論文 - 野田　賀大

Relationships between socio‐clinico‐demographic factors and global cognitive function in the oldest old living in the Tokyo Metropolitan area: Reanalysis of the Tokyo Oldest …

Y Eguchi, K Tasato, S Nakajima, Y Noda, S Tsugawa, S Shinagawa, ...

International journal of geriatric psychiatry 33 (7), 926-933 2018年

研究論文（学術雑誌）, 査読有り

Effect of education on Alzheimer’s disease-related neuroimaging biomarkers in healthy controls, and participants with mild cognitive impairment and Alzheimer’s disease: A cross …

M Wada, Y Noda, S Shinagawa, JK Chung, K Sawada, K Ogyu, R Tarumi, ...

Journal of Alzheimer's Disease 63 (2), 861-869 2018年

研究論文（学術雑誌）, 査読有り

Enhanced theta-gamma coupling associated with hippocampal volume increase following high-frequency left prefrontal repetitive transcranial magnetic stimulation in patients with …

Y Noda, R Zomorrodi, ZJ Daskalakis, DM Blumberger, M Nakamura

International Journal of Psychophysiology 133, 169-174 2018年

研究論文（学術雑誌）, 査読有り

Progress in Neuro-Psychopharmacology and Biological Psychiatry

DP Kiser, S Popp, AG Schmitt-Böhrer, T Strekalova, D Hove, KP Lesch, ...

Elsevier 2018年

Reduced prefrontal short-latency afferent inhibition in older adults and its relation to executive function: A TMS-EEG study

Noda Y., Zomorrodi R., Backhouse F., Cash R.F.H., Barr M.S., Rajji T.K., Chen R., Daskalakis Z.J., Blumberger D.M.

Frontiers in Aging Neuroscience （Frontiers in Aging Neuroscience）  9 （ MAY ）  2017年05月

研究論文（学術雑誌）, 査読有り,  ISSN  1663-4365

　概要を見る

Combining transcranial magnetic stimulation (TMS) with electroencephalography (EEG) allows for the assessment of various neurophysiological processes in the human cortex. One of these paradigms, short-latency afferent inhibition (SAI), is thought to be a sensitive measure of cholinergic activity. In a previous study, we demonstrated the temporal pattern of this paradigm from both the motor (M1) and dorsolateral prefrontal cortex (DLPFC) using simultaneous TMS-EEG recording. The SAI paradigm led to marked modulations at N100. In this study, we aimed to investigate the age-related effects on TMS-evoked potentials (TEPs) with the SAI from M1 and the DLPFC in younger (18-59 years old) and older (≥60 years old) participants. Older participants showed significantly lower N100 modulation in M1-SAI as well as DLPFC-SAI compared to the younger participants. Furthermore, the modulation of N100 by DLPFC-SAI in the older participants correlated with executive function as measured with the Trail making test. This paradigm has the potential to non-invasively identify cholinergic changes in cortical regions related to cognition in older participants.

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Characterization of Glutamatergic and GABA A-Mediated Neurotransmission in Motor and Dorsolateral Prefrontal Cortex Using Paired-Pulse TMS-EEG

Cash R.F.H., Noda Y., Zomorrodi R., Radhu N., Farzan F., Rajji T.K., Fitzgerald P.B., Chen R., Daskalakis Z.J., Blumberger D.M.

Neuropsychopharmacology （Neuropsychopharmacology）  42 （ 2 ） 502 - 511 2017年01月

研究論文（学術雑誌）, 査読有り,  ISSN  0893133X

　概要を見る

Short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) are noninvasive transcranial magnetic stimulation (TMS) measures of GABA A receptor-mediated inhibition and glutamatergic excitatory transmission, respectively. Conventionally these measures have been restricted to the motor cortex. We investigated whether SICI and ICF could be recorded from the dorsolateral prefrontal cortex (DLPFC) using combined TMS and electroencephalography (TMS-EEG). We first characterized the neural signature of SICI and ICF in M1 in terms of TMS-evoked potentials (TEPs) and spectral power modulation. Subsequently, these paradigms were applied in the DLPFC to determine whether similar neural signatures were evident. With TMS at M1, SICI and ICF led to bidirectional modulation (inhibition and facilitation, respectively) of P30 and P60 TEP amplitude, which correlated with MEP amplitude changes. With DLPFC stimulation, P60 was bidirectionally modulated by SICI and ICF in the same manner as for M1 stimulation, whereas P30 was absent. The sole modulation of early TEP components is in contradistinction to other measures such as long-interval intracortical inhibition and may reflect modulation of short latency excitatory and inhibitory postsynaptic potentials (EPSPs and IPSPs). Overall, the data suggest that SICI and ICF can be recorded using TMS-EEG in DLPFC providing noninvasive measures of glutamatergic and GABA A receptor-mediated neurotransmission. This may facilitate future research attempting to ascertain the role of these neurotransmitters in the pathophysiology and treatment of neurological and psychiatric disorders.

