論文 - 野田　賀大

Effectiveness of standard sequential bilateral repetitive transcranial magnetic stimulation vs bilateral theta burst stimulation in older adults with depression: the FOUR-D …

DM Blumberger, BH Mulsant, KE Thorpe, SM McClintock, ...

JAMA psychiatry 79 (11), 1065-1073 2022年

Decreased cortical gyrification and surface area in the left medial parietal cortex in patients with treatment‐resistant and ultratreatment‐resistant schizophrenia

K Kitajima, S Tamura, D Sasabayashi, S Nakajima, Y Iwata, F Ueno, ...

Psychiatry and clinical neurosciences 2022年

Cost-effectiveness analysis comparing repetitive transcranial magnetic stimulation therapy with antidepressant treatment in patients with treatment-resistant depression in Japan

Y Noda, C Miyashita, Y Komatsu, S Kito, M Mimura

medRxiv, 2022.12. 02.22282995 （Psychiatry Research）  330   115573 - 115573 2022年

査読有り,  ISSN  01651781

　概要を見る

Repetitive transcranial magnetic stimulation (rTMS) for patients with treatment-resistant depression (TRD) became covered by the National Health Insurance (NHI) in Japan since 2019. Although the evidence of rTMS for TRD is well established, the cost-effectiveness of rTMS versus antidepressants has not been thoroughly analyzed in Japan. Thus, we aimed to evaluate the cost-effectiveness of rTMS for TRD under the NHI system using a microsimulation model to compare the direct costs and quality-adjusted life years (QALYs). Model inputs of clinical parameters and the utility were derived from published literature. Cost parameters were estimated from the Japanese Claim Database. The robustness of the analyses was evaluated with sensitivity analysis and scenario analysis. The analysis estimated that rTMS increased effectiveness by 0.101QALYs and total cost by ¥94,370 ($689) compared with antidepressant medications. As a result, the incremental cost-effectiveness ratio (ICER) of rTMS was estimated to be ¥935,984 ($6,832)/QALY. In the sensitivity and scenario analyses, ICER did not exceed ¥5 million ($36,496)/QALY as the reference value of the Japanese public cost-effectiveness evaluation system. rTMS therapy for TRD can be a cost-effective treatment strategy compared to antidepressant medication under the NHI system in Japan.

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Autistic children and adolescents with frequent restricted interest and repetitive behavior showed more difficulty in social cognition during mask-wearing during the COVID-19 …

H Tamon, T Itahashi, S Yamaguchi, Y Tachibana, J Fujino, M Igarashi, ...

BMC psychiatry 22 (1), 608 2022年

Associations Between Structural Covariance Network and Antipsychotic Treatment Response in Schizophrenia

S Tsugawa, E Plitman, C Wannan, A Zalesky, Y Noda, R Tarumi, S Honda, ...

NEUROPSYCHOPHARMACOLOGY 47, 374-374 （Schizophrenia Bulletin）  50 （ 2 ） 382 - 392 2022年

査読有り,  ISSN  0586-7614

　概要を見る

Background and Hypothesis: Schizophrenia is associated with widespread cortical thinning and abnormality in the structural covariance network, which may reflect connectome alterations due to treatment effect or disease progression. Notably, patients with treatment-resistant schizophrenia (TRS) have stronger and more widespread cortical thinning, but it remains unclear whether structural covariance is associated with treatment response in schizophrenia. Study Design: We organized a multicenter magnetic resonance imaging study to assess structural covariance in a large population of TRS and non-TRS, who had been resistant and responsive to non-clozapine antipsychotics, respectively. Whole-brain structural covariance for cortical thickness was assessed in 102 patients with TRS, 77 patients with non-TRS, and 79 healthy controls (HC). Network-based statistics were used to examine the difference in structural covariance networks among the 3 groups. Moreover, the relationship between altered individual differentiated structural covariance and clinicodemographics was also explored. Study Results: Patients with non-TRS exhibited greater structural covariance compared with HC, mainly in the fronto-temporal and frontooccipital regions, while there were no significant differences in structural covariance between TRS and non-TRS or HC. Higher individual differentiated structural covariance was associated with lower general scores of the Positive and Negative Syndrome Scale in the non-TRS group, but not in the TRS group. Conclusions: These findings suggest that reconfiguration of brain networks via coordinated cortical thinning is related to treatment response in schizophrenia. Further longitudinal studies are warranted to confirm if greater structural covariance could serve as a marker for treatment response in this disease.

