Ishikawa, Takaaki

写真a

Affiliation

Faculty of Pharmacy, Department of Pharmacy Division of Pharmacotherapeutics ( Shiba-Kyoritsu )

Position

Research Associate/Assistant Professor/Instructor
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Licenses and Qualifications 【 Display / hide 】

  • Medical License, 2015.04

  • Board-Certified Neurosurgeon, 2022.04

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Papers 【 Display / hide 】

  • Genomic landscape and clinical impact of BRCA1/2 pathogenic variants in metastatic castration-resistant prostate cancer.

    Iida K, Urabe F, Matsui Y, Tashiro K, Yoshihara K, Urabe Y, Ishikawa T, Matsuzaki J, Kimura T, Saito Y

    NPJ precision oncology  2026.02

    ISSN  2397-768X

  • Primary subdural tumor mimicking subdural hematoma: illustrative case.

    Ishikawa T, Tsurubuchi T, Nagatomo K, Hosaka S, Fukushima H, Sakamoto N, Hirato J, Inoue Y, Ichimura K, Mizumoto M, Muroi A, Takada H, Ishikawa E

    Journal of neurosurgery. Case lessons 11 ( 5 )  2026.02

  • Esophageal cancer cells exhibit heterogeneity in DNA double-strand break repair and G2/M checkpoint arrest associated with cell viability after ionizing radiation

    Tateno K, Okuda K, Haruna S, Isono M, Ishikawa T, Okumura H, Hayashi R, Suzuki R, Takahashi T, Saito T, Yokobori T, Uchihara Y, Suzuki K, Yamauchi M, Shirabe K, Saeki H, Shibata A

    Advances in Radiation Oncology 11 ( 3 ) 101987 2026

    Research paper (scientific journal), Accepted,  ISSN  2452-1094

  • Carbon ion stimulation therapy reverses iron deposits and microglia driven neuroinflammation and induces cognitive improvement in an Alzheimer’s disease mouse model

    Lee W.S., Kokubo T., Choi Y., Hamano T., Zaboronok A., Ishikawa T., Kwon O.D., Kim E.H., Kim J.K.

    Scientific Reports 15 ( 1 )  2025.12

    Research paper (scientific journal), Joint Work, Accepted

    　View Summary

    Insoluble iron deposits often exist as iron oxide nanoparticles in protein aggregates, impaired ferritin, or activated microglia and have been implicated as major causes of neuroinflammation in Alzheimer’s disease. However, no crucial evidence has been reported to support the therapeutic effects of current iron chelators on the deposition of various molecular forms of insoluble iron. We investigated the therapeutic effect of carbon ion stimulation (CIS) via a transmission beam on insoluble iron deposits, iron inclusion bodies, and the associated biological response in 5xFAD AD mouse brains. Compared with no treatment, CIS dose-dependently induced a 33–60% reduction in the amount of ferrous-containing iron species and associated inclusion bodies in the brains of AD mice. CIS induced considerable neuroinflammation downregulation and, conversely, anti-inflammatory upregulation, which was associated with improved memory and enhanced hippocampal neurogenesis. In conclusion, our results suggest that the effective degradation of insoluble iron deposits in combination with pathogenic inclusion bodies promotes AD-modifying properties and offers a potential CIS treatment option for AD.

  • Hemagglutinating virus of Japan envelope encapsulating microRNA-34a-5p robustly induces apoptosis of malignant meningioma cells by suppressing survivin

    Ishikawa T., Matsuda M., Kaneda Y., Ishikawa E.

    Journal of Neuro Oncology 175 ( 2 ) 753 - 762 2025.11

    Research paper (scientific journal), Lead author, Accepted,  ISSN  0167594X

    　View Summary

    Purpose: Malignant meningiomas are characterized by high recurrence rates and limited therapeutic options beyond surgery and radiation. This study aimed to develop a novel nucleic acid-based therapeutic approach for malignant meningiomas and to evaluate its efficacy both in vitro and in vivo. Methods: IOMM-Lee and HKBMM cell lines were used as models of malignant meningioma. Inhibitory effects of hemagglutinating virus of Japan envelope (HVJ-E) and microRNA-34a-5p (miR-34a-5p) were assessed using cell viability assays, apoptosis assays, RT-qPCR, and western blotting. Finally, the tumor suppressive effect of HVJ-E encapsulating miR-34a-5p was evaluated using a subcutaneous xenograft model in nude mice. Result: HVJ-E significantly reduced viability of malignant meningioma cells. Furthermore, HVJ-E encapsulating miR-34a-5p demonstrated enhanced anti-tumor activity by inducing apoptosis through downregulation of survivin expression. This tumor-suppressive effect was also confirmed in a subcutaneous mouse model. Conclusion: Our findings indicate that HVJ-E encapsulating miR-34a-5p effectively inhibits the growth of malignant meningioma cells both in vitro and in vivo. This novel combination therapy holds promise as a potential treatment strategy for malignant meningiomas.

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Courses Taught 【 Display / hide 】

  • 英語演習

    2025

  • 卒業研究

    2025

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Courses Previously Taught 【 Display / hide 】

  • 微生物学

    慶應義塾大学

    2025.10
    , 

    Laboratory work/practical work/exercise

  • 化学療法1

    慶應義塾大学

    2025.10
    , 

    Autumn Semester, Undergraduate (specialized)

  • 微生物学

    慶應義塾大学

    2025.05
    , 

    Spring Semester, Undergraduate (specialized), Lecture

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