論文 - 北　洋輔

片側巨脳症における半球離断術後の非罹患側の脳波経過と発達

高橋 孝治, 中川 栄二, 竹下 絵里, 本橋 裕子, 石山 昭彦, 齋藤 貴志, 小牧 宏文, 須貝 研司, 北 洋輔, 高橋 章夫, 大槻 泰介, 佐々木 征行

てんかん研究 （(一社)日本てんかん学会）  34 （ 3 ） 619 - 627 2017年01月

査読有り,  ISSN  0912-0890

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片側巨脳症は、出生後早期から早期乳児てんかん性脳症などの難治性てんかんを認め、最重度の精神運動発達遅滞を呈することが多い発達予後不良の疾患である。薬物療法が無効のため生後早期に大脳半球離断術が行われることが多い。術後の経過中に、てんかん発作が消失しても非罹患側に脳波異常の出現を認めることがある。半球離断術によりてんかん発作が消失した症例を対象に、非罹患側の経時的脳波変化と発達月齢、発達指数との関係について後方視的に検討した。片側巨脳症の半球切除術後でてんかん発作の消失した症例では、術後の発達指数は全例で低下傾向だったが、発達月齢は運動・言語発達とも全例で緩徐ながら伸びていた。術後の発達は、発達指数よりも発達月齢で評価した方が、術後臨床的に発達を認める実態を把握しやすい。また経過中に非罹患側の突発活動が出現することがあり、その増加率が高いと表出性言語発達が遅滞する可能性が示唆された。(著者抄録)

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Pure and Short-Term Phonics-Training Improves Reading and Print-Specific ERP in English: A Case Study of a Japanese Middle School Girl

Yasuko Okumura, Yosuke Kita, Masumi Inagaki

DEVELOPMENTAL NEUROPSYCHOLOGY （ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD）  42 （ 4 ） 265 - 275 2017年

査読有り,  ISSN  8756-5641

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Although phonics is the most frequently used approach in treating students with reading difficulties, its effects have not been fully clarified at either a behavioral or neurophysiological level. The present case study administered pure and short-term (i.e., 10minutes per day for five weeks) phonics-training to a 13-year-old Japanese girl with severe difficulty in learning English. As a result, a drastic improvement in reading accuracy was associated with the enhancement of print-specific N170 in event-related potentials (ERPs) elicited by the trained words. The present finding indicates that phonics training can, by itself, remediate English reading and affect its neurophysiological bases.

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P値の呪縛

北 洋輔

脳と発達 （一般社団法人 日本小児神経学会）  49 （ 6 ） 386 - 386 2017年

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Uniqueness of action monitoring in children with autism spectrum disorder: Response types and temporal aspects

Kota Suzuki, Yosuke Kita, Kotoe Sakihara, Shogo Hirata, Ryusuke Sakuma, Hideyuki Okuzumi, Masumi Inagaki

JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY （TAYLOR & FRANCIS INC）  39 （ 8 ） 803 - 816 2017年

査読有り,  ISSN  1380-3395

　概要を見る

Background: Action monitoring, the process for evaluating the appropriateness of one's own actions, is reported to be atypical in individuals with autism spectrum disorder (ASD). Method: We examined the characteristics of action monitoring in 11 children with ASD and 12 children with typical development (TD), analyzing stimulus-locked and response-locked event-related potential components (i.e., N2; error-related negativity, ERN; and error positivity, Pe) related to execution of a flanker task. Results: We found a smaller N2 amplitude in children with ASD than in those with TD. Children with ASD also had a larger amplitude of ERN for partial error responses (electromyographic activity corresponding to the inappropriate hand side before response execution) than did children with TD. Additionally, the ERN amplitude for the partial error response was correlated with the Autistic Mannerisms of the Social Responsiveness Scale. There were no significant differences in Pe amplitudes between children with ASD and those with TD. Conclusion: The results suggest that action monitoring in children with ASD is significantly different both before and after response execution. We hypothesized that the detail-focused processing style of ASD reduces the demands of action monitoring before response execution; however, autistic mannerisms evoke excessive concern regarding trivial mistakes after response execution.

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視空間性ワーキングメモリー課題における背外測前頭前皮質の活動の発達的変化 : 近赤外分光法による検討

鈴木 浩太, 北 洋輔, 大井 雄平, 奥村 安寿子, 奥住 秀之, 稲垣 真澄

認知神経科学 （認知神経科学会）  19 （ 2 ） 92_2 - 92_2 2017年

ISSN  1344-4298

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黒胡椒嗅覚刺激により嚥下機能が改善した蘇生後脳症の小児症例

中村 達也, 野村 芳子, 加藤 真希, 北 洋輔, 鮎澤 浩一, 小沢 浩

日本重症心身障害学会誌 = Journal of severe motor and intellectual disabilities （日本重症心身障害学会）  41 （ 3 ） 445 - 449 2016年12月

査読有り,  ISSN  1343-1439

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Neural oscillations in the temporal pole for a temporally congruent audio-visual speech detection task