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Reduced Glutamatergic Cortical Facilitation Associated With Glutamate-Related Gene Expression Abnormalities in Treatment-Resistant Depression

M Wada, S Nakajima, S Honda, M Takano, K Taniguchi, Y Mimura, ...

NEUROPSYCHOPHARMACOLOGY 47 (SUPPL 1), 273-274 2022年

TMS-EEG Indices as High Potential Predictive Markers of iTBS Response in MDD

R Strafella, R Zomorrodi, J Lissemore, Y Noda, Z Daskalakis, ...

NEUROPSYCHOPHARMACOLOGY 47 (SUPPL 1), 251-251 2022年

The impact of mask-wearing influenced by restricted interest and repetitive behavior on the mental distress of individuals with autism spectrum disorder during the COVID-19 …

H Tamon, T Itahashi, S Yamaguchi, Y Tachibana, J Fujino, M Igarashi, ...

2022年

DATA-DRIVEN DISEASE PROGRESSION PATTERNS OF BRAIN MORPHOLOGY IN SCHIZOPHRENIA: A MACHINE-LEARNING APPROACH

D Sone, A Young, S Shinagawa, Y Noda, Y Iwata, R Tarumi, K Ogyu, ...

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY 56 (1_ SUPPL), 247-247 2022年

The role of gamma oscillations in the pathophysiology of substance use disorders

Ramlakhan J.U., Ma M., Zomorrodi R., Blumberger D.M., Noda Y., Barr M.S.

Journal of Personalized Medicine （Journal of Personalized Medicine）  11 （ 1 ） 1 - 18 2021年12月

研究論文（学術雑誌）, 共著, 査読有り

　概要を見る

Substance use disorders (SUDs) are a major public health problem—with over 200 million people reporting drug use in 2016. Electroencephalography (EEG) is a powerful tool that can provide insights into the impact of SUDs on cognition. Specifically, modulated gamma activity may provide an index of the pathophysiology of SUDs. Thus, the purpose of this review was to investigate the impact of alcohol, tobacco, cannabis, cocaine, and amphetamine on gamma activity, among pre-clinical and clinical populations during acute and chronic exposure and withdrawal states. We searched multiple databases for key terms related to SUDs, EEG, and gamma and ensured rigorous methods by using a standardized review reporting tool. We included 30 studies in this review and found that all substances were associated with modulation of gamma activity, across states and in both preclinical and clinical populations. Gamma oscillations appeared to be differentially modulated in clinical versus preclinical populations and had the most complex relationship with alcohol, indicating that it may act differently than other substances. The findings of this review offer insights into the pathophysiology of SUDs, providing a potential window into novel treatments for SUDs via modulation of gamma activity.

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Insights of neurophysiology on unconscious state using combined transcranial magnetic stimulation and electroencephalography: A systematic review

Arai N., Nakanishi T., Nakajima S., Li X., Wada M., Daskalakis Z.J., Goodman M.S., Blumberger D.M., Mimura M., Noda Y.

