論文 - 北　洋輔

運動の不器用さと抑制性の事象関連電位の関係

江頭 優佳, 北 洋輔, 鈴木 浩太, 白川 由佳, 加賀 佳美, 北村 柚葵, 三橋 翔太, 新垣 香菜子, 稲垣 真澄, 奥住 秀之

臨床神経生理学 （(一社)日本臨床神経生理学会）  46 （ 5 ） 445 - 445 2018年10月

ISSN  1345-7101

遺伝子多型が抑制機能の事象関連電位に及ぼす影響

北 洋輔, 鈴木 浩太, 白川 由佳, 江頭 優佳, 加賀 佳美, 北村 柚葵, 三橋 翔太, 新垣 香菜子, 稲垣 真澄, 奥住 秀之

臨床神経生理学 （(一社)日本臨床神経生理学会）  46 （ 5 ） 446 - 446 2018年10月

ISSN  1345-7101

Applicability of the Movement Assessment Battery for Children-Second Edition (MABC-2) for Japanese children aged 3-6 years: a preliminary investigation emphasizing internal consistency and factorial validity.

Hirata S, Kita Y, Yasunaga M, Suzuki K, Okumura Y, Okuzumi H, Hosobuchi T, Kokubun M, Inagaki M, Nakai A

Frontiers in Psychology 9 （ 1452 ） 1452 - 1452 2018年08月

査読有り

　概要を見る

This study investigated the applicability of the Movement Assessment Battery for Children - Second Edition (MABC-2) for 3- to 6-year-old Japanese children, particularly addressing its internal consistency and factorial validity. The MABC-2 test set for 3- to 6-year-old children was administered to 252 children. Differences between Japanese children and those of the original normative sample (i.e. United Kingdom children) were investigated along with sex differences. The Japanese children aged 3-6 years were found to have higher Manual Dexterity and Balance component scores than children of the normative sample. Girls scored higher than boys on the Balance component. Results of several analyses showed good internal consistency of the MABC-2. Confirmatory factor analysis revealed that a theoretical three-component model of the MABC-2 was not fitted to Japanese children aged 3-6 years. Instead, a new three-component model was postulated and discussed. The new three-component model of the MABC-2, with Manual Dexterity, Static Balance and Ball Skills, and Dynamic Balance, has high factorial validity in Japanese children aged 3-6 years.

• Access to Document (DOI)

The relationship between the superior frontal cortex and alpha oscillation in a flanker task: Simultaneous recording of electroencephalogram (EEG) and near infrared spectroscopy (NIRS)

Kota Suzuki, Yasuko Okumura, Yosuke Kita, Yuhei Oi, Haruo Shinoda, Masumi Inagaki

Neuroscience Research （Elsevier Ireland Ltd）  131   30 - 35 2018年06月

査読有り,  ISSN  1872-8111

　概要を見る

Activity in the alpha band of the electroencephalogram (EEG) reflects functional inhibition of the cerebral cortex. The superior frontal cortex (SFC) is known to control alpha activity. Based on this relationship between SFC and alpha, we hypothesized that SFC controlled alpha mediates proactive control over interference. In this study, we examined the relationship between SFC and alpha in the flanker task by simultaneously recording EEG and near infrared spectroscopy (NIRS). Forty participants performed a flanker task with occasional (compatible 75%, incompatible 25%) and successive (incompatible 100%) conditions. In the occasional condition, larger SFC activity was related to pre-stimulus alpha enhancement under occipital electrodes. This is consistent with a model in which SFC enhances pre-stimulus alpha activity, leading to proactive control over interference. However, we could not detect a correlation between SFC activity and alpha activity in the successive condition. Active inhibition may have been reduced by a need to continuously inhibit brain regions associated with the irrelevant information. This may have reduced the role of the SFC in controlling alpha activity. Based on these findings, we postulate that there are two cerebral mechanisms of proactive control over interference.

