Papers - Manabe, Tomohiro

マラソンの大会救護体制

真鍋知宏

臨床スポーツ医学 (文光堂)  42 ( 7 ) 743 - 747 2025.07

Research paper (scientific journal), Single Work, Lead author, Corresponding author

Strategies for Reducing Sudden Cardiac Death by Raising Public Awareness - A Statement From the Education and Implementation for Cardiac Emergency Committee of the Japanese Circulation Society -

Nishiyama C., Yoshimura S., Taniguchi T., Amano T., Ando H., Homma Y., Imamura T., Itoh T., Kiguchi T., Kiyohara K., Konno S., Makimoto H., Manabe T., Matsuzawa Y., Mitamura H., Niwamae N., Sakuma M., Sato K., Satoh Y., Tahara Y., Tsujita K., Tsukada Y.T., Uchida M., Ueda Y., Iwami T.

Circulation Journal 89 ( 3 ) 394 - 418 2025.03

ISSN  13469843

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Differences in athlete’s left ventricular morphology by sex and sports discipline categories in elite Japanese athletes

Ashikaga K., Manabe T., Tomori A., Endo N., Kamahara K.

Physician and Sportsmedicine 53 ( 4 ) 309 - 318 2025

ISSN  00913847

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Objectives: The cardiac morphology of elite athletes is related to sports disciplines and race; however, no studies have examined the effects of sports discipline on East Asian athletes. Therefore, this study aimed to assess left ventricular (LV) remodeling using transthoracic echocardiography in elite Japanese athletes and establish standard values for the indicators of the cardiac morphology of elite athletes in East Asia, considering the influence of body size. Methods: We retrospectively evaluated 1,363 elite Japanese athletes who underwent electrocardiography and transthoracic echocardiography between January 2011 and December 2021. The athletes were assigned to four sports discipline categories (skill, power, mixed, and endurance). We evaluated the differences in LV volume and mass between the groups for each sex. Results: The LV end-diastolic volume (LVEDV) and LV mass indexed to the body surface area (BSA) in the endurance group (LVEDV/BSA: 72.3 ± 11.4 mL/m2 in males and 68.7 ± 11.0 mL/m2 in females, LV mass/BSA: 121.1 ± 19.1 g/m2 in males and 106.5 ± 18.0 g/m2 in females) were significantly larger than those of any other groups. Both values were affected by sex, BSA, and endurance sport type, whereas only LV mass was affected by age. Conclusion: Cardiac remodeling is proportional to the sport type, with a significantly greater effect in athletes playing endurance sports. The remodeling is particularly evident in the left ventricle; however, the corresponding remodeling is also observed in other heart chambers. Cardiac remodeling in elite Japanese athletes is similar to that observed in elite athletes of other races, except for the changes in LV wall thickness.

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Sudden cardiac arrest during marathons among young, middle-aged, and senior runners

Manabe T., Kato J., Yamasawa F.

Resuscitation 204 2024.11

Lead author, Corresponding author,  ISSN  03009572

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Aim: There is limited evidence showing a relationship with age in the incidence of sudden cardiac arrest during exercise, which can be lethal at times. Methods: To examine the incidence by age group in sudden cardiac arrest, we prospectively observed cases of sudden cardiac arrest in full marathons certified by the Japan Association of Athletics Federations held between April 2011 and March 2019. Sudden cardiac arrest was defined as collapse during or 1 h after the race requiring chest compressions or the use of an automatic electrical defibrillation. Results: 4.1 million persons ran in 516 marathons. Of the participants, 78.6 % were men. By age group, 37.4 %, 34.7 %, 19.6 %, and 8.3 % belonged to the < 40 s, 40 s, 50 s, and ≥ 60 s groups, respectively. During the study period, 69 sudden cardiac arrests (1.7 per 100,000 participants, 95 % confidence interval [CI]: 1.3–2.1) were observed, of which 66 were men. The incidence per 100,000 runners of sudden cardiac arrest was 0.9 (95 % CI: 0.4, 1.4), 0.9 (95 % CI: 0.4, 1.4), 2.6 (95 % CI: 1.5, 3.8), and 5.5 (95 % CI: 2.9, 8.2) for those in their under 40 s, 40 s, 50 s, and over 60 s, respectively, with higher rates for older age groups. Compared to men, the cases of SCA among women were less common (only three cases), and the incidence did not differ by age group. Conclusions: Men, unlike women, had a higher incidence of sudden cardiac arrest during marathons according to age. Identification of this high-risk population could be important information in encouraging marathoners pre-participation self-screening.