Takefumi Ohki, Atsuko Gunji, Yuichi Takei, Hidetoshi Takahashi, Yuu Kaneko, Yosuke Kita, Naruhito Hironaga, Shozo Tobimatsu, Yoko Kamio, Takashi Hanakawa, Masumi Inagaki, Kazuo Hiraki

SCIENTIFIC REPORTS （NATURE PUBLISHING GROUP）  6   37973 2016年11月

査読有り,  ISSN  2045-2322

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Though recent studies have elucidated the earliest mechanisms of processing in multisensory integration, our understanding of how multisensory integration of more sustained and complicated stimuli is implemented in higher-level association cortices is lacking. In this study, we used magnetoencephalography (MEG) to determine how neural oscillations alter local and global connectivity during multisensory integration processing. We acquired MEG data from 15 healthy volunteers performing an audio-visual speech matching task. We selected regions of interest (ROIs) using whole brain time-frequency analyses (power spectrum density and wavelet transform), then applied phase amplitude coupling (PAC) and imaginary coherence measurements to them. We identified prominent delta band power in the temporal pole (TP), and a remarkable PAC between delta band phase and beta band amplitude. Furthermore, imaginary coherence analysis demonstrated that the temporal pole and well-known multisensory areas (e.g., posterior parietal cortex and post-central areas) are coordinated through delta-phase coherence. Thus, our results suggest that modulation of connectivity within the local network, and of that between the local and global network, is important for audio-visual speech integration. In short, these neural oscillatory mechanisms within and between higher-level association cortices provide new insights into the brain mechanism underlying audio-visual integration.

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Applicability of the Movement Assessment Battery for Children-Second Edition to Japanese children: A study of the Age Band 2

Yosuke Kita, Kota Suzuki, Shogo Hirata, Kotoe Sakihara, Masumi Inagaki, Akio Nakai

BRAIN & DEVELOPMENT （ELSEVIER SCIENCE BV）  38 （ 8 ） 706 - 713 2016年09月

査読有り,  ISSN  0387-7604

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Background: The diagnosis of Developmental Coordination Disorder (DCD) requires a precise assessment of motor skills via a standardized tool such as the Movement Assessment Battery for Children-Second Edition (MABC-2). Although the MABC-2 has been widely used in English-speaking countries, to the best of our knowledge, no studies have examined its applicability to Japanese children. Thus, it has been difficult to diagnose DCD in Japan.
Aims: As a preliminary investigation preceding its formal standardization in Japan, we examined the applicability of the MABC-2.
Methods and procedures: Participants comprised 132 typically developing Japanese children who completed a test set of the MABC-2 for Age Band 2. We analyzed both internal consistency and factorial validity for our Japanese sample. We also included a comparison between our sample of Japanese children and the normative sample of the MABC-2, as well as an examination of gender differences.
Outcomes and results: Our results indicated acceptable internal consistency and scale homogeneity. High factorial validity, which has not been examined in other populations, was also confirmed for the test set. Moreover, we found differences in component scores between the Japanese and normative children with respect to Manual Dexterity and Balance. We also found that girls obtained superior Manual Dexterity and Balance scores compared with boys.
Conclusions and Implications: The present findings represent the first step towards the standardization of the MABC-2 in a Japanese population. (C) 2016 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

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The Association between Children's Behavior and Parenting of Caregivers: A Longitudinal Study in Japan.

Suzuki K, Kita Y, Kaga M, Takehara K, Misago C, Inagaki M

Frontiers in public health （FRONTIERS MEDIA SA）  4   17 2016年02月

査読有り,  ISSN  2296-2565

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The purpose of this study was to elucidate the association between children's behavior (i.e., prosocial and problematic behavior) and the parenting style (i.e., laxness and overreactivity) of their caregivers by using longitudinal data in the Japanese population. These data were collected when the children were 7.5 and 9 years. We proposed three hypotheses: children's behavior at 7.5 years will predict their behavior at 9 years; children's behavior at 7.5 years will predict the parenting of their caregivers; and the parenting style of caregivers will affect their children's behavior at 9 years. We evaluated children's behavior and parenting behavior using a strength and difficulties questionnaire and a parenting scale. The hypotheses were tested using structural equation modeling (SEM). The results of the SEM showed that children's behavior at 7.5 years predicted their behavior at 9 years. Children's problematic behavior at 7.5 years triggered over-reactive parenting in their caregivers at 9 years, which increased problematic behavior and decreased prosocial behavior in the children at 9 years. These findings indicate the association between children's behavior and the parenting style of caregivers in Japan.