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Lateralized hippocampal volume increase following high-frequency left prefrontal repetitive transcranial magnetic stimulation in patients with major depression

野田 賀大

Psychiatry and Clinical Neurosciences （Psychiatry and Clinical Neurosciences）  71 （ 11 ） 747 - 758 2017年

研究論文（学術雑誌）, 査読有り,  ISSN  13231316

　概要を見る

© 2017 The Authors. Psychiatry and Clinical Neurosciences © 2017 Japanese Society of Psychiatry and Neurology Aim: Repetitive transcranial magnetic stimulation (rTMS) has been applied as a treatment for patients with treatment-resistant depression in recent years, and a large body of evidence has demonstrated its therapeutic efficacy through stimulating neuronal plasticity. The aim of this study was to investigate structural alterations in the hippocampus (HIPP) and amygdala (AM) following conventional rTMS in patients with depression. Methods: Twenty-eight patients with depression underwent 10 daily 20-Hz left prefrontal rTMS over 2 weeks. The left dorsolateral prefrontal cortex (DLPFC) was identified using magnetic resonance imaging-guided neuronavigation prior to stimulation. Magnetic resonance imaging scans were obtained at baseline and after the completion of rTMS sessions. The therapeutic effects of rTMS were evaluated with the 17-item Hamilton Depression Rating Scale (HAM-D17), and the volumes of the HIPP and AM were measured by a manual tracing method. Results: Statistical analyses revealed a significant volume increase in the left HIPP (+3.4%) after rTMS but no significant volume change in the AM. No correlation was found between the left HIPP volume increase and clinical improvement, as measured by the HAM-D17. Conclusion: The present study demonstrated that conventional left prefrontal rTMS increases the HIPP volume in the stimulated side, indicating a remote neuroplastic effect through the cingulum bundle.

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Reduced prefrontal short–latency afferent inhibition in older adults and its relation to executive function: a TMS-EEG Study.

野田 賀大

Frontiers in Aging Neuroscience. 2017年

Reduced short-latency afferent inhibition in prefrontal but not motor cortex and its association with executive function in schizophrenia: a combined TMS–EEG study.

野田 賀大

Schizophrenia Bulletin. 2017年

Characterization of the influence of age on GABAA and glutamatergic mediated functions in the dorsolateral prefrontal cortex using paired-pulse TMS-EEG

野田 賀大

Aging 9 (2), 556-572 2017年

研究論文（学術雑誌）, 査読有り

Resting-state EEG gamma power and theta-gamma coupling enhancement following high-frequency left dorsolateral prefrontal rTMS in patients with depression.

野田 賀大

Clinical Neurophysiology. 2017年

Characterization of glutamatergic and GABA A-mediated neurotransmission in motor and dorsolateral prefrontal cortex using paired-pulse TMS–EEG

RFH Cash, Y Noda, R Zomorrodi, N Radhu, F Farzan, TK Rajji, ...

Neuropsychopharmacology 42 (2), 502-511 2017年

研究論文（学術雑誌）, 査読有り

Lateralized hippocampal volume increase following high‐frequency left prefrontal repetitive transcranial magnetic stimulation in patients with major depression

S Hayasaka, M Nakamura, Y Noda, T Izuno, T Saeki, H Iwanari, ...

Psychiatry and clinical neurosciences 71 (11), 747-758 2017年

研究論文（学術雑誌）, 査読有り

Cortical Inhibition and Excitation in Late-Life Depression: A TMS Study of Baseline Abnormalities and Changes With Pharmacotherapy

J Lissemore, A Bhandari, B Mulsant, E Lenze, C Reynolds, J Karp, T Rajji, ...

NEUROPSYCHOPHARMACOLOGY 43, S408-S409 2017年

研究論文（学術雑誌）, 査読有り

Evaluation of short interval cortical inhibition and intracortical facilitation from the dorsolateral prefrontal cortex in patients with schizophrenia

Y Noda, MS Barr, R Zomorrodi, RFH Cash, F Farzan, TK Rajji, R Chen, ...

Scientific reports 7 (1), 1-12 （Scientific Reports）  7 （ 1 ） 17106 2017年

研究論文（学術雑誌）, 査読有り,  ISSN  2045-2322

　概要を見る

© 2017 The Author(s). GABAergic and glutamatergic dysfunction in the dorsolateral prefrontal cortex (DLPFC) are thought to be the core pathophysiological mechanisms of schizophrenia. Recently, we have established a method to index these functions from the DLPFC using the paired transcranial magnetic stimulation (TMS) paradigms of short interval intracortical inhibition (SICI) and facilitation (ICF) combined with electroencephalography (EEG). In this study, we aimed to evaluate neurophysiological indicators related to GABAA and glutamate receptor-mediated functions respectively from the DLPFC in patients with schizophrenia using these paradigms, compared to healthy controls. Given that these activities contribute to cognitive functions, the relationship between the TMS-evoked potential (TEP) modulations by SICI/ICF and cognitive/clinical measures were explored. Compared to controls, patients showed reduced inhibition in P60 (t22 = -4.961, p < 0.0001) by SICI and reduced facilitation in P60 (t22 = 5.174, p < 0.0001) and N100 (t22 = 3.273, p = 0.003) by ICF. In patients, the modulation of P60 by SICI was correlated with the longest span of the Letter-Number Span Test (r = -0.775, p = 0.003), while the modulation of N100 by ICF was correlated with the total score of the Positive and Negative. Syndrome Scale (r = 0.817, p = 0.002). These findings may represent the pathophysiology, which may be associated with prefrontal GABAA and glutamatergic dysfunctions, in the expression of symptoms of schizophrenia.