Neuroscience and Biobehavioral Reviews （Neuroscience and Biobehavioral Reviews）  131   293 - 312 2021年12月

最終著者, 責任著者, 査読有り,  ISSN  01497634

　概要を見る

Unconscious state has been investigated in numerous studies so far, but pathophysiology of this state is not fully understood. Recently, combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) has been developed to allow for non-invasive assessment of neurophysiology in the cerebral cortex. We conducted a systematic literature search for TMS-EEG studies on human unconscious state using PubMed with cross-reference and manual searches. The initial search yielded 137 articles, and 19 of them were identified as relevant, including one article found by manual search. This review included 10 studies for unresponsive wakefulness syndrome (UWS), 9 for minimally conscious states (MCS), 5 for medication-induced unconscious states, and 6 for natural non-rapid eye movement states. These studies analyzed TMS-evoked potential to calculate perturbational complexity index (PCI) and OFF-periods. In particular, PCI was found to be a potentially useful marker to differentiate between UWS and MCS. This review demonstrated that TMS-EEG could represent a promising neuroscientific tool to investigate various unconscious states. Further TMS-EEG research may help elucidate the neural basis of unconscious state.

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Clinical Neurophysiology, Neuroimaging, and Neuromodulation of Neuropsychiatric Disorders

Yoshihiro Noda

Journal of Personalized Medicine （MDPI AG）  11 （ 11 ） 1193 - 1193 2021年11月

筆頭著者, 最終著者, 責任著者, 査読有り

　概要を見る

The goal of this Special Issue is to introduce the cutting-edge research in clinical neurophysiology, neuroimaging, and neuromodulation. We were able to publish 11 original articles and 3 review papers that utilize the latest neuroscience approaches in the abovementioned fields. I would like to introduce these excellent works below.

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Clinical Neurophysiology, Neuroimaging, and Neuromodulation of Neuropsychiatric Disorders.

Noda Y

Journal of personalized medicine 11 （ 11 ）  2021年11月

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A randomized sham controlled comparison of once vs twice-daily intermittent theta burst stimulation in depression: A Canadian rTMS treatment and biomarker network in depression (CARTBIND) study

Blumberger D.M., Vila-Rodriguez F., Wang W., Knyahnytska Y., Butterfield M., Noda Y., Yariv S., Isserles M., Voineskos D., Ainsworth N.J., Kennedy S.H., Lam R.W., Daskalakis Z.J., Downar J.

Brain Stimulation （Brain Stimulation）  14 （ 6 ） 1447 - 1455 2021年11月

査読有り,  ISSN  1935861X

　概要を見る

Background: Intermittent theta burst stimulation (iTBS) is a newer form of repetitive transcranial magnetic stimulation (rTMS) for patients with treatment resistant depression (TRD). Applying multiple daily iTBS sessions may enable patients to achieve remission more rapidly. Objective: We compared the efficacy and tolerability of a twice-daily versus once-daily iTBS protocol in patients with TRD. We hypothesized that twice-daily iTBS would result in a greater improvement in depression scores compared to once-daily iTBS. Methods: 208 participants (131 females) with TRD were randomized to receive either iTBS (600 pulses) delivered twice-daily with a 54-min interval between treatments or once-daily (1200 pulses) with 1 sham treatment with the same interval between treatments, to ensure equal levels of daily therapeutic contact and blinding of patients and raters. The primary outcome measure was change in depression scores on the Hamilton Rating Scale for Depression (HRSD-17) after 10 days of treatment and 30 days of treatments. Results: HRSD-17 scores improved in both the twice-daily and once-daily iTBS groups; however, these improvements did not significantly differ between the two groups at either the 10-day or 30-day timepoints. Response and remission rates were low (<10%) in both groups after 10 days and consistent with prior reports at 30 days; these rates did not differ between the treatment groups. Conclusions: These results suggest that twice-daily iTBS does not accelerate response to iTBS and is not different from once-daily treatment in terms of improving depressive symptoms in patients with TRD. Clinicaltrials.gov ID: NCT02729792 (https://clinicaltrials.gov/ct2/show/NCT02729792)

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Development of an advanced sham coil for transcranial magnetic stimulation and examination of its specifications

Takano M., Havlicek J., Phillips D., Nakajima S., Mimura M., Noda Y.

