石川　隆昭 （ イシカワ　タカアキ ）

Ishikawa, Takaaki

写真a

所属（所属キャンパス）

薬学部 薬学科 薬物治療学講座 （ 芝共立 ）

職名

助教
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学歴 【 表示 ／ 非表示 】

  • 2003年04月
    -
    2007年03月

    慶應義塾大学, 理工学部, 物理情報工学科

    大学, 卒業

  • 2007年04月
    -
    2010年03月

    慶應義塾大学, 理工学研究科, 基礎理工学専攻

    大学院, 修了, 修士

  • 2010年04月
    -
    2015年03月

    筑波大学, 医学群, 医学類

    大学, 卒業

  • 2020年04月
    -
    2025年03月

    筑波大学, 人間総合科学学術院, 医学学位プログラム

    大学院, 修了, 博士

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学位 【 表示 ／ 非表示 】

  • 学士（工学）, 慶應義塾大学, 課程, 2007年03月

  • 修士（工学）, 慶應義塾大学, 課程, 2010年03月

  • 学士（医学）, 筑波大学, 課程, 2015年03月

  • 博士（医学）, 筑波大学, 課程, 2025年03月

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免許・資格 【 表示 ／ 非表示 】

  • 医師免許, 2015年04月

  • 脳神経外科専門医, 2022年04月

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論文 【 表示 ／ 非表示 】

  • Esophageal cancer cells exhibit heterogeneity in DNA double-strand break repair and G2/M checkpoint arrest associated with cell viability after ionizing radiation

    Tateno K, Okuda K, Haruna S, Isono M, Ishikawa T, Okumura H, Hayashi R, Suzuki R, Takahashi T, Saito T, Yokobori T, Uchihara Y, Suzuki K, Yamauchi M, Shirabe K, Saeki H, Shibata A

    Advances in Radiation Oncology 2026年

    研究論文（学術雑誌）, 査読有り

  • Carbon ion stimulation therapy reverses iron deposits and microglia driven neuroinflammation and induces cognitive improvement in an Alzheimer’s disease mouse model

    Lee W.S., Kokubo T., Choi Y., Hamano T., Zaboronok A., Ishikawa T., Kwon O.D., Kim E.H., Kim J.K.

    Scientific Reports 15 （ 1 ）  2025年12月

    研究論文（学術雑誌）, 共著, 査読有り

    　概要を見る

    Insoluble iron deposits often exist as iron oxide nanoparticles in protein aggregates, impaired ferritin, or activated microglia and have been implicated as major causes of neuroinflammation in Alzheimer’s disease. However, no crucial evidence has been reported to support the therapeutic effects of current iron chelators on the deposition of various molecular forms of insoluble iron. We investigated the therapeutic effect of carbon ion stimulation (CIS) via a transmission beam on insoluble iron deposits, iron inclusion bodies, and the associated biological response in 5xFAD AD mouse brains. Compared with no treatment, CIS dose-dependently induced a 33–60% reduction in the amount of ferrous-containing iron species and associated inclusion bodies in the brains of AD mice. CIS induced considerable neuroinflammation downregulation and, conversely, anti-inflammatory upregulation, which was associated with improved memory and enhanced hippocampal neurogenesis. In conclusion, our results suggest that the effective degradation of insoluble iron deposits in combination with pathogenic inclusion bodies promotes AD-modifying properties and offers a potential CIS treatment option for AD.

  • Hemagglutinating virus of Japan envelope encapsulating microRNA-34a-5p robustly induces apoptosis of malignant meningioma cells by suppressing survivin

    Ishikawa T., Matsuda M., Kaneda Y., Ishikawa E.

