研究者詳細 - 荒井　恒憲

論文 - 荒井　恒憲

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The NPe6 fluorescence measurements by using a fluorescence sensing system for skin photosensitivity risk assessment after photodynamic therapy

Ohtani K., Usuda J., Ogawa E., Maehara S., Imai K., Inoue T., Hagiwara M., Kakihana M., Kajiwara N., Ohira T., Arai T., Ikeda N.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE （Progress in Biomedical Optics and Imaging - Proceedings of SPIE） 10476 2018年

ISSN 9781510614376

© 2018 SPIE. Background: Skin photosensitivity is a major side effect of photodynamic therapy (PDT). It is induced by the photosensitizer remaining in the skin. It is usually rapidly metabolized by the liver, but the pharmacokinetic profile varies widely among individuals. This makes it difficult to predict the incidence of skin photosensitivity. Therefore, we conducted a prospective study to investigate whether the NPe6 fluorescence intensity in skin after NPe6-PDT could be measured safely in human patients using a fluorescence sensing system for judging the risk of skin photosensitivity. Methods: The NPe6 fluorescence measurements using a constructed fluorescence sensing system at the inside of the arm were acquired prior to and 5 and 10 minutes after NPe6 administration as well as at the time of PDT (4-5 hours after administration), at discharge (2 or 3 days after PDT), and at 1 or 2 weeks after PDT. Participants were interviewed as to whether they had any complications at 2 weeks after PDT. Results: Nine male patients and one female patient entered this study. All of the measurements of NPe6 fluorescence in the skin could be obtained without any complications. The spectral peak was detected at the time of discharge (2-3 days after administration) in most cases and it decreased at 1 or 2 weeks after PDT. Conclusions: The fluorescence of NPe6 in the skin could be detected feasibly using the fluorescence sensing system in human patients. Measuring fluorescence intensity in the skin might be useful to predict the incidence of skin photosensitivity after PDT.

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Skin fluorescence following photodynamic therapy with NPe6 photosensitizer

K. Ohtani, J. Usuda, E. Ogawa, S. Maehara, K. Imai, Y. Kudo, S. Ono, S.Shigefuku, D. Eriguchi, T. Inoue, J. Maeda, K. Yoshida, M. Hagiwara, M.Kakihana, N. Kajiwara, T. Ohira, T. Arai, N. Ikeda,

Photodiagnosis and Photodynamic Therapy 20 201 - 214 2017年12月

研究論文（学術雑誌）

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Development of a practical animal model of photodynamic therapy using a high concentration of extracellular talaporfin sodium in interstitial fluid: influence of albumin animal species on myocardial cell photocytotoxicity in vitro

E. Ogawa and T. Arai

Lasers in Medical Science 32 （ 9 ） 2105 - 2109 2017年10月

研究論文（学術雑誌）

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Temperature influence on myocardial cell cytotoxicity of the extracellular photosensitization reaction with talaporfin sodium and serum proteins at 17–37°C

E. Ogawa, H. Takenoya, T. Arai

Photomedicine and Laser Surgery 35 （ 10 ） 555 - 559 2017年10月

Irradiance dependence of the conduction block of an in bitro cardiomyocyte wire

E.Ogawa, M. Kurotsu, T. Arai

Photodiagnosis and Photodynamic Therapy 19 93 - 97 2017年09月

研究論文（学術雑誌）

Effect of a photosensitization reaction performed during the first 3 minutes after rat myocardial cells exposed to talaporfin sodium in vitro

M. Doi, E. Ogawa, and T. Arai

Lasers in Medical Science 32 （ 8 ） 1873 - 1878 2017年08月

研究論文（学術雑誌）

Phototoxicity of vascular endothelial cells due to contact with talaporfin sodium for 15–120 min: in vitro and in vivo study

Hamada, Risa; Ogawa, Emiyu; Arai, Tsunenori

Photomedicine and Laser Surgery 35 （ 6 ） 305 - 310 2017年06月

レーザによる革新的な非熱的不整脈治療装置：我が国発技術の実用化

小川恵美悠、荒井恒憲

月刊オプトロニクス　特集「光・レーザー医学の新潮流」（ 3 ） 2017年

研究論文（学術雑誌）

3-compartment dynamic model of talaporfin sodium pharmacokinetics in silico

荒井恒憲