• Access to Document (DOI)

Right prefrontal cortex specialization for visuospatial working memory and developmental alterations in prefrontal cortex recruitment in school-age children

Kota Suzuki, Yosuke Kita, Yuhei Oi, Yasuko Okumura, Hideyuki Okuzumi, Masumi Inagaki

Clinical Neurophysiology （Elsevier Ireland Ltd）  129 （ 4 ） 759 - 765 2018年04月

査読有り,  ISSN  1872-8952

　概要を見る

Objective: The right prefrontal cortex (PFC) plays an essential role in active processing within visuospatial working memory (VSWM). The aim of this study was to examine developmental changes in the recruitment patterns of the PFC during visuospatial memory tasks in school-age participants. Methods: We recruited 80 school-age children who were classified into three age groups: 7- to 8-year-old, 9- to 10-year-old, and 11- to 12-year-old children. We used near infrared spectroscopy (NIRS) to measure PFC activity during visuospatial memory task. Memory stimuli were presented either sequentially or simultaneously. Results: In all three groups, right-lateralized PFC activity was observed during sequential presentation, suggesting specialization of the right PFC for VSWM. During simultaneous presentation, right-lateralized PFC activity was not observed in 7- to 8-year-old children or 9- to 10-year-old children. In contrast, PFC activity was right-lateralized in 11- to 12-year-old children. Conclusions: We suggest that specialization of the right PFC for VSWM is already present before school-age, but widely distributed activity in response to visuospatial memory tasks changes to more focal activity in VSWM-specific regions during the early school years. Significance: Using NIRS, we showed developmental changes in the recruitment patterns of the PFC during visuospatial memory tasks.

• Access to Document (DOI)

ABNORMAL FEEDBACK-RELATED NEGATIVITY FOR PARTNER'S ERRORS IN CHILDREN WITH AUTISM SPECTRUM DISORDER

Yosuke Kita, Kota Suzuki, Yasuko Okumura, Shogo Hirata, Hideyuki Okuzumi, Masumi Inagaki

PSYCHOPHYSIOLOGY （WILEY）  54   S87 - S87 2017年12月

ISSN  0048-5772

PURE AND SHORT-TERM PHONICS-TRAINING IMPROVES PRINT-SPECIFIC ERP IN ENGLISH: A CASE STUDY OF A JAPANESE MIDDLE SCHOOL GIRL

Yasuko Okumura, Yosuke Kita, Masumi Inagaki

PSYCHOPHYSIOLOGY （WILEY）  54   S125 - S125 2017年12月

ISSN  0048-5772

Excessive hemodynamic activity in the superior frontal cortex during the flanker task in children with attention deficit hyperactivity disorder

Kota Suzuki, Yasuko Okumura, Yosuke Kita, Yuhei Oi, Yushiro Yamashita, Takaaki Goto, Masumi Inagaki

NEUROREPORT （LIPPINCOTT WILLIAMS & WILKINS）  28 （ 13 ） 828 - 832 2017年09月

査読有り,  ISSN  0959-4965

　概要を見る

Near-infrared spectroscopy studies in children with attention deficit hyperactivity disorder (ADHD) have shown excessive prefrontal activity responsible for coping with interference. However, it is possible that the previous results were influenced by verbal, reading, and memory developments. The flanker task is an interference task that does not require a verbal response, reading, or memorization. We examined activity in the superior frontal cortex (SFC) during the flanker task in 12 children with ADHD and 14 children with typical development using near-infrared spectroscopy. SFC activity was significantly greater in children with ADHD than in those with typical development. The results showed excessive interference coping activity in children with ADHD irrespective of verbal, reading, and memory development. Moreover, SFC activity was positively correlated with the inattention subscale score of the ADHD rating scale. We suggest that children with ADHD need greater SFC activation to cope with interference, and the inefficient mechanism is demanding and hard to sustain, which causes inattention symptoms of children with ADHD.