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Resting-state EEG gamma power and theta–gamma coupling enhancement following high-frequency left dorsolateral prefrontal rTMS in patients with depression

Y Noda, R Zomorrodi, T Saeki, TK Rajji, DM Blumberger, ZJ Daskalakis, ...

Clinical Neurophysiology 128 (3), 424-432 （Clinical Neurophysiology）  128 （ 3 ） 424 - 432 2017年

研究論文（学術雑誌）, 査読有り,  ISSN  13882457

　概要を見る

Objective We aimed to investigate neuromodulatory effects of high-frequency left dorsolateral prefrontal cortex repetitive transcranial magnetic stimulation (rTMS) on resting-state electroencephalography (EEG) and their clinical and cognitive correlates in patients with depression. Methods Thirty-one patients diagnosed with depression included in the present study. Resting-state gamma power and theta–gamma coupling (TGC) were calculated before and after a course of rTMS. We explored the relationship among gamma power, TGC, and clinical/cognitive outcomes as measured with the Hamilton Rating Scale for Depression (HAM-D17), Beck Depression Inventory (BDI), and Wisconsin Card Sorting Test (WCST). Results Following rTMS, depressed patients demonstrated significant increases of resting gamma power at the F3 and F4 electrode sites and resting TGC at the C3 and T3 electrode sites. Furthermore, the increased gamma power at the F3 electrode site was significantly correlated with improved score on the HAM-D17 and BDI, while the increased TGC at the C3 electrode site was significantly correlated with reduced number of errors on the WCST. Conclusion Thus, resting-state gamma power and TGC may represent potential biomarkers of depression associated with therapeutic effects of rTMS. Significance Resting-state EEG may provide potential biomarkers related to therapeutic effects of rTMS.

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Reduced Prefrontal Short—Latency Afferent Inhibition in Older Adults and Its Relation to Executive Function: A TMS-EEG Study

Y Noda, R Zomorrodi, F Backhouse, RFH Cash, MS Barr, TK Rajji, ...

Frontiers in aging neuroscience 9, 119 2017年

研究論文（学術雑誌）, 査読有り

Characterization of the influence of age on GABA<inf>A</inf> and glutamatergic mediated functions in the dorsolateral prefrontal cortex using paired-pulse TMS-EEG

Noda Y., Zomorrodi R., Cash R.F.H., Barr M.S., Farzan F., Rajji T.K., Chen R., Daskalakis Z.J., Blumberger D.M.

Aging （Aging）  9 （ 2 ） 556 - 572 2017年

研究論文（学術雑誌）, 査読有り,  ISSN  19454589

　概要を見る

Gamma-aminobutyric acid (GABA)ergic and glutamatergic neurotransmissions in the prefrontal cortex decreases with age. Further, cognitive function mediated through the dorsolateral prefrontal cortex (DLPFC) also declines with age. Although neuroimaging studies have demonstrated decreased levels of these substances, direct neurophysiological data investigating the effect of aging in the DLPFC in human subjects is lacking. The advent of transcranial magnetic stimulation (TMS) combined with electroencephalography (EEG) has allowed for the assessment of functional neurotransmission in vivo. In the present study, we examined short interval intracortical inhibition (SICI) and intracortical facilitation (ICF) in a group of older adults (> 60 yrs) to evaluate the strength of GABAA and glutamate-mediated neurotransmission in the DLPFC, compared to younger adults (18-59 yrs). Older adults showed an increase of amplitude of N100 by the SICI paradigm, while N45 amplitude was increased and N100 amplitude was decreased by ICF. Moreover, these modulations significantly correlated with age. Our findings provide evidence for age-related alterations of excitatory and inhibitory functions in the prefrontal cortex in healthy adults. Future studies may aim to explore these neurophysiological relationships in the DLPFC in pathological forms of aging that affect cortical functioning such as mild cognitive impairment and Alzheimer's disease.

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Characterisation of glutamatergic and GABAA-mediated neurotransmission in motor and dorsolateral prefrontal cortex using paired-pulse TMS-EEG.

野田 賀大

Neuropsychopharmacology. 2016年

A combined TMS–EEG study of short–latency afferent inhibition in the motor and dorsolateral prefrontal cortex.

野田 賀大

Journal of neurophysiology. 2016年