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Prevalence of anemia and iron deficiency and its association with body mass index in elite Japanese high school long-distance runners

Shogo Tabata, Yuka Tsukahara, Hiroshi Kamada, Tomohiro Manabe, Fumihiro Yamasawa

The Physician and Sportsmedicine (Physician and Sportsmedicine)   2023.10

Research paper (scientific journal), Joint Work, Accepted,  ISSN  00913847

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Objectives: Anemia is a common condition in long-distance runners (LDRs). Recently, not only iron deficiency (ID) but also energy deficiency has been considered as a risk factor for anemia in athletes but no evidence has yet been established. The aim of this study was to investigate the prevalence of anemia and ID and the influence of body mass index (BMI) on anemia in high-school LDRs. Methods: The participants were 406 male and 235 female elite Japanese LDRs who competed in the All-Japan High-School Ekiden Championship 2019. They submitted their anthropometric data and results of a blood test within five days after the competition. The prevalence of anemia and ID and the influence of BMI on anemia were assessed retrospectively. Results: Mean hemoglobin concentrations (Hb) were 14.8 ± 0.9 g/dl in males and 13.2 ± 0.9 g/dl in females. The prevalence of anemia (Hb < 14 g/dl in males and < 12 g/dl in females) was significantly higher in males (16.3%) than females (6.4%), but males also showed higher prevalence of non-iron deficiency anemia (NIDA) than females (11.6% and 3.0%, respectively). No significant gender difference was found in the prevalence of iron deficiency anemia (IDA) (4.7% in males and 3.4% in females). ID (serum ferritin level < 25 ng/ml) was significantly more prevalent in females (37.4%) than males (18.5%). A binary logistic regression analysis revealed that low BMI was a contributor to anemia in females (odds ratios: 0.577 (95% CI: 0.369–0.901), p = 0.012). Conclusion: In Japanese high-school LDRs, one in six males was anemic, but most males did not have ID. Conversely, one-third of females were diagnosed with ID. Lower BMI was identified as a risk for anemia in females, suggesting that leanness may also lead to anemia in females.

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スポーツと循環器学

真鍋知宏

循環器ジャーナル (医学書院)  71 ( 1 ) 140 - 144 2023.01

Research paper (scientific journal), Single Work, Lead author, Corresponding author

陸上競技と感染症

真鍋　知宏

臨床スポーツ医学 (文光堂)  38 ( 8 ) 846 - 851 2021.08

Research paper (scientific journal), Single Work

医療体制の確保

真鍋　知宏

臨床スポーツ医学 (文光堂)  38 ( 2 ) 132 - 134 2021.02

Research paper (scientific journal), Single Work

痛み止めの効果とアンチ・ドーピング

真鍋　知宏

体育の科学 (杏林書院)  70 ( 10 ) 723 - 728 2020.10

Research paper (scientific journal), Single Work

Use of nutritional supplements by elite Japanese track and field athletes

Tabata S., Yamasawa F., Torii S., Manabe T., Kamada H., Namba A., Kato J., Kaneko H., Tahara K., Tsukahara Y., Sato K.

Journal of the International Society of Sports Nutrition (Journal of the International Society of Sports Nutrition)  17 ( 1 )  2020.07

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Background: While scientific evidence supports the efficacy of only limited nutritional supplements (NS) on sports performance, the use of NS is widespread in athletes. Given the serious issues of health damage or unintended Anti-Doping Rule Violations due to ingestion of contaminated NS in sports, accurately understanding NS practices by athletes is crucial. This study therefore elucidated the use of NS by elite Japanese track and field (TF) athletes. Methods: The subjects were 574 Japanese TF athletes, including 275 junior athletes (under 20 years) and 299 senior athletes, who participated in international competitions from 2013 to 2018. Data on NS use were collected through pre-participation medical forms obtained from all entrants before their participation in competitions. NS users were requested to report the product names and primary components of all NS they were taking. Results: The overall prevalence of NS use was 63.9%. The mean number of NS products used per athlete was 1.4. The prevalence was significantly higher in women (69.2%) than in men (59.6%) (p = 0.018) and significantly higher in senior athletes (68.9%) than in junior athletes (58.9%) (p = 0.012). The prevalence of NS use was higher in long-distance runners (75.8%) and lower in jumpers (52.3%) and throwers (49.2%) than other disciplines (p < 0.001). The most prevalent components were amino acids (49.3%), followed by vitamins (48.3%), minerals (22.8%), and protein (17.8%). Conclusions: Approximately two-thirds of elite Japanese TF athletes reported the use of NS, and NS practices varied by gender, age, and discipline.