    Journal of Neuro Oncology 175 （ 2 ） 753 - 762 2025年11月

    研究論文（学術雑誌）, 筆頭著者, 査読有り,  ISSN  0167594X

    　概要を見る

    Purpose: Malignant meningiomas are characterized by high recurrence rates and limited therapeutic options beyond surgery and radiation. This study aimed to develop a novel nucleic acid-based therapeutic approach for malignant meningiomas and to evaluate its efficacy both in vitro and in vivo. Methods: IOMM-Lee and HKBMM cell lines were used as models of malignant meningioma. Inhibitory effects of hemagglutinating virus of Japan envelope (HVJ-E) and microRNA-34a-5p (miR-34a-5p) were assessed using cell viability assays, apoptosis assays, RT-qPCR, and western blotting. Finally, the tumor suppressive effect of HVJ-E encapsulating miR-34a-5p was evaluated using a subcutaneous xenograft model in nude mice. Result: HVJ-E significantly reduced viability of malignant meningioma cells. Furthermore, HVJ-E encapsulating miR-34a-5p demonstrated enhanced anti-tumor activity by inducing apoptosis through downregulation of survivin expression. This tumor-suppressive effect was also confirmed in a subcutaneous mouse model. Conclusion: Our findings indicate that HVJ-E encapsulating miR-34a-5p effectively inhibits the growth of malignant meningioma cells both in vitro and in vivo. This novel combination therapy holds promise as a potential treatment strategy for malignant meningiomas.

  • Establishment of a novel benign meningioma cell line spontaneously immortalized under hypoxic conditions

    Ishikawa T., Matsuda M., Ishikawa H., Toyomura J., Ohyama A., Sakamoto N., Zaboronok A., Ishikawa E.

    Human Cell 38 （ 1 ）  2025年01月

    研究論文（学術雑誌）, 筆頭著者, 査読有り,  ISSN  09147470

    　概要を見る

    Meningiomas are the most frequent brain tumors, typically benign and curable by surgery. However, some patients experience repeated recurrences from residual tumors. To address such cases, the development of novel therapeutic options is crucial. For this purpose, the availability of cell lines that possess the characteristics of benign meningiomas is essential. Here, we established a benign meningioma cell line under 3% O<inf>2</inf> hypoxic conditions without the induction of immortalization genes. This cell line, named TKB-MEN2, has been stably grown for over two years with more than 20 passages. There were no hotspot telomerase reverse transcriptase (TERT) promoter mutations or cyclin-dependent kinase inhibitor 2A/2B (CDKN2A/2B) homozygous deletions, which are genetic features typical of malignant meningiomas. Cultured under hypoxic conditions, this cell line showed fewer characteristics of cellular senescence, such as morphological changes, IL-6 secretion, and lower senescence-associated b-galactosidase activity, compared to the same cell line cultured under 20% O<inf>2</inf> conditions. This immortalized non-transgenic cell line appears to reflect the characteristics of a genuine benign meningioma, potentially allowing the identification of new therapeutic targets and the development of novel therapies for benign meningiomas.

  • Intraosseous schwannoma in the clivus mimicking chordoma treated with endoscopic endonasal surgery: A case report

    Ishikawa T., Akutsu H., Hara T., Tanaka S., Masumoto T., Ishikawa E.

    Surgical Neurology International 13 2022年

    研究論文（学術雑誌）, 筆頭著者, 査読有り

    　概要を見る

    Background: Intraosseous schwannomas are extremely rare and they have not yet been reported to occur in the clivus. We report a schwannoma in the clivus mimicking chordoma and review intraosseous schwannomas of the skull. Case Description: A 62-year-old man presented with gradually worsening hoarseness with dysphagia and atrophy of the left tongue, trapezius muscle, and sternocleidomastoid muscle. Magnetic resonance imaging showed that the tumor was mainly located in the clivus, and a computed tomography (CT) scan revealed an osteolytic lesion with expansion of the clivus and preservation of the bony cortex. Endoscopic endonasal surgery was performed to diagnose and treat symptoms. The tumor was subtotally removed without any complications. The histopathological findings revealed typical schwannoma, which showed Antoni A and Antoni B patterns positive for S100 protein. Based on the preoperative imaging, intraoperative and histopathological findings, the tumor was considered to be an intraosseous schwannoma in the clivus, and no recurrence was observed after 1 year of postoperative follow-up. Conclusion: Even though the intraosseous schwannoma in the clivus is uncommon, it should be considered as a differential diagnosis if an expansive lesion without destruction of the cortical bone is shown on CT as well as iso-hyperintensity on T2-weighted magnetic resonance imaging.

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担当授業科目 【 表示 ／ 非表示 】

  • 英語演習

    2025年度

  • 卒業研究

    2025年度

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担当経験のある授業科目 【 表示 ／ 非表示 】

  • 微生物学

    慶應義塾大学

    2025年10月
    , 

    実習・実験

  • 化学療法1

    慶應義塾大学

    2025年10月
    , 

    秋学期, 学部専門科目

  • 微生物学

    慶應義塾大学

    2025年05月
    , 

    春学期, 学部専門科目, 講義

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