Journal of Personalized Medicine （Journal of Personalized Medicine）  11 （ 11 ） 1058 - 1058 2021年11月

最終著者, 責任著者, 査読有り,  ISSN  2075-4426

　概要を見る

Transcranial magnetic stimulation (TMS) neurophysiology has been widely applied worldwide, but it is often contaminated by confounders other than cortical stimulus-evoked activities. Although advanced sham coils that elaborately mimic active stimulation have recently been developed, their performance is not examined in detail. Developing such sham coils is crucial to improve the accuracy of TMS neurophysiology. Herein, we examined the specifications of the sham coil by comparison with the active coil. The magnetic flux and click sound pressure changes were measured when the stimulus intensity was varied from 10% to 100% maximum stimulator output (MSO), and the changes in coil surface temperature over time with continuous stimulation at 50% MSO for each coil. The magnetic flux change at the center of the coil showed a peak of 12.51 (kT/s) for the active coil, whereas it was 0.41 (kT/s) for the sham coil. Although both coils showed a linear change in magnetic flux as the stimulus intensity increased, due to the difference in coil winding structure, the sham coil took less than half the time to overheat and had 5 dB louder coil click sounds than the active coil. The sham coil showed a sufficiently small flux change at the center of the coil, but the flux change from the periphery of the coil was comparable to that of the active coil. Future use of high-quality sham coil will extend our understanding of the TMS neurophysiology of the cortex at the stimulation site.

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Association between resilience and cortical thickness in the posterior cingulate cortex and the temporal pole in Japanese older people: A population-based cross-sectional study

Shikimoto R., Noda Y., Kida H., Nakajima S., Tsugawa S., Mimura Y., Ochi R., Takayama M., Niimura H., Mimura M.

Journal of Psychiatric Research （Journal of Psychiatric Research）  142   89 - 100 2021年10月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  00223956

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Background: Resilience is a crucial factor preventing the onset of mental illness and contributing to the well-being and healthy longevity, whose neural bases are not fully elucidated in older people. The present study aimed to identify the cortical thickness associating with resilience in older adults. Methods: This is a part of the cross-sectional Arakawa geriatric cohort study for people aged 65 years or older, consisting of 1001 individuals. A Self-Reported Resilience Scale (RS), neuropsychological batteries, face-to-face interviews for diagnosis, and a three-dimensional T1-weighted magnetic resonance imaging were conducted. Cortical thickness was computed by the FreeSurfer. The relationships among cortical thickness, total RS score, and clinico-demographic data were investigated using univariate and multivariable regression analyses. Results: The total RS score was correlated with age, education, and scores of the Mini-Mental State Examination (MMSE) and Geriatric Depression Scale (GDS) in univariate analyses. The total RS score was associated with cortical thicknesses in the left posterior cingulate (β [95 % CI of B] = 0.07 [0.16–14.84]) and the left temporal pole (β [95 % CI of B] = 0.08 [0.63–9.93]) after adjusting sex, age, imaging acquisition site, education, MMSE and GDS scores, hypertension, hyperlipidemia, diabetes mellitus, Barthel index, BMI, and living situation in multivariable regression analyses. Conclusion: The present analyses suggest that the resilience capacity may be related to the cortical thickness in the posterior cingulate and temporal cortices in older adults. Our findings warrant further longitudinal studies to confirm the causal relationship between stress events, resilience, and brain structures.

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Recent Advances and Future Directions in Brain MR Imaging Studies in Schizophrenia: Toward Elucidating Brain Pathology and Developing Clinical Tools.

Shinsuke Koike, Akiko Uematsu, Daiki Sasabayashi, Norihide Maikusa, Tsutomu Takahashi, Kazutaka Ohi, Shinichiro Nakajima, Yoshihiro Noda, Yoji Hirano

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine （Magnetic Resonance in Medical Sciences）  21 （ 4 ） 539 - 552 2021年08月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  1347-3182