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AEDと心肺蘇生

真鍋　知宏

臨床スポーツ医学 (文光堂)  37 ( 7 )  2020.07

Research paper (scientific journal), Single Work

スポーツ中の内因性重大事故の現状

真鍋　知宏

臨床スポーツ医学 (文光堂)  37 ( 6 ) 652 - 656 2020.06

Research paper (scientific journal), Single Work

スポーツと心電図変化：精査が必要な所見、人種差による特徴

真鍋　知宏

心臓 (日本心臓財団・日本循環器学会)  52 ( 4 ) 366 - 371 2020.04

Research paper (scientific journal), Single Work

高校生エリート陸上選手におけるサプリメント使用状況

酒井健介, 須永美歌子, 貴島孝太, 森丘保典, 真鍋知宏, 山本宏明, 杉田正明

陸上競技研究紀要 (公益財団法人日本陸上競技連盟)  15   81 - 93 2020.03

Research paper (other academic), Joint Work, Accepted

Notes on medical management for pain from an anti-doping perspetive

真鍋知宏

ペインクリニック (真興交易)  41 ( 3 ) 377 - 384 2020.03

Research paper (other academic), Single Work

突然死　アスリートの突然死

真鍋 知宏

日本臨床　別冊循環器症候群III    480 - 484 2019.11

Research paper (scientific journal), Single Work

スポーツ現場における医療行為の法的問題　医師がスポーツ現場で医行為を行う際に準備すべきことと知っておくべきこと

大槻 穣治, 藤谷 博人, 真鍋 知宏, 小松孝行, 山澤 文裕, 武者 春樹

日本臨床スポーツ医学会誌 27 ( 3 ) 388 - 390 2019.08

Research paper (scientific journal), Joint Work

スポーツ現場における医療行為の法的問題　スポーツ現場における医師の医療行為の現状

藤谷 博人, 大槻 穣治, 真鍋 知宏, 小松孝行, 山澤 文裕, 武者 春樹

日本臨床スポーツ医学会誌 27 ( 3 ) 399 - 401 2019.08

Research paper (scientific journal), Joint Work

中高齢者における循環器障害とスポーツ

Manabe Tomohiro

臨床スポーツ医学 35 ( 9 ) 932 - 937 2018.09

Single Work

陸上競技と心臓

Manabe Tomohiro

臨床スポーツ医学 35 ( 6 ) 608 - 614 2018.06

Joint Work

スポーツ中の心臓突然死の実態と対策 J-SPORTSCAR STUDYによるデータ集積の重要性

Manabe Tomohiro

臨床スポーツ医学 35 ( 6 ) 564 - 569 2018.06

Joint Work

スポーツ現場における医療救護体制の現状

Manabe Tomohiro

臨床スポーツ医学 35 ( 6 ) 578 - 583 2018.06

Joint Work

スポーツ現場における会場ドクター・帯同ドクターの法的問題

Manabe Tomohiro

日本臨床スポーツ医学会誌 26 ( 2 ) 217 - 218 2018.04

Joint Work

スポーツ現場における医療行為について

Manabe Tomohiro

日本臨床スポーツ医学会誌 26 ( 2 ) 215 - 216 2018.04

Joint Work

スポーツ医学総論

Manabe Tomohiro

救急医学  2018.03

Single Work

スポーツ現場における心停止とその救命

Manabe Tomohiro

週刊医学のあゆみ 262 ( 12 ) 1093 - 1097 2017.09

Single Work

【スポーツ現場における危機管理】マラソン大会の心血管イベント発生状況と対策

Manabe Tomohiro

体育の科学 67 ( 2 ) 83 - 88 2017.02

Single Work

競技種目・対象を考えたメディカルチェック（第11回）高齢者スポーツにおけるメディカルチェックの注意点

Manabe Tomohiro

臨床スポーツ医学 33 ( 11 ) 1114 - 1118 2016.11

Single Work

スポーツにおける事故分析　内因性事故を中心として

Manabe Tomohiro

日本臨床スポーツ医学会誌 24 ( 2 ) 161 - 165 2016.04

Single Work

運動負荷時の心肺機能の計測

Manabe Tomohiro

人間工学 52 ( 1 ) 13 - 18 2016.02

Single Work