• Access to Document (DOI)

Training Attention to the Other’s Need Improves Helping Behaviors in Children with Autism Spectrum Disorder: A Behavioral Analysis Using a Two-dimensional Motion Capture System

Yosuke Kita, Atsuko Gunji, Ryusuke Sakuma, Takaaki Goto, Yasuko Okumura, Masumi Inagaki

Frontiers in Education （Frontiers Media SA）  2 （ 50 ） 1 - 7 2017年09月

査読有り

• Access to Document (DOI)

The Direct/Indirect Association of ADhD/ODD Symptoms with Self-esteem, Self-perception, and Depression in Early Adolescents

Yosuke Kita, Yuki Inoue

FRONTIERS IN PSYCHIATRY （FRONTIERS MEDIA SA）  8   137 2017年07月

査読有り,  ISSN  1664-0640

　概要を見る

The present study aimed to reveal the influences of attention-deficit hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD) symptoms on self-esteem and self-perception during early adolescence and to clarify the spillover effect of self-esteem on depressive symptoms. ADHD symptoms in 564 early adolescents were evaluated via teacher-rating scales. Self-esteem and depressive symptoms were assessed via self-reported scales. We analyzed the relationships among these symptoms using structural equation modeling. Severe inattentive symptoms decreased self-esteem and hyperactive-impulsive symptoms affected self-perception for non-academic domains. Although these ADHD symptoms did not directly affect depressive symptoms, low self-esteem led to severe depression. ODD symptoms had a direct impact on depression without the mediating effects of self-esteem. These results indicated that inattentive symptoms had a negative impact on self-esteem and an indirect negative effect on depressive symptoms in adolescents, even if ADHD symptoms were subthreshold. Severe ODD symptoms can be directly associated with depressive symptoms during early adolescence.

• Access to Document (DOI)

Mental Health Inventory for Infants: Scale Development and Japanese Infants' Characteristics

Maiko Suto, Yosuke Kita, Kota Suzuki, Masumi Inagaki, Chizuru Misago

JOURNAL OF CHILD AND FAMILY STUDIES （SPRINGER）  26 （ 6 ） 1546 - 1553 2017年06月

査読有り,  ISSN  1062-1024

　概要を見る

Early detection and treatment promote positive outcomes in mental health problems among infants. This study developed a simple and reliable screening inventory for infants' mental health. Participants were 579 primary caregivers who had Japanese infants aged 2-6 years. Participants evaluated their children using the Mental Health Inventory for Infants (MHII; developed in this study), which contains 24 items. Exploratory factorial analysis identified the MHII factor structure; confirmatory factorial analysis examined its factorial validity. Internal consistency and criterion-related validity were also examined. Irritability (8 items), somatic symptoms (6 items), and signs of insecurity (4 items) were identified as factors in the MHII; each of these factors measures a critical aspect of infants' mental health. The MHII's internal consistency and scale homogeneity were acceptable; its criterion-related validity was supported. In this study, male infants exhibited greater irritability and less insecurity than females. The present results support the MHII's reliability and validity; additionally, they indicate that caregivers may use the MHII to quickly screen for three critical aspects of infants' mental health. We expect that the MHII will be used for early detection of mental health difficulties in infants to facilitate treatment.

• Access to Document (DOI)

Spatial working memory encoding type modulates prefrontal cortical activity

Yuhei Oi, Yosuke Kita, Kota Suzuki, Yasuko Okumura, Hideyuki Okuzumi, Haruo Shinoda, Masumi Inagaki

NEUROREPORT （LIPPINCOTT WILLIAMS & WILKINS）  28 （ 7 ） 391 - 396 2017年05月

査読有り,  ISSN  0959-4965

　概要を見る

Spatial working memory (SWM) involves both simultaneous and sequential encoding, but the differences in their neural correlates are unclear. We investigated the differences in prefrontal cortex activity related to these SWM encoding types. We also examined the patterns of brain activity influencing individual visuospatial abilities (VSA). We conducted SWM tasks with two different conditions, sequential and simultaneous encoding, and examined hemodynamic activity in 39 healthy adults using nearinfrared spectroscopy. The bilateral dorsolateral prefrontal cortex was activated more strongly in the sequential condition compared with the simultaneous condition. This suggests that prefrontal cortex activity underlying SWM is modulated by the type of encoding. We also found that individuals with high VSA showed weaker activation in the right-dorsolateral prefrontal cortex compared with those with lower VSA during the simultaneous condition. This hypoactivation is thought to reflect neural efficiency in the individuals with high ability. These findings are expected to lead to a better understanding of neural substrates for SWM. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.

