaturated fatty acid (PUFA)-derived mediators are formed by enzymatic oxidation through the action of cyclooxygenases (COX), lipoxygenases (LOX), and cytochrome P450 monooxygenases (CYP). By using LC-MS/MS-based lipidomics, we provided new insights into the cellular and molecular mechanisms of inflammatory resolution, especially the functional roles of 12/15-LOX-expressing eosinophils and macrophages in controlling the resolution of inflammation. Also our research is focused on understanding omega-3 PUFA’s function using genetic and lipidomic approaches, and has identified novel metabolic pathway and bioactive metabolites that may link to omega-3 PUFA’s anti-inflammatory actions. These endogenous mediators with potent anti-inflammatory property could lead to the development of novel therapeutics for disease when sustained inflammation is suspected as key components of pathogenesis. Also we put a lot of efforts into development and application of target and non-target multi-lipidomics platform to discover novel link between lipid metabolism and biological phenotypes.

Career 【 Display / hide

  • 1997.04
    -
    2000.06

    The University of Tokyo, Graduate School of Pharmaceutical Sciences, Assistant Professor

  • 2000.07
    -
    2003.06

    Brigham&Women's Hospital / Harvard Medical School, Postdoctoral Fellow

  • 2003.07
    -
    2006.09

    Brigham&Women's Hospital / Harvard Medical School, Instructor

  • 2006.10
    -
    2007.03

    JST, PRESTO, Researcher

  • 2007.04
    -
    2014.03

    The University of Tokyo, Graduate School of Pharmaceutical Sciences, Associate Professor

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Academic Background 【 Display / hide

  • 1988.04
    -
    1992.03

    The University of Tokyo, Faculty of Pharmaceutical Sciences

    University, Graduated

  • 1992.04
    -
    1994.03

    The University of Tokyo, Graduate School of Pharmaceutical Sciences

    Graduate School, Completed, Master's course

  • 1994.04
    -
    1997.03

    The University of Tokyo, Graduate School of Pharmaceutical Sciences

    Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide

  • 博士(薬学), The University of Tokyo, Coursework, 1997.03

    ビタミンE輸送タンパク質の生理機能の解明

 

Research Areas 【 Display / hide

  • Molecular biology

  • Functional biochemistry

  • Biological pharmacy

  • General medical chemistry

Research Keywords 【 Display / hide

  • Metabolomics

  • Lipoquality

  • Regulation of Inflammation

  • Bioactive molecules

  • Lipid Biochemistry

Research Themes 【 Display / hide

  • リピドームアトラスの創出, 

    2021.10
    -
    Present

  • Quality of lipids in biological systems, 

    2015.07
    -
    Present

  • Development and application of target and non-target multi-lipidomics platform, 

    2014.04
    -
    Present

  • Mediator lipidomics in acute inflammation and resolution, 

    2006.10
    -
    Present

  • Genetic and lipidomic approach to understand anti-inflammatory property of omega-3 PUFAs, 

    2000.07
    -
    Present

 

Books 【 Display / hide

  • 実験医学別冊:メタボロミクス実践ガイド

    有田誠, 羊土社, 2021

    Scope: 生命の脂質多様性から解き明かす病態・バイオロジー研究,  Contact page: 283-285

  • ヒトマイクロバイオーム研究最前線Vol.2

    岡橋伸幸、上田政宏、有田誠, NTS, 2020

    Scope: マイクロバイオームのリピドミクス,  Contact page: 71-78

  • 医学のあゆみ増刊:脂質クオリティ研究の基礎と臨床(有田誠/編)

    医歯薬出版, 2019

  • 実験医学別冊:脂質解析ハンドブック

    有田誠, 羊土社, 2019

    Scope: 第1部 生体における脂質の構造と機能 4.脂肪酸,  Contact page: 49-54

  • 実験医学増刊:脂質クオリティ -生命機能と健康を支える脂質の多様性-(有田誠/編)

    羊土社, 2018

    Scope: 編集、序、概論、第1章-1

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Papers 【 Display / hide

  • Group IIA secreted phospholipase A2 controls skin carcinogenesis and psoriasis by shaping the gut microbiota.

    Miki Y, Taketomi Y, Kidoguchi Y, Yamamoto K, Muramatsu K, Nishito Y, Park J, Hosomi K, Mizuguchi K, Kunisawa J, Soga T, Boilard E, Gowda SG, Ikeda K, Arita M, *Murakami M.