【スポーツドクターに必要なドーピング禁止物質の知識】循環器疾患治療におけるドーピング禁止物質

Manabe Tomohiro

臨床スポーツ医学 33 ( 2 ) 138 - 145 2016.02

Single Work

【冬季スポーツにおける外傷・障害】　ランニングと低体温症

Manabe Tomohiro

臨床スポーツ医学 32 ( 11 ) 1094 - 1097 2015.11

Single Work

【パフォーマンス向上のためのスポーツ医科学】スポーツパフォーマンスに必要な心肺機能

Manabe Tomohiro

臨床スポーツ医学 32 ( 2 ) 114 - 119 2015.02

Single Work

アスリートの陳旧性足関節外側靱帯損傷に対する短腓骨筋腱を用いた足関節外側靱帯再建術の検討

Manabe Tomohiro

日本臨床スポーツ医学会誌 23 ( 1 ) 45 - 49 2015.01

Joint Work

【ランニングのスポーツ医学】　内科疾患と栄養：循環器疾患に対する安全性対策

Manabe Tomohiro

臨床スポーツ医学 31 ( 9 ) 840 - 843 2014.09

Single Work

AEDとテーピングの基礎知識

Manabe Tomohiro

健 43 ( 5 ) 28 - 31 2014.08

Joint Work

スポーツドクターと薬の処方　—スポーツ外来での実際—　循環器疾患：高血圧、不整脈

Manabe Tomohiro

臨床スポーツ医学 30 ( 11 ) 1029-1035 2013.11

Research paper (scientific journal), Single Work

ランニングブームを検証するー循環器疾患に対する安全性対策ー

Manabe Tomohiro

日本臨床スポーツ医学会誌 21 ( 2 ) 304-308 2013.04

Research paper (scientific journal), Single Work

東京マラソンにおける内因性事故対策

Yamasawa Fumihiro, Manabe Tomohiro, Mitsuhashi Toshitake

循環器内科 73 ( 1 ) 80-85 2013.01

Research paper (scientific journal), Joint Work

ダーレオーエン選手の事例に学ぶー循環器系疾患への対応

Manabe Tomohiro

トレーニングジャーナル 34 ( 10 ) 40-41 2012.10

Research paper (scientific journal), Single Work

スポーツ中の突然死

Manabe Tomohiro

健 41 ( 7 ) 10-12 2012.10

Research paper (scientific journal), Single Work

安全なロードレースを目指して

Manabe Tomohiro

呼吸と循環 60 ( 5 ) 509-518 2012.05

Research paper (scientific journal), Joint Work

アスリートの突然死の疫学

Manabe Tomohiro

臨床スポーツ医学 29 ( 2 ) 139-145 2012.02

Research paper (scientific journal), Single Work

Team Doctor Meeting 2010　チームドクターとして知っておくべき知識　内科的メディカルチェック

Manabe Tomohiro

臨床スポーツ医学 28 ( 9 ) 1049-1051 2011

Research paper (conference, symposium, etc.), Single Work

安全なロードレースを目指して　日本陸連医事委員会の取り組み(解説)

Manabe Tomohiro

心臓 43 ( Suppl.2 ) 198-203 2011

Research paper (scientific journal), Single Work

A case of transient mid-ventricular akinesia(a variant form of Takotsubo cardiomyopathy) followed with I-123-beta-metyl-iodophenyl pentadecanoic acid and I-123-meta iodobenzyl-guainidine myocardial scintigraphy

Moriya Manabu, Naito Kotaro, Takahashi Masahiko, Ozoe Akiyuki, Manabe Tomohiro, Hosaka Haruhiko, Suzuki Masahiro

Journal of Cardiology 53   140-145 2009

Research paper (scientific journal), Joint Work, Accepted

A novel cardiac hypertrophic factor, neurotrophin-3, is paradoxically downregulated in cardiac hypertrophy.