• Access to Document (DOI)

子どもの運動の不器用さがメンタルヘルスに与える影響の解明 : メンタルヘルスの悪化予防に向けて

北 洋輔, 鈴木 浩太, 平田 正吾, 奥村 安寿子, 崎原 ことえ, 安永 正則, 中井 昭夫, 奥住 秀之, 稲垣 真澄

若手研究者のための健康科学研究助成成果報告書 = Research-aid report （明治安田厚生事業団）  32   23 - 28 2017年04月

査読有り

片側巨脳症における半球離断術後の非罹患側の脳波経過と発達

高橋 孝治, 中川 栄二, 竹下 絵里, 本橋 裕子, 石山 昭彦, 齋藤 貴志, 小牧 宏文, 須貝 研司, 北 洋輔, 高橋 章夫, 大槻 泰介, 佐々木 征行

てんかん研究 （(一社)日本てんかん学会）  34 （ 3 ） 619 - 627 2017年01月

査読有り,  ISSN  0912-0890

　概要を見る

片側巨脳症は、出生後早期から早期乳児てんかん性脳症などの難治性てんかんを認め、最重度の精神運動発達遅滞を呈することが多い発達予後不良の疾患である。薬物療法が無効のため生後早期に大脳半球離断術が行われることが多い。術後の経過中に、てんかん発作が消失しても非罹患側に脳波異常の出現を認めることがある。半球離断術によりてんかん発作が消失した症例を対象に、非罹患側の経時的脳波変化と発達月齢、発達指数との関係について後方視的に検討した。片側巨脳症の半球切除術後でてんかん発作の消失した症例では、術後の発達指数は全例で低下傾向だったが、発達月齢は運動・言語発達とも全例で緩徐ながら伸びていた。術後の発達は、発達指数よりも発達月齢で評価した方が、術後臨床的に発達を認める実態を把握しやすい。また経過中に非罹患側の突発活動が出現することがあり、その増加率が高いと表出性言語発達が遅滞する可能性が示唆された。(著者抄録)

• Access to Document (DOI)

Pure and Short-Term Phonics-Training Improves Reading and Print-Specific ERP in English: A Case Study of a Japanese Middle School Girl

Yasuko Okumura, Yosuke Kita, Masumi Inagaki

DEVELOPMENTAL NEUROPSYCHOLOGY （ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD）  42 （ 4 ） 265 - 275 2017年

査読有り,  ISSN  8756-5641

　概要を見る

Although phonics is the most frequently used approach in treating students with reading difficulties, its effects have not been fully clarified at either a behavioral or neurophysiological level. The present case study administered pure and short-term (i.e., 10minutes per day for five weeks) phonics-training to a 13-year-old Japanese girl with severe difficulty in learning English. As a result, a drastic improvement in reading accuracy was associated with the enhancement of print-specific N170 in event-related potentials (ERPs) elicited by the trained words. The present finding indicates that phonics training can, by itself, remediate English reading and affect its neurophysiological bases.