    JCI Insight 7   e152611 2022.01

    Research paper (scientific journal), Joint Work, Accepted

  • The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation.

    Dore E, Joly-Beauparlant C, Morozumi S, Mathieu A, Levesque T, Allaeys I, Duchez A, Cloutier N, Leclercq M, Bodein A, Payre C, Martin C, Petit-Paitel A, Gelb M, Rangachari M, Murakami M, Davidovic L, Flamand N, Arita M, Lambeau G, Droit A, *Boilard E.

    JCI Insight 7   e152638 2022.01

    Research paper (scientific journal), Joint Work, Accepted

  • Intestinal microbiome-dependent 3 lipid metabolite KetoA prevents inflammatory diseases in mice and cynomolgus macaques.

    Nagatake T, Kishino S, Urano E, Murakami H, Kitamura N, Konishi K, Ohno H, Tiwari P, Morimoto S, Node E, Adachi J, Abe Y, Isoyama J, Sawane K, Honda T, Inoue A, Uwamizu A, Matsuzaka T, Miyamoto Y, Hirata S, Saika A, Shibata Y, Hosomi K, Matsunaga A, Shimano H, Arita M, Aoki J, Oka M, Matsutani A, Tomonaga T, Kabashima K, Miyachi M, Yasutomi Y, Ogawa J, *Kunisawa J.

    Mucosal Immunology in press 2022.01

    Research paper (scientific journal), Joint Work, Accepted

  • Oxidized phospholipids and neutrophil elastase coordinately play critical roles in NET formation.

    Tokuhiro T, Ishizawa A, Sato H, Takita S, Yoshikawa A, Anzai R, Sato S, Aoyagi R, Arita M, Aratani Y, Shimizu S, Tanaka M, *Yotsumoto S.

    Frontiers in Cell and Developmental Biology 9   718586 2021.09

    Research paper (scientific journal), Joint Work, Accepted

  • Comparative analysis of single-molecule dynamics of TRPV1 and TRPV4 channels in living cells

    Kuwashima Y, *Yanagawa M, Abe M, Hiroshima M, Ueda M, Arita M, *Sako Y

    Int J Mol Biol  22   8473 2021.08

    Research paper (scientific journal), Joint Work, Accepted

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • Structures and functions of the gut microbial lipidome

    Morozumi S, Ueda M, Okahashi N, *Arita M

    Biochim Biophys Acta Mol Cell Biol Lipids 1867 ( 3 ) 159110 2022.01

    Introduction and explanation (scientific journal), Joint Work

  • Characterization of the structural diversity and structure-specific behavior of oxidized phospholipids by LC-MS/MS.

    Aoyagi R, Yamamoto T, Furukawa Y, *Arita M.

    Chem Pharm Bull 69 ( 10 ) 953 - 961 2021.10

    Introduction and explanation (scientific journal), Joint Work

  • Dysregulated metabolism of polyunsaturated fatty acids in eosinophilic allergy diseases.

    *Miyata J, Fukunaga K, Kawashima Y, Ohara O, Kawana A, Asano K, Arita M.

    Prostaglandins Other Lipid Mediat  150   106477 2020.07

    Introduction and explanation (scientific journal), Joint Work

  • Cysteinyl leukotriene metabolism of human eosinophils in allergic disease.

    Miyata J, *Fukunaga K, Kawashima Y, Ohara O, Arita M.

    Allergol Int 69   28 - 34 2020.01

    Introduction and explanation (scientific journal), Joint Work

  • Current state and future prospect of therapeutic strategy targeting cysteinyl leukotriene metabolism in asthma.

    Yamamoto T, *Miyata J, Arita M, Fukunaga K, Kawana A.

    Respir Invest  57 ( 6 ) 534 - 543 2019.11

    Introduction and explanation (scientific journal), Joint Work

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Presentations 【 Display / hide

  • リピドミクス新技術と脂質多様性 (リポクオリティ)の生物学:健康と天然物

    有田誠

    日本学術会議シンンポジウム「地球と生命をつなぐ高度な化学物質ネットワーク」, 2021.12, Symposium, Workshop, Panelist (nomination)

  • Advanced lipidomics technology and its application in biology

    Makoto Arita

    5th RIKEN IMS-Stanford ISCBRM Joint Symposium 2021, 2021.11, Symposium, Workshop, Panelist (nomination)

  • Omega-3 fatty acid metabolism that controls inflammation and tissue homeostasis