Kawaguchi-Manabe H, Ieda M, Kimura K, Manabe T, Miyatake S, Kanazawa H, Kawakami T, Ogawa S, Suematsu M, Fukuda K.

Life Sci. 81 ( 5 ) 385-392 2007.07

Research paper (scientific journal), Joint Work, Accepted

Oral sildenafil improves primary pulmonary hypertension refractory to epoprostenol.

Kataoka M, Satoh T, Manabe T, Anzai T, Yoshikawa T, Mitamura H, Ogawa S.

Circ J. 69 ( 4 ) 461-465 2005.04

Research paper (scientific journal), Joint Work, Accepted

Marked improvement with sildenafil in a patient with primary pulmonary hypertension unresponsive to epoprostenol.

Kataoka M, Satoh T, Manabe T, Anzai T, Yoshikawa T, Mitamura H, Ogawa S.

Intern Med. 43 ( 10 ) 945-950 2004.10

Research paper (scientific journal), Joint Work, Accepted

Bone Marrow-Derived Regenerated Cardiomyocytes（CMG Cells）Express Functional Adrenergic and Muscarinic Receptors

Hakuno D, Fukuda K, Makino S, Konishi F, Tomita Y, Manabe T, Suzuki Y, Umezawa A, Ogawa S

Circulation 105 ( 3 ) 380-386 2002.02

Research paper (scientific journal), Joint Work

Role of EGF receptor and Pyk2 in endothelin-1-induced ERK activation in rat cardiomyocytes

Kodama Hiroaki, Fukuda Keiichi, Takahashi Toshiyuki, Sano Motoaki, Kato Takahiro, Tahara Satoko, Hakuno Daihiko, Sato Toshihiko, Manabe Tomohiro, Konishi Fusako, Ogawa Satoshi

Journal of Molecular and Cellular Cardiology 34 ( 2 ) 139-150 2002.02

Research paper (scientific journal), Joint Work

Bone marrow-derived egenerated cardiomyocytes (CMG cell) expressed functionally active adrenergic and muscarinic receptors

Hakuno Daihiko, Fukuda Keiichi, Makino Shinji, Konishi Fusako, Tomitra Yuichi, Manabe Tomohiro, Suzuki Yusuke, Hisaka Yasuyo, Umezawa Akihiro, Ogawa Satoshi

Circulation 105 ( 3 ) 380-386 2002.01

Research paper (scientific journal), Joint Work

Bone marrow-derived regerated cardiomyocytes(CMG cells) express functional adrenergic and muscarinic receptors

Hakuno D, Fukuda D, Makino S, Konishi F, Tomita Y, Manabe T, Suzuki Y, Umezawa A, Ogawa S

Circulation 105 ( 3 ) 380-386 2002.01

Research paper (scientific journal), Joint Work

Bone marrow-derived regerated cardiomyocytes(CMG cells) express functional adrenergic and muscarinic receptors

Hakuno D, Fukuda D, Makino S, Konishi F, Tomita Y, Manabe T, Suzuki Y, Umezawa A, Ogawa S

Circulation 105 ( 3 ) 380-386 2002.01

Research paper (scientific journal), Joint Work

Role of EGF Receptor and Pyk2 in Endothelin-1-induced ERK Activation in Rat Cardiomyocytes

Kodama H, Fukuda K, Takahashi T, Sano M, Kato T, Tahara S, Hakuno D, Sato T, Manabe T, Konishi F, Ogawa S

Journal of molecular and cellular cardiology 34   1369-150 2002

Research paper (scientific journal), Joint Work

骨髄細胞から心筋細胞への分化誘導』

Fukuda Keiichi, Ma

外科 63 ( 3 ) 291-295 2001.03

Research paper (scientific journal), Joint Work

幹細胞移植

Fukuda Keiichi，Manabe Tomohiro

Heart View 5 ( 2 ) 116-122 2001.02

Research paper (scientific journal), Joint Work

骨髄間質細胞由来の心筋細胞におけるカテコラミン・アセチルコリン受容体の発現および機能解析

Hakuno Daihiko，Fukuda Keiichi，Konishi Satoko，Tomita Yuuichi，Manabe Tomohiro，Suzuki Yuusuke，Umezawa Akihiro，Ogawa Satoshi