• Access to Document (DOI)

Uniqueness of action monitoring in children with autism spectrum disorder: Response types and temporal aspects

Kota Suzuki, Yosuke Kita, Kotoe Sakihara, Shogo Hirata, Ryusuke Sakuma, Hideyuki Okuzumi, Masumi Inagaki

JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY （TAYLOR & FRANCIS INC）  39 （ 8 ） 803 - 816 2017年

査読有り,  ISSN  1380-3395

　概要を見る

Background: Action monitoring, the process for evaluating the appropriateness of one's own actions, is reported to be atypical in individuals with autism spectrum disorder (ASD). Method: We examined the characteristics of action monitoring in 11 children with ASD and 12 children with typical development (TD), analyzing stimulus-locked and response-locked event-related potential components (i.e., N2; error-related negativity, ERN; and error positivity, Pe) related to execution of a flanker task. Results: We found a smaller N2 amplitude in children with ASD than in those with TD. Children with ASD also had a larger amplitude of ERN for partial error responses (electromyographic activity corresponding to the inappropriate hand side before response execution) than did children with TD. Additionally, the ERN amplitude for the partial error response was correlated with the Autistic Mannerisms of the Social Responsiveness Scale. There were no significant differences in Pe amplitudes between children with ASD and those with TD. Conclusion: The results suggest that action monitoring in children with ASD is significantly different both before and after response execution. We hypothesized that the detail-focused processing style of ASD reduces the demands of action monitoring before response execution; however, autistic mannerisms evoke excessive concern regarding trivial mistakes after response execution.

• Access to Document (DOI)

P値の呪縛

北 洋輔

脳と発達 （一般社団法人 日本小児神経学会）  49 （ 6 ） 386 - 386 2017年

• Access to Document (DOI)

視空間性ワーキングメモリー課題における背外測前頭前皮質の活動の発達的変化 : 近赤外分光法による検討

鈴木 浩太, 北 洋輔, 大井 雄平, 奥村 安寿子, 奥住 秀之, 稲垣 真澄

認知神経科学 （認知神経科学会）  19 （ 2 ） 92_2 - 92_2 2017年

ISSN  1344-4298

• Access to Document (DOI)

黒胡椒嗅覚刺激により嚥下機能が改善した蘇生後脳症の小児症例

中村 達也, 野村 芳子, 加藤 真希, 北 洋輔, 鮎澤 浩一, 小沢 浩

日本重症心身障害学会誌 = Journal of severe motor and intellectual disabilities （日本重症心身障害学会）  41 （ 3 ） 445 - 449 2016年12月

査読有り,  ISSN  1343-1439

Neural oscillations in the temporal pole for a temporally congruent audio-visual speech detection task

Takefumi Ohki, Atsuko Gunji, Yuichi Takei, Hidetoshi Takahashi, Yuu Kaneko, Yosuke Kita, Naruhito Hironaga, Shozo Tobimatsu, Yoko Kamio, Takashi Hanakawa, Masumi Inagaki, Kazuo Hiraki

SCIENTIFIC REPORTS （NATURE PUBLISHING GROUP）  6   37973 2016年11月

査読有り,  ISSN  2045-2322

　概要を見る

Though recent studies have elucidated the earliest mechanisms of processing in multisensory integration, our understanding of how multisensory integration of more sustained and complicated stimuli is implemented in higher-level association cortices is lacking. In this study, we used magnetoencephalography (MEG) to determine how neural oscillations alter local and global connectivity during multisensory integration processing. We acquired MEG data from 15 healthy volunteers performing an audio-visual speech matching task. We selected regions of interest (ROIs) using whole brain time-frequency analyses (power spectrum density and wavelet transform), then applied phase amplitude coupling (PAC) and imaginary coherence measurements to them. We identified prominent delta band power in the temporal pole (TP), and a remarkable PAC between delta band phase and beta band amplitude. Furthermore, imaginary coherence analysis demonstrated that the temporal pole and well-known multisensory areas (e.g., posterior parietal cortex and post-central areas) are coordinated through delta-phase coherence. Thus, our results suggest that modulation of connectivity within the local network, and of that between the local and global network, is important for audio-visual speech integration. In short, these neural oscillatory mechanisms within and between higher-level association cortices provide new insights into the brain mechanism underlying audio-visual integration.

• Access to Document (DOI)