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ADHD児におけるニューロフィードバック療法の効果予測

奥村 安寿子, 北 洋輔, 大森 幹真, 鈴木 浩太, 福田 亜矢子, 安村 明, 稲垣 真澄

認知神経科学 （認知神経科学会）  18 （ 2 ） 86_2 - 86_2 2016年

ISSN  1344-4298

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Down症児の粗大運動発達力が摂食嚥下機能の発達に与える影響

中村 達也, 鮎澤 浩一, 北 洋輔, 甲斐 智子, 小沢 浩

言語聴覚研究 （日本言語聴覚士協会 ; 2004-）  13 （ 1 ） 3 - 10 2016年

査読有り,  ISSN  1349-5828

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ADHD児の空間性ワーキングメモリにかかわる脳血流動態の特徴

大井 雄平, 北 洋輔, 鈴木 浩太, 奥村 安寿子, 奥住 秀之, 山下 裕史朗, 稲垣 真澄

認知神経科学 （認知神経科学会）  18 （ 2 ） 93_2 - 93_2 2016年

ISSN  1344-4298

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学習障害の成人期までの経過と治療の考え方 (特集 出口を見据えた精神医療 : 何処をめざし如何に診るか)

北 洋輔, 稲垣 真澄

精神保健研究 = Journal of mental health : official journal of the National Institute of Mental Health, NCNP, Japan （国立精神・神経医療研究センター精神保健研究所）   （ 29 ） 73 - 80 2016年

査読有り,  ISSN  0915-065X

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視覚誘発電位を用いた緑内障・高眼圧症の大細胞系機能評価

山崎 広子, 北 洋輔, 小林 朋佳, 加我 牧子, 稲垣 真澄

臨床神経生理学 （一般社団法人 日本臨床神経生理学会）  44 （ 1 ） 11 - 19 2016年

査読有り

　概要を見る

<p>緑内障・高眼圧症の大細胞系機能の他覚的評価のため低空間周波数, 高時間周波数, 低コントラストの視覚刺激 (M刺激) を新たに作成し, pattern reversal条件でVEPを記録した。緑内障例8名, 高眼圧症例5名, 健常対照13名のOz部VEP波形をComplex demodulation法により解析しpeak振幅を求めた。疾患群のVEP peak振幅値はコントラスト10%と15%で有意に低下した。コントラストの対数値対peak振幅のプロットに基づく回帰直線から算出したコントラスト閾値は疾患群で有意に高値を示した (<i>p</i><0.05) 。疾患群の13眼中6眼において, コントラスト閾値が健常群の平均+2SDの値 (4.49%) を超えていた。以上からM刺激によるVEP検査は, 緑内障・高眼圧症症例の網膜から第一次視覚野までの大細胞系機能障害を早期に, 他覚的かつ定量的に捉えうることが示された。</p>

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Lateralized frontal activity for Japanese phonological processing during child development

Takaaki Goto, Yosuke Kita, Kota Suzuki, Toshihide Koike, Masumi Inagaki

FRONTIERS IN HUMAN NEUROSCIENCE （FRONTIERS MEDIA SA）  9   417 2015年07月

査読有り,  ISSN  1662-5161

　概要を見る

Phonological awareness is essential for reading, and is common to all language systems, including alphabetic languages and Japanese. This cognitive factor develops during childhood, and is thought to be associated with shifts in brain activity. However, the nature of this neurobiological developmental shift is unclear for speakers of Japanese, which is not an alphabetical language. The present study aimed to reveal a shift in brain functions for processing phonological information in native-born Japanese children. We conducted a phonological awareness task and examined hemodynamic activity in 103 children aged 7-12 years. While younger children made mistakes and needed more time to sort phonological information in reverse order, older children completed the task quickly and accurately. Additionally, younger children exhibited increased activity in the bilateral dorsolateral prefrontal cortex (DLPFC), which may be evidence of immature phonological processing skills. Older children exhibited dominant activity in the left compared with the right DLPFC, suggesting that they had already acquired phonological processing skills. We also found significant effects of age and lateralized activity on behavioral performance. During earlier stages of development, the degree of left lateralization appears to have a smaller effect on behavioral performance. Conversely, in later stages of development, the degree of left lateralization appears to have a stronger influence on behavioral performance. These initial findings regarding a neurobiological developmental shift in Japanese speakers suggest that common brain regions play a critical role in the development of phonological processing skills among different languages systems, such as Japanese and alphabetical languages.

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自閉症スペクトラム障害児の不器用さに対する認知指向型・家族参加型グループリハビリテーションの試み : しまはちチャレンジグループの有効性と課題

多辺田 俊平, 相崎 貢一, 北 洋輔

作業療法 = Japanese occupationai therapy researh : JOTR （日本作業療法士協会 ; 1982-）  34 （ 3 ） 307 - 316 2015年06月

査読有り,  ISSN  0289-4920

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[Brain functions in developmental dyslexia].

Kita Y

No to hattatsu. Brain and development 47 （ 3 ） 194 - 197 2015年05月

査読有り,  ISSN  0029-0831

A preliminary study of the Movement Assessment Battery for Children-Second Edition on Japanese children: Age band 1

Suzuki K, Hirata S, Kita Y, Sakihara K, Inagaki M, Nakai A

Journal of Comorbidity 5   101 2015年

査読有り

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Longitudinal change in motor skills in children with autism spectrum disorders

Hirata S, Kita Y, Suzuki K, Okuzumi H, Kokubun M, Nakai A

Journal of Comorbidity 5   83 2015年

査読有り

A preliminary study of the Movement Assessment Battery for Children-Second Edition on Japanese children: Age Band 2

Kita Y, Hirata S, Suzuki K, Sakihara K, Inagaki M, Nakai A

Journal of Comorbidity 5   86 2015年

査読有り

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