心筋の構造と代謝 23   145-154 2001

Research paper (scientific journal), Joint Work

Significance of ERK cascade compared with JAK/STAT and PI3-K pathway in gp130-mediated cardiac hypertrophy

Kodama Hiroaki, Fukuda Keiichi, Pan Jing, Sano Motoaki, Takahashi Toshiaki, Kato Takahiro, Makino Shinji, Manabe Tomohiro, Murata Mitsushige, Ogawa Satoshi

American Journal of Phisiology. Heart and Circulation Physiology 279 ( 4 ) H1635-H1644 2000.10

Research paper (scientific journal), Joint Work

A cardiomyocyte cell line to overcome fibrotic myocardium

Fukuda Keiichi, Makino Shinji, Konishi Fusako, Hakuno Daihiko, Manbe Tomohiro, Ogawa Satoshi

Microcirculation Annual 16   17-18 2000.06

Research paper (scientific journal), Joint Work

Autocrine/paracrine secretion of IL-6 family cytokines causes angiotensin II-induced delayed STAT3 activation

Sano Motoaki, Fukuda Keiichi, Kodama Hiroaki, Takahashi Toshiyuki, Kato Takahiro, Hakuno Daihiko, Sato Toshihiko, Manabe Tomohiro, Tahara Satoko, Ogawa Satoshi

Biochemical and Biophysical Research Communications 269 ( 3 ) 798-802 2000.03

Research paper (scientific journal), Joint Work

Hypertrophic stimuli augment expression of cMG1/ERF-1, a putative zinc-finger transcription factor, in rat cardiomyocytes

Manabe Tomohiro, Fukuda Keiichi, Pang Jing, Nagasaki Koichi, Yamaguchi Ken, Ogawa Satoshi

FEBS Letters 463 ( 1-2 ) 39-42 1999.12

Research paper (scientific journal), Joint Work

心室頻拍および治療抵抗性心室性不整脈の治療

Manabe Tomohiro, Ogawa Satoshi

臨床成人病 29 ( 11 ) 1553-1558 1999.11

Research paper (scientific journal), Joint Work

Characterization of insulin-like growth factor-1 -induced activation of the JAK/STAT pathway in rat cardiomyocytes

Takahashi T, Fukuda K, Pan J, Kodama H, Sano M, Makino S, Kato T, Manabe T, Ogawa S

Circulation Research 85 ( 10 ) 884-891 1999.11

Research paper (scientific journal), Joint Work

心肥大促進因子のオートクリン，パラクリンネットワーク：アンギオテンシン2刺激によるIL-6族サイトカインの誘導とその意義

Sano Motoaki, Fukuda Keiichi, Kodama Hiroaki, Han Sei, Takahashi Toshiyuki, Makino Shinji, Katou Takahiro, Manabe Tomohiro, Hakuno Daihiko, Satou Toshihiko, Konishi Fusako, Ogawa Satoshi

心筋の構造と代謝 21   61-69 1999.09

Research paper (scientific journal), Joint Work

Identification of a novel gene, DAM1, amplified at chromosome 1p13.3-21 region in human breast cancer cell lines

Nagasaki Koichi, Nicholai Maass, ManabeTomohiro, Hanzawa Hiroaki, Tsukada Toshihiko, Kikuchi Kiyoshi, Yamaguchi Ken

Cancer Letters 140 ( 1-2 ) 219-226 1999.06

Research paper (scientific journal), Joint Work

Involvement of gp130-mediated signaling in pressure overload induced activation of the JAK/STAT pathway in rodent heart

Pan Jing, Fukuda Keiichi, Kodama Hiroaki, Sano Motoaki, Takahashi Toshiyuki, Makino Shinji, Kato Takahiro, Manabe Tomohiro, Hori Shingo, Ogawa Satoshi

Heart and Vessels 13   199-208 1999.06

Research paper (scientific journal), Joint Work

Identification of a novel gene, LDOC1, down-regulated in cancer cell lines

Nagasaki Koichi, Manabe Tomohiro, Hanzawa Hiroaki, Nicholai Maass, Tsukada Toshihiko, Yamaguchi Ken

Cancer Letters 140 ( 1-2 ) 227-234 1999.06

Research paper (scientific journal), Joint Work