　概要を見る

Schizophrenia is a common severe psychiatric disorder that affects approximately 1% of general population through the life course. Historically, in Kraepelin’s time, schizophrenia was a disease unit conceptualized as dementia praecox; however, since then, the disease concept has changed. Recent MRI studies had shown that the neuropathology of the brain in this disorder was characterized by mild progression before and after the onset of the disease, and that the brain alterations were relatively smaller than assumed. Although genetic factors contribute to the brain alterations in schizophrenia, which are thought to be trait differences, other changes include factors that are common in psychiatric diseases. Furthermore, it has been shown that the brain differences specific to schizophrenia were relatively small compared to other changes, such as those caused by brain development, aging, and gender. In addition, compared to the disease and participant factors, machine and imaging protocol differences could affect MRI signals, which should be addressed in multi-site studies. Recent advances in MRI modalities, such as multi-shell diffusion-weighted imaging, magnetic resonance spectroscopy, and multimodal brain imaging analysis, may be candidates to sharpen the characterization of schizophrenia-specific factors and provide new insights. The Brain/MINDS Beyond Human Brain MRI (BMB-HBM) project has been launched considering the differences and noises irrespective of the disease pathologies and includes the future perspectives of MRI studies for various psychiatric and neurological disorders. The sites use restricted MRI machines and harmonized multi-modal protocols, standardized image preprocessing, and traveling subject harmonization. Data sharing to the public will be planned in FY 2024. In the future, we believe that combining a high-quality human MRI dataset with genetic data, randomized controlled trials, and MRI for non-human primates and animal models will enable us to understand schizo-phrenia, elucidate its neural bases and therapeutic targets, and provide tools for clinical application at bedside.

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Polygenic risk scores for major psychiatric and neurodevelopmental disorders contribute to sleep disturbance in childhood: Adolescent Brain Cognitive Development (ABCD) Study

Ohi K., Ochi R., Noda Y., Wada M., Sugiyama S., Nishi A., Shioiri T., Mimura M., Nakajima S.

Translational Psychiatry （Translational Psychiatry）  11 （ 1 ） 187 - 187 2021年06月

研究論文（学術雑誌）, 共著, 査読有り

　概要を見る

Sleep disturbance is a common symptom of psychiatric and neurodevelopmental disorders and, especially in childhood, can be a precursor to various mental disorders. However, the genetic etiology of mental illness that contributes to sleep disturbance during childhood is poorly understood. We investigated whether the polygenic features of psychiatric and neurodevelopmental disorders are associated with sleep disturbance during childhood. We conducted polygenic risk score (PRS) analyses by utilizing large-scale genome-wide association studies (GWASs) (n = 46,350–500,199) of five major psychiatric and neurodevelopmental disorders (autism spectrum disorder, schizophrenia, attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), and bipolar disorder) and, additionally, anxiety disorders as base datasets. We used the data of 9- to 10-year-olds from the Adolescent Brain Cognitive Development study (n = 9683) as a target dataset. Sleep disturbance was assessed based on the Sleep Disturbance Scale for Children (SDSC) scores. The effects of PRSs for these psychiatric and neurodevelopmental disorders on the total scores and six subscale scores of the SDSC were investigated. Of the PRSs for the five psychiatric and neurodevelopmental disorders, the PRSs for ADHD and MDD positively correlated with sleep disturbance in children (ADHD: R2 = 0.0033, p = 6.19 × 10−5, MDD: R2 = 0.0042, p = 5.69 × 10−6). Regarding the six subscale scores of the SDSC, the PRSs for ADHD positively correlated with both disorders of initiating and maintaining sleep (R2 = 0.0028, p = 2.31 × 10−4) and excessive somnolence (R2 = 0.0023, p = 8.44 × 10−4). Furthermore, the PRSs for MDD primarily positively correlated with disorders of initiating and maintaining sleep (R2 = 0.0048, p = 1.26 × 10−6), followed by excessive somnolence (R2 = 0.0023, p = 7.74 × 10−4) and sleep hyperhidrosis (R2 = 0.0014, p = 9.55 × 10−3). Despite high genetic overlap between MDD and anxiety disorders, PRSs for anxiety disorders correlated with different types of sleep disturbances such as disorders of arousal or nightmares (R2 = 0.0013, p = 0.011). These findings suggest that greater genetic susceptibility to specific psychiatric and neurodevelopmental disorders, as represented by ADHD, MDD, and anxiety disorders, may contribute to greater sleep problems among children.