    Makoto Arita

    World Congress of OMEGA3 Science and Technology (WCOST), 2021.11, Oral Presentation(guest/special)

  • Advanced non-targeted lipidomics and its application to vascular biology

    Makoto Arita

    19th International Symposium on Atherosclerosis (ISA2021), 2021.10, Symposium, Workshop, Panelist (nomination)

  • 好酸球の脂肪酸代謝と炎症・アレルギー疾患の制御

    有田誠

    EOS Summit, 2021.10, Symposium, Workshop, Panelist (nomination)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 有田リピドームアトラスプロジェクト

    2021.10
    -
    2027.03

    科学技術振興機構(JST), 戦略的創造研究推進事業総括実施型研究(ERATO), Makoto Arita, Joint research, Principal Investigator

  • リピドミクスのメタデータに基づく赤痢アメーバ脂質代謝解析―赤痢アメーバの生化学・生理学と創薬標的・リード化合物の提供―

    2021.08
    -
    2024.03

    国立研究開発法人日本医療研究開発機構(AMED), 新興・再興感染症研究基盤創生事業(多分野融合研究領域), 見市文香, Commissioned research, Co-investigator

  • 日本型持続可能な次世代養殖システムの開発

    2021.06
    -
    2026.03

    科学技術振興機構(JST), 未来社会創造事業(探索加速型), 中山一郎, Commissioned research, Co-investigator

  • 脂肪酸代謝ネットワークによる生体制御およびその制御破綻による疾患メカニズムの解明

    2020.04
    -
    2024.03

    日本学術振興会, 科学研究費助成事業(科学研究費補助金), 有田誠, 基盤研究(A), Research grant, Principal Investigator

  • ヒト子宮内膜を用いた着床障害のリピドミクス解析

    2020.04
    -
    2022.03

    国立研究開発法人日本医療研究開発機構(AMED), 革新的先端研究開発支援事業ステップタイプ(FORCE), 廣田泰, Commissioned research, Co-investigator

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Awards 【 Display / hide

  • Commendation for Science and Technology by the Minister of MEXT

    有田誠, 2021.04, 文部科学省, 生命の脂質多様性の解明と生物学的意義に関する研究

    Type of Award: International Academic Awards

  • 日本脂質栄養学会ランズ賞学術賞

    有田誠, 2016.09, 日本脂質栄養学会, ω3脂肪酸の代謝と抗炎症作用に関する研究

    Type of Award: Awards of National Conference, Council and Symposium

  • Young Scientists' Prize of Ministry of Education, Culture, Sports, Science and Technology, Japan

    2009.04, 文部科学省, オメガ3脂肪酸由来の抗炎症性脂質メディエーターの研究

    Type of Award: International Academic Awards

  • Young Investigator Award: 9th International Conference of Eicosanoids other Bioactive Lipids in Cancer, Inflammation & Related Diseases (San Francisco)

    2005

    Type of Award: Awards of International Conference, Council and Symposium

 

Courses Taught 【 Display / hide

  • VISUALIZING PATHOPHYSIOLOGY UNDER THE SEVERE STRESS IN ACUTE CARE

    2021

  • STUDY OF MAJOR FIELD: (PHYSIOLOGICAL CHEMISTRY AND METABOLISM)

    2021

  • SPECIAL LECTURES BY GUEST SPEAKERS

    2021

  • SPECIAL LECTURES BY GUEST SPEAKERS

    2021

  • SPECIAL LECTURES BY GUEST SPEAKERS

    2021

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Courses Previously Taught 【 Display / hide

  • 代謝生化学

    Keio University, 2017, Spring Semester, General education subject, Lecture

  • 実験法概論

    Keio University, 2017, Autumn Semester, Lecture

  • 薬学基礎実習

    Keio University, 2017, Autumn Semester, Laboratory work/practical work/exercise

  • 細胞の機能と構成分子

    Keio University, 2017, Autumn Semester, General education subject, Lecture

  • 生化学2

    Keio University, 2017, Autumn Semester, General education subject, Lecture

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Memberships in Academic Societies 【 Display / hide

  • 日本抗加齢医学会, 

    2021.04
    -
    Present
  • 日本脂質栄養学会, 

    2014.04
    -
    Present
  • 日本分子生物学会, 

    2012.04
    -
    Present
  • 日本免疫学会, 

    2012.04
    -
    Present
  • 日本医用マススペクトル学会, 

    2008.04
    -
    Present

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