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Photobiological neuromodulation of resting-state eeg and steady-state visual-evoked potentials by 40 hz violet light optical stimulation in healthy individuals

Noda Y., Takano M., Hayano M., Li X., Wada M., Nakajima S., Mimura M., Kondo S., Tsubota K.

Journal of Personalized Medicine （Journal of Personalized Medicine）  11 （ 6 ） 557 - 557 2021年06月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  2075-4426

　概要を見る

Photobiological neuromodulation and its clinical application has been investigated in recent years. The response of the gamma-oscillation to human visual stimuli is known to be both burst and resonant in nature, and the coupling between alpha and gamma oscillations may play a functional role in visual processing. To date, there is no study that examined the effects of gamma-frequency violet light (VL) stimulation on human electroencephalography (EEG). In this study, we investigated the neurophysiological changes induced by light stimulation using EEG. The purpose of this study was to evaluate the specific effects of 40 Hz gamma-frequency VL stimulation on EEG activity by comparing the effects of white light (WL) with the same condition. Twenty healthy participants (10 females: 37.5 ± 14.3 years; 10 males: 38.0 ± 13.3 years) participated in this study and the following results were observed. First, when compared with the power spectrum density (PSD) of baseline EEG, 40 Hz-WL induced significant increase of PSD in theta band. Second, compared the PSDs between EEG with 40 Hz-VL and EEG with 40 Hz-WL, 40 Hz-VL induced significantly lower enhancement in delta and theta bands than 40 Hz-WL. Third, when focused on the occipital area, negative peak of VEP with 40 Hz-VL was smaller than that of 40 Hz-WL. Fourth, 40 Hz-VL induced an increase of alpha-gamma coupling during the VEP at the F5 electrode site as well as post-EEG at the C4 electrode site, compared with baseline EEG. Thus, the present study suggested that 40 Hz-VL stimulation may induce unique photobiological neuromodulations on human EEG activity.

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Tms-eeg research to elucidate the pathophysiological neural bases in patients with schizophrenia: A systematic review

Li X., Honda S., Nakajima S., Wada M., Yoshida K., Daskalakis Z.J., Mimura M., Noda Y.

Journal of Personalized Medicine （Journal of Personalized Medicine）  11 （ 5 ）  2021年05月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  2075-4426

　概要を見る

Schizophrenia (SCZ) is a serious mental disorder, and its pathogenesis is complex. Recently, the glutamate hypothesis and the excitatory/inhibitory (E/I) imbalance hypothesis have been proposed as new pathological hypotheses for SCZ. Combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) is a non-invasive novel method that enables us to investigate the cortical activity in humans, and this modality is a suitable approach to evaluate these hypotheses. In this study, we systematically reviewed TMS-EEG studies that investigated the cortical dysfunction of SCZ to examine the emerging hypotheses for SCZ. The following search terms were set in this systematic review: (TMS or ‘transcranial magnetic stimulation’) and (EEG or electroencephalog*) and (schizophrenia). We inspected the articles written in English that examined humans and were pub-lished by March 2020 via MEDLINE, Embase, PsycINFO, and PubMed. The initial search generated 379 studies, and 14 articles were finally identified. The current review noted that patients with SCZ demonstrated the E/I deficits in the prefrontal cortex, whose dysfunctions were also associated with cognitive impairment and clinical severity. Moreover, TMS-induced gamma activity in the prefrontal cortex was related to positive symptoms, while theta/delta band activities were associated with negative symptoms in SCZ. Thus, this systematic review discusses aspects of the pathophysiological neural basis of SCZ that are not explained by the traditional dopamine hypothesis exclusively, based on the findings of previous TMS-EEG research, mainly in terms of the E/I imbalance hypothesis. In conclusion, TMS-EEG neurophysiology can be applied to establish objective biomarkers for better diagnosis as well as to develop new therapeutic strategies for patients with SCZ.

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